Author's response to reviews
|
|
- Jane Evans
- 6 years ago
- Views:
Transcription
1 Author's response to reviews Title: Associations between toenail arsenic accumulation and dietary factors in a New Hampshire populationassociations between toenail arsenic accumulation and dietary factors in a New Hampshire population Authors: Joann F Gruber (joann.gruber@unc.edu) Margaret R Karagas (margaret.karagas@dartmouth.edu) Diane Gilbert-Diamond (diane.gilbert-diamond@dartmouth.edu) Pamela J Bagley (pamela.bagley@dartmouth.edu) Vicki Sayarath (vicki.sayarath@dartmouth.edu) Tracy Punshon (tracy.punshon@dartmouth.edu) M Scot Zens (m.scot.zens@dartmouth.edu) J Steven Morris (MorrisJ@missouri.edu) Kathryn L Cottingham (kathryn.cottingham@dartmouth.edu) Version: 2 Date: 1 March 2012 Author's response to reviews: see over
2 29 February 2012 Dear Editor-in-Chief: Dartmouth College Department of Biological Sciences Class of 1978 Life Sciences Building, 78 N. College St. HANOVER NEW HAMPSHIRE TELEPHONE: (603) FAX: (603) Please find enclosed our revised manuscript entitled, Associations between toenail arsenic concentration and dietary factors in a New Hampshire population (MS: ). We were encouraged by the generally positive reviewer comments received in November 2011, and have taken nearly all of their comments into account in making our revisions. In the rest of this letter, we briefly explain how we have addressed each concern. The reviewer comments appear as bold font, and then our responses follow. In addition, to help make our changes easier to locate, we have enabled continuous line numbering in the Word document containing the manuscript and use these line numbers to direct the editor and reviewers to our changes. We have also used yellow highlights in the text to identify changes made All authors have read and approved these revisions. The manuscript has not been published previously nor is it being considered by any other peer-reviewed journal. We hope that you find this revision suitable for publication in Nutrition Journal and look forward to hearing from you. Sincerely, Kathryn L. Cottingham, Professor Department of Biological Sciences, Dartmouth College 78 N. College St., Hanover, NH kathryn.cottingham@dartmouth.edu, Phone: , FAX: Joann F. Gruber, Graduate Student UNC Gillings School of Global Public Health joann.gruber@unc.edu, Phone:
3 DETAILED RESPONSE TO REVIEWERS Megan Hall Minor Essential Revisions The finding that many dietary lipids were inversely associated with toenail arsenic is unexpected and somewhat surprising. The authors speculate that: "From a physiological perspective it is conceivable that fat could form a complex with arsenic, inhibiting its absorption and resulting in decreased exposure and decreased accumulation in toenails. For example, lipid particles associated with proteins can interact with arsenic, which could provide an alternative mechanism for detoxification." There is an equally plausible explanation for these findings that deserves mention. The authors adjusted for total energy intake in multiple regression models using the "Standard Multivariate" approach, i.e., by including total energy intake as a covariate in the model. With this approach, the beta coefficient for dietary lipids represents the effect of substituting dietary fat for calories from other sources (i.e., protein and carbohydrates) - see Willett, Nutritional Epidemiology text, 1998, Chapter 11. This might suggest that protein and carbohydrate rich foods contribute more to dietary arsenic exposure in this population than do foods higher in dietary fat. We thank Dr. Hall for this suggestion, and have added the following sentence to the Results and Discussion: Another plausible explanation is that foods with higher fat content contribute relatively less dietary arsenic compared to carbohydrate- and protein-rich foods (such as rice and fish) resulting in negative correlations in our energy adjusted analysis (lines ). Tejo Prakash N Nagaraja Minor Essential Revision The authors need to provide a brief outline of how NAA analysis was carried out for Arsenic estimation or how FA analysis was carried out for dietary components, although citation with references associated with methodology are given. This is important as the analysis has been carried out after sample collection way back in 1998, and the standards/protocols have varied during the time that has passed. We thank Dr. Nagaraja for pointing out the brevity in the earlier manuscript, and agree that providing a reference to the original Karagas et al. study, which in turn cites the technical references for neutron activation analysis, was not ideal. We now provide the reader with a bit more detail on the overall approach (lines ), together with a specific reference for the detailed NAA procedures to make this information easier to locate for readers (line 126). However, due to the highly complex nature of the NAA analyses and the fact that the toenail arsenic data has been previously published, we have chosen not to describe the NAA procedures in detail in this manuscript. 2
