Ministry of higher education, (Tunisia) Educational activity and supervision of the research works Supervision of masters, doctorates

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1 Curriculum Vitae PERSONAL INFORMATION Nadia Fenina Mankai WORK EXPERIENCE October 1992 Present Professor Ministry of higher education, (Tunisia) Educational activity and supervision of the research works Supervision of masters, doctorates October 2012 December 2014 General Director of Pharmacy and Medicine Administration Ministry of Health, (Tunisia) Drug Regulatory Evaluation of drug files July 2007 September 2012 Director of drugs and pharmaceutical Industry Ministry of Health, (Tunisia) Drug Regulatory Evaluation of drug files Evaluation of medicines with particular status and clinical trials EDUCATION AND TRAINING September 1989 December 1991 Doctor in pharmacy Monitoring and Clinic Pharmacokinetic October 1988 October 1991 DES Specialist in Pharmacy hospital pharmacy and collectivity September 1988 December 1989 Master - research Fundamental Pharmacokinetic and Clinic September 1990 September 1991 University diploma of Cosmetology Dermo- Cosmetology September 1989 December 1991 Doctorate in Sciences Pharmaceutical - specialty pharmacology - Aix-Marseille II; (PhD) Contribution à l'étude métabolique et pharmacocinétique in vitro et in vivo de deux rétinoïdes : isotrétinoïnde et témarotène ADDITIONAL INFORMATION Expertise University, research, health, administration pharmacology, metabolism, pharmacokinetic, toxicology, herbal drugs, Pharmaco-economic, doping 19/1/15 European Union, Page 1 / 5

2 ) Publications PUBLICATIONS Many Conferences, publications and communications else Doctorates, Masters (About pharmacology, metabolism, pharmacokinetic, toxicology, herbal drugs, Pharmaco-economic, doping ) 1- Ehsen Haloui 1, Zohra Marzouk 1*, Belsem Marzouk 2, Ibtissem Bouftira 3, Abderrahman Bouraoui 4 andnadia Fenina 1 Pharmacological activities and chemical composition of the Olea europaea L. leaf Essential oils from Tunisia. Journal of Food, Agriculture & Environment Vol.8 (2): Helsinki, Finland 2- Rym Ben Mustapha 1*, Christine Lafforgue 1 and Nadia Fenina 2 Percutaneous absorption of piroxicam : In vitro release and percutaneous absorption from different concentration gels Journal of Food, Agriculture & Environment Vol.8 (3&4) : Rym Ben Mustapha*(a), Christine LAFFORGUE (a), Nadia FENINA (b) Skin permeation : Influence of the drug concentration in the diffusion parameters of caffeine Journal of Pharmacy & bioresources Faculty of Pharmaceutical Sciences, University of Jos, Jos. Nigeria. Vol. 7 Number 2, September 2010 (voir article + lettre d acceptation) 4- Zohra Marzouk 1 *, Belsem Marzouk 2, Mohamed Ali Mahjoub 3, Ehsen Haloui 1, Zine Mighri 3, Mahjoub Aouni 2 and Nadia Fenina 1 Screening of the antioxidant and the free radical scavenging potential of Tunisian Citrullus colocynthis Schrad. From Mednine Journal of Food, Agriculture & Environment Vol.8 (2) : Belsem Marzouka, Zohra Marzoukb, Rachel Décorc, Hayet Edziri a, Ehsen Halouid, Nadia Feninad, Mahjoub Aounia,. Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Journal of Ethnopharmacology 125 (2009) Belsem Marzouka, Zohra Marzoukb, Ehsen Halouib, Nadia Feninab, Abderrahman Bouraouic, Mahjoub Aounia,. Screening of analgesic and anti-in.ammatory activities of Citrullus colocynthis from southern Tunisia Journal of Ethnopharmacology 128 (2010) Belsem Marzouk 1, Hayet Edziri 1, Ihsen Haloui 2, Manel Issawi 3, Imed Chraief 3, Mahjoub El- Ouni1, Nadia Fnina 2 and Zohra Marzouk 4* Chemical composition, antibacterial and antioxidant activities of a new chemotype of Tunisian Thymus vulgaris oils growing in Sayada Journal of Food, Agriculture & Environment Vol.7 (2): Emna Chtourou, Christine Fernandez, Claire Lamotte, Fathi Safta, Robert Farinotti, Nadia FENINA Mise au point d une méthode de dosage de la Ribavirine dans le Plasma par CLHP Essaydali N 116 Septembre H Oueslatti, A Fenina, R Tabka. N Fenina Mankaï Etude pharmacoéconomique des antibiotiques dans cinq hôpitaux tunisiens : Farhat Hached de Sousse, Fattouma Bourguiba de Monastir, Hôpital d enfants, Charles Nicolle et la Rabta de Tunis Essaydali N 103 juin W Bechraoui, M Guerfali, C Hasni, N Ennaifer, N Fenina Mankaï Evaluation de la satisfaction des patients de la qualité des prestations sanitaires à l hôpital la Rabta au cours de l année 2004 Essaydali N 105 Décembre Emna Chtourou, N. Fenina, K. IDDIR, I. Lasoued, M. Madiouni, S. Chaïb, A. Toumi 19/1/15 European Union, Page 2 / 5

