SA DIGESTIVE HEALTH INDUSTRY LANDSCAPE REPORT

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1 SA DIGESTIVE HEALTH INDUSTRY LANDSCAPE REPORT COMPILED: SEPTEMBER 2017

REPORT OVERVIEW The South African Digestive Health Industry Landscape Report 2017 (111 pages) provides a dynamic synthesis of industry research, examining the local and global Digestive Health

2 REPORT OVERVIEW The South African Digestive Health Industry Landscape Report 2017 (111 pages) provides a dynamic synthesis of industry research, examining the local and global Digestive Health industry from a uniquely holistic perspective, with detailed insights into the entire value chain from manufacturing to retail trends and pricing analysis. SOME KEY QUESTIONS THE REPORT WILL HELP YOU TO ANSWER: For the Global Digestive Health Industry Section: What are the current segmentation and market dynamics of the Digestive Health industry? What are the Digestive Health industry trends, drivers, and restraints? For the South African Digestive Health Industry Section: What are the current market dynamics, market size and forecasts for the SA Digestive Health industry? Who are the key manufacturing players in the SA Digestive Health industry? What are the South African industry trends, drivers and restraints? For the South African Retail and Pricing Analysis Section: Who are the key retail players (retail pharmacies, in-store retail pharmacies, hospital-based pharmacies, general pharmacies) in the SA Digestive Health industry? What are the prices of popular Digestive Health OTC medication across SA retail pharmacy outlets? 2

3 SCREENSHOTS FROM REPORT 111-page report filled with detailed charts, graphs, tables and insights 3

SAMPLE FROM REPORT: GLOBAL INDUSTRY OVERVIEW: PREVALENCE Kantar health surveyed men and women in several countries on various health metrics.

Women, in particular, are seen as being the principal force behind growth in probiotics.

25% 20% 15% 10% 5% With the exception of China, women generally have more gastrointestinal conditions than men as shown in the adjacent graph.

4 SAMPLE FROM REPORT: GLOBAL INDUSTRY OVERVIEW: PREVALENCE Kantar health surveyed men and women in several countries on various health metrics. As shown in the graph below, gastrointestinal conditions are common, and more prevalent in the United States and Europe. Women, in particular, are seen as being the principal force behind growth in probiotics. Female consumers buying decisions are impacted by the focus on maintaining their families' health, and their high interest in digestive health ranges from Baby Boomers to Millennials. 25% 20% 15% 10% 5% With the exception of China, women generally have more gastrointestinal conditions than men as shown in the adjacent graph. PREVALENCE OF DIAGNOSED GASTROINTESTINAL CONDITIONS IN SELECTED COUNTRIES AS OF % 20% 18% 12% 11% 9% 100% 80% 60% 40% 20% 0% DISTRIBUTION OF DIAGNOSED GASTROINTESTINAL CONDITIONS IN SELECTED COUNTRIES AS OF 2016, BY GENDER 58% 60% 60% 61% 46% 56% 42% 41% 40% 39% 54% 44% United states EU-5 Brazil Russia China Japan *Note: Results from Kantar Health research: Base numbers of surveyed adult populations: United States: n = 97,700; European Union (EU-5): n = 80,600; Japan: n = 39,000; China: n = 26,000; Brazil: n = 15,600; Russia: n = 10,000. Female Male 0% United States EU-5 Brazil Russia China Japan Source: Statista; Statista; Global Newswire Image Source: Onnit; Bulletproof Blog; Chris Kresser

SAMPLE FROM REPORT: SA INDUSTRY MARKET TRENDS The New Era of the Digestive Wellness Trend Digestive Wellness is a long established benefit platform which is now entering a new era due to the

Emerging Digestive Health ingredients include proteolytic enzymes which are primed to grow in popularity with the trend towards high protein, as these enzymes are thought to help digest protein.

