HMOs. ( 2'-Fucosyllactose) Cell Factory For. Human
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1 HMOs ( 2'-Fucosyllactose) Cell Factory For Human
2 Introduction 1. Vision "Cell factory for human" Redesign of microorganisms High cell density culture High efficiency purification Commercialization technology Human milk oligosaccharides Process development Recombinant Proteins 2. History Foundation (Seoul National University) 2001 Process development service for customer proteins rprotein production for research (hgh, IFN, GCSF ) Bioconversion process (detoxification of chemical) Manufacturing proteins for biopharmaceutical process (ProteinA, Growth factors) HMOs development Technology development research (Metabolic engineering) Construction of HMOs plant Capacity : approx. 100ton/year 3. Products and services HMOs (Human Milk Oligosaccharides) : 2'-Fucosyllactose (2'-FL), 3-Fucosyllactose (3-FL) Proteins : ProteinA/G/L, Collagenase H/G, EGF, IGF Process development for recombinant protein (Customized)
3 4. Human Milk Oligosaccharides (HMOs) Benefits of breastfeeding Human Milk Component (g/l) Bovine Milk 8 Protein Fat Lactose Oligosaccharides 0.05 (5~8) 2'-FL (<0.001) WHO strongly recomends breastfeeding for more than 6 months Promotes brain cell protection, brain development Reduction of pediatric rheumatoid arthritis Visual acuity is higher in babies fed human milk Reduction of allergic reaction such as atopy Prevention of external infection via ear and respiratory system Breastfed children have lower cholesterol Prevention of gastrointestinal infection and diarrhea Decrease on child s obesity and the likelihood of occurrence of diabetes Decreased risk of childhood cancer and helps to mature immune system 2'-Fucosyllactose (2'-FL) is major component of HMOs Develop beneficial gut microbium Lower inflammatory cytokines Lower virus infection (animal tests) Alleviate food allergy (animal tests) Increase learning capabilities (animal tests)
4 Success Strategy 1. Strength of our 2'-FL project Experience & Know-how (fermentation & downstream processing) GRAS strain (consumer friendly) Year Capacity(est.) ton / year ,000 ton / year Strong Scientific Advisory Committee (8 groups : domestic & international) Scientific Advisory Committee Strong Global IP Plan (8 patents & 5 trademarks) Patents
5 Core Technology 1. Technology for Production of Oligosaccharide Selection of target materials Strain development Process development HMOs (2'-FL, 3-FL ) Metabolic engineering Fermentation & purification 2. Technology for Process Developmont of rprotein (AD-Pure System ) Comparison for Technology Number of steps Yield (hgh) Existing technology Complicated process (over 10 steps) 200 mg /l broth Our technology Simplified process (5 steps) 1.5g/l broth AD-Pure system with high yield and purity ADzyme exactly cut off the fusion partner from the target protein
6 R&D Center Research for process development (18516) 5, Mosan-gil, Botong-ri, Jeongnam-myeon, Hwaseong-si, Gyeonggi Province, Republic of Korea Tel Fax Headquaters (16229) 147, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi Province, Republic of Korea Tel Fax Seoul Incheon International Airport HMOs Plant - 2'-FL, 3-FL plan to construct in Chungnam Province in Capacity : approx. 1,000ton/year (estimates) Bioconversion Plant - Production of material for bioconversion by microorganism (18329) 82-4, Buncheon-gil 95 beon-gil, Buncheon-ri, Bongdam-eup, Hwaseong-si, Gyeonggi Province, Republic of Korea Contact Us aptech@aptech.biz Website
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