New NOW Product Launches

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1 New NOW Product Launches Dr. Thalia Charney, ND ( i n a c t i v e ) Nutrition and Health Education Manager S e p t - O c t

2 New NOW Product Launches NOW84004 American Ginseng 500mg 100vcap NOW83159 Hyaluronic Acid w/antioxid. 473mL NOW83802 EVE Women's Multi 90gel NOW83880 ADAM Men's Multi 90gel 2

3 American Ginseng 500mg 100vcap Directions: Adult Dosage: Take 2 capsules 1 to 3 times daily. Ingredients: (each capsule contains): American Ginseng (Panax quinquefolius) (Root extract) mg Non-Medicinal Ingredients: Veg Capsule (hypromellose, water), Rice Flour, Magnesium Stearate (vegetable source). 3

4 American Ginseng 500mg 100vcap American Ginseng (Panax quinquefolius) Panax means all healing Quinquefolius means five leaves Native to eastern North America Quebec to Manitoba, northern Florida, Alabama and Oklahoma Used by traditional herbalists for centuries Bioactive compounds = terpenoid saponins called ginsenosides 4

5 American Ginseng 500mg 100vcap Helps maintain a healthy immune system Used in Herbal Medicine as an adaptogen High potency 500mg Vegetarian / Vegan 5

6 What is an adaptogen? Stress-induced damage Physical, emotional, environmental & mental Enhance performance increase working capacity, mental stamina, physical endurance In a background of fatigue and stress Are innocuous (normalizing influence) Versus conventional CNS stimulants that deplete resources and have S/E 6

7 American Ginseng (Panax quinquefolius) True Ginsengs are from the genus Panax Panax ginseng (Korean/Asian) are most popular P. Ginseng is more stimulating P. Quinquefolius is more adaptogenic Properties: Adaptogen, tonic, stimulant Investigated for nearly every potential disease-preventing mechanism in either cell culture, animal and/or human study Panax = all healing Numerous systemic reviews 7

8 Some studies Highest evidence Diabetes in doses 100 mg 3 gram daily (PMID: ) Upper Respiratory Infections, mg daily 3-6 months during flu season (PMID: ) Other Hypertension in diabetics 1 gram 3x daily for 12 weeks (PMID: ) Short-term memory, mg, taken 1-6 hours prior to cognitive testing (PMID: ) Systemic Review 2010 (PMID: ) Cancer-related fatigue, 2 gram twice daily for 8 weeks ( ) Systemic Review 2018 Fatigue (PMID: ) 8

9 SUMMARY American Ginseng 500mg 100vcap Claim: Helps maintain a healthy immune system; Used in Herbal Medicine as an adaptogen Feature Safer, gentler ginseng Broad applicability Safe Benefit Less stimulating than P. Ginseng from China so better for those with signs of excess Long history for overall well being and many chronic diseases Adaptogens are considered generally to be innocuous 9 Code: NOW84004 UPC: Size: 100vcap Category: Supplements Days Supply: Why carry this product?: Best dosage per dollar value NOW offers vcaps Single Species not a blend of ginsengs, other ingredients Brand supports Health Food Stores

10 Hyaluronic Acid w/antioxidant 473mL Directions: Adult Dosage: Take 1 tablespoon (15 ml) 1 to 2 times daily. Can be taken directly or mixed with water or juice. Ingredients: (each tablespoon (15 ml) contains): Hyaluronic Acid (Sodium Hyaluronate) mg L-Proline mg L-Lysine mg Vitamin D (as Ergocalciferol) IU (10 mcg) Vitamin A (as Retinyl Palmitate) IU (300 mcg RAE) Vitamin E (as d-alpha Tocopherol) IU (20 mg AT) Non-Medicinal Ingredients: Deionized Water, Vegetable Glycerin, Xylitol, Natural Flavours, Citric Acid, Potassium Sorbate 10

11 Hyaluronic Acid w/antioxidant 473mL Helps support joint health Helps support bone health Helps in collagen formation Added vitamin and amino acids Liquid form Sweetened with Xylitol Natural berry flavour Vegetarian / Vegan 11

12 About Hyaluronic Acid (sodium hyaluronate) Present in every tissue of the body Highest concentrations found in connective tissues (i.e. skin, cartilage, tendons, ECM) Constituent of joint fluid One of the most hydrophilic substances known Binds 1000 times its weight in water Serves as a lubricant and provides elasticity Holds water to form a gel-like matrix Role in resisting compressive forces (Chondroitin sulfate too) Lower in aged and those with osteoarthritis Low levels means more susceptible to cartilage injury 12

