IMD - Intestinal Metals Detox

Transcription

1 IMD - Intestinal Metals Detox A System for Removing Metals from the Intestines and Catalyzing Whole-Body Detoxification 1. Summary Quicksilver Scientific has developed an innovative supplement product known as IMD (Intestinal Metals Detox), designed to promote the safe and effective therapeutic detoxification of mercury and other toxic metals from the body. This proprietary compound r eboots and optimizes key biological detoxification processes for the safe removal of metals through the intestines and reduces the liver and kidney stress common with pharmaceutical chelation therapy. IMD optimizes the natural action of glutathione in the intestines by using insoluble thiol groups to bind and remove heavy metals accumulated in the intestines and to directly quench free-radicals. IMD: 2. Theory Binds mercury and other heavy metals in the intestines and escorts these harmful contaminants out of the body. Intercepts methylmercury and other heavy metals trapped in enterohepatic circulation. Leads to lowering of blood mercury levels, allowing organ and tissue bound mercury to safely drain into the blood at a natural rate (Figure 2, page 5). Improves the body s natural detoxification ability by quenching free radicals and stopping metalcatalyzed free-radical reactions which can lead to inflammation and cause down-regulation of detox transporters (Phase III transporters OATs, cmoat, MRPs, etc). 1 Fortifies the link between the intestines and the immune system. 2.1 Active Chemistry of IMD The Intestinal Metals Detox (IMD) is a proprietary formula that consists of highly purified silica with covalently attached metal-binding groups. Both the silica base and the binding agent are GRAS (generally recognized as safe) by the FDA for use in human food. The specific chemistry of the compound has several benefits over other detoxification remedies: The active binding groups out-compete other compounds for metals in the intestines. Because IMD does not enter the bloodstream, it will not lead to spikes in blood mercury levels or kidney/liver overload. In fact, preliminary data suggests increased liver functioning in some patients, as measured by changes in bilirubin levels. The chemistry of the attachment between binding groups and silica ensures the compound will not suffer significant breakdown in the intestines. 2.2 Disruptions in Natural Body-Wide Detoxification Intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the body s natural detoxification pathways. 1 Ironically, exposure to certain toxins contributes to intestinal inflammation. For example, the corrosion of silver dental amalgam alloy results in mercuric mercury (Hg II ) release. When swallowed with saliva, Hg II can cause intestinal inflammation and initiate this negative feedback. 2 Quicksilver Scientific IMD White Paper Page 1 of 7

2 Healthy Detoxification (Figure 1, left) Detoxification processes occur throughout the body. A healthy detoxification pathway typically involves three phases. Phase I involves oxidative activation of a toxin. This prepares the toxin for conjugation to a hydrophilic biomolecule in Phase II. The conjugate is then moved through a series of Phase III transporters, leading to intestinal or kidney excretion. Impaired Detoxification (Figure 1, right) Intestinal inflammation disrupts detoxification in two ways. 1) Inhibiting the conjugation of toxins throughout the body and inhibiting transport of toxins into the intestines. Intestinal inflammation down-regulates Phase III transporters. When transporters downregulate, Phase II activity, which is coupled to Phase III, is also turned down. 3 Phase I activity, however, does not get down-regulated. Phase I oxidation continues but is no longer coupled to Phase II conjugation. 2) Inhibiting glutathione activity in the intestines. Phase III transporters bring glutathione (GSH) into the intestines from the liver. 4 GSH is the primary anti-oxidant for quenching free-radical reactions in the intestines. 5 A deficiency of GSH is a symptom of inflammatory bowel diseases, including Crohn s Disease. 6 Thus down-regulation of Phase III transporters can be self-propagating as oxidative stress stops the flow of this crucial antioxidant. Recent research at the Nestle Cancer Center in Switzerland 8 examined genetic expression of the body s detoxification pathways and found that the small intestine and the liver work together to coordinate detoxification and metabolism. The Nestle Center also found that glutathione activity is predominantly modulated from the small intestine. This finding supports our model of Phase III transporters in the intestines controlling Phase II pathways and points to the centrality of the intestines in any detoxification protocol. 3. Data Supporting IMD Safety and Efficacy Figure 1. Comparing Healthy and Impaired Detoxification Healthy Detoxification Impaired Detoxification Phase I Oxidative Activation Phase I Oxidative Activation 4 Oxidative Stress From Phase I/Phase II mismatch Phase II Glutathione Conjugation Sulfation Glucuronidation Phase II Glutathione Conjugation Sulfation Glucuronidation Phase III Cellular MRP2 Blood OATP LIVER MRP2 Phase III 3 Build-up of both cellular and blood-borne toxins 1 Inflammation causes Downregulation of MRP2 Cellular MRP2 Blood OATP LIVER MRP2 Negative Feedback Inhibition of Phase II 2 Normal Small Intestine Transporters between liver and intestines function well. This permits conjugates to enter the intestines for excretion. Also the transporters bring chemicals, such as glutathione, into the intestines, allowing for detoxification of the intestines as well. Quicksilver Scientific IMD White Paper Page 2 of 7 Inflamed Small Intestine Intestinal inflammation down regulates transporters. This leads to accumulation of toxins in the intestines and throughout the body. Oxidative damage caused by toxic buildup in the intestines causes further intestinal inflammation inhibition of transporters.

