SAFETY DATA SHEET. SECTION 1: Identification of the substance/mixture and of the company/undertaking

Transcription

1 SAFETY DATA SHEET SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Trade name or designation of the mixture Registration number Synonyms Issue date Version number 01 Revision date - Supersedes date - - None. 08-January Relevant identified uses of the substance or mixture and uses advised against Identified uses Reagent. Uses advised against None known Details of the supplier of the safety data sheet Supplier Company name Illumina United Kingdom Address Chesterford Research Park Little Chesterford Nr Saffron Walden, Essex CB10 1XL UK Telephone General Information: Contact person Emergency telephone 24 Hour Emergency: SECTION 2: Hazards identification 2.1. Classification of the substance or mixture The mixture has been assessed and/or tested for its physical, health and environmental hazards and the following classification applies. Classification according to Directive 67/548/EEC or 1999/45/EC as amended This preparation does not meet the criteria for classification according to Directive 1999/45/EC as amended. Classification Xi;R36/37/38 The full text for all R-phrases is displayed in section 16. Classification according to Regulation (EC) No 1272/2008 as amended Health hazards Skin corrosion/irritation Serious eye damage/eye irritation Specific target organ toxicity - single exposure Hazard summary Physical hazards Health hazards Environmental hazards Specific hazards Main symptoms 2.2. Label elements Category 2 Category 2 Not classified for physical hazards. Category 3 respiratory tract irritation Irritating to eyes, respiratory system and skin. Not classified for hazards to the environment. Irritant effects. Label according to Regulation (EC) No. 1272/2008 as amended Contains: D,L-Dithio threitol (DTT) H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation Version No.: 01 Revision date: - Issue date: 08-January / 7

2 Hazard pictograms Signal word Hazard statements Precautionary statements Prevention Response Storage Disposal Warning H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P304 + P340 - IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 - Call a POISON CENTRE or doctor/physician if you feel unwell. P405 - Store locked up. Supplemental label information Not applicable Other hazards None known. SECTION 3: Composition/information on ingredients 3.2. Mixtures P501 - Dispose of contents/container in accordance with local/regional/national/international regulations. General information Chemical name % CAS-No. / EC No. REACH Registration No. INDEX No. Notes D,L-Dithiothreitol (DTT) Classification: DSD: Xn;R22, Xi;R36/37/ * - - CLP: Acute Tox. 4;H302, Skin Irrit. 2;H315, Eye Irrit. 2;H319, STOT SE 3;H335 SECTION 4: First aid measures General information First aid personnel must be aware of own risk during rescue Description of first aid measures Inhalation If symptomatic, move to fresh air. Get medical attention if symptoms persist. Skin contact Eye contact Ingestion 4.2. Most important symptoms and effects, both acute and delayed 4.3. Indication of any immediate medical attention and special treatment needed SECTION 5: Firefighting measures Immediately flush with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes. Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Get medical attention if symptoms persist. Seek medical advice. Exposure may aggravate pre-existing skin or respiratory disorders. Treat symptomatically. General fire hazards 5.1. Extinguishing media Suitable extinguishing media Unsuitable extinguishing media 5.2. Special hazards arising from the substance or mixture No unusual fire or explosion hazards noted. Water. Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2). None known. Thermal decomposition or combustion may liberate toxic gases or fumes Version No.: 01 Revision date: - Issue date: 08-January / 7

3 5.3. Advice for firefighters Special protective equipment for firefighters Special fire fighting procedures Self-contained breathing apparatus and full protective clothing must be worn in case of fire. None known. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency Wear appropriate personal protective equipment. personnel For emergency responders Keep unnecessary personnel away Environmental precautions Avoid discharge into drains, water courses or onto the ground Methods and material for containment and cleaning up Absorb spill with vermiculite or other inert material, then place in a container for chemical waste for proper disposal Reference to other sections Large Spills: Flush area with water. Prevent runoff from entering drains, sewers, or streams. Dike for later disposal. For personal protection, see Section 8 of the SDS. For waste disposal, see Section 13 of the SDS. SECTION 7: Handling and storage 7.1. Precautions for safe handling 7.2. Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Reagent. SECTION 8: Exposure controls/personal protection 8.1. Control parameters Occupational exposure limits Biological limit values Recommended monitoring procedures Derived no-effect level (DNEL) Avoid breathing mist or vapour. Avoid contact with eyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Wash thoroughly after handling. Keep container tightly closed and in a well-ventilated place. Store locked up. No exposure limits noted for ingredient(s). No biological exposure limits noted for the ingredient(s). Predicted no effect concentrations (PNECs) 8.2. Exposure controls Appropriate engineering controls Ensure adequate ventilation, especially in confined areas. Individual protection measures, such as personal protective equipment General information Personal protective equipment should be chosen according to the CEN standards and in discussion with the supplier of the personal protective equipment. Eye/face protection Skin protection Wear safety glasses with side shields (or goggles). Wear a full-face respirator, if needed. - Hand protection Chemical resistant gloves are recommended. - Other Wear chemical-resistant gloves, footwear, and protective clothing appropriate for the risk of exposure. Contact health and safety professional or manufacturer for specific information. Respiratory protection Thermal hazards Hygiene measures Environmental exposure controls If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. Respirator type: Air-purifying respirator with an appropriate, government approved (where applicable), air-purifying filter, cartridge or canister. Contact health and safety professional or manufacturer for specific information. Not applicable. Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants. Environmental manager must be informed of all major releases Version No.: 01 Revision date: - Issue date: 08-January / 7

