Table of Contents. Void Fillers. Early Intervention. Ligament Reconstruction. Meniscus. Peripheral Nerve Defects. Cartilage.

Transcription

1 Product Catalogue

2 Table of Contents About Hospital Innovations About Hospital Innovations Partners Viscosupplementation Monovisc Orthovisc Orthovisc Mini Amniotic Tissue AmnioFix Tendon Allografts Non-Bone Tendons Bone Tendons Fascia Lata Revision ACL Surgery Bone Dowel Allograft Soft Tissue Fixation PULLUP LIGAFIX Meniscal Repair CMI SharpShooter Meniscal Allograft Transplantation Meniscal Allografts Articular Fresh Osteochondral Allograft Demineralised Bone Matrix BioSet BioReady BioAdapt BLX Powder Cubes Strips Fibres Demineralised Sponge Fibres Optium Chips & Cubes Cancellous Bone Chips Corticocancellous Bone Chips Cancellous Cubes Struts Strips Wedges HTO Wedges Iliac Crest Wedges Patellar Wedges Calcaneus Wedges Fibular Wedges Whole & Hemi Shafts Proximal & Distal Bone Allografts Fresh Frozen Femoral & Humeral Heads Whole Bones Avance Nerve Graft AxoGuard Nerve Protector AxoGuard Nerve Connector Orthopaedic... 66

3 About Hospital Innovations About Hospital Innovations Partners Since 2008, Hospital Innovations has been supplying a growing range of specialist products for use in orthopaedic and corrective surgery; with an emphasis on high quality, value added products and services. Hospital Innovations is a Human Tissue Authority (HTA) licensed tissue bank, allowing us to store and distribute allograft tissue and bone with the support of our valued international partners. Since 2011, Hospital Innovations has saved the NHS in excess of 2million with our pioneering Tissue Return Service RTI Surgical is a leading global surgical implant company, providing surgeons with safe biologic, metal and synthetic implants. RTI is accredited by the American Association of Tissue Banks (AATB). LifeNet Health is a non-profit, global company in regenerative medicine and the world s largest provider of allograft bio-implants and organs for transplantation. LifeNet Health is accredited by the AATB. MiMedx is a global premier processor and distributor of human amniotic tissue. MiMedx has distributed over 500,000 amniotic tissue grafts worldwide; providing a ground breaking amniotic tissue that promotes bioactive healing. Hospital Innovations is comprised of six distinct divisions; each with a unique focus, but all operating under Hospital Innovations aim of delivering innovative, safe and effective solutions. Across all divisions, Hospital Innovations endeavours to responsibly deliver outstanding customer support within our service levels and product range. Innomed, Inc. is a manufacturer of surgical instrumentation for orthopaedic surgery; with hundreds of unique instruments, many of which were designed by orthopaedic surgeons. Symmetry Surgical is dedicated to developing high-quality surgical instruments, offering a comprehensive suite of instrumentation across all surgical divisions. Ivy Sports Medicine is a young, dynamic company with extensive expertise in the development and production of meniscus implants. As customer education is at the forefront of Hospital Innovations philosophy, we consistently seek to provide collaborative, bespoke training for the benefit of all staff involved; including surgeons, nursing staff, procurement and administrative support. Safety, effectiveness and value added service are Hospital Innovations core values; with a mindful and sensitive appreciation that the end-user is a person in need. AxoGen, Inc. is a leading medical technology company dedicated to peripheral nerve repair. The company has created and licensed a unique combination of patented nerve repair technologies to change the standard of care for patients with peripheral nerve injuries. Anika Therapeutics is a global medical technology company at the forefront of pain management, tissue regeneration and wound healing. Anika Therapeutics proprietary technology is based on Hyaluronic acid (HA). SBM specialises in the design, manufacturing and distribution of soft tissue fixation and bone repair systems for use in orthopaedic surgery

4 Viscosupplementation Monovisc Monovisc is a single injection, high-dose, HA viscosupplement for the treatment of osteoarthritis pain. Monovisc is lightly cross-linked to extend the duration of the effect of HA molecules in the joint space, whilst delivering 88mg of HA in a single injection; providing faster pain relief that lasts longer. Orthovisc Orthovisc is an ultra-pure, high molecular weight, injectable HA viscosupplement used to treat the joint pain caused by osteoarthritis; delivering a total dosage of 90mg of HA over 3 injections. Orthovisc Mini Orthovisc Orthovisc Orthovisc Mini brings the trusted formulation of Orthovisc to a smaller size for the management of osteoarthritis pain in small joints. Orthovisc Mini is provided in 1ml of volume; delivering a total dosage of 15ml of HA. Monovisc Orthovisc Mini Monovisc Orthovisc Mini

5 Amniotic Tissue AmnioFix Injectable AmnioFix Injectable is a bioactive tissue matrix composed of human amnion/chorion membrane; dehydrated and micronised for local injection to modulate inflammation, reduce scar tissue formation and enhance healing. AmnioFix Injectable provides over 226 soluble growth factors, cytokines and chemokines to help enhance soft tissue healing. MiMedx s patented PURION process safely and gently separates placental tissues, cleans and reassembles layers; and then dehydrates the tissue to preserve the key elements associated with healing. The PURION process has been specifically designed to deliver a clinically effective and minimally manipulated allograft tissue. AmnioFix Injectable is indicated for use in areas such as tendinopathy, osteoarthritis attenuation and plantar fasciitis treatment; however, AmnioFix Injectable can be used in any area where soft tissue injuries have occurred. AI-5050 AI-5125 AI-5200 AmnioFix Injectable: 40mg AmnioFix Injectable: 100mg AmnioFix Injectable: 160mg AmnioFix Injectable contains over 226 soluble growth factors, cytokines and chemokines, including the following: Name bfgf EGF PDGF TGF-α TGF-ß1 VEGF PIGF IL-4 IL-10 Function Heparin-binding protein with mitogenic activity; potent angiogenesis stimulator. Stimulates proliferation, differentiation, and survival in numerous cell types. Stimulates proliferation, migration and angiogenesis. Stimulates proliferation/migration of keratinocytes; potent angiogenesis stimulator. Controls proliferation, differentiation and apoptosis of numerous cell types. Stimulates endothelial cell migration/activation; potent angiogenesis stimulator. Stimulates proliferation/migration of endothelial cells; potent angiogenesis stimulator. Stimulates proliferation of activated B cells and T cells. Enhances B cell survival, proliferation and antibody production. A selection of key AmnioFix Injectable growth factors, chemokines and cytokines AmnioFix Injectable 08 09