3 3.1 Historical Use of Insoluble Thiolated Compounds The concept of an IMD-type product is not entirely new. It was successfully tested and used in the 1970 s. However, absorbable chelators such as DMSA and DMPS received greater clinical exposure and were adopted by the medical community during the 1980 s and 90 s. The most researched version of an IMDtype product used in the 1970 s took the form of thiol ligand attached to a polymer backbone (polystyrenedivinylbenzene a polymerized organic solvent similar to toluene). This thiolated polymer resin (termed polythiol resin) was well-researched to prove safety and efficacy in animal and human studies. In fact, it was used during a mercury poisoning outbreak in Iraq. The Quicksilver innovation of a silicon dioxide (same formula as quartz) backbone for IMD provides a much more natural substrate for the human body that will not provoke a reaction from the immune system in the gut. Potential toxicity will be due to the thiol groups more than the backbone, so the toxicity studies on the polythiol resin outlined below apply to IMD Animal Safety Study A safety study was conducted in 1973 by Schwetz et al. to evaluate the effects of the polythiol resin on embryonal, fetal and neonatal development in rats 9. The study evaluated doses of 150 and 1500 mg/kg/day (administered at various time periods to evaluate different periods of development). Assuming a 75 kg human, this is 11,250 mg per day at the low dose and 112,250 mg per day at the high dose. A normal dose of IMD is mg and the density of silica is roughly 2X that of the polymer resin. A polymer resin has roughly 2X the amount of thiols per weight due to its higher volume, so 100mg of IMD has the equivalent volume and equivalent amount of thiol as 50mg polythiol resin. This makes the low dose of the safety study ~220 times the lower normal dosage of IMD and the high dosage in the study ~2200 time the lower normal dose of IMD. Despite the high dosing, the 150mg/kg/day dosage showed no effect on the developing embryo, fetus, or neonate. The high dosing (2200X our dosing rate) showed some delay in ossification of skull bones but no teratogenic effects. Some effect is not surprising at this high dose Animal Efficacy Study Effectiveness of the polythiol resin at lowering body burden of mercury was evaluated in a feeding trial where mice were injected with methylmercury and then fed a control diet or the same diet with polythiol resin added to it 10. After 42 days of resin treatment, mercury levels in blood, brain, kidney and liver had been reduced by a factor of 7.2, 6.0, 7.2 and 10.0 respectively. The comparison between treated and untreated animals is highlighted in the reproduced table below. The reduction in organ levels points to the rapid redistribution of methylmercury that occurs throughout the body (quotes in panel to left). The mechanism of cleaning the blood through the intestines leads to efficient lowering of organ burdens as well. The study also found that the resin reduces absorption of mercury in the diet by 50%, which has profound implications for prophylaxis of people with high-fish diets. Quicksilver Scientific IMD White Paper Page 3 of 7

4 3.1.3 Human Use for Iraq Methylmercury Poisoning The polythiol resin was used to treat human subjects during the methylmercury poisoning outbreak of , where homemade bread was made from wheat treated with a methylmercury fungicide. 11 The efficacy was judged against absorbable chelators DMPS (dimercapto propane sulfonate), PEN (D-penicillamine), and NAP (n-acetyl-dlpenicillamine). The results (reproduced at left) showed a ~3-fold lowering of methylmercury ½-life in the blood. Based on the findings of the animal study, we can presume that this lowering of methylmercury also occurs in the brain/organs. The polythiol resin outperformed PEN and NAP. It also compared favorably with DMPS (the most powerful, but also the most aggressive and potentially nephrotoxic mercury chelator). 3.2 Recent Results with Silica-based Thiol - IMD Small-scale clinical trials and case studies with IMD provide results consistent with the Iraq polythiol trial, however at a ~10 to100-fold lower dosage. Iraq poisoning dosage ranged from 2,250 to 16,500 mg/day for a 75-kg person. Typical IMD use is only mg/day. This increase in efficacy is made possible by the unique proprietary thiol group linked to the silica particle Half-life Lowering with IMD Blood MeHg (ng/ml) blood MeHg Fecal MeHg Excretion /10/08 08/20/08 08/30/08 09/09/08 09/19/08 09/29/08 10/09/08 10/19/08 10/29/08 Table 1. Blood Mercury Change in Patients in 7-10 Day Intervention - Dental revision in conjunction with IMD and nutritional support Clinic 1 IMD (n=8) % Change HgT % Change MeHg % Change Hg II No Treatment (n=4) Half-life of MeHg was measured after a single dose of high-hg fish. With a dosage of 200mg/day of IMD, the half life was measured at 17 days and the time back to baseline at 40 days. This compares with an untreated half-life of 60 days and a polythiol resin treatment half-life of 19 days (Iraq study). 11 A study of fish-mercury half-life done by Clarkson 12 shows a half-life of days and a time to baseline of 160 days after a single dose of high-hg fish. IMD is showing a roughly 4- fold increase in depuration rate in comparison to no treatment Short-Term Clinical Use Small-scale clinical trials were conducted with patients undergoing dental amalgam revision. In Clinic 1, after 7-10 days of treatment with IMD, patients experienced an average 23.9% decrease in total blood mercury (Table 1 at left). Very little change is seen in people who did not use IMD. This period of rapid decay in blood level is usually followed by a slower decay as the body reequilibrates and releases mercury from both intracellular and extracellular spaces into the blood. Fecal MeHg (ng/g-ww) Quicksilver Scientific IMD White Paper Page 4 of 7