4 We have also clarified that the analyses were generally done contemporaneous with the toenail sampling (lines ). We did not do FA analysis as part of this analysis, but instead used the FFQ and nutrient databases used by the Nurses Health Study (Willett et al., 1987). We now provide additional information to reflect this in the text (lines ). Melissa Slotnick Major revisions I would recommend separating out results and discussion, and I feel that the discussion needs to be elaborated on significantly. We thank Dr. Slotnick for her many helpful suggestions. We have opted not to separate the Results and Discussion into separate sections, as it made the manuscript much longer due to the need to repeat subheadings and reorient the reader to each result. Instead, we have made the recommended changes within our joint Results/Discussion section, which we hope will prove an adequate compromise. Specifically, since there is so much speculation about why these dietary factors may influence toenail arsenic concentrations, there should be some discussion about how arsenic is incorporated into the nail (and, consequently, a bit about arsenic metabolism). It seems that this is a missing link that might tie in some of the speculation. We have expanded the paragraph in the Background section (lines 66-75) to include more details on the metabolism of arsenic, especially the affinity of inorganic arsenic for keratin in nails and hair. Additionally, the term arsenic accumulation is used in reference to toenail arsenic levels. I think one should be careful with this wording, and discuss and/or clarify if the toenail is measuring accumulation, excretion, or exposure. This is a good point (and was also raised by Dr. Steinmaus). We have changed the word accumulation to concentration throughout the manuscript, when referring to concentrations of arsenic in toenails. Additionally, it is important to discuss some of the limitations of the study. In particular, the level of error in the dietary assessment is a bit concerning and needs to be addressed. Toenails, in theory, measure arsenic exposure occurring over a longer period of time which is assumed to be relatively constant if drinking water sources haven t changed significantly. Dietary exposures can change dramatically over a period of a few months. 3
5 Additionally, the timing of the dietary assessment versus the timing of the toenail clipping (and the period of exposure it represents) should be addressed. We have added a new section to the Results and Discussion (lines ) that mentions the limitations brought up by Dr. Slotnick and Dr. Steinmaus. We have also added a statement in the Methods that clarifies the relative timing of the food frequency questionnaire and the toenail collection (lines ). Since the amount of arsenic in toenails represents approximately a one-year period (12-18 months, Fleckman 1985), the one-year FFQ should reflect the levels of dietary factors potentially influencing the arsenic concentrations during that year for the majority of the subjects. Were all of the analyses conducted on all 920 individuals? Did results change when looking at the 213 participants with water concentrations >1 mcg/l? Yes, the analyses reported in this manuscript include all individuals. Results did change somewhat when we focused on the 213 participants with arsenic concentrations >1 µg/l, in that not all of the effects detected for all subjects or the low-arsenic subjects only (<1 µg/l) were statistically significant for the higher-arsenic group. Thus, we generally attributed any observed differences to the reduced power for n=213 versus n=707 (subjects with <=1 µg/l) or n=920. To help clarify this point, we edited the sentence in the Methods referring to stratified analyses (lines ) and added a short paragraph to the Results and Discussion explaining our findings for stratified data (lines ). It would be interesting to see analyses examining whether or not the dietary factors assessed were modifying the association between the drinking water exposure and the toenail arsenic levels. We agree, and will consider this in future work. However, this analysis is outside the scope of our goals here regarding the relation between dietary factors and toenail arsenic. Paragraph 3 in the Background section needs to be expanded. As noted above, we have expanded paragraph three in the Background (lines 66-75) to include a brief overview of arsenic metabolism and different arsenic species. Minor revisions A visual (e.g., scatterplot) of some of the stronger associations may be interesting. We have added a scatterplot for total fat and alcohol, to help readers visualize the associations discussed in the text (lines 222 and 279). 4
6 What was the mean toenail arsenic concentration for participants with drinking water levels greater than 1mcg/L? To facilitate comparisons among drinking water strata for those interested in the details, we have revised Table 1 to provide covariate and toenail arsenic concentration data on the entire study population, those exposed to <1 µg/l of arsenic in water, those exposed to levels between 1 and 10, and those exposed to levels >10 µg/l. Were specifics on concentrations of nutrients in dietary supplements obtained? These concentrations and consumed doses can vary widely. To what extent might this influence results? There is certainly the potential for error in the FFQ estimates. The FFQ used in this study asks participants first about multivitamins, and obtains exact brand-name information and frequency of consumption. It then asks specifically about separate supplements both length of consumption and doses for individual vitamins and minerals (vitamins A, C, B6, E; selenium, iron, zinc, calcium). Finally, it asks for whether participants take other supplements, but without dose information: folic acid, vitamin D, B-complex vitamins, cod liver oil, omega-3 fatty acids, iodine, copper, brewer s yeast, beta-carotene, and magnesium. We believe any errors due to mis-estimation are likely conservative, since errors in the estimates of the predictor variables (like the dietary factors studied here) typically bias parameter estimates in a regression model towards zero (Draper & Smith 1998). The first sentence of the conclusion needs to reflect the focus of the discussion and results. This is an interesting sentence, but the conclusion wasn t really structured in a way to support this sentence. Good point. This was not a strong topic sentence for the ensuing content. We have revised it so that it better sets up the surprising results of our study (lines ). In the background and conclusion relatively well-nourished population exposure to varying levels of arsenic, varying is a relative term. I would suggest replacing it with the actual concentration/exposure values. As it is written it suggests that there is wide variability, while the analyses were really conducted on individuals with relatively low exposures. This was a good suggestion that helps clarify our message. In the Abstract, we have changed the text to read, relatively low levels instead of varying (line 32 and 46) Likewise, we have changed varying to relatively low concentrations in the Conclusion (line 327). 5