3 Application du Concept DDD (Defined Daily Dose) à la consommation des aminosides en Tunisie Essaydali N 91 juin N Fenina, H Bun, B Lacarelle, A Durand Effet du phénobarbital et de la carbamazépine sur le comportement pharmacocinétique de l isotrétinoïne chez le lapin Essaydali N 91 juin «Hydroxytyrosol and oleuropein from olive leaves: Potent anti-inflammatory and analgesic activities» published in the journal : Journal of Food, Agriculture & Environment, Vol.9 (3&4), July- October 2011 Author: Ehsen Haloui 1, Belsem Marzouk 2, Zohra Marzouk 1*, Abderrahman Bouraoui 3 and Nadia Fenina 1 Received 5 June 2011, accepted 22 September «Anti-inflammatory evaluation of immature fruit and seed aqueous extracts from several populations of Tunisian Citrullus colocynthis Schrad» African Journal of Biotechnology Vol. 10 (20), pp , 2011 ISSN Academic Journals Belsem Marzouk1*, Zohra Marzouk2, Ehsen Haloui2, Manel Turki3, Abderrahman Bouraoui3, Mahjoub Aouni1 and Nadia Fenina2 15. Comparative evaluation of the analgesic activity of several populations of Tunisian Citrullus colocynthis Schrad. immature fruits. Article accepté au journal «Open Science Publishers LLP / Registered under Section 12(1)(b) of the LLP Act, Reg. No. AAB-0678» Belsem Marzouka, Ehsen Halouib, Nadia Feninab, Mahjoub Aounia, Zohra Marzoukb a- Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives, Faculté de Pharmacie de Monastir, Rue AVICENNE 5000 Monastir-TUNISIE. b- Unité de Pharmaco-économie et Développement des Médicaments, Laboratoires de Biologie Végétale et Laboratoire de Pharmacologie, Faculté de Pharmacie de Monastir, TUNISIE. Abstract Plant extracts are some of the most attractive sources of new drugs and have shown promising results for the treatment of pains, inflammations and immune-related diseases. Citrullus colocynthis Schrad., (cucurbitaceae) endemic in Tunisia, is widely used in folk medicine to treat many inflammation disorders. The aim of this study is to quantify the alkaloid level and to evaluate the acute toxicity of different populations of Citrullus colocynthis fruit aqueous extracts at immature state and then to screen their analgesic activities. After identification and acute toxicity essay, different populations of Citrullus colocynthis Schrad. aqueous fruit extracts were screened for analgesic activity using the acetic acid writhing test in mice. Yields of prepared extracts and alkaloid level are gravimetrically determined. Results show that alkaloid level vary upon the Citrullus colocynthis population. All extracts displayed analgesic activity at different doses without inducing acute toxicity. Topic results were obtained with immature fruits from south Tunisia. Experimental results have revealed that Citrullus colocynthis Schrad. is a potentially useful drug suitable for further evaluation, and its folk medicinal use, in all Tunisia, as an analgesic agent is validated for all tested Tunisian populations. Keywords: Citrullus colocynthis Schrad.; fruits; alkaloid; toxicity; analgesic. 16. evaluation of immature fruit and seed aqueous extracts from several populations of Tunisian Citrullus colocynthis Schrad Article soumis au journal BMC Alternative Medecine - «Anti-inflammatory Belsem Marzouk1*, Zohra Marzouk2, Ehsen Haloui2, Manel Turki3, Abderrahman Bouraoui3, Mahjoub Aouni1 and Nadia Fenina2 1Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives, Faculté de Pharmacie de Monastir, Rue AVICENNE 5000 Monastir, Tunisie. 2Unité de Pharmaco-économie et Développement des Médicaments, Laboratoires de Biologie Végétale et Laboratoire de Pharmacologie, Faculté de Pharmacie de Monastir, Tunisie. 3Unité de recherche URSAM, Laboratoire de Pharmacologie, Faculté de Pharmacie, Monastir, 19/1/15 European Union, Page 3 / 5