6 Tendon Allografts (Length) BioCleanse Tissue Sterilisation Process All tendon allografts supplied by Hospital Innovations undergo RTI Surgical s BioCleanse Tissue Sterilisation Process. The BioCleanse Tissue Sterilisation Process sterilises tissue to a Sterility Assurance Level (SAL) of 10-6 using a complex, proprietary combination of mechanical and chemical processes working in conjunction with each other. The mechanical processes involve oscillating positive and negative pressure, allowing the gentle perfusion throughout the tissue of chemical agents, which remove blood and lipids; and inactivates or removes pathogenic microorganisms. Consequently, the BioCleanse process does not utilise irradiation to sterilise soft tissue. Non-Bone Tendons Hospital Innovations non-bone tendons are sterilised via the BioCleanse Tissue Sterilisation Process; ensuring a SAL of All grafts are carefully pre-trimmed at the proximal and distal ends, resulting in robust grafts for suturing. Non-bone tendons are interchangeable as graft options. AL10011 AL10012 AL10030 AL10031 AL10032 BioCleanse Gracilis Tendon: Medium, mm BioCleanse Gracilis Tendon: Long, Over 240mm BioCleanse Semitendinosus Tendon: Short, Up to 200mm BioCleanse Semitendinosus Tendon: Medium, mm BioCleanse Semitendinosus Tendon: Long, Over 240mm BioCleanse Anterior Tibialis Tendon (Length) AL10002 AL10003 AL10021 BioCleanse Anterior Tibialis Tendon: Medium, mm BioCleanse Anterior Tibialis Tendon: Long, Over 240mm BioCleanse Peroneus Tendon: Medium, mm BioCleanse Gracilis Tendon AL10022 AL10026 AL10027 BioCleanse Peroneus Tendon: Long, Over 240mm BioCleanse Posterior Tibialis Tendon: Medium, mm BioCleanse Posterior Tibialis Tendon: Long, Over 240mm 10 11

7 Tendon Allografts Bone Tendons Hospital Innovations bone tendons are sterilised via the BioCleanse Tissue Sterilisation Process; ensuring a SAL of 10-6 without the use of irradiation. Pre-shaped bone blocks are available, minimising theatre time by eliminating the need for intra-operative shaping of the bone blocks. AL10500 AL10505 AL10506 AL10510 AL10515 BioCleanse Achilles Tendon: Conventional with Bone Block BioCleanse Achilles Tendon: Pre-Shaped with 10mm Bone Block BioCleanse Achilles Tendon: Pre-Shaped with 11mm Bone Block BioCleanse Achilles Tendon: Hemi BioCleanse Achilles Tendon: Pre-Trimmed BioCleanse Pre-Trimmed Achilles Tendon AL10705 AL10710 AL10720 BioCleanse Patellar Tendon: 10mm BTB BioCleanse Patellar Tendon: Hemi BTB BioCleanse Patellar Tendon: Pre-Shaped BioCleanse Whole Patellar Tendon FWPLQEXT Full Quadricep Expansion (Extensor Mechanism) with Patellar 12 13

8 Tendon Allografts BTB Select The BTB Select allograft is an innovative solution that allows for precision size-matching relative to the intra-articular length of the patient. The BTB Select allograft is sterilised via the BioCleanse Tissue Sterilisation Process; ensuring a SAL of 10-6 without the use of irradiation. Adjustable Length BTB Allograft The Adjustable Length BTB allograft is a revolutionary concept in ACL reconstruction, allowing the surgeon the ability to adjust the length of the BTB graft intra-operatively, providing a precise match for the patient s intra-articular length. The Adjustable Length BTB allograft is sterilised via the BioCleanse Tissue Sterilisation Process; ensuring a SAL of 10-6 without the use of irradiation. BioCleanse BTB Select AL10700 BioCleanse BTB Select : 10/10mm On Request On Request BioCleanse Adjustable Length BTB: Femoral Bone Block with Eyelet BioCleanse Adjustable Length BTB: Tendon with Assembled Bone Block BioCleanse Adjustable Length BTB 14 15

9 Fascia Lata Hospital Innovations fascia lata is recovered from the fibrous covering of muscle on the lateral aspect of the thigh and is indicated for use in labral reconstruction in the hip, ACL reconstruction, PCL reconstruction, Achilles tendon reconstruction and rotator cuff reconstruction. Our fascia lata are fully sterilised via the Allowash XG sterilisation process and are available freeze-dried. (Width x Length) FL Strip Fascia Lata: Strip, 3mm x 150mm (Pack of 2) FL S Fascia Lata: Small, 30mm x 60mm FL M Fascia Lata: Medium, 30mm x 150mm FL L Fascia Lata: Large, 80mm x 200mm FL C Fascia Lata: Custom, 60mm x 100mm Revision ACL Surgery Bone Dowel Allografts Hospital Innovations bone dowel allografts provide a pre-shaped allograft option for bony deficiencies in ACL revision procedures and are sterilised via the BioCleanse Tissue Sterilisation Process; ensuring a SAL of 10-6 without the use of irradiation. Bone dowel allografts are available freeze-dried and come fully cannulated. D02808 D02810 D02811 D02812 D02814 D02816 D02818 (Diameter x Length) Unicortical Dowel: 8mm x 30-35mm Unicortical Dowel: 10mm x 30-35mm Unicortical Dowel: 11mm x 30-35mm Unicortical Dowel: 12mm x 15-35mm Unicortical Dowel: 14mm x 15-35mm Unicortical Dowel: 16mm x 15-35mm Unicortical Dowel: 18mm x 15-35mm Fascia Lata Unicortical Dowel 16 17

10 Soft Tissue Fixation PULLUP Adjustable Loop Suspensory Fixation Designed by renowned ACL surgeon Dr Philippe Colombet, PULLUP is an adjustable loop suspensory fixation device, offering a novel solution that addresses concerns with both conventional fixed loop and adjustable loop suspensory fixation devices. Soft Tissue Fixation LIGAFIX Bioabsorbable Interference Screw LIGAFIX is a bioabsorbable interference screw made from Duosorb, a unique material comprised of ß-TCP and Poly DL Lactic Acid (PDLA); providing an osteoconductive, resorbable and bioactive material with excellent mechanical resistance and reduced inflammatory response. Novel, patented locking mechanism designed to minimise graft slippage during tensioning. 1 Secondary, positive flip suture ensures accurate seating of the button against the cortex. 1 PULLUP adjustable loop eliminates the need for intra-operative calculations and avoids limitations in tunnel length and graft choice. 1 PULLUP fills the tunnel with tendon graft, avoiding concerns on graft stability and bone tendon healing. 1 PULLUP PULLU01201 PULXL01202 (Diameter x Length) PULLUP Suspensory Fixation Device: For Cortical Tunnels up to Ø4.5mm PULLUP XL Suspensory Fixation Device: For Cortical Tunnels Ø5-10mm 1. Data on File at SBM LIGAFIX is available in two configurations: LIGAFIX 30-30% ß-TCP/70% PDLA; improved mechanical strength for use with BTB grafts. LIGAFIX 60-60% ß-TCP/40% PDLA; increased resorption for use with soft tissue grafts. COM COM COM COM COM COM COM COM COM COM COM COM COM (Head, Diameter x Length) LIGAFIX 30 Interference Screw: Rounded, Ø7mm x 20mm LIGAFIX 30 Interference Screw: Rounded, Ø7mm x 25mm LIGAFIX 30 Interference Screw: Rounded, Ø7mm x 30mm LIGAFIX 30 Interference Screw: Rounded, Ø8mm x 20mm LIGAFIX 30 Interference Screw: Rounded, Ø8mm x 25mm LIGAFIX 30 Interference Screw: Rounded, Ø8mm x 30mm LIGAFIX 30 Interference Screw: Rounded, Ø8mm x 35mm LIGAFIX 30 Interference Screw: Rounded, Ø9mm x 20mm LIGAFIX 30 Interference Screw: Rounded, Ø9mm x 25mm LIGAFIX 30 Interference Screw: Rounded, Ø9mm x 30mm LIGAFIX 30 Interference Screw: Rounded, Ø9mm x 35mm LIGAFIX 30 Interference Screw: Flat, Ø10mm x 30mm LIGAFIX 30 Interference Screw: Flat, Ø10mm x 35mm