5 3.2.3 Long-term Use Case Studies Long-term data from Dr. Christopher Shade shows that IMD use combined with dental revision steadily decreases methyl (MeHg) and inorganic mercury (Hg II ) blood levels over a period of months. Blood Hg II shows a two-phase reduction featuring a rapid initial decrease followed by slower decrease (Figure 2). Fecal excretion data (not shown) reveals release and excretion from bodily stores (from 1/30 th to 1/10 th of the blood burden of MeHg excreted per day). Blood MeHg levels constantly equilibrate with (and track) the body burden, which is consistent with other reports. 13 These decreases are especially significant when comparing these results to a large-scale baseline study of patients undergoing dental revision without any detoxification. 14 This study showed that total blood mercury levels did not decrease following revision. Dental revision actually promoted an increase in MeHg over time (Figure 3), whereas patients who did not undergo dental revision had stable levels of blood MeHg and Hg II. The increase in blood MeHg after revision is consistent with our model: Following removal of the intestine s irritating mercury source (i.e. amalgam), activity of Phase II enzyme Glutathione S- Transferase increases and moves mercury Methylmercury MeHg Inorganic Hg(II) Total HgT Methylmercury MeHg Inorganic Hg(II) Total HgT Patient Before #1: Fish Blood Mercury Consumption Comparison Ceased Concentration of Mercury (ng/ml or ug/l) Before Blood Mercury Comparison Patient #2: Fish Consumption Continued Concentration of Mercury (ng/ml or ug/l) Patient #3: Fish Consumption Ceased and Amalgams Removed 3/14/ /10/2008 QS Average 8/8/2008 1/23/2009 QS Average MeHg Methylmercury Inorganic Mercury Concentration of Hg in Blood (ng/ml) 2/12/209 4/16/2009 5/7/2009 7/8/2009 8/25/2009 Figure 2. Long-Term Blood Mercury Decrease Figure 3. Baseline Study of Dental Revison MeHg Revision Group MeHg No Revision Group Hg II No Revision Group Hg II Revision Group out of cells into the bloodstream. Unfortunately, enterohepatic circulation prevents it from leaving the body. Other Long-Term Case Studies: Several hundred patients have now used IMD during long-term detoxification. Monitoring data from three of the initial patients is shown to the left. Patient #1 was a long-time fish consumer that had amalgams for most of her life they were removed several years before the detox. She ceased fish consumption during the detox and her MeHg levels fell ~70% over three months. Patient #2 still had dental amalgams and ate a lot of fish. He neither removed his amalgams nor ceased fish consumption, yet still managed to have a 30% decrease in MeHg over 6 months of use. Patient #3 had amalgams and ate large amounts of tuna salad. With removal of his amalgams and cessation of fish consumption, he achieved an 80% removal of MeHg and 90% removal of HgII in 6 months. Quicksilver Scientific IMD White Paper Page 5 of 7

6 3.2.4 Evidence for Opening of Phase III Transporters with IMD Bilirubin is a by-product of hemoglobin breakdown. Accumulation of bilirubin in the blood is the cause of jaundice and is generally considered to be a sign of poor liver function. Extensive experimentation demonstrates that the major problem associated with bilirubin excretion is the failure of Phase III transporters to move the conjugated bilirubin from the liver into the intestines. 4 This is the same transporter that moves glutathione and glutathione conjugates (including mercury-glutathione 15 ) into the intestines and sulfate conjugates into the urine. 16 There is abundant anecdotal evidence of a connection between mercury toxicity and bilirubin buildup. This anecdotal connection is seen on Gilbert Syndrome Web Forums, where flare-ups of GS are cited after amalgam placements or unprotected amalgam removals. In the IMD trials conducted on patients with recent dental revision, there has been rapid and dramatic lowering of blood bilirubin in those with elevated levels of this compound. This data supports the model demonstrating that IMD opens Phase III transporters and consequently up-regulates Phase II conjunctions. According to the model, Phase III transporters up-regulate as a result of the reduced amount of inflammation and toxic metals present in the gut (Figure 1, Page 2). Table 2. Bilirubin Levels on Select Patients with Elevated Blood Bilirubin (From Clinics 1 & 2, 7-10 interventions) Before After % Change Because of these broad-spectrum effects on the whole detoxification system, many practitioners are using IMD outside the scope of metals-specific detoxification. IMD is now becoming an important component in whole-body/general detoxification protocols. DISCLAIMER Quicksilver Scientific does not imply that IMD will cure any disease. This document is designed to aid health practitioners by synthesizing multiple studies on human detoxification pathways. Cited references and further information on our clinical studies, received testimonials and plans for future studies are available upon request. Distributed by info@mhpvitamins.com Quicksilver Scientific IMD White Paper Page 6 of 7

