Ever wonder what s really happening on the inside?

Transcription

1 For Practitioners Ever wonder what s really happening on the inside? Are your patients suffering from diarrhea, constipation, bloating, gas or indigestion? Rocky Mountain Analytical is now offering Gut-Well Digestive Stool Analysis. This simple, non-invasive digestive stool analysis will provide a broad range of information about your patients overall gut health. A SIMPLE, NON-INVASIVE, AT-HOME TEST.

2 DO YOU HAVE PATIENTS WITH UNEXPLAINED GASTROINTESTINAL (GI) SYMPTOMS? Rocky Mountain Analytical is now offering Gut-Well Digestive Stool Analysis Gut-Well Digestive Stool Analysis is a thorough evaluation of your patient s stool, which may help in the management of many GI issues. Gut-Well Digestive Stool Analysis can provide important clinical insights for patients suffering from the following: Acute or chronic pancreatitis Celiac disease Chronic constipation Diabetes Diarrhea Flatulence and/or bloating Food sensitivities, intolerances or allergies Gluten sensitivity Hypochlorhydria (low stomach acid) Inflammatory Bowel Disease (IBD) Intestinal permeability Irritable Bowel Syndrome (IBS) Nutrient deficiency Weight loss

3 What is Gut-Well Digestive Stool Analysis? Gut-Well Digestive Stool Analysis is a thorough evaluation of stool that may help in the management of many GI symptoms. Gut-Well Digestive Stool Analysis will provide you with information regarding your patient s: Digestion and Absorption Biomarkers include: Elastase, a marker of exocrine pancreatic function Fecal fat, a marker of fat digestion and absorption Gut Ecology Biomarkers include: Beneficial Short-Chain Fatty Acids (SCFA), markers of fiber and starch fermentation Putrefactive SCFAs, markers of protein fermentation Inflammation and Immune Function Biomarkers include: Calprotectin, a marker of neutrophildriven inflammation Secretory IgA, a marker of gut secretory immunity, tolerance and exclusion of bacteria Pathogen Profile Tests include: Bacteriology, to identify potential bacterial pathogens Parasitology, to identify potential GI parasites

4 Digestion and Absorbtion Measures key components of digestive function, and helps assess your patient s ability to absorb the nutrients they need. Does your patient show signs of GI dysfunction? How well are they digesting fats? Gut-Well TM Digestive Stool Analysis helps answer these questions by measuring: Pancreatic elastase The pancreas secretes enzymes such as elastase to aid in the digestion and absorption of nutrients. The concentration of elastase correlates well with other pancreatic enzymes, making it an excellent biomarker for overall pancreatic function. Total fecal fat Dietary fat is normally digested and absorbed in the small intestine, resulting in only small amounts of fat in the stool. High fecal fat concentrations are a sign of fat maldigestion and/or malabsorption, often due to pancreatic insufficiency. Gut Ecology Measures a key function of your patient s intestinal microbiota. Is your patient eating the right kind of fiber to support a healthy microbiome? Is colonic fermentation of protein contributing to digestive issues? Gut-Well Digestive Stool Analysis helps answer these questions by measuring: Beneficial Short-Chain Fatty Acids (SCFAs) Certain kinds of dietary fiber (e.g., inulin, wheat dextrin, oligosaccharides, resistant starches, raw guar gum and beta-glucan from oats & barley) are fermented by bacteria in the colon to produce beneficial SCFAs (i.e., butyrate, acetate, and propionate). In particular, butyrate serves as the major fuel source for colonocytes. The amount and type of fecal SCFAs are important markers of overall GI health. Putrefactive SCFAs If protein is not completely digested by the time it reaches the distal colon, it is fermented by resident bacteria and putrefactive SCFAs are formed. Elevated putrefactive SCFAs may be an indication of low fiber intake, high protein intake, malabsorption, pancreatic insufficiency or low stomach acid. High fecal levels of putrefactive SCFAs valerate, isovalerate and isobutyrate may be associated with colorectal cancer and inflammatory bowel disease.

5 Inflammation and Immunology May identify GI inflammation in your patient by using a measure of mucosal immune response. Is your patient s GI tract responding appropriately to internal and external environments? Gut-Well TM Digestive Stool Analysis helps answer these questions by measuring: Calprotectin Neutrophils activated by intestinal inflammation release cellular proteins like calprotectin. The amount of calprotectin present in feces is proportional to the number of neutrophils in the gastrointestinal mucosa, and is therefore used as an indirect marker of intestinal inflammation. Measurement of fecal calprotectin is used to distinguish between Inflammatory Bowel Disease and non-inflammatory bowel conditions like Irritable Bowel Syndrome. Secretory IgA (siga) Secretory IgA, an immunoglobulin, is present in mucus secretions, including saliva, sweat and gastrointestinal secretions. In the gastrointestinal tract, siga has several roles, including nurturing the growth and adhesion of beneficial bacteria and preventing invasion and damage from pathogens. Elevated fecal siga levels can be an indicator of food sensitivities or of pathogenic infections. Low levels of siga may be an indicator of chronic stress, dysbiosis or immunosuppression. Pathogen Profile Identifies pathogens present in your patient s GI tract. What pathogenic GI bacteria are present in your patient s GI tract? How should you treat them? Gut-Well Digestive Stool Analysis helps answer these questions by using: Bacteriology This test indicates the presence of specific, potentially pathogenic bacteria, such as Salmonella, Campylobacter, C. difficile, Shiga toxin-producing E. coli and others. Antibiotic sensitivities will be reported for any pathogens present. Parasitology This test indicates the presence of intestinal parasites and their eggs, such as Cryptosporidium, Cyclospora, Dientamoeba, Blastocystis and Giardia species. With a complete panel of GI tests, Gut-Well Digestive Stool Analysis can help identify the cause of your patient s symptoms.