11 COM3010R25 COM3010R33 COM COM (Head, Diameter x Length) LIGAFIX 30 Interference Screw: Rounded, Ø10mm x 25mm LIGAFIX 30 Interference Screw: Rounded, Ø10mm x 33mm LIGAFIX 30 Interference Screw: Flat, Ø11mm x 30mm LIGAFIX 30 Interference Screw: Flat, Ø11mm x 35mm COM LIGAFIX 60 Interference Screw: Rounded, Ø7mm x 20mm COM COM COM LIGAFIX 60 Interference Screw: Rounded, Ø7mm x 25mm LIGAFIX 60 Interference Screw: Rounded, Ø7mm x 30mm LIGAFIX 60 Interference Screw: Rounded, Ø8mm x 20mm COM LIGAFIX 60 Interference Screw: Rounded, Ø8mm x 25mm COM COM COM LIGAFIX 60 Interference Screw: Rounded, Ø8mm x 30mm LIGAFIX 60 Interference Screw: Rounded, Ø8mm x 35mm LIGAFIX 60 Interference Screw: Rounded, Ø9mm x 20mm LIGAFIX, Rounded Head COM LIGAFIX 60 Interference Screw: Rounded, Ø9mm x 25mm COM LIGAFIX 60 Interference Screw: Rounded, Ø9mm x 30mm COM COM LIGAFIX 60 Interference Screw: Rounded, Ø9mm x 35mm LIGAFIX 60 Interference Screw: Flat, Ø10mm x 30mm COM LIGAFIX 60 Interference Screw: Flat, Ø10mm x 35mm COM6010R25 COM6010R30 COM6010R33 COM LIGAFIX 60 Interference Screw: Rounded, Ø10mm x 25mm LIGAFIX 60 Interference Screw: Rounded, Ø10mm x 30mm LIGAFIX 60 Interference Screw: Rounded, Ø10mm x 33mm LIGAFIX 60 Interference Screw: Flat, Ø11mm x 30mm COM LIGAFIX 60 Interference Screw: Flat, Ø11mm x 35mm LIGAFIX, Flat Head

12 Meniscal Repair Collagen Implant (CMI ) CMI is a biological and completely resorbable implant made from 97.5% highly purified bovine Type I collagen and 2.5% glycosaminoglycans; featuring a porous structure for optimal ingrowth of cells. Indicated for use in segmental meniscal loss, CMI serves as a guide for the migration of the body s own cells; repairing the defect and potentially reducing the development of osteoarthritis within the knee. CMI Medial XL 4600 CMI Implant: Medial, 7.5mm 4601 CMI Implant: Medial, 9.0mm 4612 CMI Implant: Medial XL (9.5mm) 4607 CMI Implant: Lateral, 9.5mm 4608 CMI Measuring Device Cannula 4610 CMI Delivery Clamp 4618 CMI Measuring Rod, Sterile CMI Lateral 9.5mm CMI Measuring Device Cannula CMI Delivery Clamp 22 23

13 Meniscal Repair SharpShooter The SharpShooter repair system is a simple, easy-to-use method for repairing the meniscus via the inside-out suture technique. This technique can be used to fix meniscal tears, CMI implants or when performing a complete meniscal allograft transplant. The system includes a unique method to deliver high strength 2-0 UHMWPE sutures using a patented delivery handle and cannulae to reach all areas of the meniscus arthroscopically IV 4701-IV SharpShooter Handle Surgical Suture for SharpShooter Handle, Box of 10 Units 4750 Cannula for SharpShooter Handle: Right Posterior 4751 Cannula for SharpShooter Handle: Left Posterior 4752 Cannula for SharpShooter Handle: Right Middle 4753 Cannula for SharpShooter Handle: Left Middle 4754 Cannula for SharpShooter Handle: Right Anterior 4755 Cannula for SharpShooter Handle: Left Anterior HS4704/1 SharpShooter Surgical Suture, High Strength Fibre, Non-Absorbable, UHMWPE, White HS4704/10 SharpShooter Surgical Suture, High Strength Fibre, Non-Absorbable, UHMWPE, White, Box of SharpShooter Handle SharpShooter Sutures and Cannulae

14 Meniscal Allograft Transplantation Meniscal Allograft Hospital Innovations meniscal allografts offer a natural, biological solution for the management of meniscal transplantation, avoiding concerns with osteoarthritis degeneration accelerated by the absence of healthy meniscus. Hospital Innovations provide the only sterile 10-6 meniscal allograft; supplied with an attached bone block, allowing for use with a range of surgical techniques. Using the Pollard et al. 2 technique, Hospital Innovations provide custom graft sizing and patient matching; ensuring the patient receives the highest quality meniscal allograft possible Lateral: Left Lateral: Right Medial: Left Medial: Right Lateral: No Bone Bridge Meniscal Allograft 1. Data on File at RTI Surgical, Inc. 2. Pollard, M. E. et al. (1995). Radiographic Sizing for Meniscal Transplantation. Arthroscopy. 11(6):

15 Articular Fresh Osteochondral Allograft Hospital Innovations range of fresh osteochondral (OC) allografts enable the surgeon to resurface large cartilage defects (>2.5cm 2 ) with mature hyaline cartilage and repair subchondral bone in a single procedure. Our fresh OC allografts are aseptically processed and stored fresh and refrigerated to ensure the maintenance of chondrocyte viability. 1 All of Hospital Innovations fresh OC allografts have guaranteed chondrocyte viability of 45 days* post-recovery and are patient matched using MRIs/ measured X-rays to ensure your patient receives an optimised allograft. Fresh OC Femoral Condyle Fresh OC Patella Fresh Osteochondral Allograft: Left Lateral Condyle Fresh Osteochondral Allograft: Left Medial Condyle Fresh Osteochondral Allograft: Right Lateral Condyle Fresh Osteochondral Allograft: Right Medial Condyle Fresh OC Trochlea Fresh OC Talus Fresh Osteochondral Allograft: Left Patella Fresh Osteochondral Allograft: Right Patella Fresh Osteochondral Allograft: Left Trochlea Fresh Osteochondral Allograft: Right Trochlea Fresh OC Distal Tibia Fresh Osteochondral Allograft: Left Talus Fresh Osteochondral Allograft: Right Talus Fresh Osteochondral Allograft: Left Distal Tibia Fresh Osteochondral Allograft: Right Distal Tibia 1. McCulloch, P. C. et al. (2007). Prospective Evaluation of Prolonged Fresh Osteochondral Allograft Transplantation of the Femoral Condyle: Minimum 2-Year Follow-Up. American Journal of Sports Medicine. 35: * 45 day viability begins from time of recovery. Your sales representative can inform you of the graft expiration date