7 Percentiles might be nice to include for exposure variables. There s a range of drinking water arsenic concentrations, but how many individuals fall into the higher exposure range? (e.g., >10 mcg/l) As mentioned above, we have provided some stratified data in Table 1 so readers can better understand the distribution of water and toenail arsenic concentrations in the population. It may be helpful for some researchers to see descriptive stats for the dietary intake variables (e.g., range of intake, mean, median, etc). This could help to facilitate crosspopulation comparisons. We have created a new Additional File 2, which provides a table of descriptive statistics about the dietary factors related to toenail arsenic concentration in this population. Craig M. Steinmaus Minor Essential Revisions It s not clear what the authors mean by the word accumulation. As noted in response to Dr. Slotnick s review, we have changed accumulation to concentration throughout the manuscript to avoid ambiguity. The past difficulties other researchers have had with measuring arsenic in toenails, especially in low exposure studies such as this one, is not discussed (Orloff et al., J Toxicol Environ Health B, , 2009). We have added a paragraph to the new Limitations section in the Results and Discussion to address this concern (lines ). The large majority of subjects were cancer cases. It seems that this should be mentioned early in the paper, maybe even in the abstract. I don t see this as a major flaw (since most are skin cancers). However, it seems at least possible that diet-toenail arsenic relationships could be different in people with cancer than those without (e.g. from the cancer process itself, from chemotherapy/medications, from changes in diet ). Thus the generalizability of these findings to non-cancer subjects should be discussed. Simply putting case-control status in the statistical model would not explain any effect modification caused by cancer status. Good point. We added a mention of the case-control study to the Abstract (line 34), Methods (line 90), and Results and Discussion (lines ; ). 6
8 As a side note, we also tried some additional analyses in response to this comment. First, we looked for interactions between our case-control status indicator variable and each of the dietary factors we explored, and no statistically significant interactions were found. Second, we looked to see whether results for Controls only were similar to those reported here, and turned up only a few differences. In both cases, though, it is not clear what role the reduced power of n=277 played in these findings. The participation rates should be given. We have added some information about participation rates in the original case-control studies to the Methods (lines ) as well as response rates for FFQ collection and toenail samples (lines ). It s difficult to understand the practical meaning of their results. In other words, what does a B-coefficient of -5.8 x 10(-3) mean in terms of actual toenail arsenic levels. Does it mean a doubling, a tripling, and 1% increase of arsenic toenail as we go from the upper to lower quartile of total fat? The authors should help the readers interpret their findings in practical terms. This was an important suggestion for helping make our points clearer. We have added columns to Table 2 that provide the predicted percent change in toenail arsenic when moving from the first quartile to the third quartile for each of the dietary factors, for both males and females (see lines in Methods, and related text in Results lines 198, , and ). Several of the regression coefficients change dramatically from the unadjusted to the adjusted model. For fat, the coefficient changes from -1.5 x 10(-3) to -5.8 x 10(-3), almost a 400% increase in magnitude. Several other diet variables also have very big changes with adjustment. This 400% increase seems like a huge change. Can the authors identify what factor caused such huge confounding. Our explorations with the model and data indicate that these differences are primarily due to the inclusion of the categorical variable for BMI (which is not available for all subjects) and the continuous variable Calories in the adjusted model. Fortunately, our qualitative conclusions as to which dietary factors show significant associations and the magnitudes of effect of dietary factors (% change as discussed in the previous comment) are robust to the inclusion of these factors. As such, we have opted not to draw explicit attention to this issue in the manuscript. 7
Title: A Prospective Study of Dietary Selenium Intake and Risk of Type 2 Diabetes
Author's response to reviews Title: A Prospective Study of Dietary Selenium Intake and Risk of Type 2 Diabetes Authors: Saverio Stranges (S.Stranges@warwick.ac.uk) Sabina Sieri (Sabina.Sieri@istitutotumori.mi.it)
More informationVITAMIN SURVEY FORM CODE: VIT Version B
ARIC MRI VITAMIN SURVEY FORM CODE: VIT Version B ID Number: Contact Year: 16 Instructions: Whenever numerical responses are required, enter the number so that the last digit appears in the rightmost box.