13 Making Hyaluronic Acid Glucose Glucosamine N- Acetylglucosamine Hyaluronic Acid Chondroitin sulfate 13

14 General uses for Hyaluronic Acid Eyes: Cataracts (injections), Dry eye syndrome (drops) Gums: Oral mucositus (orally) Skin GERD (orally) Urinary Tract Infections (intravesical) Joints Hair 14

15 How it may work on the joints? After intraarticular injection, hyaluronic acid is present for only a few days, but its effects last for about 6 months Modulating immune response and improving wound healing?? Inhibit the release of enzymes that break down cartilage?? Anabolic effect Enhance proteoglycan synthesis in human cartilage Enhanced chondrocyte proliferation and chondroitin sulfate synthesis in rabbit chondrocytes Anti-inflammatory effects Inhibit PGE2 production by human osteoarthritic synovial cells Inhibit AGEs J of Applied Nutrition, volume 54, #1, 2004 Review 15

16 16 Hyaluronic Acid and Joints

17 Hyaloronic acid and joints This cell culture study confirms a stimulatory effect of hyaluronic acid on chondrocyte metabolism (a cell that has secreted the matrix of cartilage and become embedded in it) 17

18 Double-blind Placebo-controlled Trial at 8 weeks the changes from baseline within the treatment group were SS Limitations small sample size (20 adults), single dose, questionnaire reliability, and small period of time (8 weeks) 18

19 Oral use of Hyaluronic acid Absorption proven by radio-labelling as well as clinical efficacy Our HA is vegan Our HA is high molecular weight (a million daltons) Major differences in activities' are based on molecular weight Longer life Replenishes and stimulates production of HA Higher viscosity (better buffering and lubrication) Pharmaceutical grade Non-animal based Lower amounts for higher effectiveness Bioidentical to native HA 19

20 Low versus high molecular weight Hyaluronic Acid (HA) The Anti-Aging Answer For the Whole Body, Dr. Chis D Meletis, ND Power Point 20

21 Amino acids and connective tissue Proline, Lysine and Glycine build collagen Collagen is the most abundant protein in our body Collagen and gelatin contain: Hydroxyproline strands Hydroxylation requires vitamin C Glycine Collagen is key for connective tissues hair, skin, muscle, cartilage, blood vessels, organs Collagen provides tensile strength resistance to break under tension AA supplements like proline may provide the necessary substrates for collagen unknown if they actually accelerating collagen synthesis 21

22 Building Collagen L-lysine occupies anchor sites that collagen digesting enzymes can bind to prevent uncontrollable disintegration Source: tthias-rath-cancer-book-vitamin-c-and-lysine-forcancer-treatment 22

23 SUMMARY Hyaluronic Acid w/antioxidant 473mL Claim:Helps support joint health; Helps support bone health; Helps in collagen formation Feature Collagen building blocks (lysine, proline) Joint fluid HA Other Benefit Key for integrity of hair, skin, muscle, cartilage, blood vessels, organs Addition joint benefit for lubrication and compression. Potential benefits for UTIs, dry eyes, skin, hair Code: NOW83159 UPC: Size: 473mL Category: Supplements Days Supply: Why carry this product?: Synergistic formula including L-Proline, L-Lysine, Vit A, D, E Largest size for convenience Provides added delivery system liquid for absorption; ease of swallowing Recognizable retail brand supports IHF store 23

24 EVE Women's Multi 90gel 24 Ingredients: (each softgel contains): Beta-Carotene mcg (1666 IU) (as all-trans beta-carotene) (Betatene ) Vitamin C (from Calcium Ascorbate) mg Vitamin D (as Cholecalciferol) mcg (333 IU) Vitamin E (as d-alpha-tocopheryl) mg AT (50 IU) (Soybean (Glycine max) Oil) Vitamin K (as Menaquinone and Phytonadione) mcg Thiamine (from Thiamine Hydrochloride) mg Riboflavin mg Niacinamide mg Niacin (from Inositol Hexanicotinate)... 1 mg Vitamin B6 (from Pyridoxine HCl and Pyridoxal-5-Phosphate) mg Folate (as Folic Acid) mcg Vitamin B12 (as Methylcobalamin)...40 mcg Biotin mcg Pantothenic Acid (from Calcium-D-Pantothenate) mg Calcium (from Calcium Ascorbate,Calcium Carbonate and Aquamin F (Lithothamnion corralioides) mg Iodine (from Potassium Iodide)...75 mcg Iron (from Ferrochel Iron Bisglycinate*)... 2 mg Magnesium (from Magnesium Citrate and Aquamin F) (Lithothamnion corralioides) mg