16 Demineralised Bone Matrix (DBM) BioSet DBM Hospital Innovations BioSet DBM provides a natural scaffold to support cellular ingrowth and provide osteoinductive* potential. BioSet DBM is composed of allograft demineralised bone, a highly purified porcine gelatin carrier and is available with or without corticocancellous chips. When combined with fluid (i.e. the patient s blood, sterile saline or sterile water) the graft becomes pliable and mouldable; allowing easy placement of the grafting material and excellent handling properties. BioSet DBM is sterilised via the Cancelle SP DBM Sterilisation Process BioSet IC Freeze-Dried RT Allograft Paste Mouldable: 2cc BioSet IC Freeze-Dried RT Allograft Paste Mouldable: 5cc BioSet IC Freeze-Dried RT Allograft Paste Mouldable: 10cc BioSet IC Freeze-Dried RT Allograft Paste Mouldable: 20cc BioSet Freeze-Dried RT Flowable Allograft Paste Syringe: 0.5cc BioSet Freeze-Dried RT Flowable Allograft Paste Syringe: 1cc BioSet Freeze-Dried RT Flowable Allograft Paste Syringe: 5cc BioSet Freeze-Dried RT Flowable Allograft Paste Syringe: 10cc BioSet Frozen Allograft Paste Syringe: 0.5cc BioSet Frozen Allograft Paste Syringe: 1cc BioSet Frozen Allograft Paste Syringe: 5cc BioSet Frozen Allograft Paste Syringe: 10cc * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results BioSet IC Frozen Mouldable Allograft Paste Syringe: 5cc BioSet IC Frozen Mouldable Allograft Paste Syringe: 10cc BioSet IC Frozen Mouldable Allograft Paste Syringe: 20cc BioSet IC Frozen Mouldable Strip: 50mm, 6cc (2 Each) BioSet IC Frozen Mouldable Strip: 90mm, 10cc (2 Each) BioSet IC Frozen Allograft Full Disc: 20mm x 3mm, 1cc BioSet IC Frozen Allograft Full Disc: 30mm x 3mm BioSet IC Frozen Allograft Full Disc: 45mm x 5mm BioSet IC Frozen Allograft Partial Disc: 75mm x 5mm BioSet IC Frozen Allograft Full Disc: 90mm x 5mm, 32cc BioSet IC Frozen Allograft Partial Disc: 90mm x 5mm BioSet DBM Flowable BioSet DBM Mouldable BioSet DBM Discs

17 BioReady DBM Hospital Innovations BioReady DBM is a ready-to-use bone graft with osteoinductive potential* that provides convenience, robust handling and unsurpassed safety. Processed from 100% donated human tissue, BioReady DBM is available in a variety of options to meet all surgical needs. BioReady DBM does not require any preparation such as thawing or mixing and is processed via the Cancelle SP DBM Sterilisation Process to achieve a SAL of D00100 D00101 D00102 D00105 D00110 D00300 D00301 D00302 D00305 D00310 D00320 BioReady DBM Putty: 0.5cc BioReady DBM Putty: 1cc BioReady DBM Putty: 2cc BioReady DBM Putty: 5cc BioReady DBM Putty: 10cc BioReady DBM Putty with Chips: 0.5cc BioReady DBM Putty with Chips: 1cc BioReady DBM Putty with Chips: 2cc BioReady DBM Putty with Chips: 5cc BioReady DBM Putty with Chips: 10cc BioReady DBM Putty with Chips: 20cc BioReady DBM Putty with Chips BioReady DBM Putty BioAdapt DBM Hospital Innovations BioAdapt DBM is a pre-formed DBM comprised of 100% donated human musculoskeletal tissue. BioAdapt DBM provides an open matrix which allows for bony ingrowth, as well as exposure of a full range of proteins known to induce the signal for bone formation. 1 BioAdapt DBM can be hydrated with various types of fluid, providing a contoured fit for bony defects. To provide the highest level of safety, the carrier component of BioAdapt DBM is sterilised via the BioCleanse Tissue Sterilisation Process; whilst the DBM component is sterilised via the Cancelle SP DBM Sterilisation Process. DU0015 DU0025 DU0060 DU0110 DU0125 (Length x Width x Height) BioAdapt DBM Foam: Small Strip, 15mm x 15mm x 8mm BioAdapt DBM Foam: Medium Strip, 50mm x 25mm x 5mm BioAdapt DBM Foam: Disc BioAdapt DBM Foam: 2 x Skinny Strip, 100mm x 10mm x 8mm BioAdapt DBM Foam: Large Strip, 100mm x 25mm x 5mm BioAdapt DBM Foam: Small BioAdapt DBM Foam: Medium * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results BioAdapt DBM Foam: Large BioAdapt DBM Foam: Skinny

18 ReadiGRAFT BLX DBM Putty and Crunch Putty Hospital Innovations BLX DBM putty and crunch putty is an advanced DBM with exceptional handling and proven osteoinductive* properties. BLX DBM is formulated for optimal osteoinductive* potential via the PAD demineralisation technology, achieving optimal residual calcium levels of 1-4%; whilst sterilisation via the Allowash XG sterilisation process ensures patient safety via a SAL of BLX DBM Putty BF BF BF BF BF BL BL BL BL BL BLX DBM Putty: 0.5cc BLX DBM Putty: 1cc BLX DBM Putty: 2.5cc BLX DBM Putty: 5cc BLX DBM Putty: 10cc BLX DBM Crunch Putty: 0.5cc BLX DBM Crunch Putty: 1cc BLX DBM Crunch Putty: 2.5cc BLX DBM Crunch Putty: 5cc BLX DBM Crunch Putty: 10cc DBM Powder Hospital Innovations DBM powder serves as a bone void filler in many surgical applications. The DBM powder is processed through the Cancelle SP DBM Sterilisation Process; achieving a SAL of 10-6 and verifying osteoinductive potential via 100% lot testing.* DBM Powder: 5cc DBM Powder: 10cc DBM Powder: 15cc DBM Powder ReadiGRAFT BLX DBM Cubes Hospital Innovations DBM cubes serve as a bone void filler in many surgical applications. Our DBM cubes are formulated for optimal osteoinductive* potential via the PAD demineralisation technology, achieving optimal residual calcium levels of 1-4%; whilst sterilisation via the Allowash XG sterilisation process ensures patient safety via a SAL of DBM Cubes OSC1003 OSC1000 OSC1001 OSC1002 DBM Cubes: 8mm x 8mm x 8mm DBM Cubes: 10mm x 10mm x 10mm DBM Cubes: 12mm x 12mm x 12mm DBM Cubes: 14mm x 14mm x 14mm * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results.