4 Tunisie. Plant extracts are some of the most attractive sources of new drugs and have shown promising results for the treatment of inflammation and immune-related diseases, including rheumatoid arthritis. Citrullus colocynthis Schrad. (Cucurbitaceae) endemic in Tunisia, is widely used in folk medicine to treat many inflammation disorders. The aim of this study is to quantify the alkaloid and the flavonoid levels of different populations of C. colocynthis fruit and seed aqueous extracts at immature state. After acute toxicity assay, these extracts were screened for anti-inflammatory activity using the carrageenaninduced paw oedema assay in rats. Alkaloid and flavonoid levels vary among the population. The best anti-inflammatory activities were obtained with immature fruits from south Tunisia. Therefore, C. colocynthis Schrad. could be a potential useful product suitable for further evaluation for inflammatory diseases. Key words: Citrullus colocynthis Schrad., alkaloids, flavonoids, toxicity, anti-inflammatory, Tunisia. 17. Antiproliferative effect on human cancer cells and antioxidant activity of Tunisian Citrullus colocynthis Schrad. immature fruit and seed organic extracts. Belsem Marzouka, Francesca Mussib-d, Najla ilkbairc, Serena Galatib, Nadia Feninac, Abderrahman Bouraouic, Mahjoub Aounia, Zohra Marzoukc*, Annamaria Buschinib* a- Laboratory of Transmissible Diseases and Bio-active Substances, Faculty of Pharmacy of Monastir; University of Monastir; Tunisia. b- Department of Biosciences; University of Parma, Italy. c- Laboratoire of Genome, Diagnostic and Valorisation; Faculty of Pharmacy of Monastir; Tunisia. d- Departement of Life Sciences; University of Modena and Reggio Emilia; Italy. * Same contributions Corresponding author: Tel ; address: belsemmarzouk@yahoo.fr. Abstract Citrullus colocynthis Schrad., traditional Tunisian medicinal plant, showed beneficial effects against oxidative stress mediated diseases, namely its fruits and seeds which contain several compounds with biological activity. The present study reports the antioxidant and the antiproliferative properties of different seed and fruit organic extracts. Antioxidant activity was assessed by the ability to quench the free DPPH and the superoxide anion radicals and inhibit the ABTS cation. Methanol extracts presented the highest DPPH scavenging (seeds IC50 = mg/ml; fruit IC50 = mg/ml) and superoxide scavenging (seeds IC50 = µg/ml; fruits IC50 = µg/ml) activities. All extracts inhibited the ABTS radical formation. The most interesting TEAC values were registered with methanol extracts (seeds = and fruits = 1.120). Petroleum ether seed extract showed the lower antioxidant action. Seed and fruit organic extracts were also tested for their antiproliferative activity on HT-29 human cell line. All extracts induced a concentration dependent growth inhibition. Petroleum ether seed extract exhibited the higher growth inhibition activity (IC50 = 321 µg/ml), while methanol fruit extract showed the less antiproliferative efficiency (IC50 >500 µg/ml). Data obtained indicate indicate that seeds and fruits constitute an excellent source of effective natural antioxidants and chemopreventive agents. Keywords: Citrullus colocynthis ; phenolic contents; antioxidant; antiproliferative. 18. Analgesic activity of several polpulations of Citrullus colocynthis Schrad. fruits Belsem Marzouka, Nadia Feninab, Abderrahman Bouraouib, Mahjoub Aounia, Zohra Marzoukb. a- Laboratoire des maladies transmissibles et substances biologiquement actives, Faculté de Pharmacie, Monastir-Tunisia. b- Unité de Pharmacoéconomie et développement des médicaments 4th day on the valorization of bioresources at Sousse organized by the Tunisian Association for the promotion of bio-resources. Projects - Contribution to the study of evaluation of a Biosimilar «enoxaparaine». - Implementation of the African medicines Agency (project of the African union in collaboration with NEPAD and WHO 19/1/15 European Union, Page 4 / 5

5 Memberships - Member of some scientific societies : Société tunisienne des sciences pharmaceutiques STSP, ATREP... - Expert / Member WHO - Expert / Member with Africain - Union - Select by US program "Women Science Hall fame" Other Relevant Information 19/1/15 European Union, Page 5 / 5