25 EVE Women's Multi 90gel Ingredients: (each softgel contains): Zinc (from Zinc Glycinate*)... 5 mg Selenium (from Selenium HVP Chelate*) mcg Copper (from Copper HVP Chlelate*) mcg Manganese (from Manganese HVP Chelate*) mg Chromium (from Chromium HVP Chelate*)...40 mcg Molybdenum (from Molybdenum Glycinate*)...25 mcg Potassium (from Potassium Chloride) mg Evening Primrose Oil (Oenothera biennis L. (Onagraceae)) (Seed) mg Cranberry Concentrate (20:1) (Vaccinium macrocarpon Aiton (Ericaceae)) (Fruit) mg Horsetail Extract (Esquisetum arvense) (Aerial Parts) (Min. 8% Silicon) mg Alpha Lipoic Acid (ALA) mg Choline (from Choline Bitartrate) mg Grape Seed Extract (Vitis vinifera) (Seed) mg Green Tea Extract (Camellia sinensis) (Leaf) (< 0.5 mg caffeine) mg Inositol mg Coenzyme Q10 (as Ubiquinone) mg Lycopene (Tomato Fruit Extract) (LYC-O-MATO ) mcg Lutein (Calendula officinalis) (Marigold Flowers) (FloraGLO ) mcg * = TRAACS Albion Non-Medicinal Ingredients: Softgel Capsule (Gelatin, Glycerin, Water, Carob Extract), Flax Seed Oil, Lecithin (from soy), Yellow Beeswax. Directions: Adult Dosage: Take 3 softgels daily. 25

26 EVE Women's Multi 90gel Maintains good health Bones, eyesight, skin, membranes & immune function Softgel version Easier to swallow Easier to absorb (oil-based) High dosage B-Complex Active coenzyme vitamin forms Aquamin and Bisglycinate minerals Phyto-based antioxidant complex 26

27 Beta-carotene Betatene natural mixed carotenoids extracted from Dunaliella salina algae beta-carotene, alpha-carotene, lutein, zeaxanthin and crytoxanthin cis- and trans-isomers of beta-carotene synthetic beta-carotene typically just trans isomer cultivated in ponds in Australia 27

28 Aquamin (Magnesium and Calcium) (harvesting) Sustainably sourced seaweed minerals Location Iceland Natural matrix with 72 trace minerals Certified organic harvesting Unique honeycombed structure 28

29 HVP Chelates by Albion Minerals Chele comes from Greek word Lobster claw Chelation 2 AA bend in a ring and bond to mineral in the centre and keep it in tact As if it were a natural dipeptide = organic form NOT salt Things that happen to salts in digestion - two charged particles, don t happen to a chelate Absorbed 2-4 times more effectively The more your body needs the mineral the higher the absorption Less digestive upset and higher potential for absorption Stability constant so wider area of absorption potential Inorganic minerals cause GI upset Ferrous sulphate constipation and nausea zinc sulphate nausea 29

30 Ferrochel Iron Bisglycinate Ferrous sulphate is not well absorbed compared to meat iron which is naturally chelated Iron glycine chelate mimics animal forms Chelated form has lower danger The more you have in storage the lower the iron chelate will be absorbed. Natural protective mechanism. For inorganic no more than 30 mg daily without a prescription. Absorption is 5-30% depending on stores % is average absorbed for Ferrochel in studies. 30

31 Ferrochel Iron Bisglycinate Short versus long-term supplementation Most bioavailability studies on salt irons are single dose studies When you dose daily after about 3 weeks there is a dramatic reduction in bioavailability (Swedish, Hellberg) Day 1 is 14% day 21 is 6% Bioavailability is a moving target Body must be protective - mucosal block! Doctor ends up raising dose and S/E increase but bioavailability stays low 31