4 SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Appearance Clear liquid. Physical state Liquid. Form Liquid. Colour Odour Characteristic. Odour threshold ph Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Flammability (solid, gas) Upper/lower flammability or explosive limits Flammability limit - lower (%) Flammability limit - upper (%) Vapour pressure Vapour density Relative density Solubility(ies) Partition coefficient (n-octanol/water) Auto-ignition temperature Decomposition temperature Viscosity Fully miscible. No data available. Explosive properties Oxidizing properties 9.2. Other information No relevant additional information available. SECTION 10: Stability and reactivity Reactivity The product is stable and non reactive under normal conditions of use, storage and transport Chemical stability Material is stable under normal conditions Possibility of hazardous reactions Conditions to avoid None known. Hazardous polymerisation does not occur Incompatible materials Acids. Alkalines. Strong oxidising agents Hazardous decomposition products SECTION 11: Toxicological information No hazardous decomposition products are known. General information Causes skin, eye and respiratory tract irritation. Information on likely routes of exposure Ingestion May cause discomfort if swallowed. Inhalation May cause respiratory tract irritation. Skin contact Causes skin irritation. Eye contact Causes serious eye irritation. Symptoms Irritation Information on toxicological effects Acute toxicity Version No.: 01 Revision date: - Issue date: 08-January / 7

5 Skin corrosion/irritation Serious eye damage/eye irritation Respiratory sensitisation Skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity - single exposure Specific target organ toxicity - repeated exposure Aspiration hazard Mixture versus substance information Other information Causes skin irritation. Causes serious eye irritation. This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. May cause respiratory irritation. Not applicable. SECTION 12: Ecological information Toxicity This material has not been tested for environmental effects. Components D,L-Dithiothreitol (DTT) (CAS ) Aquatic Crustacea LC50 Species Water flea (Daphnia magna) Test results mg/l, 48 hours Persistence and degradability No data available Bioaccumulative potential Partition coefficient n-octanol/water (log Kow) Bioconcentration factor (BCF) No data available Mobility in soil Results of PBT and vpvb assessment Other adverse effects No data available. SECTION 13: Disposal considerations Not a PBT or vpvb substance or mixture Waste treatment methods Residual waste Contaminated packaging EU waste code Disposal methods/information Dispose of in accordance with local regulations. Since emptied containers retain product residue, follow label warnings even after container is emptied. Waste codes should be assigned by the user based on the application for which the product was used. Do not discharge into drains, water courses or onto the ground. Discharge, treatment, or disposal may be subject to national, state, or local laws. SECTION 14: Transport information ADR RID ADN IATA IMDG Version No.: 01 Revision date: - Issue date: 08-January / 7

6 14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code This substance/mixture is not intended to be transported in bulk. SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU regulations Regulation (EC) No. 1005/2009 on substances that deplete the ozone layer, Annex I Regulation (EC) No. 1005/2009 on substances that deplete the ozone layer, Annex II Regulation (EC) No. 850/2004 On persistent organic pollutants, Annex I as amended Regulation (EC) No. 689/2008 concerning the export and import of dangerous chemicals, Annex I, part 1 as amended Regulation (EC) No. 689/2008 concerning the export and import of dangerous chemicals, Annex I, part 2 as amended Regulation (EC) No. 689/2008 concerning the export and import of dangerous chemicals, Annex I, part 3 as amended Regulation (EC) No. 689/2008 concerning the export and import of dangerous chemicals, Annex V as amended Regulation (EC) No. 166/2006 Annex II Pollutant Release and Transfer Registry Regulation (EC) No. 1907/2006, REACH Article 59(1) Candidate List as currently published by ECHA Authorisations Regulation (EC) No. 1907/2006, REACH Annex XIV Substances subject to authorisation, as amended Restrictions on use Regulation (EC) No. 1907/2006, REACH Annex XVII Substances subject to restriction on marketing and use as amended Directive 2004/37/EC: on the protection of workers from the risks related to exposure to carcinogens and mutagens at work Not regulated. Directive 92/85/EEC: on the safety and health of pregnant workers and workers who have recently given birth or are breastfeeding Not regulated. Other EU regulations Directive 96/82/EC (Seveso II) on the control of major-accident hazards involving dangerous substances Not regulated. Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work Directive 94/33/EC on the protection of young people at work National regulations Chemical safety assessment SECTION 16: Other information No Chemical Safety Assessment has been carried out. List of abbreviations References Information on evaluation method leading to the classification of mixture HSDB - Hazardous Substances Data Bank National Toxicology Program (NTP) Report on Carcinogens ACGIH Documentation of the Threshold Limit Values and Biological Exposure Indices Version No.: 01 Revision date: - Issue date: 08-January / 7

7 Full text of any statements or R-phrases and H-statements under Sections 2 to 15 Training information Disclaimer R22 Harmful if swallowed. R36/37/38 Irritating to eyes, respiratory system and skin. H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Although reasonable care has been taken in the preparation of this document, Illumina makes no warranties or representations of any kind as to the accuracy or completeness of the information contained herein, and Illumina assumes no responsibility regarding the suitability of this information or the product for the user s intended purposes or for the consequences of use of this information or the use of the product. The user of this SDS and product should make a determination as to the suitability of the information and the product for their particular purpose(s). To the extent provided by applicable law, Illumina shall not be held liable for any damage or expenses of any kind resulting from handling, use, storage, or disposal of the product Version No.: 01 Revision date: - Issue date: 08-January / 7