Research Knowledge Forum Trauma Q3 Report

Transcription

1 Research Knowledge Forum Trauma 2015-Q3 Report

2 Steering committee Alex Vaccaro (Chairman) Thomas Jefferson University Philadelphia, USA Start of Term: 01 Apr 2013 End of Term: 30 Jun 2016 Jens Chapman S. Rajasekaran Swedish Neurosciene Institute Ganga Hospital Seattle, USA Coimbatore, India Start of Term: 01 Jan 2012 Start of Term: 01 Mar 2012 End of Term: 31 Dec 2017 End of Term: 28 Feb 2018 Cumhur Öner (Chairman elect) Marcel Dvorak University Medical Center Vancouver General Hospital Utrecht, Netherlands Vancouver, Canada Start of Term: 01 Jan 2012 Start of Term: 01 Jan 2012 End of Term: 31 Dec 2017 End of Term: 31 Dec 2017 Frank Kandziora Klaus Schnake Unfallklinik Frankfurt Schön Klinik Nürnberg Fürth Frankfurt, Germany Fürth, Germany Start of Term: 01 Jan 2012 Start of Term: 01 Jun 2015 End of Term: 31 Dec 2017 End of Term: 31 May 2018 New Knowledge Forum Manager María Alvarez Sánchez AOSpine International Clavadelerstrasse Davos Switzerland T malvarez@aospine.org

3 Projects Spine Trauma Classification Title: Development of an AOSpine trauma injury classification system. Principal Investigator: Alex Vaccaro Aim: To develop and validate a comprehensive classification system of traumatic spine injuries: phase 1: TL system, phase 2: cervical system and phase 3: pelvic system Co-Principal Investigator: Cumhur Öner Co-investigators TL system: Name Institute City Country Region Last First Kepler Chris Thomas Jefferson University Philadelphia USA NA Schnake Klaus Schön Klinik Nürnberg Fürth Fürth Germany EU Bellabarba Carlo University of Washington Seattle USA NA Reinhold Max Klinikum Südstadt Rostock Germany EU Vialle Luiz Catholic University Curitiba Brazil LA Collaborating Surgeons TL system validation: Region Number Asia Pacific 35 Europe 17 North America 18 Latin America 20 Middle East 18 Africa 1 Publications: Abstract submitted: 2 Podium presentation: 9 Manuscripts submitted: 2 Manuscripts published: 11 Awards & Nominations: None Status: TL system: Data analysis and reporting Cervical system: Planning Pelvic system: Planning Link: Surgery References agnosis&bone=spine&segment=traumathoracolumbar

4 Outcome measurement Title: Development of an AOSpine trauma outcome instrument Principal Investigator: Cumhur Öner Participating sites (empirical study): Aim: To develop and validate a multidisciplinary and universal outcome instrument for spinal trauma patients, which includes both the patients and health professionals perspective on health and functioning. Phase 1: define core set Phase 2: international consensus conference Phase 3: validation Local PI Last First Institute City Country Region Vaccaro Alex Thomas Jefferson University Philadelphia USA NA Oner Cumhur University Medical Center Utrecht Netherlands EU Fehlings Michael University of Toronto Toronto Canada NA Dvorak Marcel Vancouver General Hospital Vancouver Canada NA Vialle Luiz Catholic University Curitiba Brazil LA Aarabi Bizhan University of Maryland Baltimore USA NA Kandziora Frank Unfallklinik Frankfurt Frankfurt Germany EU Rajasekaran Shanmuganathan Ganga Hospital Coimbatore India AP Dunn Robert Groote Schuur Hospital Cape Town South Africa EU Publications: Abstracts submitted: 2 Podium presentation: 1 Manuscripts submitted: 2 Manuscripts published: 5 Awards & Nominations: None Status: Executing - data analysis

5 Value of CT and MRI Title: The additional value of CT and MRI in determining the fracture severity and management in spinal column injuries Principal Investigator: Shanmuganathan Rajasekaran Aim: To define and determine the value of a CT scan and an MRI in addition to plain radiographs in a cohort of spinal fractures of various severities Co-Investigators: n/a Collaborating Surgeons CT/MRI study: Region Number Asia Pacific 14 Europe 5 Latin America 12 Middle East 7 North America 2 Africa 1 Publications: Abstracts presented: 0 Podium presentation: 0 Manuscripts submitted: 1 Manuscripts published: 0 Awards & Nominations: None Status: Disseminating Thoracolumbar Burst Fractures Title: Thoracolumbar Burst Fractures (AOSpine A3, A4) in neurologically intact patients: An observational, multicenter cohort study comparing surgical versus non-surgical treatment Principal Investigator: Marcel Dvorak Aim: To establish and quantify the difference in the patients clinical outcome after surgical treatment as compared to nonsurgical treatment of thoracolumbar burst fractures within the first year after treatment with the Oswestry Disability Index (ODI). Co-Investigators: Cumhur Öner Publications: Abstracts presented: 0 Podium presentation: 0 Manuscripts submitted: 0 Manuscripts published: 0 Awards & Nominations: None Status: Executing

