Quantidoc AS. The presence of health. Slimy Barriers: The first defense in disease

Transcription

1 Quantidoc AS The presence of health Slimy Barriers: The first defense in disease 1

2 HIGH MORTALITY & LOW PERFORMANCE in fish farming Costs have increased by more than 50% in 10 years. Transfer losses 11 % Directorate of Fisheries 2014 review: 33.8% mortality of salmon juveniles Mortality; 1,3% Sales marketing; 2,4% Depreciation 3,0% Well boat; 3,8% Maintenanc 3,5% Other; 13,0% Includes vaccination/treatment Feed; 48,1 % Industrial development in reverse? Smolt; 8,9% Salary; 5,8% Primary processing; 10,2% Cost includes mortalities & treatment Breakdown of salmon production costs

3 SEA LICE IS INDUSTRY CHALLENGE #1... Sealice treatments = 10 % of production costs Strictly regulated - Sampling - Maximum levels - 10 tonnes of active compounds (Slice etc) tonnes of hydrogen peroxide - Mandatory culling due to lice levels In the fight against lice we forgot the salmon biology It is biology, not chemicals! 3

4 THE NATURAL PROTECTION MECHANISM Mucus Boosting Feed Lice/disease HEALTH Fish 4

5 WHAT ANY SPORTSFISHERMAN KNOWS Mortality in Atlantic salmon* Slime wiped off Damaged skin Control group Survival is better with a good mucous layer Applies to all fish species Applies to any infection Days after exposure for Vibrio bacteria It s basic biology!! 5 Svendsen and Bøgwald 1997*

6 THE SKIN REACTS IMMEDIATELY TO LICE From a controlled trial: Infestation of lice-free salmon juveniles by sea lice copepodites: 1. Skin turns blue at «landing sites» 2. All early stages of lice washed off IF the mucous layer is active Adult lice inhibits mucous - production, natural response stops Attached adult lice clear the way for new copepodites 6

7 MUCOSAL MAPPING IN SALMONIDS 7 Parasites go where mucosal cells are small and few

8 Resting state Responding state Parasite arrives Mucous cells at rest Large mucous cells are replaced by larger quantities of smaller and smaller cells that move quicker through the skin Many smaller cells wash off the parasites Skin returns to resting state if parasites are removed 8

9 ANIMATION OF THE STRESS RESPONSE

10 1 0 WHERE TO MEASURE HEALTH, BESIDES THE BLOOD? Whole fish (Growth, mortality) Organ level (skin, gills, guts) Summarizes effect of several hundred genes Gene level

11 SLIME IS PROACTIVE KEY COMPONENTS substance antibacterial antifungal antiviral antiparasitic H2A peptider 11 H1 oncorhyncin2 H6 oncorhyncin3 pleurocidin Sal-2 complement factors hydrolytic enzymes (proteases etc) Antigenantibody Antigenantibody Antigenantibody Antigenantibody degrade degrade degrade degrade IgM, IgT basic antibodies basic antibodies basic antibodies basic antibodies lectins pathogen recognition pathogen recognition pathogen recognition pathogen recognition mucous extract interferon

12 KNOWLEDGE & ADDED VALUE IN THE VALUE CHAIN A weather forecast for fish health and welfare From gut feeling to measurement Improve fish health and performance This know-how reduces production cost Fresh water Sea water Slaughter and processing Market and consumer Brood stock and genetics Quantify selected traits and innate immune system status 12 Fish feed Quantify effects of feed ingredients Robustness of juveniles Vaccination interactions Quantifiable health & welfare index Labelling, quality index and certification Lice treatment programmes Treatment frequency Mucosal recovery, Environmental stress and disease response

13 MUCOSAL MAPPING Product 1. Quantifies and documents the fish s HEALTH A diagnostic method health status of skin, gills and guts Quantitative, objective & comparable Statistically robust Links diet, and handling procedures with immunity 2. Scientifically proven (3 peer-reviewed publications) Scope A B2B decision-making tool for fish health and welfare 1. Quantidoc owns IPR 2. The method applies for any mucous barrier, scope far beyond fish Human health and any other animal 3. Applies for parasites, sealice is only the first. Also bacteria & virus 4. Applied in 4 countries, on 4 species and on 3 tissues 13

14 The team involved COB CEO (ai) CSO & Director Director Director Director International business Hans Runshaug Ole Jacob Myre Prof. Karin Pittman Jørgen Borthen Bjarne Ravnøy Barbara Salopek (BTO) Dr. E. Sweetman 14 A strong and complementary team with: - An in-depth scientific knowledge - A commercial focus - A proven industry track record - An international network for other species - Fully owned by the team involved

15 OUR BUSINESS IDEA: «Quantidoc helps customers save money by providing a better biological decision making tool.» For more information: www. quantidoc.com 15