More informationTitle:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey
Author's response to reviews Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey Authors: Anne Helen Hansen
More informationARIC Data Book. Cohort, Exam 3. Vitamin Survey Form: FORM CODE=VIT VERSION=A
Page 1 of 12 Vitamin Survey Form: FORM CODE=VIT VERSION=A Instructions: This form is completed in several stages by appropriately trained persons at the workstations identified for this purpose. Whenever
More informationTitle: Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study
Author's response to reviews Title: Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study Authors: Marie F Sorbo (marie.flem.sorbo@ntnu.no) Hilde Grimstad (hilde.grimstad@ntnu.no)
More informationTitle: Identifying work ability promoting factors for home care aides and assistant nurses
Author's response to reviews Title: Identifying work ability promoting factors for home care aides and assistant nurses Authors: Agneta Larsson (agneta.larsson@ltu.se) Lena Karlqvist (lena.karlqvist@ltu.se)
More informationPEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW. Ball State University
PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (see an example) and are provided with free text boxes to
More informationAuthor s response to reviews
Author s response to reviews Title: The validity of a professional competence tool for physiotherapy students in simulationbased clinical education: a Rasch analysis Authors: Belinda Judd (belinda.judd@sydney.edu.au)
More informationTitle: The role of cognitive stimulation at home in low-income preschoolers' nutrition, physical activity and Body Mass Index
Reviewer s report Title: The role of cognitive stimulation at home in low-income preschoolers' nutrition, physical activity and Body Mass Index Version: 1 Date: 23 Feb 2017 Reviewer: Pattanee Winichagoon
More informationTitle:Video-confidence: a qualitative exploration of videoconferencing for psychiatric emergencies
Author's response to reviews Title:Video-confidence: a qualitative exploration of videoconferencing for psychiatric emergencies Authors: Marianne V Trondsen (marianne.trondsen@telemed.no) Stein Roald Bolle
More informationMJ - Decision on Manuscript ID BMJ
MJ - Decision on Manuscript ID BMJ.2018.044966 Body: 12-Jul-2018 Dear Dr. Khandwala Manuscript ID BMJ.2018.044966 entitled "The Association of Paternal Age and Perinatal Outcomes between 2007 and 2016
More informationPlease revise your paper to respond to all of the comments by the reviewers. Their reports are available at the end of this letter, below.
Dear editor and dear reviewers Thank you very much for the additional comments and suggestions. We have modified the manuscript according to the comments below. We have also updated the literature search
More informationAuthor's response to reviews
Author's response to reviews Title: Gender differences in Greek centenarians. A cross-sectional nation-wide study, examining multiple socio-demographic and personality factors and health locus of control.
More informationVariability of the Nutrient Composition of Multivitamin Supplements
3th National Nutrient Databank Conference Variability of the Nutrient Composition of Multivitamin Supplements Song-Yi Park, PhD Suzanne P. Murphy, PhD, RD Donna Au, MPH, RD Laurence N. Kolonel, MD, PhD
More informationBMJ - Decision on Manuscript ID BMJ
BMJ - Decision on Manuscript ID BMJ.2018.043414 Body: 19-Feb-2018 Dear Mr. Lee Manuscript ID BMJ.2018.043414 entitled "Predicted lean body mass, fat mass, and all-cause and cause-specific mortality in
More informationTitle:The self-reported health of U.S. flight attendants compared to the general population
Author's response to reviews Title:The self-reported health of U.S. flight attendants compared to the general population Authors: Eileen McNeely (emcneely@hsph.harvard.edu) Version:4Date:30 January 2014
More informationChallenges in setting Dietary Reference Values. Where to go from here? Inge Tetens & Susan Fairweather-Tait
Challenges in setting Dietary Reference Values. Where to go from here? Inge Tetens & Susan Fairweather-Tait EFSA symposium on DRVs at FENS Berlin, 22 October 2015 Conflict of interest regarding this presentation:
More informationModule 1 An Overview of Nutrition. Module 2. Basics of Nutrition. Main Topics
Module 1 An Overview of Nutrition Module 2 What is Nutrition? What Are Nutrients? Units of Energy Why we need energy? Maintaining energy balance Daily energy requirements Calorie Requirements for Different
More informationTitle:Spousal diabetes as a diabetes risk factor: A systematic review and meta-analysis
Author's response to reviews Title:Spousal diabetes as a diabetes risk factor: A systematic review and meta-analysis Authors: Aaron Leong (aaron.leong@mail.mcgill.ca) Elham Rahme (elham.rahme@mcgill.ca)
More informationManuscript ID BMJ entitled "Benzodiazepines and the Risk of Allcause Mortality in Adults: A Cohort Study"
12-Jan-2017 Dear Dr. Patorno Manuscript ID BMJ.2016.036319 entitled "Benzodiazepines and the Risk of Allcause Mortality in Adults: A Cohort Study" Thank you for sending us your paper. We sent it for external
More informationTitle: Persistent tumor cells in bone marrow of early breast cancer patients after primary surgery are associated with inferior outcome
Author's response to reviews Title: Persistent tumor cells in bone marrow of early breast cancer patients after primary surgery are associated with inferior outcome Authors: Kjersti Tjensvoll (ktje@sus.no)
More informationPAGE 1 of 6. Summative Assessment - Dietary Analysis Report Data Worksheets
1 PAGE 1 of 6 Name _ S.A. # Hour Summative Assessment - Dietary Analysis Report Data Worksheets READ CAREFULLY!!! Welcome to the PROJECT part of your Dietary Analysis Report. You will be entering information
More informationTitle: Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives
Author s response to reviews Title: Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives Authors: Robert Beckett (rdbeckett@manchester.edu) Kathryn
More informationD.K.M COLLEGE FOR WOMEN (AUTONOMOUS) VELLORE-1 DEPARTMENT OF FOODS AND NUTRITION ESSENTIAL OF MICRO NUTRIENTS
D.K.M COLLEGE FOR WOMEN (AUTONOMOUS) VELLORE-1 DEPARTMENT OF FOODS AND NUTRITION ESSENTIAL OF MICRO NUTRIENTS Class: II M.Sc Subject Code: 15CPFN3A Unit - I (6 Marks Questions) 1. Write a note on performed
More informationWe want youloknow about. nutrition labels on food. Oregon State University Extension Service
We want youloknow about nutrition labels on food % Oregon State University Extension Service NUTRITION LABELING Many food processors are putting nutrition information on their food labels. All fortified
More informationAuthor's response to reviews
Author's response to reviews Title: The Older People, Omega-3, and Cognitive Health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain
More informationAuthor's response to reviews
Author's response to reviews Title: Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and risk of psychotic-like symptoms in a cohort of 33 000 women from the general population
More informationEligibility The NCSF online quizzes are open to any currently certified fitness professional, 18 years or older.