32 About Ferrous sulphate (iron salt) Ferrous sulphate absorbs only when soluble which requires Ph <3 Can t be reached by those with low acid, or using acid blockers Buffering around pancreas crystallizes F sulphate so can t be absorbed Chelates may not be so ph dependent thus absorbed over a great surface which may explain fewer side effects (Dr. Bortz) Iron is very toxic thus it must always be wrapped in a protein in transport or storage (chelated) Body has no effective way of getting rid of iron Phytates/Tannins/polyphenols in tea complex with iron to prevent absorption Chelate is like a Trojan Horse You can inject a chelator into the blood to get rid of excess iron and reduce its toxic effect Chelate must be strong enough to protect the iron from inhibitory substances in the stomach but not strong enough to hold onto it all the way down the GI tract which is what occurs with these chelates. 32

33 About Ferrous sulphate (iron salt) Smaller AA are especially effective chelators as they are nutritive and not too large etc. Food iron is FERRIC form which is oxidized (red hill tops is from oxidized iron in the soil) Can only be absorbed by an enzyme that reduces it to a Ferrous which is soluble FERRIC >FERROUS (can get 3 mg daily max) FERROUS form taken with food can be complexed with phytates etc. so absorb much less because of this. Taking iron AWAY form food of any kind is better as it reduces the chances of being bound up with food phytates/tannins/polyphenols but it is 5x less bioavailable in salt form than chelate 33

34 Special Ingredients Evening Primrose Oil (GLA) - hot flashes, PMS, mastalgia, atopic dermatitis, Raynaud s Cranberry Concentrate - UTIs Horsetail Extract - osteoporosis (mineral rich) Alpha Lipoic Acid - antioxidant Choline brain signaling, cell membrane, fatty liver, neural tube defect prevention Grape Seed Extract - antioxidant Green Tea Extract antioxidant 34

35 Special Ingredients Inositol PCOS, metabolic syndrome, severe anxiety Coenzyme Q10 (Ubiquinone) energy, heart health Lycopene LYC-O-MATO antioxidant, hypertension Lyc-O-Mato is a registered trademark of LycoRed Ltd. all-natural standardized extract full spectrum of tomato carotenoids and other antioxidants beta-carotene, tocopherols, phytosterols Study: increases the carotenoid level in plasma, skin, and adipose tissue 35

36 Lutein (Calendula/Marigold) FloraGLO clinical trials Protects eyes from blue light and may help with fatigue, dry eyes and prevention of damage (AMD)

37 SUMMARY EVE Women's Multi 90gel Claim: Maintains good health; Helps in the maintenance of bones, eyesight, skin, membranes & immune function. Feature Softgel oil-based Chelates and active forms Female extras Benefit delivery easier to absorb Superior absorption and safety Herbs and nutrients for bones, hormones, cardiovascular system and eyes Code: NOW83802 UPC: Size: 90 Gel Category: Supplements Days Supply: 30 days 37 Trademarked/Registered Superior quality check Why carry this product?: Best value in category. Trademarked ingredients and superior forms. Brand supports IHF stores 6 ingredients with additional benefit of research and history Matrix interference testing

38 ADAM Men's Multi 90gel 38 Ingredients: (each softgel contains): Beta-Carotene (Betatene ) mcg (3000 IU) Vitamin A (as Vitamin A palmitate) mcg RAE (2000 IU) Vitamin C (from Calcium Ascorbate) mg Vitamin D-3 (as Cholecalciferol) mcg (500 IU) Vitamin E (as d-alpha-tocopherol) mg AT (75 IU) Vitamin K mcg Vitamin K mcg Thiamine (Vitamin B1) (from Thiamine Hydrochloride) mg Riboflavin (Vitamin B2) mg Niacin (as Niacinamide) mg Vitamin B6 (from Pyridoxine HCl and Pyridoxal-5-Phosphate) mg Folate (as Folic Acid) mcg Vitamin B12 (as Methylcobalamin and Cyanocobalamin) mcg Biotin mcg Pantothenic Acid (from Calcium d-pantothenate) mg Calcium (from Calcium Ascorbate, Aquamin Seaweed Derived Minerals and Calcium d-pantothenate) mg Magnesium (from Magnesium Citrate and, Aquamin Seaweed Derived Minerals) mg