19 ReadiGRAFT BLX DBM Strips Hospital Innovations DBM strips serve as a bone void filler in many surgical applications. Our DBM strips are formulated for optimal osteoinductive* potential via the PAD demineralisation technology, achieving optimal residual calcium levels of 1-4%; whilst sterilisation via the Allowash XG sterilisation process ensures patient safety via a SAL of OSS3001 OSS3002 OSS3003 OSS3004 OSS3005 OSS3006 (Width x Length x Height) DBM Strip: 10mm x 10mm x 2mm DBM Strip: 15mm x 40mm x 2mm DBM Strip: 20mm x 50mm x 2mm DBM Strip: 20mm x 25mm x 6mm DBM Strip: 15mm x 20mm x 6mm DBM Strip: 10mm x 20mm x 8mm DBM Strips ReadiGRAFT BLX DBM Hospital Innovations DBM fillers serve as a bone void filler in many surgical applications. Our DBM fillers are formulated for optimal osteoinductive* potential via the PAD demineralisation technology, achieving optimal residual calcium levels of 1-4%; whilst sterilisation via the Allowash XG sterilisation process ensures patient safety via a SAL of ReadiGRAFT Fibres Comprised of 100% bone matrix, our DBM fibres are formulated for optimal osteoinductive* potential via the PAD demineralisation technology, achieving optimal residual calcium levels of 1-4%; whilst sterilisation via the Allowash XG sterilisation process ensures patient safety via a SAL of ReadiGRAFT BLX DBM Fibres Hospital Innovations DBM fibres comprise of both cortical and cancellous fibres and provide a bone void filler with customisable hydration for many surgical applications. DF-1002 DF-1003 DF-1006 DF-1004 DBM Fibres: 2cc DBM Fibres: 5cc DBM Fibres: 10cc DBM Fibres: 15cc DF-1005 DBM Fibres: 30cc DBM Fibres FlexiGRAFT DBM Sponge Fibres Hospital Innovations DBM sponge fibres comprise of cortical fibres only and provide a bone void filler with customisable hydration for many surgical applications. DBM OSF2000 OSF2001 OSF2002 DBM : 2.5cc DBM : 5cc DBM : 10cc * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results BL BL BL BL DBM Sponge Fibres: 1cc DBM Sponge Fibres: 2.5cc DBM Sponge Fibres: 5cc DBM Sponge Fibres: 10cc * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results.

20 Optium DBM Hospital Innovations Optium DBM offers consistent handling properties and proven clinical results for any bone filling application. LifeNet Health s proprietary processing technology, Allowash XG, sterilises the allograft to a SAL of 10-6, whilst PAD ensures effective demineralisation to 1-4% residual calcium; proven to provide the most powerful osteoinductive* potential. 1,2 Optium DBM is available, ready for use, in gel or putty formulations and in a range of volumes to accommodate a variety of clinical indications. TGEL01 TGEL05 TGEL10 TPUT01 TPUT02 TPUT05 TPUT10 Optium DBM Gel: 1cc Optium DBM Gel: 5cc Optium DBM Gel: 10cc Optium DBM Putty: 1cc Optium DBM Putty: 2.5cc Optium DBM Putty: 5cc Optium DBM Putty: 10cc Optium DBM Gel Chips & Cubes Preservon Technology Preservon is a proprietary, glycerol-based preservation technology that allows allograft bio-implants to be stored in a fully hydrated state at ambient temperature. Preservon treated cancellous bone chips provide the handling qualities of fresh bone, whilst eliminating the need for lengthy rehydrating, thawing or milling. Cancellous Bone Chips Hospital Innovations cancellous bone chips provide an osteoconductive scaffold for bone ingrowth and allow remodelling with the patient s own bone. Our cancellous bone chips are fully sterilised to a SAL of 10-6 through the Allowash XG sterilisation process and are available freeze-dried, frozen or treated via LifeNet Health s patented Preservon technology; allowing cancellous chips to be stored fully hydrated at ambient temperature. PCAN5 12 PCAN15 12 PCAN30 12 Preservon Cancellous Chips: 0.1-2mm, 5cc Preservon Cancellous Chips: 0.1-2mm, 15cc Preservon Cancellous Chips: 0.1-2mm, 30cc Optium DBM Putty * These products induced bone formation when evaluated using the modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results. 1. Herold, R. W. et al. (2002). The Effects of Varying Degrees of Allograft Decalcification on Cultured Porcine Osteoclast Cells. J Peridontal. 73: Turonis, J. W. et al. (2006). The Affects of Residual Calcium in Decalcified Freeze-Dried Bone Allograft in a Critical Sized Defect in Rattus Norvegicus Calvarium. J Oral Implantol. 32: PCAN5 14 PCAN15 14 PCAN1/4 14 PCAN30 14 PCAN1/2 14 PCAN60 14 PCAN90 14 Preservon Cancellous Chips: 1-4mm, 5cc Preservon Cancellous Chips: 1-4mm, 15cc Preservon Cancellous Chips: 1-4mm, 20cc Preservon Cancellous Chips: 1-4mm, 30cc Preservon Cancellous Chips: 1-4mm, 40cc Preservon Cancellous Chips: 1-4mm, 60cc Preservon Cancellous Chips: 1-4mm, 90cc

21 PCAN5 Preservon Cancellous Chips: 1-8mm, 5cc CAN15 14BP Freeze-Dried Crushed Cancellous Chips: 1-4mm, 15cc PCAN15 Preservon Cancellous Chips: 1-8mm, 15cc Cancellous Chips 1-4mm CAN30 14BP Freeze-Dried Crushed Cancellous Chips: 1-4mm, 30cc PCAN1/4 Preservon Cancellous Chips: 1-8mm, 20cc CAN60 14BP Freeze-Dried Crushed Cancellous Chips: 1-4mm, 60cc PCAN30 Preservon Cancellous Chips: 1-8mm, 30cc CAN90 14BP Freeze-Dried Crushed Cancellous Chips: 1-4mm, 90cc PCAN1/2 Preservon Cancellous Chips: 1-8mm, 40cc PCAN60 Preservon Cancellous Chips: 1-8mm, 60cc CAN15 Freeze-Dried Crushed Cancellous Chips: 1-8mm, 15cc PCAN90 Preservon Cancellous Chips: 1-8mm, 90cc CAN30 Freeze-Dried Crushed Cancellous Chips: 1-8mm, 30cc CAN60 Freeze-Dried Crushed Cancellous Chips: 1-8mm, 60cc PCAN Preservon Cancellous Chips: 4-10mm, 15cc CAN90 Freeze-Dried Crushed Cancellous Chips: 1-8mm, 90cc PCAN Preservon Cancellous Chips: 4-10mm, 30cc PCAN Preservon Cancellous Chips: 4-10mm, 60cc PCAN Preservon Cancellous Chips: 4-10mm, 90cc PCAN20 14 Preservon Crushed Cancellous Chips: 1-4mm, 20cc Freeze-Dried Crushed Cancellous Chips: 4-10mm, 5cc PCAN40 14 Preservon Crushed Cancellous Chips: 1-4mm, 40cc CAN15 410BP Freeze-Dried Crushed Cancellous Chips: 4-10mm, 15cc PCAN80 14 Preservon Crushed Cancellous Chips: 1-4mm, 80cc CAN30 410BP Freeze-Dried Crushed Cancellous Chips: 4-10mm, 30cc PCAN1 Preservon Crushed Cancellous Chips: 1-8mm, 80cc CAN60 410BP Freeze-Dried Crushed Cancellous Chips: 4-10mm, 60cc PCAN10 Preservon Crushed Cancellous Chips: 1-8mm, 10cc CAN90 410BP Freeze-Dried Crushed Cancellous Chips: 4-10mm, 90cc PCAN Preservon Crushed Cancellous Chips: mm, 15cc Cancellous Chips 4-10mm PCAN Preservon Crushed Cancellous Chips: mm, 60cc PCAN Preservon Crushed Cancellous Chips: mm, 90cc PCAN30 36 Preservon Crushed Cancellous Chips: 3-6mm, 30cc 40 41