5 SAMPLE FROM REPORT: SA INDUSTRY MARKET TRENDS The New Era of the Digestive Wellness Trend Digestive Wellness is a long established benefit platform which is now entering a new era due to the emergence of new technologies, new products, and the new understanding of the broad effects that gut health has on overall health, especially in relation to the gut microbiome. Emerging Digestive Health ingredients include proteolytic enzymes which are primed to grow in popularity with the trend towards high protein, as these enzymes are thought to help digest protein. Furthermore, next generation plusbiotics claim to support the regrowth of intestinal mucosa (the innermost layer of the gastrointestinal tract) by repairing damage and strengthening the intestinal lining. There is a growing excitement amongst researchers and consumers alike at the plethora of possibilities that unique microbe strains may bestow upon Gut Health. Although Probiotics and more so Prebiotics have long been recognised for their digestive and immune health benefits, seeing as 70% of immune cells reside within the digestive tract, new products are quickly emerging in this growing market. Within food and beverages, prebiotics is one of the leading digestive health ingredients, becoming increasingly popular amongst consumers as treatment for digestive issues. 5 Source: Khni.Kerry Image Source: Tasteforlife; Thrivemarket; Performatrin

Rand in millions SAMPLE FROM REPORT: SA MANUFACTURER OVERVIEW: ADCOCK INGRAM Adcock Ingram s OTC turnover for the year ended 30 June 2017 improved by 11% to R1.

6 Rand in millions SAMPLE FROM REPORT: SA MANUFACTURER OVERVIEW: ADCOCK INGRAM Adcock Ingram s OTC turnover for the year ended 30 June 2017 improved by 11% to R1.8 billion, in comparison to the previous period. This contributed 31% to the group s revenue. Over-the-counter (OTC) medicines are Adcock Ingram s second-biggest contributor to revenue but biggest contributor to profit. Adcock Ingram grew overall revenue by 7% to R5.9 billion and after-tax profit was up 213% to R561 million in the year to end- June Trading profit grew 10%, to R342 million, contributing 47% of the group s total. 6 On 1 April 2017, Adcock Ingram Healthcare Proprietary Limited acquired 100% of the shareholding of Virtual Logistics Proprietary Limited (Virtual), a national distribution company. Virtual complements the Adcock's reach and capacity, allowing for improved service levels to customers. As illustrated in the graph below, Adcock Ingram s turnover for the year ending 30 June 2017 increased from R5.5 billion to R5.9 billion for the period. ADCOCK INGRAM REVENUE FOR THE YEAR ENDED 30 JUNE 2017 (IN BILLION RANDS) The group declared a final dividend of 76c, taking its total share price for the year to R1.39, a 34% increase on the prior year s R1.04. In the year to date, the share price is up 34.8%. Prescription turnover improved by 5.9% to R1.9 billion, compared to R1.8 billion in June 2016 and this was substantially aided by the SEP increases Audited Revenue for the year ended 30 June 2016 Audited Revenue for the year ended 30 June Source: Adcock Ingram annual results for the year ended 30 June 2017; Business Live Image Source: Adcock Ingram

7 SAMPLE FROM REPORT: SA RETAIL OVERVIEW A product price analysis conducted by Insight Survey in mid-september 2017 between Dis-Chem, Durbell, MediRite, Clicks and Pick n Pay pharmacies shows that, across a selected basket of products, Dis-Chem offers the cheapest option for OTC Digestive Health medication. A contributing factor for Dis-Chem being the cheapest retail pharmacy at the time of the analysis was because four of their Digestive Health products were at a low cost. Durbell was the second cheapest basket of selected OTC Digestive Relief products. Gelacid, for example, had the lowest price at Durbell. Product Dis-Chem Durbell Pick n Pay Clicks MediRite Alkafizz 60g R39.55 R39.95 R38.99 R43.95 R49.99 Citro-Soda 60g R49.95 R47.95 R54.99 R47.95 R47.99 Eno Active Fruit Salts 200g Gaviscon Heartburn Relief 8 Tabs R63.95 R69.95 R72.99 R67.95 R69.99 R12.95 R14.95 R15.99 R14.95 R15.99 Gelacid 100ml R47.95 R39.95 R41.99 R46.95 R54.99 ProbiFlora Classic Bowel Support 30 Caps Rennie Antacid Aniseed 48 Tabs R R R R R R42.95 R44.95 R47.99 R45.95 R44.99 Total R R R R R MediRite Pharmacy was the most expensive retail pharmacy store. The basket was R36.68 more expensive than Dis-Chem s total. 7 Source: Insight Survey Image Source: Pixabay; Clicks Online