6 Effect of Riluzole on osteogenic differentiation Title: Effect of Riluzole on osteogenetic differentiation of human mesenchymal stem cells and human osteoblast Aim: To understand the effects of Riluzole on mesenchymal stem cells' ability to convert to osteoblasts, on osteogenic and differentiation and possible toxicity of the drug on these cells. Principal Investigator: Alex Vaccaro Co-Investigators: Cumhur Öner Publications: Abstracts presented: 2 Podium presentation: 0 Manuscripts submitted: 0 Manuscripts published: 0 Awards & Nominations: None Status: Executing Publication Summary Abstracts Submitted (under review) 1. Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S, Chapman JR, Kandziora F, Schnake K, Dvorak MF, Oner C, Vaccaro AR. Effect of Riluzole on human bone marrow stromal cells and osteoblasts. Global Spine Congress, Dubai, United Arab Emirates, April, Bellabarba C, Schroeder GD, Kepler CK, Kurd MF, Krieg JC, Kleweno CP, Firoozabadi R, Chapman JR, Kandziora F, Schnake K, Rajasekaran S, Holstein JH, Sagi HC, Dvorak MF, Vialle LR, Oner C, Vaccaro AR.. The AOSpine Sacral Fracture Classification. Global Spine Congress, Dubai, United Arab Emirates, April, Schroeder GD, Vaccaro AR, Kepler CK, Kurd MF, Krieg JC, Kleweno CP, Firoozabadi R, Kandziora F, Schnake K, Rajasekaran S, Holstein JH, Sagi HC, Dvorak MF, Vialle LR, Oner C, Bellabarba C, Chapman JR. The development of a universally accepted Sacral Fracture Classification: A survey of AOSpine and AOTrauma Members. Global Spine Congress, Dubai, United Arab Emirates, April, Sadiqi S, Verlaan JJ, Lehr AM, Oner FC. Development of a universal disease-specific outcome instrument for spine trauma patients The AOSpine Clinician Reported Outcome Spine Trauma (AOSpine CRSOT). Global Spine Congress, Dubai, United Arab Emirates, April, Sadiqi S, Lehr AM, Post MW, Oner FC. Development of a universal disease-specific outcome instrument for spine trauma patients The AOSpine Patient Reported Outcome Spine Trauma (AOSpine PRSOT). Global Spine Congress, Dubai, United Arab Emirates, April, Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S, Chapman JR, Kandziora F, Schnake K, Dvorak MF, Oner C. Effect of Riluzole on human bone marrow stromal cells and osteoblasts. Philadelphia Spine Research Symposium, Philadlephia, United States of America, 9-12 November, Accepted for Presentation Podium Presentations: 7. Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease specific outcome instrument for spine trauma surgeon reported outcome. Eurospine, Copenhagen, Denmark, 2-4 September, E-poster Presentations: 8. Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S, Chapman JR, Kandziora F, Schnake K, Dvorak MF, Oner C. Effect of Riluzole on human bone marrow stromal cells and