Eligibility The NCSF online quizzes are open to any currently certified fitness professional, 18 years or older. Deadlines Course completion deadlines correspond with the NCSF Certified Professionals certification
More informationTitle: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer
Author's response to reviews Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer Authors: Ronan W Glynn (ronanglynn@doctors.net.uk)
More informationStrategies to Develop Food Frequency Questionnaire
Strategies to Develop Food Frequency www.makrocare.com Food choices are one of the health related behaviors that are culturally determined. Public health experts and nutritionists have recognized the influence
More informationNutritional Risk Factors for Peripheral Vascular Disease: Does Diet Play a Role?
Nutritional Risk Factors for Peripheral Vascular Disease: Does Diet Play a Role? John S. Lane MD, Cheryl P. Magno MPH, Karen T. Lane MD, Tyler Chan BS, Sheldon Greenfield MD University of California, Irvine
More informationSection Editor Steven T DeKosky, MD, FAAN Kenneth E Schmader, MD
Prevention of dementia Author Daniel Press, MD Michael Alexander, MD Section Editor Steven T DeKosky, MD, FAAN Kenneth E Schmader, MD Deputy Editor Janet L Wilterdink, MD Last literature review version
More informationAuthor's response to reviews
Author's response to reviews Title: Diabetes duration and health-related quality of life in individuals with onset of diabetes in the age group 15-34 years - a Swedish population-based study using EQ-5D
More informationTitle: Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study
Author s response to reviews Title: Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study Authors: Jin Young Nam (jynam@yuhs.ac) Juyoung Kim
More informationAuthor's response to reviews
Author's response to reviews Title: Gender, ethnicity, health behaviour & self-rated health in Singapore Authors: Wei-Yen Lim (Lim_Wei_Yen@moh.gov.sg) Stefan Ma (Stefan_Ma@moh.gov.sg) Derrick Heng (Derrick_Heng@moh.gov.sg)
More informationAuthor's response to reviews
Author's response to reviews Title: Physiotherapy interventions in scientific physiotherapy publications focusing on interventions for children with cerebral palsy: A qualitative phenomenographic approach.
More informationMyPlate.gov Assignment
Name: Class Hour: MyPlate.gov Assignment Directions: In 2011 the USDA came out with MyPlate.gov, a way to help Americans live a more healthy life. In this assignment you will explore the site and see how
More informationThe composition of the food groups
2. Food and nutrients 2.2 The nutritional value of food 2.2.2 The composition of the food groups NUTRIENT CONTENT Foodstuffs are grouped according to their nutrient content. They often comprise several
More information6 ESSENTIAL NUTRIENTS PART II VITAMINS MINERALS WATER
6 ESSENTIAL NUTRIENTS PART II VITAMINS MINERALS WATER VITAMINS What Are They? Tasteless organic compounds that you need in small amounts for growth, reproduction, and overall good health. The DO NOT provide
More informationPEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)
PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)
More informationContinuous update of the WCRF-AICR report on diet and cancer. Protocol: Breast Cancer. Prepared by: Imperial College Team
Continuous update of the WCRF-AICR report on diet and cancer Protocol: Breast Cancer Prepared by: Imperial College Team The current protocol for the continuous update should ensure consistency of approach
More informationThe response of the Netherlands Ministry of Health, Welfare and Sport is based on three principles;
Response of the Ministry of Health, Welfare and Sport (The Netherlands) on the Discussion Paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs. The Dutch Ministry
More informationCalifornia State University, Chico Department of Nutrition and Food Sciences NFSC 642 Topics in Vitamins and Minerals. Fall 2015
California State University, Chico Department of Nutrition and Food Sciences NFSC 642 Topics in Vitamins and Minerals Fall 2015 Instructor: Lauren L. Atwell, Ph.D., R.D. Office Location: Holt Hall 106
More informationAuthor's response to reviews
Author's response to reviews Title: Effects of a commercial product containing Guarana on psychological well-being, anxiety and mood: a single-blind, placebo-controlled study in heathy subjects Authors:
More informationRESPONSE TO DECISION LETTER
RESPONSE TO DECISION LETTER Dear Editor-in-chief, We are grateful to the editors and reviewers for their time and constructive comments on our manuscript. We have implemented their comments and suggestions
More informationTitle: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study
Author's response to reviews Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Authors: Atsuko Sekita (atsekita@med.kyushu-u.ac.jp)
More informationTitle: A survey of attitudes toward clinical research among physicians at Kyoto University Hospital