7 Cited Literature 1. Kalitsky-Szirtes, J.; Shayeganpour, A.; Brocks, D. R.; Piquette-Miller, M., Suppression of drugmetabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metabolism and Disposition 2004, 32, (1), Nadarajah, V.; Neiders, M. E.; Aguirre, A.; Cohen, R. E., Localized cellular inflammatory responses to subcutaneously implanted dental mercury. Journal of Toxicology and Environmental Health 1996, 49, (2), (14). 3. Cnubben, N. H. P.; Rietjens, I. M. C. M.; Wortelboer, H. M.; van Zanden, J.; van Bladeren, P. J., The interplay of glutathione-related processes in antioxidant defense. Environmental Toxicology and Pharmacology 2001, 10, Oude Elferink, R. J. P.; Ottenhoff, R.; Liefting, W.; de Haan, J.; Jansen, P., L.M., Hepatobiliary transport of glutathione and glutathione cojugate in rats with hereditary hyperbilirubinemia. Journal of Clinical Investigation 1989, 84, Martensson, J.; Jain, A.; Meister, A., Glutathione is required for intestinal function. Proceding of the Natural Academy of Sciences 1990, 87, Sido, B.; Hack, V.; Hochlehnert, A.; Lipps, H.; Herfarth, C.; Droge, W., Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 1998, 42, Ruemmele, F. M.; Bier, D.; Marteau, P.; Rechkemmer, G.; Bourdet-Sicard, R.; Walker, W. A.; Goulet, O., Clinical evidence for immunomodulatory effects of probiotic bacteria. Journal of Pediatric Gastroenterology and Nutrition 2009, 48, Much, D. M.; Crespy, V.; Clough, J.; Henderson, C. J.; Lariani, S.; Mansourian, R.; Moulin, J.; Wolf, R.; Williamson, G., Hepatic cytochrome P-450 reductase-null mice show reduced trascriptional response to quercetin and reveal physiological homeostasis between jejunum and liver. American Journal of Physiology - Gastrointestinal and Liver Physiology 2006, 291, G63-G Schwetz, BA; Spencer HC; Gehring PJ, A study of prenatal and postnatal toxicity of a sulfhydryl resin in rats. Toxicology and Applied Pharmacology 1974, 27, Clarkson, TW; Small, H; Norseth, T, Excretion and absorption of methyl mercury after polythiol resin treatment. Archives of Environmental Health 1973, 26, Clarkson, TW; Magos, L.; Cox, C.; Greenwood, MR; AMin-Zaki, L; Majeed, MA; Al-Damluji., K; Test of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak. Journal of Pharmacology and Experimental Therapeutics 1981, 218, (1), Kershaw, TG; Dhahir, PH; Clarkson, TW, The relationship between blood levels and dose of methylmerucry in man. Archives of Environmental Health 1980, 35(1), Berglund, F; Berlin, M, Risk of methylmercury cumulation in man and mammals and the relation between body burden of methyl mercury and toxic effects, in Miller M, Berg GG (eds): Chemical Fallout. Springfield, IL, Charles Thomas Publisher, 1969, p Halbach, S.; Vogt, S.; Kohler, W.; Felgenhauer, N.; Welzl, G.; Kremers, L.; Zilker, T.; Melchart, D., Blood and urine mercury levels in adult amalgam patients of a randomized controlled trial: Interaction of Hg species in erythrocytes. Environmental Research 2008, 107, Wortelboer, H. M.; Balvers, M. G. J.; Usta, M.; van Bladeren, P. J.; Cnubben, N. H. P., Glutathionedependent interaction of heavy metal compounds with multidrug resistanc proteins MRP1 and MRP2. Environmental Toxicology and Pharmacology 2008, 26, Ng, K. H.; Lim, B. G.; Wong, K. P., Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney International 2003, 63, Quicksilver Scientific IMD White Paper Page 7 of 7

8 Clear Way Detox System Page 1 of 3 Quicksilver Clear Way Detoxification System Quicksilver s Clear Way Detoxification System is a comprehensive program for metal detoxification. The system restores and amplifies the body s natural detoxification system (the glutathione system) to safely remove metals and other toxins from the body, primarily through the intestines. The system has three main components: 1) IMD Intestinal Cleanse and its homeopathic dosage 2) Clear Way Cofactor phytonutrient antioxidant blend 3) Lipid-Encapsulated therapeutic compounds. The dosages of the components, especially the dosage of IMD, can be used to modulate the speed of the detoxification. 1. Detoxification System Components IMD Intestinal Cleanse: 1) IMD Intestinal Cleanse 2) IMD 3X Homeopathic 3) Quinton Marine Plasma Isotonic Phytonutrient Antioxidant Blend: 1) Clear Way Cofactors Etheric Delivery Phospholipid Encapsulation Therapeutic Compounds: 1) Vitamin C with R-Lipoic Acid 2) Glutathione 3) EDTA with R-Lipoic Acid Additional Optional Support may include: 1) Quinton Marine Plasma Hypertonic 2) Multi-Mineral Supplements (Pure Encapsulations Mineral 650 & MHP Trace Mineral Concentrate) 3) Adaptogenic Tonic Herbs (e.g. Ashwaganda) 4) Homeopathic drainage remedies for Kidney, Liver, or Lymph 5) Probiotics and Prebiotics 6) Essential Fatty Acids (4:1 DHA/EPA, fish oil, pumpkin oil, blends) The system works in cycles of use and then rest. The use periods provoke drainage from the body, which uses the body s resources for detoxification. The rest periods allow redistribution of resources. Mountain States Health Products info@mhpvitamins.com

9 Detox Protocol Month #1 Quicksilver Therapeutic Detoxification Protocol Level 1 5 days on/2 days off Take detox products for 5 days consecutively and then take a 2 day break. (Start on a Monday and the 2 days off will be the weekend) DAYS ON Morning On rising IMD 1 scoop Etheric Vitamin C with R-Lipoic Acid - 4 pumps (Mix both in 4-6 oz water and drink immediately) min later Clear Way Cofactors - 2 caps Breakfast Etheric Glutathione - 4 pumps (take directly by mouth or mix in water or juice) Rentone (Ayush Herbs) - 1 cap Lunch Time Lunch Quinton Isotonic 1-2 vials Pure Encapsulations Mineral650-2 caps Rentone (Ayush Herbs) - 1 cap Dinner Time 30 min before Dinner Before Bed Etheric Vitamin C with R-Lipoic Acid - 4 pumps (take directly by mouth or mix in water or juice) Rentone (Ayush Herbs) - 1 cap Etheric Glutathione - 4 pumps (take directly by mouth or mix in water or juice) DAYS OFF Morning On rising IMD 3X (homeopathic) 1 dose away from meals Breakfast Ashwagandha 1-2 caps Lunch Time Lunch Quinton Hypertonic 1-2 vials Pure Encapsulations Mineral650-6 caps Before Bed IMD 3X (homeopathic) 1 dose away from meals What is flexible? All timing blocks are flexible. If there is fatigue, take the IMD at night before bed and the Vitamin C & Glutathione in the morning. If Clear Way gives any stomach upset, take with meals.