7 osteoblasts. Philadelphia Spine Research Symposium, Philadlephia, United States of America, 9-12 November, Presented Podium Presentations: 1. Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease specific outcome instrument for spine trauma results of an international consensus meeting. 11 th International Turkish Spine Congress. Izmir, Turkey, 29April-3 May, Sadiqi S, Lehr AM, Oner FC. Towards developing a specific outcome instrument for spine trauma - An empirical cross-sectional multicenter ICF-based study by the AOSpine Knowledge Forum Trauma. 11 th International Turkish Spine Congress. Izmir, Turkey, 29April-3 May, Sadiqi S, Lehr AM, Oner FC. Towards the development of an outcome instrument for spine trauma An international survey of spinal surgeons. 11 th International Turkish Spine Congress. Izmir, Turkey, 29April-3 May, Oner FC, Jacobs WC, Lehr AM, Sadiqi S. Towards the development of a universal outcome instrument for spine trauma A systematic review and content comparison of outcome measures used in spine trauma research. 11 th International Turkish Spine Congress. Izmir, Turkey, 29April-3 May, Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the Injury Severity of Thoracolumbar Trauma: Confirmation of the Hierarchical Structure of the AOSpine Thoracolumbar Spine Injury Classification System. Global Spine Congress. Buenos Aires, Argentina Schroeder GD, Kepler CK, Chapman J, Oner FC, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Rajasekaran S, Schnake KJ, Reinhold M, Kandziora F, Vaccaro AR. Is there a regional difference in morphology interpretation of A3 / A4 fractures among different cultures. Global Spine Congress. Buenos Aires, Argentina Kepler CK, Vaccaro AR, Koerner JD, Chapman J, Dvorak M, Kandziora F, Rajasekaran S, Aarabi B, Vialle L, Fehlings MG,, Schroeder GD, Reinhold M, Audige L, Schnake KJ, Bellabarbra C, Oner FC. Reliability Analysis of the AOSpine thoracolumbar Spine Injury Classification System by a Worldwide Group of Naïve Spinal Surgeons. Global Spine Congress. Buenos Aires, Argentina Vaccaro AR, Kepler CK, Koerner JD, Chapman J, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Rajasekaran S, Schroeder GD, Schnake KJ, Reinhold M, Kandziora F, Oner FC. AOSpine Subaxial Cervical Spine Injury Classification System. Global Spine Congress. Buenos Aires, Argentina Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease specific outcome instrument for spine trauma. Global Spine Congress. Buenos Aires, Argentina CK, Koerner JD, Oner C, Fehlings MG, Aarabi B, Dvorak M, Reinhold M, Kandziora F, Bellabarba C, Chapman J, Vialle L, Vaccaro AR. A Worldwide Analysis of the Reliability and Perceived Importance of an Injury to the Posterior Ligamentous Complex in AO Type A Fractures. The Lumbar Spine Research Society. Chicago, IL May Vaccaro AR, Schroeder GD, Kepler CK, Oner F.C, Vialle L, Kandziora F, Koerner JD, Kurd MF, Reinhold M, Schnake KJ, Chapman J, Aarabi B, Fehling MG, Dvorak M, The Surgical Algorithm for the AOSpine Thoracolumbar Spine Injury Classification System. The Lumbar Spine Research Society. Chicago, IL, May Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the Injury Severity of Thoracolumbar Trauma: Confirmation of the Hierarchical Structure of the AOSpine Thoracolumbar Spine Injury Classification System. The International Society for the Study of the Lumbar Spine. San Francisco, June Kepler CK, Vaccaro AR, Koerner JD, Chapman J, Dvorak M, Kandziora F, Rajasekaran S, Aarabi B, Vialle L, Fehlings MG, Schroeder GD, Reinhold M, Audige L, Schnake KJ, Bellabarbra C, Oner FC. Reliability Analysis of the AOSpine thoracolumbar Spine Injury Classification System by a Worldwide Group of Naïve Spinal Surgeons. The International Society for the Study of the Lumbar Spine. San Francisco, June Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the Injury Severity of Thoracolumbar Trauma: Confirmation of the Hierarchical Structure of the AOSpine Thoracolumbar Spine Injury Classification System. The Lumbar Spine Research Society. Chicago, IL, May E-poster Presentations: Manuscripts Submitted 1. Sadiqi, S., F. C. Oner, M. F. Dvorak, B. Aarabi, G. D. Schroeder and A. R. Vaccaro (2015). "The influence of spine surgeons' experience on the classification and intraobserver reliability of the novel AOSpine Thoracolumbar Spine Injury Classification System - an international study." Spine (Phila Pa 1976). (Accepted)