Author's response to reviews Title: A survey of attitudes toward clinical research among physicians at Kyoto University Hospital Authors: Eriko Sumi (sumieri@kuhp.kyoto-u.ac.jp) Toshinori Murayama (murayama@kuhp.kyoto-u.ac.jp)
More informationProgress in Development of the Dietary Supplement Ingredient Database
Progress in Development of the Dietary Supplement Ingredient Database JT Dwyer, MF Picciano, JM Betz, K Fisher, LG Saldanha, EA Yetley & PM Coates, ODS NIH; K Radimer, & B Bindewald, NHANES/NCHS; K Sharpless,,
More informationTiago Villanueva MD Associate Editor, The BMJ. 9 January Dear Dr. Villanueva,
Tiago Villanueva MD Associate Editor, The BMJ 9 January 2018 Dear Dr. Villanueva, Thank you for your thoughtful re-review of our Manuscript (BMJ.2017.041528) entitled "Immune-related Toxicities in PD-1
More informationTitle:Systematic review and meta-analysis of the effect of increased vegetable and fruit consumption on body weight and energy intake
Author's response to reviews Title:Systematic review and meta-analysis of the effect of increased vegetable and fruit consumption on body weight and energy intake Authors: Oliver T Mytton (otm21@medschl.cam.ac.uk)
More informationPatient: Shawn Baker March 06, 2018
Mr. Shawn Baker Dear Participant: Our team at SpecialtyHealth has received your lab work and the results have been reviewed. In this letter you will find a summary of the results along with numerous charts
More informationTitle:Emergency ambulance service involvement with residential care homes in the support of older people with dementia: an observational study
Author's response to reviews Title:Emergency ambulance service involvement with residential care homes in the support of older people with dementia: an observational study Authors: Sarah Amador (s.amador@herts.ac.uk)
More informationWhy we get hungry: Module 1, Part 1: Full report
Why we get hungry: Module 1, Part 1: Full report Print PDF Does Anyone Understand Hunger? Hunger is not simply a signal that your stomach is out of food. It s not simply a time when your body can switch
More informationTitle: Home Exposure to Arabian Incense (Bakhour) and Asthma Symptoms in Children: A Community Survey in Two Regions in Oman
Author's response to reviews Title: Home Exposure to Arabian Incense (Bakhour) and Asthma Symptoms in Children: A Community Survey in Two Regions in Oman Authors: Omar A Al-Rawas (orawas@squ.edu.om) Abdullah
More informationTitle: Reliability and Relative Validity of a Food Frequency Questionnaire to Assess Food Group Intakes in New Zealand Adolescents
Author's response to reviews Title: Reliability and Relative Validity of a Food Frequency Questionnaire to Assess Food Group Intakes in New Zealand Adolescents Authors: Jyh Eiin Wong (jyh.wong@otago.ac.nz)
More informationTitle:Decisions on statin therapy by patients' opinions about survival gains: Cross sectional survey of general practitioners.
Author's response to reviews Title:Decisions on statin therapy by patients' opinions about survival gains: Cross sectional survey of general practitioners. Authors: Peder Andreas Halvorsen (peder.halvorsen@kraftlaget.no)
More informationAuthor's response to reviews
Author's response to reviews Title:Mental health problems in the 10th grade and non-completion of upper secondary school: the mediating role of grades in a population-based longitudinal study Authors:
More informationHealthy Eating Pattern Development Proposed Methodology. Pre-conference workshop Canadian Nutrition Society Annual Conference Halifax May 3, 2018
Healthy Eating Pattern Development Proposed Methodology Pre-conference workshop Canadian Nutrition Society Annual Conference Halifax May 3, 2018 1 Objective of the presentation Share the proposed methodology
More informationSupplements are needed by individuals with vitamin or mineral deficiencies.
IT is estimated that more than half of U.S. adults take at least one dietary supplement daily, or occasionally but a group of researchers are now saying that vitamin and mineral supplements may be doing
More informationSTAT 201 Chapter 3. Association and Regression
STAT 201 Chapter 3 Association and Regression 1 Association of Variables Two Categorical Variables Response Variable (dependent variable): the outcome variable whose variation is being studied Explanatory
More informationTHE STATSWHISPERER. Introduction to this Issue. Binary Logistic Regression: The Rock Star of Regression
Spri ng 2 01 3, V o l u m e 3, I s su e 1 + THE STATSWHISPERER The StatsWhisperer Newsletter is published by Dr. William Bannon and the staff at StatsWhisperer. For other resources in learning statistics
More informationCANADA S NEW FOOD LABELLING REGULATIONS
CANADA S NEW FOOD LABELLING REGULATIONS an ebook from ESHA Research 2 TABLE OF CONTENTS Introduction... 3 The Nutrition Facts Overview... 4 Changes in Daily Value... 4 Formatting... 5 Nutrient Changes...