00 R129.99 R119.95 N/A R12.95 R14.50 N/A N/A N/A Agiolax 4x10g Sachets R36.95 R37.95 N/A R39.

8 SAMPLE FROM REPORT: PRICING ANALYSIS: DIGESTIVE HEALTH BRAND AND QUANTITY A.Vogel Adco- Mayogel 200 Gastronol Tablets 200ml Molkosan Original Prebiotic Food Supplement 100ml Suspension Antacid R99.95 R99.95 N/A R99.95 N/A R R R R N/A R12.95 R14.50 N/A N/A N/A Agiolax 4x10g Sachets R36.95 R37.95 N/A R39.95 N/A Alkafizz Amipro 250g 60g Gastric Antacid 70 Caps Colon Ecology 60 Caps Digestizyme R R N/A R N/A R39.55 R43.95 R49.99 R39.95 R38.99 R N/A N/A N/A N/A R N/A N/A R N/A Anusol 10 Supp R24.75 N/A N/A N/A N/A This pricing analysis was conducted at pharmacies during w/c 11 September

TABLE OF CONTENTS 1. Executive Summary (3 pages): 1.1 Global Industry Snapshot 1.2 South African Industry Snapshot 1.3 Industry Drivers and Restraints 2.

9 TABLE OF CONTENTS 1. Executive Summary (3 pages): 1.1 Global Industry Snapshot 1.2 South African Industry Snapshot 1.3 Industry Drivers and Restraints 2. Global Digestive Health Industry (22 pages): 2.1 Global Digestive Health Industry Overview: Background 2.2 Global Digestive Health Overview: Related Health Conditions: LEADING WORLDWIDE CONSUMER HEALTH COMPLAINTS: HEALTH CONDITIONS AND DIGESTIVE HEALTH (Graph & Table) 2.3 Global Digestive Health Overview: Segmentation 2.4 Global Digestive Health Overview: Prebiotics 2.5 Global Digestive Health Overview: Probiotics 2.6 Global Digestive Health Overview: Digestive Enzymes 2.7 Global Digestive Health Overview: Antacids 2.8 Global Digestive Health Overview: Laxatives: TYPES AND THEIR DESCRIPTION (Table) 2.9 Global Digestive Health Overview: Antidiarrhoeal Medications: DRUG CLASS SEGMENTS; LEADING GLOBAL CAUSES OF DEATH AMONG CHILDREN UNDER 5; WHICH HEALTH RISKS WOULD CAUSE YOU TO CHANGE YOUR TRAVEL PLANS? (Graphs & Table) 9

10 TABLE OF CONTENTS 2. Global Digestive Health Industry (cont.) (22 pages): 2.10 Global Digestive Health Industry Overview: Prevalence: PREVALENCE OF DIAGNOSED GASTROINTESTINAL CONDITIONS IN SELECTED COUNTRIES AS OF 2016; DISTRIBUTION OF DIAGNOSED GASTROINTESTINAL CONDITIONS IN SELECTED COUNTRIES AS OF 2016, BY GENDER (Graphs) 2.11 Global Key Markets Overview: Regional North America: TOP 5 SPECIALTY SUPPLEMENT TYPES IN THE U.S. AMONG ADULTS 2016 (Graph) 2.12 Global Key Markets Overview: Regional Asia-Pacific 2.13 Global Key Markets Overview: Regional Europe: ATTITUDES TO HEALTHY FOODS IN EUROPE (Graph) 2.14 Global Industry Trends 2.15 Global Industry Drivers 2.16 Global Industry Restraints 3. South African Digestive Health Industry (48 pages): 3.1 South African Digestive Health Industry Overview (15 pages) SA Industry Market Environment: THE SOUTH AFRICAN PHARMACEUTICAL MARKET BY SEGMENT (IN PERCENTAGE): 2016 (Graph) SA Industry Overview: Pharmaceutical Market: GROWTH OF THE SA PRIVATE PHARMACEUTICAL MARKET SECTOR (IN ZAR BILLION): 2016 & 2020(f) (Graph) SA Industry Overview: Over-the-Counter Market: PHARMACEUTICAL MARKET SEGMENTATION: 2016 (Graph) SA Industry Size: Digestive Health Market : VALUE OF DIGESTIVE HEALTH REMEDIES , VALUE GROWTH % ; VALUE AND VOLUME OF INDIGESTION AND HEARTBURN REMEDIES, LAXATIVES, DIARRHOEAL REMEDIES (Graphs and Tables), FORECASTS SA Industry Market Trends SA Industry Market Drivers SA Industry Market Restraints 10