10 Detox Protocol Month #2 Quicksilver Therapeutic Detoxification Protocol Level 1 5 days on/2 days off Take detox products for 5 days consecutively and then take a 2 day break. (Start on a Monday and the 2 days off will be the weekend) DAYS ON Morning On rising IMD 1 scoop Etheric Vitamin C with R-Lipoic Acid - 5 pumps (Mix both in 4-6 oz water and drink immediately) min later Clear Way Cofactors - 2 caps Breakfast Etheric Glutathione - 5 pumps (take directly by mouth or mix in water or juice) Rentone (Ayush Herbs) - 1 cap Lunch Time Lunch Quinton Isotonic 1-2 vials Pure Encapsulations Mineral650-2 caps Rentone (Ayush Herbs) - 1 cap Dinner Time ~30 min before Dinner Before Bed Clear Way Cofactors - 2 caps Etheric Vitamin C with R-Lipoic Acid - 5 pumps (take directly by mouth or mix in water or juice) Rentone (Ayush Herbs) - 1 cap Etheric Glutathione - 5 pumps (take directly by mouth or mix in water or juice) DAYS OFF Morning On rising IMD 3X (homeopathic) 1 dose away from meals Breakfast Ashwagandha 1-2 caps Lunch Time Lunch Quinton Hypertonic 1-2 vials Pure Encapsulations Mineral650-6 caps Before Bed IMD 3X (homeopathic) 1 dose away from meals What is flexible? All timing blocks are flexible. If there is fatigue, take the IMD at night before bed and the Vitamin C & Glutathione in the morning. If Clear Way gives any stomach upset, take with meals.

11 Detox Protocol Month #3 Quicksilver Therapeutic Detoxification Protocol Level 1 5 days on/2 days off Take detox products for 5 days consecutively and then take a 2 day break. (Start on a Monday and the 2 days off will be the weekend) DAYS ON Morning On rising IMD 1 scoop Etheric Vitamin C with R-Lipoic Acid - 6 pumps (Mix both in 4-6 oz water and drink immediately) min later Clear Way Cofactors - 3 caps Breakfast Etheric Glutathione - 6 pumps (take directly by mouth or mix in water or juice) Rentone (Ayush Herbs) - 1 cap Lunch Time Lunch Quinton Isotonic 1-2 vials Pure Encapsulations Mineral650-2 caps Rentone (Ayush Herbs) - 1 cap Dinner Time ~30 min before Dinner IMD - 1 scoop Etheric Vitamin C with R-Lipoic Acid - 6 pumps (Mix both in 4-6 oz water and drink immediately) Rentone (Ayush Herbs) - 1 cap min later Clear Way Cofactors - 3 caps Before Bed Dinner Etheric Glutathione - 6 pumps (take directly by mouth or mix in water or juice) DAYS OFF Morning On rising IMD 3X (homeopathic) 1 dose away from meals Breakfast Ashwagandha 1-2 caps Lunch Time Lunch Quinton Hypertonic 1-2 vials Pure Encapsulations Mineral650-6 caps Before Bed IMD 3X (homeopathic) 1 dose away from meals

12 Quicksilver Therapeutic Detoxification Protocol Level 1 Next Steps After three months of this program, take at least 2 weeks to re-mineralize and strengthen the body with the Mineral650, Quinton Hypertonic, and Ashwagandha. Then start another three-month protocol. This protocol is designed to be taken in waves of three-month intervals. Depending on the level of toxicity, the patient may need to be on this program for 1-2 years. The protocols listed above are for patients that can detoxify at a normal rate. Some people who are very sensitive and/or have high toxic burdens need to move much more slowly through the program starting off with fractional doses (i.e. 1/3 or 1/2 scoop of IMD per day) and working slowly up. If the patient had to keep low dosages through the first three months, go to higher doses in the next three months. A long, lower-intensity phase is essential for getting deep, long-lasting detoxification, whereas the first three month intense phase retrains the detox system and pulls the worst loads out. It is important to allow the process to take the time it needs so as not to retoxify the patient with too rapid of a drain instead of detoxifying them with a safe and controlled drain rate. A strong detox reaction in usually an indication that more Pre-Tox time needs to be spent with homeopathic drainage remedies and IMD 3X homeopathic before full IMD usage. Please request the Pre-Tox protocols. EDTA If the patient is tolerating the detox program well, EDTA can be added to the protocols above during the 2 nd Month. If the patient is very sensitive, start the EDTA in the 1 st month of the second round (4 th month). Suggested Dosage: 1 tsp per day, taken with the IMD and C/RLA, 5 days per week. Sensitive patients: 1/2 tsp 3 times per week. Children 12 and up: 1/8 tsp 3 times per week. Mineral supplementation is very important while taking EDTA. Do not skip taking minerals at the appropriate times.