8 2. Vaccaro, A. R., J. D. Koerner, K. E. Radcliff, F. C. Oner, M. Reinhold, K. J. Schnake, F. Kandziora, M. G. Fehlings, M. F. Dvorak, B. Aarabi, S. Rajasekaran, G. D. Schroeder, C. K. Kepler and L. R. Vialle (2015). "AOSpine subaxial cervical spine injury classification system." Eur Spine J. (Accepted) 3. Kepler, C. K., A. R. Vaccaro, J. D. Koerner, M. Dvorak, F. Kandziora, S. Rajasekaran, L. Vialle, M. Fehlings, G. D. Schroeder, M. Reinhold, K. Schnake, C. Bellabarba and C. Oner (2015). "Reliability Analysis of the AOSpine thoracolumbar Spine Injury Classification System by a Worldwide Group of Naïve Spinal Surgeouns." European Spine Journal. (Accepted) 4. Schroeder GD, Kepler CK, Koerner JD, Oner FC, Fehlings MG, Aarabi B, Marcel D, Reinhold M, Bellabarba C, Chapman J, Vialle L, Vaccaro AR. A Worldwide Analysis of the Reliability and Perceived Importance of an Injury to the Posterior Ligamentous Complex in AO Type A Fractures. Global Spine Journal. (Accepted) 5. Schroeder GD, Vaccaro AR, "Variations in the treatment of thoracolumbar burst fractures". Contemporary Spine Surgery (Accepted) 6. Schroeder GD, Kepler CK, Koerner JD, Chapman J, Bellabarba C, Oner FC, Reinhold M, Dvorak M, Aarabi B, Vialle L, Fehlings MG, Rajasekaran S, Kandziora F, Vaccaro AR. Is there a regional difference in morphology interpretation of A3/A4 fractures among different cultures? Global Spine J. (Accepted) 7. Kepler CK, Vaccaro AR, Schroeder GD, Koerner JD, Vialle L, Aarabi B, Rajasekaran S, Bellabarba C, Chapman J, Kandziora F, Dvorak M, Reinhold M, Oner FC. The Thoracolumbar AOSpine Injury Score (TL AOSIS). Gobal Spine J. (Accepted) 8. Vaccaro AR, Schroeder GD, Kepler CK, Oner F.C, Vialle L, Kandziora F, Koerner JD, Kurd MF, Reinhold M, Schnake KJ, Chapman J, Aarabi B, Fehling MG, Dvorak M, The Surgical Algorithm for the AOSpine Thoracolumbar Spine Injury Classification System The European Spine Journal (Accepted) 9. Oner, F. C., W. C. H. Jacobs, A. M. Lehr, S. Sadiqi, M. W. Post, B. Aarabi, J. Chapman, M. Dvorak, M. Fehlings, F. Kandziora, S. Rajasekaran and A. R. Vaccaro. "Towards the development of a universal outcome instrument for spine trauma - A systematic review and content comparison of outcome measures used in spine trauma research using the ICF as reference." Spine (Phila Pa 1976). (Accepted) 10. Chaudhary, B. R., M. Fehlings, L. Vialle, K. Schnake, C. K. Kepler, J. D. Koerner, M. Dvorak, F. Kandziora, S. Rajasekaran, B. Aarabi, G. D. Schroeder, M. Reinhold, C. Bellabarba, C. Oner and A. R. Vaccaro "The AO Spine Thoracolumbar Spine Injury Classification System: The ability of Surgeons to Correctly Classify Different Fracture Subtypes." Spine (Phila Pa 1976). (In Review) 11. Geuze, R. E., D. H. R. Kempen, P. de Baat, S. P. J. Mujis, A. M. Lehr, S. Rajasekaran, F. Kandziora, A. R. Vaccaro and C. Oner "Regional variations in treatment of thoracic and lumbar burst fractures, a review of recent literature." Spine (Phila Pa 1976). (In Review) 12. Sadiqi, S., A. M. Lehr, M. W. Post, W. C. H. Jacobs, B. Aarabi, J. Chapman, R. N. Dunn, M. Dvorak, M. Fehlings, S. Rajasekaran, L. Vialle, A. R. Vaccaro and C. Oner "The selection of core International Classification of Functioning, Disability and Health (ICF) categories for patient reported outcome measurement in spine trauma patients - results of an international consensus process." Spine (Phila Pa 1976). (In Review) 13. Rajasekaran, S., A. R. Vaccaro, R. M. Kanna, G. D. Schroeder, F. C. Oner, L. Vialle, J. Chapman, M. Dvorak, M. Fehlings, A. P. Shetty, K. Schnake, A. Maheshwaran and F. Kandziora (2015). "The Value of CT and MRI in the evaluation and management of patients with thoracolumbar spinal injuries." Spine (Phila Pa 1976). (In Review) 14. Sadiqi, S., J. J. Verlaan, A. M. Lehr, M. Dvorak, F. Kandziora, S. Rajasekaran, K. Schnake, A. R. Vaccaro and C. Oner (2015). "Universal disease specific outcome instruments for spine trauma - A global perspective on relevant parameters to evaluate clinical and functional outcomes of thoracic and lumbar spine trauma patients." Spine (Phila Pa 1976). (In Review) Published 1. Sadiqi, S., A. M. Lehr, M. W. Post, A. R. Vaccaro, M. F. Dvorak and F. C. Oner (2015). "Toward a specific outcome instrument for spinal trauma: how to measure function and health." Spine (Phila Pa 1976) 40(10): E Oner, F. C., S. Sadiqi, A. M. Lehr, M. F. Dvorak, B. Aarabi, J. R. Chapman, M. G. Fehlings, F. Kandziora, S. Rajasekaran and A. R. Vaccaro (2015). "Towards the development of an outcome instrument for spinal trauma: an international survey of spinal surgeons." Spine (Phila Pa 1976) 40(2): E Schroeder, G. D., A. R. Vaccaro, C. K. Kepler, J. D. Koerner, F. C. Oner, M. F. Dvorak, L. R. Vialle, B. Aarabi, C. Bellabarba, M. G. Fehlings, K. J. Schnake and F. Kandziora (2015). "Establishing the injury severity of thoracolumbar trauma: confirmation of the hierarchical structure of the AOSpine Thoracolumbar Spine Injury Classification System." Spine (Phila Pa 1976) 40(8): E Rubenstein, R., J. D. Koerner, D. Oh, C. K. Kepler, F. Kandziora, R. Shanmuganathan, M. Dvorak, B. Aarabi, L. Vialle, C. Oner and A. R. Vaccaro (2015). "Thoracolumbar Injury Severity Scoring Systems: A Review and Rationale for a New System Based on the AOSpine Thoracolumbar Injury Classification System." International Journal of Physical Medicine and Rehabilitation 3(2). 5. Vaccaro, A. R., C. Oner, C. K. Kepler, M. Dvorak, K. Schnake, C. Bellabarba, M. Reinhold, B. Aarabi, F. Kandziora, J. Chapman, R. Shanmuganathan, M. Fehlings, L. Vialle, A. O. S. C. Injury and F. Trauma Knowledge (2013). "AOSpine thoracolumbar spine injury classification system: fracture description, neurological status, and key modifiers." Spine (Phila Pa 1976) 38(23):