22 FCAN15 14 FCAN30 14 FCAN60 14 FCAN90 14 Frozen Crushed Cancellous Chips: 1-4mm, 15cc Frozen Crushed Cancellous Chips: 1-4mm, 30cc Frozen Crushed Cancellous Chips: 1-4mm, 60cc Frozen Crushed Cancellous Chips: 1-4mm, 90cc Corticocancellous Bone Chips Hospital Innovations corticocancellous bone chips provide an osteoconductive scaffold for bone ingrowth and allow remodelling with the patient s own bone. Our corticocancellous bone chips are fully sterilised to a SAL of 10-6 through the Allowash XG sterilisation process and are available freeze-dried or treated via LifeNet Health s patented Preservon technology; allowing corticocancellous chips to be stored fully hydrated at ambient temperature. FCAN FCAN FCAN FCAN * Other sizes available on request. Frozen Crushed Cancellous Chips: 4-10mm, 15cc Frozen Crushed Cancellous Chips: 4-10mm, 30cc Frozen Crushed Cancellous Chips: 4-10mm, 60cc Frozen Crushed Cancellous Chips: 4-10mm, 90cc Hospital Innovations is also pleased to offer a range of synthetic bone, available on request; including putty, chips and granules PCC5 12 PCC15 12 PCC30 12 PCC15 14 PCC30 14 PCC60 14 PCC90 14 PCC10 PCC15 PCC1/4 PCC30 PCC1/2 PCC60 PCC90 Preservon Corticocancellous Chips: 0.1-2mm, 5cc Preservon Corticocancellous Chips: 0.1-2mm, 15cc Preservon Corticocancellous Chips: 0.1-2mm, 30cc Preservon Corticocancellous Chips: 1-4mm, 15cc Preservon Corticocancellous Chips: 1-4mm, 30cc Preservon Corticocancellous Chips: 1-4mm, 60cc Preservon Corticocancellous Chips: 1-4mm, 90cc Preservon Corticocancellous Chips: 1-8mm, 10cc Preservon Corticocancellous Chips: 1-8mm, 15cc Preservon Corticocancellous Chips: 1-8mm, 20cc Preservon Corticocancellous Chips: 1-8mm, 30cc Preservon Corticocancellous Chips: 1-8mm, 40cc Preservon Corticocancellous Chips: 1-8mm, 60cc Preservon Corticocancellous Chips: 1-8mm, 90cc

23 CC90(S) CC10 CC1/4 CC30 CC1/2 Freeze-Dried Corticocancellous Chips: 1-4mm, 90cc Freeze-Dried Corticocancellous Chips: 1-8mm, 10cc Freeze-Dried Corticocancellous Chips: 1-8mm, 20cc Freeze-Dried Corticocancellous Chips: 1-8mm, 30cc Freeze-Dried Corticocancellous Chips: 1-8mm, 40cc Cancellous Cubes Hospital Innovations cancellous cubes provide an osteoconductive scaffold for bone ingrowth and allow remodelling with the patient s own bone. Our cancellous cubes are fully sterilised to a SAL of 10-6 through the Allowash XG sterilisation process and are available freeze-dried or treated via LifeNet Health s patented Preservon technology; allowing cancellous cubes to be stored fully hydrated at ambient temperature. CC60 CC90 Freeze-Dried Corticocancellous Chips: 1-8mm, 60cc Freeze-Dried Corticocancellous Chips: 1-8mm, 90cc CANCUBE05 S CANCUBE15 S Freeze-Dried Cancellous Cubes: 0.5cm x 0.5cm x 0.5cm, 5cc Freeze-Dried Cancellous Cubes: 0.5cm x 0.5cm x 0.5cm, 15cc CANCUBE1/4 Freeze-Dried Cancellous Cubes: 1cm x 1 cm x 1cm, 20cc, 8 Cubes CANCUBE30 Freeze-Dried Cancellous Cubes: 1cm x 1cm x 1cm, 30cc, 12 Cubes CANCUBE1/2 Freeze-Dried Cancellous Cubes: 1cm x 1cm x 1cm, 40cc, 16 Cubes CANCUBE05 SP Preservon Cancellous Cubes: 0.5cm x 0.5cm x 0.5cm, 5cc Corticocancellous Chips CANCUBE15 SP PCANCUBE1/4 Preservon Cancellous Cubes: 0.5cm x 0.5cm x 0.5cm, 15cc Preservon Cancellous Cubes: 1cm x 1 cm x 1cm, 20cc, 8 Cubes PCANCUBE30 Preservon Cancellous Cubes: 1cm x 1cm x 1cm, 30cc, 12 Cubes PCANCUBE1/2 Preservon Cancellous Cubes: 1cm x 1cm x 1cm, 40cc, 16 Cubes Cancellous Cubes

24 Struts Cortical Struts Hospital Innovations cortical struts provide an osteoconductive matrix for bone ingrowth whilst giving structural support in the treatment and management of fractures such as non-unions or periprosthetic fractures. Our struts are available freeze-dried and frozen; and come in a range of sizes to accommodate a variety of surgical applications. All cortical struts are provided sterile to a SAL of (Width x Length) FCS1.5 Frozen Cortical Strut: 15mm x 120mm FCS Frozen Cortical Strut: 20mm x 200mm Frozen Cortical Strut: Approx. 10cm Frozen Cortical Strut: Approx cm Frozen Cortical Strut: Over 25cm (Width x Length) Freeze-Dried Cortical Strut: Approx. 10cm Freeze-Dried Cortical Strut: Approx cm Freeze-Dried Cortical Strut: Over 25cm FTCS FCS1.0 FCSQ Frozen Tibial Cortical Strut: 20mm x 200mm (1 Per Pack) Frozen Femoral Cortical Strut: 10mm x 45mm (1 Per Pack) Frozen Femoral Cortical Strut Quarter: 210mm or Greater Cortical Strut CST Freeze-Dried Tibial Cortical Strut: 15mm x 100mm (2 Per Pack) CST1 Freeze-Dried Tibial Cortical Strut: 15mm x 100mm (1 Per Pack) CS Freeze-Dried Femoral Cortical Strut: 15mm x 100mm (2 Per Pack) CS1 Freeze-Dried Femoral Cortical Strut: 15mm x 100mm (1 Per Pack) CMS Freeze-Dried Femoral Cortical Match Sticks: 5mm x 100mm (6 Per Pack) Tibial Cortical Strut 46 47