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17 Etheric Delivery Phospholipid Encapsulation System EDTA with R-Lipoic Acid Liposomal 4 oz bottle EDTA (Ethylenediaminetetraacetic acid) is a chelating agent that binds heavy metals including: arsenic, calcium, and lead.* EDTA chelation therapy is approved by the U.S. Food and Drug Administration (FDA) as a treatment for lead and heavy metal poisoning. It is also used as an emergency treatment for hypercalcemia (excessive calcium levels) and the control of ventricular arrhythmias (abnormal heart rhythms) associated with digitalis toxicity. EDTA chelation therapy may decrease levels of certain vitamins and minerals in the body, including vitamin C, magnesium, iron, and calcium. Mineral supplementation is required while using this product. EDTA is suggested to be able to remove calcium plaque associated with heart disease, although more studies are needed to support this claim.* Oral Liposomal EDTA is convenient and effective, and has excellent results compared with IV EDTA.* EDTA with R-Lipoic Acid - Supplement Facts Serving size: 1 teaspoon; Servings per container: 24 EDTA (disodium EDTA) R-Lipoic Acid Phosphatidyl Choline (from purified soy lecithin 65% linoleic acid) 210 mg 33 mg 450 mg Other ingredients: water, glycerin, ethanol, sodium hydroxide. Liposomes are microscopic single- or multi-layer spheres made of phospholipids (the basic building blocks of cell membranes) that encapsulate a compound in order to bypass the digestive processes that normally degrade or limit its absorption. Quicksilver s Etheric Delivery Phospholipid Encapsulation System improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, nanospheres like ours also demonstrate the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enhance lymphatic circulation of therapeutic compounds. New Production Technology Features: Made with injectable grade Phosphatidyl Choline, purified from soy lecithin. Does not contain soy proteins normally associated with soy allergies. Tightly controlled small sizing, verified by Laser Dynamic Light Scattering on each batch. Liposome mean size nm Mixes easily in water or juice Mountain States Health Products info@mhpvitamins.com *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

18 Etheric Delivery Phospholipid Encapsulation System **NEW PRODUCTS** Liposomal GABA and Artemisinin GABA Liposomal 1.7 oz pump GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system. Best form for maximum absorption Healthy levels have been associated with positive mood* Plays a central role in regulating cell-to-cell communication Regulates neuronal excitability throughout the nervous system Artemisinin Liposomal 4 oz bottle Artemisinin also known as Qinghaosu is a compound isolated from plant Artemisia annua, sweet wormwood. Artemisinin is used clinically for the treatment of malaria, parasites, Lyme disease, and some cancers.* Helps maintain microbial balance in the intestines* Lipsomal Artemisinin has enhanced absorption and effectiveness GABA - Supplement Facts Serving size: 4 pumps (2 ml); Servings per container: 50 GABA (gamma amino butyric acid) Phosphatidyl Choline (from purified soy lecithin 65% linoleic acid) 200 mg 135 mg Other ingredients: water, glycerin, ethanol, Vitamin E (as d-alpha tocopherol polyethylene glycol 1000 succinate) Artemisinin - Supplement Facts Serving size: 1 teaspoon; Servings per container: 24 Artemisinin Phosphatidyl Choline (from purified soy lecithin 65% linoleic acid) 40 mg 450 mg Other ingredients: water, glycerin, ethanol, phospholipids Mountain States Health Products info@mhpvitamins.com *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

19 Homeopathic Detox Support Kidney Liquid (L13) Provides homeopathic support and drainage in kidney disorders.* Liver Liquid (L15) Supports liver function and drainage.* Homeopathic Formula: Benzoic Acid 4X uric acid diathesis, with urine highly colored and very offensive, and gouty symptoms, renal insufficiency Berberis Vulgaris 3X Kidney disorders with pain in back, severe pain in kidneys, cystitis and gravel Juniperus Comminus 2X Stimulating diuretic, catarrhal inflammation of kidneys Uva Ursi 2X, 3X Urinary antiseptic, Diuretic action, Cystitis Kidney 3X sarcode for tissue support Bladder 4X sarcode for tissue support Equisetum 3X Severe pains renal region right side, tenderness of bladder aggravated by pressure, feeling of heaviness not relieved by micturation, urine flows drop by drop, frequent urging and burning at close of urination Solidago 1X Pain in kidneys extend forward to abdomen and bladder, Clear and offensive urine Taraxacum Officinale 3X Urination frequent, copious discharge, Bilious remedy Eupatorium Purpureum 3X Deep, dull pain in kidneys, Insufficient flow, milky urine, bladder feels full Cantharis 12X bladder irritation; intolerable, constant urging to urinate, Dysria, Nephritis with bloody urine; urine jelly-like, shreddy, Burning pain Nitricum Acidum 8X Scanty, dark urine with offensive odor, Urine burns and stings, bloody and albuminous, alteration of cloudy, phosphatic urine with profuse urinary secretion in old prostatic cases Other ingredients: purified water, 20% alcohol USP. Homeopathic Formula: Lycopodium 2X Failures of digestive powers, where the function of the liver is seriously disturbed, Ascities, (an accumulation of serous fluid in the peritoneal cavity) in liver disease Ptelea Trifoliata 2X Liver sore, swollen, sensitive to pressure, aching and heaviness in the region of the liver is greatly aggravated by lying on the left side Hydrastis 2X Liver torpid, tender, jaundice Uva Ursi 2X Urinary antiseptic, Diuretic action, Cystitis Beta Vulgaris 2X: Influences chronic catarrhal states Carduus Marianus 2X Action centered in the liver and portal system, causing soreness, pain and jaundice, hemorrhages, especially connected with hepatic disease, hyperemia of liver with jaundice, cirrhosis with dropsy. Chionanthus Virginica 6X Hepatic region tender, enlarged, with jaundice and constipation Taraxacum Officinale 2X, 3X Urination frequent, copious discharge, Bilious remedy Chelidonium 2X Jaundice skin, enlarged liver Raphanum 3X, 6X Produces pain and stitches in liver and spleen, Increase of bile and salivary secretion Phosphorus 7X Causes yellow atrophy of the liver and sub-acute hepatitis, disorganizes the blood, causing fatty degeneration of blood vessels and every tissue and organ of the body, gives rise to hemorrhages and jaundice Liver 3X, 7X sarcode for tissue support Gallbladder 3X, 7X sarcode for tissue support Other ingredients: purified water, 20% alcohol USP. MOUNTAIN STATES HEALTH PRODUCTS, INC Fax: *Please Note: This information is not intended to constitute as professional advice for medical diagnosis or treatment. The products and statements about specific products have not been evaluated by the United States Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