More informationInfant formula and formulas for special medical purpose intended for infants
BICS 67.100.10 X 82 National Standard of P.R.C. Substitute for GB10767-1997, GB10765-1997, GB10766-1997 GB Infant formula and formulas for special medical purpose intended for infants (Draft) - - Publish
More informationTips on Successful Writing and Getting Published Rita F. Redberg, MD, MSc, FACC, FAHA Professor of Medicine Editor, JAMA Internal Medicine
Tips on Successful Writing and Getting Published Rita F. Redberg, MD, MSc, FACC, FAHA Professor of Medicine Editor, JAMA Internal Medicine Rita F. Redberg, MD, MSc and 1 Helpful Hints!!! Correct journal
More informationPEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)
PEER REVIEW HISTORY BMJ Paediatrics Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form and are provided with free text boxes to elaborate
More informationResponse to reviewer comment (Rev. 2):
Response to reviewer comment (Rev. 2): The revised paper contains changes according to comments of all of the three reviewers. The abstract was revised according to the remarks of the three reviewers.
More informationAuthor's response to reviews
Author's response to reviews Title:Examining the influence of a text message-based sleep and physical activity intervention among young adult smokers in the United States: a randomized controlled trial
More informationUNIVERSITY OF CALIFORNIA, LOS ANGELES
UNIVERSITY OF CALIFORNIA, LOS ANGELES BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO UCLA SANTA BARBARA SANTA CRUZ DEPARTMENT OF EPIDEMIOLOGY SCHOOL OF PUBLIC HEALTH CAMPUS
More informationNutrition. Chapter 45. Reada Almashagba
Nutrition Chapter 45 1 Nutrition: - Nutrient are organic substances found in food and are required for body function - No one food provide all essential nutrient Major function of nutrition: providing
More informationCUDDALORE DEPARTMENT OF BIOCHEMISTRY SECTION-A ANSWER IN ONE SENTENCE
ST. JOSEPH S COLLEGE OF ARTS & SCIENCE (AUTONOMOUS CUDDALORE 607001 DEPARTMENT OF BIOCHEMISTRY Subject: Nutritional Biochemistry Class: I B.Sc Subject Code: BC204S Staff Incharge: Dr. R.Ramakrishnan &
More informationInstructions for 3 Day Diet Analysis for Nutrition 219
Name Instructions for 3 Day Diet Analysis for Nutrition 219 1. Keep a record of everything you eat and drink for 3 days. Be specific. Was it white or wheat bread, 1% or 2% milk, 1 cup or 1½ cups, did you
More informationEconomics 2010a. Fall Lecture 11. Edward L. Glaeser
Economics 2010a Fall 2003 Lecture 11 Edward L. Glaeser Final notes how to write a theory paper: (1) A highbrow theory paper go talk to Jerry or Drew don t listen to me. (2) A lowbrow or applied theory
More informationTHE NATIONAL ACADEMIES
THE NATIONAL ACADEMIES NATIONAL ACADEMY OF SCIENCES INSTITUTE OF MEDICINE NATIONAL ACADEMY OF ENGINEERING NATIONAL RESEARCH COUNCIL DIVISION ON EARTH AND LIFE STUDIES BOARD ON AGRICULTURE AND NATURAL RESOURCES
More informationNutrition Basics. Chapter McGraw-Hill Higher Education. All rights reserved.
Nutrition Basics Chapter 12 1 The Body s Nutritional Requirements Essential nutrients The Six Essential Nutrients: Proteins, Fats, Carbohydrates, Vitamins, Minerals, Water Defined as : Nutrients one must
More informationLifePak Health Benefits. LifePak is optimum supplementation for:
LifePak What is LifePak? Our comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being. LifePak Health
More informationTitle: Use of Beta-blockers and Mortality Following Ovarian Cancer Diagnosis: A Population-Based Cohort Study
Author's response to reviews Title: Use of Beta-blockers and Mortality Following Ovarian Cancer Diagnosis: A Population-Based Cohort Study Authors: Sigrun A Johannesdottir (saj@dce.au.dk) Morten Schmidt
More informationAuthor's response to reviews
Author's response to reviews Title:Placebo-Controlled Randomized Clinical Trial of Fish Oil's Impact on Fatigue, Quality of Life, and Disease Activity in Systemic Lupus Erythematosus Authors: Cristina
More informationTitle: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka
Author s response to reviews Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka Authors: Ishanka Talagala (drmaheshkeerthi@gmail.com;drishanka@gmail.com)
More informationModule 8 BONE HEALTH
Module 8 BONE HEALTH 2012, Integrative 2015Nutrition, Integrative Inc. Nutrition, Inc. 2 BONE HEALTH Approximately 25 million people in the United States are effected by osteoporosis. 40% of women and
More informationTitle: Defensive coping and health-related quality of life in Chronic Kidney Disease: a cross-sectional study
Author's response to reviews Title: Defensive coping and health-related quality of life in Chronic Kidney Disease: a cross-sectional study Authors: Anna Kaltsouda (akalts@cc.uoi.gr) Petros Skapinakis (p.skapinakis@gmail.com)
More informationBecome A Health Coach Certification. Pillar 1: Nutrition, Health & Wellness Week 1. Copyright All Rights Reserved. Pillar 1 Week 1 Video 2 1
Become A Health Coach Certification Pillar 1: Nutrition, Health & Wellness Week 1 1 Essential Nutrition : The Distilled Top 20% Of Nutrition, Health & Wellness Knowledge That Matters For Health Coaches
More informationFacts that you need to know