6 Acetate (52-62%) Butyrate (12-24%) Propionate (15-22%) Putrefactive (3-8%) 0% 20% 40% 60% 100% Acetate Butyrate Propionate 60% 14% 19% 7% Co-Signing Physician: Clare Westmacott, MD Calgary, AB Phone (403) Putrefactive Gut health at a glance Your patient s Gut-Well TM Digestive Stool Analysis results are summarized in a visual report, so that you can easily identify clinically actionable measures. E: info@rmalab.com P: F: Date of Collection: 2017/05/02 Time of Collection: 7:00AM Date of Receipt: 2017/11/28 Reported On: 2018/02/20 Gut-Well Accession: Healthcare Professional Dr Vera Goode Patient Thomas Age: 35 Date of Birth: 1982/02/02 Gender: Male Short Chain Fatty Acid (SCFA) Profile 20% 40% 60% Range 80% 0% 100% Analyte Result Rank Total SCFA (umol/ml) % Short Chain Fatty Acid (SCFA) Profile Analyte Result Range 80% Rank Total SCFA (umol/ml) Total Beneficial SCFA (umol/ml) Fiber/Carbohydrate-derived Total Putrefactive SCFA (umol/ml) Protein-derived SCFA n-butyrate (umol/ml) % % % % Total Beneficial SCFA (umol/ml) Fiber/Carbohydrate-derived Total Putrefactive SCFA (umol/ml) Protein-derived SCFA n-butyrate (umol/ml) % % % SCFA Distribution (percentages of Total SCFA) Normal Distribution: SCFA Distribution (percentages of Total SCFA) Normal Distribution: Breakdown of Normal Reference Population Acetate (52-62%) Butyrate (12-24%) Propionate (15-22%) Putrefactive (3-8%) Your Distribution A division of LifeLabs LP CPSA Accreditation # L Interpretation of your patient s results will be simplified with this easy-to-read report. Gut-Well Digestive Stool Analysis can help patients like Thomas Thomas has been dealing with GI symptoms for quite some time, and has been unable to determine the cause. Meet Thomas: 35 years old Sedentary, high-stress job Very lean (BMI = 18.4 kg/m 2 ) Restricts food intake by choice Chronic digestive issues Family history of colon cancer Thomas symptoms Infrequent bowel movements (1 or 2 per week) Painful defecation Flatulence Fatigue I I ve always had issues with constipation and I ve tried to manage it on my own. I I m sick of feeling like this.

7 Gut-Well Digestive Stool Analysis can reveal important clinical details about Thomas gut health: Gut-Well Digestive Stool Analysis shows: Decreased levels of Beneficial and putrefactive SCFAs Fecal fats Butyrate Secretory IgA Normal levels of Calprotectin Elastase Distribution of SCFAs Microbiology: No pathogens or parasites found Interpretations Long intestinal transit time can lead to decreased fecal fat and short-chain fatty acids, including butyrate Low fecal butyrate is associated with increased risk of colon cancer Despite overall low levels, distribution of SCFAs is normal Negative calprotectin effectively rules out Inflammatory Bowel Disease Low siga is associated with chronic stress and/or restricted food intake, which may also be consistent with congenital siga deficiency Therapeutic Recommendations Increase intake of butyrate via diet or supplementation Increase fibre intake to improve SCFA concentrations and aid intestinal motility Increase overall variety of plant-based foods to support a more diverse colony of gut microbes Suggest prokinetic herbs/supplements to improve intestinal transit time Assess serum total IgA to rule out congenital IgA deficiency Conduct diurnal cortisol testing (i.e., saliva or urine) to assess impact of stress on adrenal glands Increase healthy dietary fat intake to maintain healthy body mass via caloric intake SD = standard deviation

8 Now available through Rocky Mountain Analytical! Rocky Mountain Analytical is an accredited Canadian medical laboratory, providing clear and reliable tests to preventive and integrative medicine professionals since With a commitment to keeping your patients healthy, Rocky Mountain Analytical is proud to offer Gut-Well Digestive Stool Analysis in our portfolio of laboratory tests telling you what you need to know about your patients GI symptoms. Register with us online at rmalab.com. Once registered, you can order Gut-Well Digestive Stool Analysis by: site Going online Giving us a call Sending us an info@rmalab.com Visit rmalab.com for more information. Order Gut-Well Digestive Stool Analysis today to get to the bottom of your patients GI symptoms Rocky Mountain Analytical, a division of LifeLabs LP. All company and product names and logos are trademarks or registered trademarks of their respective owners.