20 Homeopathic Detox Support Homeopathic Formula: Lymph Liquid (LLYM) Provides support of lymphatic fluid movement, neck stiffness and sore throats with indurated glands in neck and parotid area.* Baryta Iodata 12X Acts on the lymphatic system, Increased leucocytosis, quinsy, indurated glands, especially tonsils and breasts. Capsicum Frutescens 12X promotes the flow of saliva, which break down carbohydrates; and stomach secretions Lymph 3X, 7X sarcode for tissue support Thymus 3X, 7X sarcode for tissue support Lapis Albus 6X Burning, stinging pain in breast, stomach and uterus. Connective tissue about glands specially affected. Scophularia Nodosa 1X Enlarged glands, eczema of the ear Mammary 3X, 6X sarcode for tissue support Cistus Canadenis 3X IMD 3X (IMD3X) This is a homeopathic preparation of the IMD (Intestinal Metals Detox) powder from Quicksilver Scientific. Designed especially for sensitive patients and children. This product is used as a pretox before the actual IMD protocol is started. This helps acclimate the body to the IMD product, and will help increase tolerance for sensitive patients.* Homeopathic Formula: IMD 3X Readies the body for the IMD detox. Other ingredients: purified water, 20% alcohol USP. Other ingredients: purified water, 20% alcohol USP. MOUNTAIN STATES HEALTH PRODUCTS, INC Fax: *Please Note: This information is not intended to constitute as professional advice for medical diagnosis or treatment. The products and statements about specific products have not been evaluated by the United States Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

21 Rentone Call for current pricing Ayush Herbs - Rentone 90 caplets Herbal Kidney Support Rentone is a formula for kidney and urinary support with a unique combination of Eastern and Western herbs in addition to other nutrients that increase its optimal effect on the eliminative system. Didymocarpus pedicellata is an Ayurvedic herb also known as pathar phori. In Sanskrit, the name means that which breaks stones. Saxifraga ligulata has a similar meaning, the plant which breaks rocks in order to grow and also has astringent, laxative, diuretic, and lithotrophic properties, as does Tribulus terrestris. Rubia cordifolia has antiseptic and deobstruent properties. Ocimum sanctum (holy basil) is used here for its immune-supporting and diuretic actions. Shilajit is an asphaltum (mineral pitch) obtained in the Himalayan region of India and is considered a rasayana (adaptogen). Shilajit contains at least 85 minerals in ionic form and has been used traditionally for centuries for genitourinary and immune support, as well as for its aphrodisiac and purifying properties. Arctostaphylos uva-ursi is a European herb, the leaves of which contain 10% of the most active principles of arbutin, which splits into glucose and hydroquinone in the kidneys. Cranberry has traditionally been used to support the reduction in the ability of bacteria to adhere to the lining of the bladder and urethra. Mimosa pudica (lajja, or lajwanti) is traditionally used for urinary conditions. Dolichos biflorus is also known as Kulatha beans, the seeds of which are astringent, diuretic, and tonifying, and have been used traditionally in support of renal and urinary bladder conditions. Cyperus rotundus is a dried tuberous root known as soucher, which is known to have diuretic, diaphoretic, and astringent properties. It is traditionally used for stomach and bowel complaints. Crataeva religiosa, also known as varuna (threeleaved caper), contains saponins and tannins in its bark. In Ayurvedic medicine, varuna is used to tonify the muscles of the bladder. It also helps support a healthy inflammatory response of the genitourinary system and has a diuretic effect. Achyranthus aspera (apamarg) is traditionally used as a diuretic and to normalize ph. 1 caplet contains: Vitamin B6 25 mg Magnesium aspartate 100 mg Proprietary blend: Cranberry extract, Tribulus terrestris, Mimosa pudica, 250 mg Dolichos b and Equestrium arvense. Didymocarpus pedicellata 100 mg Saxifraga ligulata 100 mg Ocimum sanctum 25 mg Achyranthes aspera 25 mg Asphaltum punjabianum 25 mg Cyperus rotundus 25 mg Crataeva religiosa 25 mg Uva ursi 25 mg Other ingredients: dicalcium phosphate, stearic acid, magnesium stearate, silicon dioxide. Free from milk, soy, egg, and wheat. MOUNTAIN STATES HEALTH PRODUCTS, INC Fax: *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