NUTRITION This article explores the basic concepts of nutrition and provides useful tips on healthy diet My neighbor walks up to me asking whether I am aware of the nutritional value of a new food product
More informationResearch Article A Study to Assess Relationship Between Nutrition Knowledge and Food Choices Among Young Females
Cronicon OPEN ACCESS EC NUTRITION Research Article A Study to Assess Relationship Between Nutrition Knowledge and Food Choices Among Young Females Maidah Nawaz 1 *, Samia Khalid 1 and Sania Ahmed 2 1 Department
More informationJuly 13, Dear Ms. Davis:
July 13, 2010 Carole Davis Co-Executive Secretary and Designated Federal Officer of the Dietary Guidelines Advisory Committee Center for Nutrition Policy and Promotion U.S. Department of Agriculture 3101
More informationTitle: Socioeconomic conditions and number of pain sites in women
Author's response to reviews Title: Socioeconomic conditions and number of pain sites in women Authors: Finn E Skjeldestad (fisk@fhi.no) Toril Rannestad (Toril.Rannestad@hist.no) Version: 2 Date: 17 January
More informationThe Goods on Nutrition: Eat to Live
The Goods on Nutrition: Eat to Live 2 Lesson 1: The Goods on Nutrition Vocabulary list Reference Notes alternative n. something available in place of another. anemia n. a blood disorder characterized by
More information2-3 class periods, time outside of class to track foods and beverages consumed for one day
MyPlate is Great! Time Frame: 2-3 class periods, time outside of class to track foods and beverages consumed for one day Overview: Students will create and categorize an alphabetical list of foods into
More informationTitle: Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry
Author's response to reviews Title: Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry Authors: Johan Maertens (johan.maertens@uz.kuleuven.ac.be)
More informationAuthor's response to reviews
Author's response to reviews Title: Smoking, alcohol consumption, physical activity, and family history and the risks of acute myocardial infarction and unstable angina pectoris: a prospective cohort study
More informationPEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)
PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)
More informationTitle: Co-morbidities, complications and causes of death among people with femoral neck fracture - A three-year follow-up study.
Author s response to reviews Title: Co-morbidities, complications and causes of death among people with femoral neck fracture - A three-year follow-up study. Authors: Monica Berggren (monica.langstrom@umu.se)
More informationPublishing Your Study: Tips for Young Investigators. Learning Objectives 7/9/2013. Eric B. Bass, MD, MPH
Publishing Your Study: Tips for Young Investigators Eric B. Bass, MD, MPH Learning Objectives To apply a logical approach to organizing & presenting your work in a manuscript To recognize the importance
More informationTitle:Medically Unexplained Symptoms and the risk of loss of labor market participation - A prospective study in the Danish population
Author's response to reviews Title:Medically Unexplained Symptoms and the risk of loss of labor market participation - A prospective study in the Danish population Authors: Katja Loengaard (nfa.klo@gmail.com)
More informationHypomagnesemia May Lead to Insulin Resistance
Hypomagnesemia May Lead to Insulin Resistance Nutritional Biochemistry NDFS 435 21 February 2013 Heidi Washburn Dr. Parker Hypomagnesaemia has been associated with increased insulin resistance. It is thought
More informationA Proposed Randomized Trial of Cocoa Flavanols and Multivitamins in the Prevention of Cardiovascular Disease and Cancer
A Proposed Randomized Trial of Cocoa Flavanols and Multivitamins in the Prevention of Cardiovascular Disease and Cancer JoAnn E. Manson, MD, DrPH Howard D. Sesso, ScD, MPH Brigham and Women's Hospital
More informationThe Meaning of Essential. Building Blocks of Your Wellness
The Meaning of Essential Building Blocks of Your Wellness The Age Of Convenience According to nutrition experts, the average Western diet contains too much sugar and too little fiber. 2 The combination
More informationManuscript ID BMJ entitled "Long-term Gluten Consumption and the Risk of Coronary Heart Disease"
BMJ - Decision on Manuscript ID BMJ.2017.037490 Body: 23-Feb-2017 Dear Dr. Lebwohl Manuscript ID BMJ.2017.037490 entitled "Long-term Gluten Consumption and the Risk of Coronary Heart Disease" Thank you
More informationCalifornia State University, Chico Department of Nutrition and Food Sciences NFSC 642, Topics in Vitamins and Minerals
California State University, Chico Department of Nutrition and Food Sciences NFSC 642, Topics in Vitamins and Minerals Professor: Julie Schneider Office location: Holt 104 Telephone: (530) 898-6567 Email:
More informationSTATISTICS 8 CHAPTERS 1 TO 6, SAMPLE MULTIPLE CHOICE QUESTIONS
STATISTICS 8 CHAPTERS 1 TO 6, SAMPLE MULTIPLE CHOICE QUESTIONS Circle the best answer. This scenario applies to Questions 1 and 2: A study was done to compare the lung capacity of coal miners to the lung
More informationRE: Title: Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis
September 10, 2018 Professor Xue-Jiao Wang, MD Science Editor Editorial Office 'World Journal of Gastroenterology' RE: 40814 Title: Practical fecal calprotectin cut-off value for Japanese patients with
More information