39 ADAM Men's Multi 90gel Iodine (from Potassium Iodide) mcg Zinc (from Zinc Picolinate) mg Selenium (from Selenium Glycinate) mcg Copper (from Copper Bisglycinate) (TRAACS ) mcg Manganese (from Manganese Bisglycinate) (TRAACS )... 1 mg Chromium (from Chromium Nicotinate Glycinate) mcg Molybdenum (from Molybdenum Bisglycinate) (TRAACS ) mcg Potassium (from Potassium Chloride) mg Saw Palmetto Extract (Serenoa repens) (85% Fatty Acids) mg Plant Sterol Esters (with beta-sitosterol) mg Alpha Lipoic Acid mg Choline (from Choline Bitartrate) mg Grape Seed Extract (Vitis vinifera) mg Inositol... 5 mg Coenzyme Q10 (as Ubiquinone)... 5 mg Lycopene (LYC-O-MATO (natural Tomato fruit extract) from Lycopersicon esculentum) mg Lutein (FloraGLO extract of Tagetes erecta) mcg Cinnamon Bark Essential Oil, Ceylon Type (Cinnamomum verum) mg Non-Medicinal Ingredients: Softgel Capsule (gelatin, glycerin, water, carob), Pumpkin Seed Oil, Sunflower Lecithin, Beeswax. 39 Directions: Adult Dosage: Take 2 softgels daily with food

40 ADAM Men's Multi 90gel Easier to swallow Easier to absorb (oil-based) High dosage B-Complex Active coenzyme vitamin forms Aquamin and Bisglycinate minerals Phyto-based antioxidant complex Men's ingredients : Saw Palmetto, Lycopene, Phytosterols, pumpkin seed oil and CoQ10 40

41 ADAM Men's Multi 90gel Helps maintain ability to metabolize nutrients Helps in tissue formation Maintains proper muscle function Active coenzyme vitamin forms Bisglycinate minerals Phyto-based antioxidant complex 41

42 Unique Ingredients Saw Palmetto Extract BPH, Transurethral resection of the prostate (TURP) Plant Sterol Esters (with beta-sitosterol) BPH, hypercholesteremia Cinnamon Bark Essential Oil male fertility Alpha Lipoic Acid - antioxidant Choline brain signaling, cell membrane, fatty liver Grape Seed Extract - antioxidant Green Tea Extract antioxidant Inositol metabolic syndrome, severe anxiety Coenzyme Q10 (Ubiquinone) energy, heart health Lycopene LYC-O-MATO BPH, antioxidant, hypertension Lutein (Calendula/Marigold) FloraGLO Pumpkin seed oil androgenic alopecia and BPH 42

43 Cinnamon Oil s Role in Male Fertility Conclusion:. long-term CBO consumption protects male reproductive system of rats 43

44 SUMMARY ADAM Men's Multi 90gel Claim: Helps in the body s ability to metabolize nutrients Helps in tissue formation and the maintenance of proper muscle function. Feature Softgel oil-based Chelates and active forms Male extras Benefit delivery easier to absorb Superior absorption and safety Herbs and nutrients for prostate, cardiovascular system, fertility and eyes 44 Code: NOW83880 UPC: Size: 90 gel Category: Supplements Days Supply: 30 days Trademarked/Registered Superior quality check Why carry this product?: Best Value in category NOW contains Betatene; Vit K (1 & 2), Full potency Vitamin D 1000 IU, Coenzyme B6, Bisglycinates Brand supports IHF stores 6 ingredients with additional benefit of research and history Matrix interference testing

45 Complimentary Product NOW84004 American Ginseng 500mg 100vcap NOW83159 Hyaluronic Acid w/antioxid. 473mL Oct. available NOW83802 EVE Women's Multi 90gel NOW83880 ADAM Men's Multi 90gel 45

46 NOW Continuing Education Programs NOW University / NOW Product-ology Learn and Earn 2018 earn free products now!! Incorporates training sessions on a variety of healthy topics and ingredients To register Fill in required information Your Code is PS100 You will be sent 2 s; 1 with password info & 1 welcome Ongoing access to courses, go to: Lead Contact thalia.charney@puresource.ca 46

47 NOW Complimentary Product Request Please with the following information 1. Your store name & telephone phone number 2. Your name 3. The phone number that you called from when you called into the tele-training 4. The name of the tele-training session 5. The name and/or sku number of the product 6. The password given during the training 47

48 New NOW Product Launches S e p t - O c t

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