11 TABLE OF CONTENTS 3. South African Digestive Health Industry (cont.) (48 pages): 3.2 South African Digestive Health Manufacturing Overview (33 pages) SA Digestive Health Manufacturers: Adcock Ingram: Overview: ADCOCK INGRAM REVENUE FOR THE YEAR ENDED 30 JUNE 2017 (IN BILLION RANDS) (Graph) SA Digestive Health Manufacturers: Adcock Ingram: Digestive Health Brands SA Digestive Health Manufacturers: Ascendis Health: Overview: ASCENDIS HEALTH REVENUE FOR THE YEAR ENDED 30 JUNE 2017 (IN BILLION RANDS) (Graph) SA Digestive Health Manufacturers: Ascendis Health: Digestive Health Brands SA Digestive Health Manufacturers: Aspen Pharmacare: Overview: ASPEN PHARMACARE REVENUE FOR THE SIX MONTHS ENDED 31 DECEMBER 2016 (IN BILLION RANDS) (Graph) SA Digestive Health Manufacturers: Aspen Pharmacare: Digestive Health Brands SA Digestive Health Manufacturers: Austell Laboratories: Overview SA Digestive Health Manufacturers: Austell Laboratories: Digestive Health Brands SA Digestive Health Manufacturers: Bayer: Overview SA Digestive Health Manufacturers: Bayer: Digestive Health Brands SA Digestive Health Manufacturers: Biogen: Overview SA Digestive Health Manufacturers: Cipla: Overview SA Digestive Health Manufacturers: Cipla: Digestive Health Brands SA Digestive Health Manufacturers: CoMED Health: Overview SA Digestive Health Manufacturers: CoMED Health: Digestive Health Brands 11

TABLE OF CONTENTS 3. South African Digestive Health Industry (cont.) (48 pages): 3.2 South African Digestive Health Manufacturing Overview (cont.) (33 pages) 3.2.16 SA Digestive Health Manufacturers: GSK: Overview 3.

12 TABLE OF CONTENTS 3. South African Digestive Health Industry (cont.) (48 pages): 3.2 South African Digestive Health Manufacturing Overview (cont.) (33 pages) SA Digestive Health Manufacturers: GSK: Overview SA Digestive Health Manufacturers: GSK: Digestive Health Brands SA Digestive Health Manufacturers: Nativa: Overview SA Digestive Health Manufacturers: Nativa: Digestive Health Brands SA Digestive Health Manufacturers: Nature s Choice: Overview SA Digestive Health Manufacturers: Nature s Choice: Digestive Health Brands SA Digestive Health Manufacturers: Reckitt Benckiser: Overview SA Digestive Health Manufacturers: Reckitt Benckiser: Digestive Health Brands SA Digestive Health Manufacturers: SA Natural Products: Overview SA Digestive Health Manufacturers: SA Natural Products: Digestive Health Brands SA Digestive Health Manufacturers: Sanofi: Overview SA Digestive Health Manufacturers: Sanofi: Digestive Health Brands SA Digestive Health Manufacturers: Other Manufacturers/Distributors 12

