Weight and Wellness. CTL, Inc Research Road Las Cruces, NM CR-004

Transcription

1 Weight and Wellness Profile est ID: X , EN Prepared For: lpha ES Report: L, Inc Research Road Las ruces, NM R004

2 2

3

4 ENEIS 101 ENEIS 101 DN is the genetic material in our cells that makes us who we are. You inherit this genetic material, half from mother and half from father. It determines physical appearance, like hair and eye color. pearance, like hair and eye color. make a protein that leaves the body susceptible to disease. DN is made up of billions of base pairs. environment determine how body responds to the SNPs that you have. For example, you may have other genes that compensate for the You get half of DN from mother and half from father. functions, such as whether you are tions to the body to perform certain actions. For example, some base pairs contain instructions on making entoo, such as telling only certain skin cells to make hair while other skin cells do not. mistake in the copying. Or you may have compensated for the error by eating (or not eating) certain foods. You and another person may have the to have high blood pressure. Knowing says can help you understand possibly overcome any negative genetic tendencies. Your genotype is genetic makeup, actual strands of DN comprised of a 3 billion base strand in Sometimes, when DN is being copied to make new cells, mistakes are made in the copying of bases. SNPs or singlenucleotide polymorphisms. For example, in a series where the original base says, the copied base may say. genotype. It tells you what SNPs you have, or where alterations happened in copying genetic material. Understanding the potential issues personal genotype contains will help you deal with and possibly even overcome the way those genes may be ex which each individual base is one of cal suggestions to potentially improve types of bases are: adenine (), thy phenotype, or the expression of mine (), guanine (), and cytosine genetic material, and potentially chains of DN, and a piece of DN containing millions of base pairs packed tightly is called a chromosome. Sometimes mistakes called SNPs occur in our DN. like a typo or a mistake in a computer program, can change the instructions the DN gives to the live a healthier lifestyle. ERMS YOU SHOULD KNOW DN (DeoxyriboNucleic enotype Phenotype SNP (SingleNucleotide cid): nucleic acid that makeup of an organism of a certain trait based on Polymorphism): com carries genetic information genetic and environmental monly found change in a contained in each cell single nucleotide base in a DN sequence 4

5 HOW O RED HIS REPOR Your eneral Obesity Index Your Food hoices Your Exercise and ctivity Your Health Your Behavior Vitamins & You to give you an overall score. YOUR FOOD HOIES IMP OF ENOYPE ENE LOION PO2 rs5082 SM PLE Individual SNPs evaluates 22 SNPs that have been studied and shown to be related to a genetic risk of obesity. Each green (positive) or red (negative) bar shows a SNP and how it re EN OYPE 6.4 Overall Score SU DY REF NO SSOIED BENEFI FROM LOWF DIE IEMS YOU SHOULD KNOW large study of over 3,000 people from 3 independent populations found a genediet interaction associated with increased BMI (6.2%) ll possible genotypes saturated fats. he impact of the genotype Your particular genotype of a healthy diet. SMPLE he gene and SNP location FO FO rs rs BENEFI FROM LOWF DIE certain associated genotypes should avoid fats and increase physical activity. What the study said SMPLE LIP rs he reference number of the NO KNOWN BENEFI FROM LOWF DIE are at the end (references of the report) his gene is associated with the amount of highdensity lipoprotein (HDL), or "good" cholesterol, produced by the body. hose with lower HDL levels should avoid lowcarb, highfat diets. show that you have no increased risk of obesity, while other SNPs show that obesity risk is increased. Rememect genes have on health, including foods you eat, exercise ber that many factors contribute to the e DIPOQ BENEFI FROM LOWF DIE rs level, and other environmental factors. Knowing genotype gives you the power to control many of In a study of over 1,000 people relating to obesity, BMI, and waist and hip circumference, this gene was associated with a lower BMI with these environmental factors and improve overall health. a lowfat diet where fat was less than 13% of caloric intake. PPR rs LDN,Inc. Inc. ll llrights Rights Reserved 2011 Deseret Biologicals, Reserved NO KNOWN BENEFI FROM LOWF DIE 5