9 6. Schroeder, G. D., C. K. Kepler, J. D. Koerner, C. Oner, M. Fehlings, B. Aarabi, F. Kandziora, L. Vialle and A. R. Vaccaro (2015). "Can a Thoracolumbar injury severity score be uniformly applied from T1 to L5 or are modifications necessary?" Global Spine J(5): Oner, F. C., S. Sadiqi, A. M. Lehr, B. Aarabi, R. N. Dunn, M. F. Dvorak, M. G. Fehlings, F. Kandziora, M. W. Post, S. Rajasekaran, L. Vialle and A. R. Vaccaro (2015). "Toward Developing a Specific Outcome Instrument for Spine Trauma: An Empirical Cross-sectional Multicenter ICF-Based Study by AOSpine Knowledge Forum Trauma." Spine (Phila Pa 1976) 40(17): Book Chapters 1. GD. Schroeder and AR. Vaccaro. Cervical Spine Trauma. 2 nd Ed. for Handbook of Spine Surgery. New York. Thieme. In Press 2. BI. Woods, GD. Schroeder, AR. Vaccaro. Fractures and dislocations of the cervical spine from C-3 to C-7. Chapman's Orthopaedic Surgery, 4th Edition Publisher: Lippincott Williams & Wilkins. In press 3. JD. Koerner, AR. Vaccaro. Evaluation and Classification and Treatment of Cervical (C3-C7) Injuries. In HR. Winn (Ed.), Youmans Neurological Surgery, 7 th Edition. Philadelphia PA. Elsevier. In press 4. P. Kumar, BA and K. Lau, P. Millhouse, CK. Kepler, AR. Vaccaro. New classification and management of thoracolumbar spine injury. Techniques in Spine Surgery. Seoul. Springer Korea Limited. In Press. 5. Schroeder GD. Kepler CK. Vaccaro AR. Thoracolumbar trauma classification and surgical treatment. In Vaccaro AR, Baron EM ed. Atlas of Operative Techniques in Spinal Surgery In Press. 6. GD. Schroeder, PW Millhouse, AR Vaccaro, FC Oner. The AOSpine Subaxial Cervical Classification System. In Vialle LR, Oner FC, Vaccaro AR ed. In LR.Vialle, KD. Riew & M. Ito (Eds.), AOSpine Masters Series Volume 4. New York: Thieme.

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