13 TABLE OF CONTENTS 4. South African Digestive Health Retail Analysis (23 pages): 4.1 South African Digestive Health Retail Overview (2 pages) SA Retail Overview: NUMBER OF STORES PER PHARMACY: 2017; PRODUCT PRICE ANALYSIS: DIS-CHEM, DURBELL, CLICKS, MEDIRITE, PICK N PAY (Graph & Table) 4.2 South African Pharmacies (8 pages) SA Pharmacies: Clicks: Overview: PERCENTAGE CONTRIBUTION TO TOTAL SALES OF CLICKS PER HEALTH AND BEAUTY SALES CATEGORY FOR (6 MONTHS ENDED 28 FEBRUARY 2017) (Graph) SA Pharmacies: Clicks: Digestive Health Medication SA Pharmacies: Durbell: Overview SA Pharmacies: Dis-Chem: Overview SA Pharmacies: Dis-Chem: Digestive Health Medication SA Pharmacies: Other SA Retailers: MEDIRITE; PICK N PAY PHARMACY; SPAR PHARMACY; MEDICLINIC PHARMACY; NETCARE PHARMACY; LINK; ALPHA PHARM; WELLNESS WAREHOUSE 13

TABLE OF CONTENTS 4. South African Digestive Health Retail Analysis (cont.) (23 pages): 4.3 South African Digestive Health Pricing Analysis (13 pages) (conducted w/c 11 September 2017) 4.3.1 SA Digestive Health Pricing Analysis: A.

14 TABLE OF CONTENTS 4. South African Digestive Health Retail Analysis (cont.) (23 pages): 4.3 South African Digestive Health Pricing Analysis (13 pages) (conducted w/c 11 September 2017) SA Digestive Health Pricing Analysis: A.Vogel; Adco-Mayogel; Agiolax; Alkafizz; Amipro; Anusol; Bio-harmony; Biogen; Black Forest Herbal tea; Brooklax; Citro-Soda; Combiforte Spray; Creche Guard; Dulcolax; Duphalac; Eno; Enteron; Entiro; Flora Force; Food State; Freshen; Gaviscon; Gelacid; GNC; Iberogast; Imsyser; Inteflora 250; Lacson; Lactovita; Laxador; Laxette; Lennon; Lenolax Enema; Maalox Plus Suspension; Met-S Dietary Fibre; Movicol; Nativa; Natsure; Natura; Nature s Choice; Naturmade; Normacol Plus; NRF FoodMatrix Digestive Enzyme; NutriLida Lp299v; Pharma-Choice Gastro Choice IBS; Phipps; Phyto Nova African Ginger; Phyto-Force Ginger Tablets; Preparation H; Pro-B6 Suspension; ProbiFlora; Prosit Alcohol Free; Pure Nutrition Technology; Rennie Antacid Aniseed; Reuterina; Select Digest; Senokot Natural Laxative; Smecta Diosmecite For Diarroea; Soflax; Solal; Spasmopep Digest; Stillen; Tasectan; Tim Jan; Ulsanic Suspension; Vitaforcce; Wellvita - Comparative Pricing at Dis-Chem, Clicks, MediRite Pharmacy, Durbell Pharmacies, Pick n Pay Pharmacy. 14

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COMPANY OVERVIEW Insight Survey is a South African B2B market research company with almost 10 years of heritage, focusing on business-to business (B2B) market research to ensure smarter,

16 COMPANY OVERVIEW Insight Survey is a South African B2B market research company with almost 10 years of heritage, focusing on business-to business (B2B) market research to ensure smarter, more-profitable business decisions are made with reduced investment risk. We offer B2B market research solutions to help you to successfully improve or expand your business, enter new markets, launch new products or better understand your internal or external environment. 16

COMPETITIVE INTELLIGENCE Our bespoke Competitive Business Intelligence Research can help give you the edge in a global marketplace, empowering your business to

From strategic overviews of your business s competitive environment through to specific competitor profiles, our customised Competitive Intelligence Research is

17 COMPETITIVE INTELLIGENCE Our bespoke Competitive Business Intelligence Research can help give you the edge in a global marketplace, empowering your business to overcome industry challenges quickly and effectively, and enabling you to realise your potential and achieve your vision. From strategic overviews of your business s competitive environment through to specific competitor profiles, our customised Competitive Intelligence Research is designed to meet your unique needs. OUR RESEARCH SOLUTIONS Competitor pricing research Store visits and store checks Competitor interviews Customer interviews Company website analysis Governmental held records 17

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