25 Strips Ilium Tricortical Strips Hospital Innovations ilium tricortical strips are used in procedures that restore segmental bone loss in the extremities, pelvis and spine due to trauma, osteoporosis, removal of tumours, or to aid in the surgical correction of a deformity. Our ilium tricortical strips are fully sterilised either through the BioCleanse Tissue Sterilisation Process and terminally sterilised using validated gamma irradiation or via the Allowash XG Sterilisation Process; and are available frozen, freeze-dried or Preservon treated. (Length) Frozen Ilium Tricortical Strip: 28-45mm Frozen Ilium Tricortical Strip: 46-57mm Frozen Ilium Tricortical Strip: 57mm or Longer (Length) Freeze-Dried Ilium Tricortical Strip: 28-45mm Freeze-Dried Ilium Tricortical Strip: 46-57mm Freeze-Dried Ilium Tricortical Strip: 57mm or Longer Wedges HTO Wedge Allografts Hospital Innovations HTO wedge allografts are shaped for use in high tibial osteotomy procedures and are sterilised through the BioCleanse Tissue Sterilisation Process and terminally sterilised using a validated gamma irradiation dose, ensuring a SAL of This allograft solution provides a natural scaffold for bone ingrowth and may contribute to decreased post-operative pain and decreased rehabilitation time; and eliminates harvest site morbidity that may result from autograft removal. Our HTO wedge allografts are available freeze-dried and frozen; and come in a range of sizes and angles for enhanced patient fit Freeze-Dried HTO Wedge: 6, 7.5mm Freeze-Dried HTO Wedge: 8, 10mm Freeze-Dried HTO Wedge: 10, 12.5mm Freeze-Dried HTO Wedge: 12, 15mm Freeze-Dried HTO Wedge: 14, 17.5mm HTO Wedge Allograft Ilium Tricortical Strip (Height x Length) IC Preservon Ilium Tricortical Strip: 45mm x 22mm Frozen HTO Wedge: 6, 7.5mm IC Preservon Ilium Tricortical Strip: 50mm x 22mm Frozen HTO Wedge: 8, 10mm IC Preservon Ilium Tricortical Strip: 55mm x 22mm Frozen HTO Wedge: 10, 12.5mm IC Preservon Ilium Tricortical Strip: 60mm x 22mm Frozen HTO Wedge: 12, 15mm IC Preservon Ilium Tricortical Strip: 60mm x 35mm Frozen HTO Wedge: 14, 17.5mm 48 49

26 Iliac Crest Wedges Hospital Innovations iliac crest wedges are pre-sized for convenience in procedures such as spinal fusions. Our iliac crest wedges are sterilised via the Allowash XG sterilisation process to achieve a SAL of 10-6 and are available both freeze-dried and processed via Preservon. ICW0.6 ICW0.7 ICW0.8 ICW0.9 ICW1 ICW2 ICW5 ICW8 ICWS ICW2.5 (Height) Freeze-Dried Iliac Crest Wedge: 6mm Freeze-Dried Iliac Crest Wedge: 7mm Freeze-Dried Iliac Crest Wedge: 8mm Freeze-Dried Iliac Crest Wedge: 9mm Freeze-Dried Iliac Crest Wedge: 10mm Freeze-Dried Iliac Crest Wedge: 12mm Freeze-Dried Iliac Crest Wedge: 15mm Freeze-Dried Iliac Crest Wedge: 18mm Freeze-Dried Iliac Crest Wedge: 20mm Freeze-Dried Iliac Crest Wedge: 25mm PICW0.6 PICW0.7 PICW0.8 PICW0.9 PICW1 PICW2 PICW5 PICW8 PICWS PICW2.5 Iliac Crest Wedge (Height) Preservon Iliac Crest Wedge: 6mm Preservon Iliac Crest Wedge: 7mm Preservon Iliac Crest Wedge: 8mm Preservon Iliac Crest Wedge: 9mm Preservon Iliac Crest Wedge: 10mm Preservon Iliac Crest Wedge: 12mm Preservon Iliac Crest Wedge: 15mm Preservon Iliac Crest Wedge: 18mm Preservon Iliac Crest Wedge: 20mm Preservon Iliac Crest Wedge: 25mm Patellar Wedges Hospital Innovations patellar wedges are pre-sized for convenience in procedures such as high tibial osteotomies and spinal fusions. Our patella wedges are sterilised via the Allowash XG sterilisation process to achieve a SAL of 10-6 and are available freeze-dried. PAT.WEDGE PAT.WEDGE5 PAT.WEDGE8 (Height) Freeze-Dried Tricortical Patellar Wedge: 12mm Freeze-Dried Tricortical Patellar Wedge: 15mm Freeze-Dried Tricortical Patellar Wedge: 18mm Calcaneus Wedges Hospital Innovations calcaneus wedges are pre-sized for convenience in procedures such as ankle and spinal fusions. Our calcaneus wedges are sterilised via the Allowash XG sterilisation process to achieve a SAL of 10-6 and are available freeze-dried. Calcaneus Wedge POD.WEDGE POD.WEDGE8 (Height) Freeze-Dried Calcaneus Wedge: 15mm Freeze-Dried Calcaneus Wedge: 18mm Patellar Wedge

27 Fibular Wedges Hospital Innovations fibular wedges are pre-sized for convenience in trauma and spinal fusion procedures. Our fibular wedges are sterilised via the Allowash XG sterilisation process to achieve a SAL of 10-6 and are available freeze-dried and frozen. Whole & Hemi Shafts Hospital Innovations whole and hemi allograft bone shafts are used in procedures that restore segmental bone loss in the extremities, pelvis and spine due to trauma, osteoporosis, removal of tumours or to aid in the surgical correction of a deformity. Our whole and hemi allograft bone shafts are available in select, pre-cut lengths to reduce preparation time; and are available freeze-dried and frozen. Hospital Innovations bone shafts are sterilised via the BioCleanse Tissue Process followed by terminal sterilisation using validated gamma irradiation to a SAL of 10-6 ; ensuring patient safety. FIBW0.6 FIBW0.8 FIBW1 FIBW2 FIBW4 FIBW6 FIBW8 (Height) Freeze-Dried Fibular Wedge: 6mm Freeze-Dried Fibular Wedge: 8mm Freeze-Dried Fibular Wedge: 10mm Freeze-Dried Fibular Wedge: 12mm Freeze-Dried Fibular Wedge: 14mm Freeze-Dried Fibular Wedge: 16mm Freeze-Dried Fibular Wedge: 18mm Fibular Wedge (Length) Freeze-Dried Femoral Shaft: mm Freeze-Dried Femoral Shaft: mm Freeze-Dried Femoral Shaft: mm Frozen Femoral Shaft: mm Frozen Femoral Shaft: mm Frozen Femoral Shaft: mm Femoral Shaft (Height) FFIBW8 Frozen Fibular Wedge: 18mm Hemi Femoral Shaft (Length) Freeze-Dried Hemi Femoral Shaft: mm Freeze-Dried Hemi Femoral Shaft: mm Freeze-Dried Hemi Femoral Shaft: mm Frozen Hemi Femoral Shaft: mm Frozen Hemi Femoral Shaft: mm Frozen Hemi Femoral Shaft: mm