6 PERSONL ENEI PROFILE his report is tailored to you, based on individual and unique DN. Using the latest discoveries in genetic research, we ve analyzed how genes impact health and wellness. More importantly, we ve highlighted the steps you can take to achieve optimal health, by taking advantage of genetic strengths and countering genetic weaknesses. By following the guidelines we provide you can reach full wellness potential! 9.5 Your Obesity Index is a number, between 1 and 10, calculated by examining 22 base pairs in DN that have been associated with weight issues including BMI, waist circumference, and body fat percentage. Your score is 9.5, which indicates a very high genetic propensity for obesity. Your genes are working against you, but several studies have demonstrated that a healthy diet and exercise can counter genetic tendencies. See the other panels for specific steps you can take to reduce obesity risk. MONIOR OL F INKE Your genotype shows an association between fat intake and BMI and waist and hip circumference. Even more than most people, you will benefit from a very lowfat diet. Montitor total dietary fat intkae MODERE F INKE FOR INRESED HDLS he amount of dietary fat that you consume will have a greater impact on HDL (good) cholesterol levels than it does for those with a different genotype. You may see improvements in HDL cholesterol by avoiding high dietary fat intake. REDUE OL F ND SURED F INKE Your genotype is associated with extremely efficient fat processing, leading to an average increase in BMI of 6.2%. his means that, more than others with a different genotype, body quickly and efficiently processes and stores fat. Emphasize plantsourced fats and keep animal fats at a minimum. Be espeicially cautious with saturated fat intake 6

7 YOUR EXERISE & IVIY YOUR BEHVIOR EXERISE O INRESE OOD HOLESEROL You will have a significantly greater increase in highdensity lipoprotein (HDL or good cholesterol) with endurance exercise than people with a different genotype. Make endurance/aerobic exercise a part of health routine; this type of exercise will have a positive impact on HDL levels and reduce risk of heart disease. POSSIBLE ENDENY O OVERE Your genotype shows that if you are female, you may be prone to overeating because of a genetic tendency toward disinhibition. Watch portion sizes and stop eating after a reasonable amount. BE WRE OF FOOD RVINS USE FSWIH MUSLES You share a genotype with many worldclass athletes. Your body uses alphaactinin3 protein more efficiently to provide a boost to fasttwitch muscle fibers that generate force at high velocity. Discover abilities by exploring activities that use fasttwitch muscle fibers, such as weight training, sprinting, jumping, and other explosive activities. You are more drawn to pleasurable activities than people with a different genotype and may seek favorite foods for the effect they have on mood and brain chemistry. When you find self craving food, focus on other activities that increase dopamine levels in the brain, such as moderate exercise (a brisk walk) or conversation with a loved one. YOUR HELH POSSIBLE DERESE IN HOLESEROL Men with genotype may have a decreased risk of cardiovascular disease because of a genetic tendency toward decreased cholesterol. Monitor cholesterol levels anyway to take advantage of genetic tendency. INRESE ENDURNE EXERISE You may experience enhanced effects from exercise, such as lower cholesterol levels and better insulin sensitivity. hough anyone will benefit from exercising to increase stamina and endurance, genotype has been associated with enhanced benefits from this type of exercise. EXERISE O REDUE BLOOD PRESSURE Your genotype indicates that blood pressure will tend to be high, but exercise will lower blood pressure more effectively than for others with a different genotype. Make regular exercise a normal part of health routine. ny sort of exercise will help to reduce blood pressure and associated risks. VIMINS & YOU POSSIBLE VIMIN D DEFIIENY Your genotype indicates that you may be prone to Vitamin D deficiency. onsider Vitamin D (cholecalciferol) supplementation and regular serum 25hydroxy Vitamin D testing, especially if you live in a northern climate. POSSIBLE VIMIN E DEFIIENY Your genotype indicates that you may be prone to Vitamin E deficiency. onsider supplementing with all four tocopherol isomers of Vitamin E. POSSIBLE FOLE DEFIIENY Your genotype indicates that you may be prone to folate deficiency. onsider supplementing with 5methyl tetrahydrafolate. POSSIBLE VIMIN B12 DEFIIENY Your genotype indicates that you may be prone to Vitamin B12 deficiency. onsider B12 supplementation (as methylcobalamin) and H. pylori testing. L, Inc Las ruces NM 88003, ES ID: X lpha ES Report: Deseret LDN, Biologicals, Inc. Inc. ll Rights ll Rights Reserved Reserved 7