22 Quinton s Hypertonic & Isotonic Hypertonic 30 vials per box Undiluted 3.3% Salinity Used to revitalize and re-mineralize the biological terrain Re-establishes vitality after prolonged fatigue Prevents energy loss before, during and after significant physical or mental challenges Improves endurance and strength Best for Parasympathetic dominant physiologies and slow oxidation Contains a high concentration of sodium patients on a low sodium diet must be monitored when on this product Yang, Warming, Energizing, Replenishing, Building, Tonifying, Menopausal Yin Deficiency, Restores Reproductive Drive and Chi Helps improve sympathetic and parasympathetic balance Contact MHP for specific protocols Isotonic 30 vials per box Precisely diluted to match the 0.9% salinity of human blood plasma Gentler for sensitive patients Used to re-establish physiological homeostasis or internal balance Sodium levels are safe for patients on restricted sodium diets Best for Sympathetic dominant physiologies and fast oxidation Helps improve sympathetic and parasympathetic balance Facilitates mental and physiological balance Great for children, elderly, and people with fragile immune systems, and hypersensitive/allergic patients Used to address nervous or anxious states Supports reduction of hypersensitivities to foods and other allergens Yin, Cooling, Sedating, Balancing, Calms the Shen/Spirit, Reduces Heart Fire Contact MHP for specific protocols MOUNTAIN STATES HEALTH PRODUCTS, INC Fax: **These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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25 THE QS MERCURY TRI-TEST: A COMPLETE ANALYTICAL SOLUTION Quicksilver Scientific s Tri-Test is the only clinical testing suite that measures both the exposures and excretion abilities for each of the two main forms of mercury we are exposed to. The QS Tri-Test utilizes mercury speciation analysis, a patented advanced technology that separates methyl mercury from inorganic mercury and measures each directly. This technique provides unprecedented information for the healthcare practitioner to assess the patient s difficulties with each form of mercury and plan a successful detoxification strategy. The Analytical Suite and Results Reporting The full analytical suite includes three tests: (1) mercury speciation analysis of patient s blood, (2) mercury speciation analysis of patient s urine, and (3) total mercury analysis of patient s hair. Mercury speciation analysis shows 2 forms of mercury: Inorganic mercury (Hg II ) in blood usually reflects a dental amalgam exposure and its main excretion route is urine. The urine:blood ratio gives an index of excretion efficiency for inorganic mercury. Methylmercury (MeHg) reflects seafood consumption, though some is made in the gut from swallowed amalgam-based mercury. Excretion of methylmercury is reflected in the hair. The hair:blood ratio gives an index of excretion efficiency of methylmercury Our customized reports contain raw and graphical data (sample, right). Each graphic provides references to help practitioners and patients interpret results. To order Mercury Testing Lab Kits: Patient Physician Name Dates Taken 9/1/2010 Date Of Birth 3/2/1958 NA Blood Results Patient Reference Ranges Results (ng/ml) QS n=410; CDC n=1928 Percentile 9/1/2010 NA % Change Source Range Average 50th 75th 90th 95th Methylmercury MeHg NA NA QS <0.003 to Inorganic Mercury Hg II NA NA QS <0.007 to Sum HgT NA NA CDC to Blood Reference Values: Quicksilver Scientific (QS) Data represents 410 males and females that have * utilized All values our testing. are concentrations CDC data represents of ng 1928 Hg females, per ml ages of blood 16 to 49. QS blood Hg concentrations are higher Blood that Reference CDC because Values: QS analyzes mercury blood speciation a population performed that already at Quicksilver suspects Scientific, mercury toxicity. reported as ng/ml (same as µg/l); CDC data Data and Analysis Information: Mercury speciation was performed at Quicksilver Scientific, and all values are in concentrations of ng Hg per ml of blood represents 1928 females, ages 16 to 49; data reproduced from CDC Metals Biomonitoring Study Urine HgII (ng/ml) MeHg HgII HgT Physician Urine Results Hair Results A) Average Excretion: Mercury output is average or above Patient average when at a ratio of at least 375:1 HgT in hair to MeHg in Urine Results (ng/ml) Hair (ng/g) blood and 6.9:1 HgT in urine to HgII in blood. B) Below Average Excretion: Mercury output is below average 9/1/2010 NA %Change 9/1/2010 when the tissue Hg comparisons are below ratios mentioned above NA NA NA (red area) Methylmercury MeHg NA NA NA NA NA Inorganic Mercury Hg II Sum HgT Arrived Indication of Kidney Mercury Excretion Ability Blood HgII (ng/ml) Legend Blood Mercury Comparison Concentration of Mercury (ng/ml or ug/l) Hair HgT (ng/g) NA Analyzed 9/2/2010 9/17/2010 Indication of Mercury Excretion Ability Blood MeHg (ng/ml) NA 9/1/2010 CDC Average QS Average us with your contact and shipping information and # of kits: Kits@QuicksilverScientific.com **** If you need a blood draw kit (tourniquet and butterfly) sent with each QS Mercury Tri-test Kit, please indicate this on the as well, otherwise the kits come without blood draw items. Wholesale cost per analysis is $ in the continental U.S. (Canada - $ and Hawaii / Alaska - $260.00) (Suggested retail - $350.00/$395 Canada/$375 Hawaii & Alaska). These prices include our pre-printed, prepaid RETURN shipping documentation and packaging for ease of your lab kit returns to Quicksilver Scientific. If you choose to use your own shipping and packaging to return the lab kit, the price remains the same. Also, you are receiving Patient Requisition Forms with your kits. All kits returning to us should have a completed Patient Requisition Form or they will not get processed. It is on this form that you will record your collection times and contact information. Please include payment information on the form, either the practitioner s or the patient s. Thank you! A four-page color instruction hand-out included with your kits will guide practitioners and clients through the sample gathering process, as well as how to return the samples to Quicksilver Scientific. You will receive results approximately 2-3 weeks after sending your samples to us. ** There are no cpt codes for this test yet and we do not handle insurance reimbursement. Contact Quicksilver Scientific 1376 Miners Drive, Ste Lafayette, CO Scientific.com