28 (Length) Freeze-Dried Humeral Shaft: mm Freeze-Dried Humeral Shaft: mm Frozen Humeral Shaft: mm Humeral Shaft (Length) Freeze-Dried Fibula Shaft: 50-75mm Freeze-Dried Fibula Shaft: 76-98mm Freeze-Dried Fibula Shaft: mm Fibula Shaft Frozen Humeral Shaft: mm Frozen Fibula Shaft: 50-75mm Frozen Fibula Shaft: 76-98mm Frozen Fibula Shaft: mm (Length) Freeze-Dried Tibial Shaft: 50-75mm Freeze-Dried Tibial Shaft: mm Freeze-Dried Tibial Shaft: mm Tibial Shaft Frozen Tibial Shaft: 50-75mm Frozen Tibial Shaft: mm Frozen Tibial Shaft: mm 54 55

29 Proximal & Distal Bone Allografts (Length) Hospital Innovations proximal and distal bone allograft solutions are used as a sterile source of cortical and cancellous bone, as well as in procedures that restore segmental and critical bone loss in the extremities, pelvis and spine due to trauma, bone disease, or from the removal of tumours. Our proximal and distal bone allografts are provided with the existing cartilage still intact, in short and long pre-cut lengths; and are sterile to a SAL of Proximal Humerus: Left, mm Proximal Humerus: Right, mm Proximal Humerus: Left, mm Proximal Humerus: Right, mm Distal Humerus: Left, mm Proximal Humerus (Length) Proximal Femur: Left, mm Proximal Femur: Right, mm Proximal Femur Distal Humerus: Right, mm Distal Humerus: Left, mm Distal Humerus: Right, mm Distal Humerus Distal Femur: Left, mm Distal Femur: Right, mm Distal Femur: Left, mm Distal Femur: Right, mm Distal Femur Proximal Tibia Distal Tibia (Length) Proximal Tibia: Left, mm Proximal Tibia: Right, mm Proximal Tibia: Left, mm Proximal Tibia: Right, mm Distal Tibia: Left, mm Distal Tibia: Right, mm Distal Tibia: Left, mm Distal Tibia: Right, mm 56 57

30 Heads Femoral & Humeral Heads Hospital Innovations femoral and humeral heads are used as a sterile source of cortical and cancellous bone; as well as in procedures that restore segmental and critical bone loss in the extremities, pelvis and spine due to trauma, bone disease or from the removal of tumours. Our femoral heads are provided stripped of cartilage and free from blood and lipids; reducing theatre preparation time. All femoral heads are guaranteed to have a head diameter >46mm. Our humeral heads can be provided with existing cartilage if required and have a minimum head diameter of >43mm. Both femoral and humeral heads are sterilised to a SAL of 10-6 ; our femoral heads are sterilised via the Allowash XG sterilisation process, whilst our humeral heads are sterilised via either the BioCleanse Tissue Process or the Allowash XG sterilisation process (code dependent). Humeral Head FFH FFHN Femoral Head Femoral Head: 43mm or Greater with Neck Humeral Head: Left Humeral Head: Right FHH Humeral Head: 43mm or Greater Femoral Head 58 59

31 Whole Bones Whole Femur Whole Tibia Hospital Innovations whole bones are used as a sterile source of cortical and cancellous bone in procedures that require the restoration of segmental and critical bone loss due to trauma, bone disease, or from the removal of tumours. Our whole bone allografts are available as left or right grafts, are pre-cut to selected lengths and are fully sterilised to a SAL of Whole Femur: Left Whole Femur: Right Whole Radius Whole Ulna Whole Tibia: Left Whole Tibia: Right Whole Radius: Left Whole Radius: Right Whole Ulna: Left Whole Fibula: Left Whole Fibula: Right Whole Ulna: Right Whole Fibula Whole Humerus Whole Humerus: Left 60 61

32 Avance Nerve Graft Hospital Innovations Avance Nerve Graft is a peripheral nerve allograft for the reconstruction of peripheral nerve discontinuities. The graft guides and structurally supports axonal regeneration across a nerve gap. Avance Nerve Graft is decellularised and sterilised via the Avance process, providing an extracellular matrix processed from human peripheral nerve tissue. The Avance Nerve Graft gives the natural nerve structure of an autograft, as well as the ease and availability of off-the-shelf products. Hospital Innovations Avance Nerve Graft is available in a range of lengths and diameters and comes frozen, requiring thawing prior to implantation Avance Nerve Graft: 70mm x Ø1-2mm Avance Nerve Graft: 70mm x Ø2-3mm Avance Nerve Graft: 70mm x Ø3-4mm Avance Nerve Graft: 70mm x Ø4-5mm Avance Nerve Graft: 15mm x Ø1-2mm Avance Nerve Graft: 15mm x Ø2-3mm Avance Nerve Graft: 15mm x Ø3-4mm Avance Nerve Graft: 15mm x Ø4-5mm Avance Nerve Graft: 30mm x Ø1-2mm Avance Nerve Graft: 30mm x Ø2-3mm Avance Nerve Graft: 30mm x Ø3-4mm Avance Nerve Graft: 30mm x Ø4-5mm Avance Nerve Graft: 50mm x Ø1-2mm Avance Nerve Graft: 50mm x Ø2-3mm Avance Nerve Graft: 50mm x Ø3-4mm Avance Nerve Graft: 50mm x Ø4-5mm Avance Nerve Allograft

33 AxoGuard Nerve Protector Hospital Innovations AxoGuard Nerve Protector is designed to protect and isolate the peripheral nerve during the healing process after surgery. AxoGuard is a multi-laminar extracellular matrix that separates and protects the nerve from the surrounding tissues during the healing process. The patient s own cells incorporate into the extracellular matrix to remodel and form a tissue similar to the nerve epineurium. Our AxoGuard Nerve Protector is manufactured from porcine extracellular matrix, provided sterile, freeze-dried, is for single use only and comes in a range of sizes. AG0220 AG0320 AG0520 AG0720 AG1020 AG0340 AG0540 AG0740 AG1040 (Diameter x Length) AxoGuard Nerve Protector: 2mm x 20mm AxoGuard Nerve Protector: 3.5mm x 20mm AxoGuard Nerve Protector: 5mm x 20mm AxoGuard Nerve Protector: 7mm x 20mm AxoGuard Nerve Protector: 10mm x 20mm AxoGuard Nerve Protector: 3.5mm x 40mm AxoGuard Nerve Protector: 5mm x 40mm AxoGuard Nerve Protector: 7mm x 40mm AxoGuard Nerve Protector: 10mm x 40mm AxoGuard Nerve Protector AxoGuard Nerve Connector Hospital Innovations AxoGuard Nerve Connector is a coaptation aid that allows for the close approximation of severed nerves. AxoGuard Nerve Connector is a tubular, multi-laminar extracellular matrix with an open lumen where the severed nerve ends are placed. Typically, the AxoGuard Nerve Connector is used to align and connect nerves with less than a 5mm gap between the severed nerve ends. The AxoGuard Nerve Connector material allows the body s natural healing process to repair the nerve by isolating and protecting it during the healing process. The patient s own cells incorporate into the extracellular matrix to remodel and form a tissue similar to the nerve epineurium. Our AxoGuard Nerve Connector is manufactured from porcine extracellular matrix, provided sterile, freeze-dried, is for single use only and comes in a range of sizes. AGX110 AGX210 AGX310 AGX410 AGX510 AGX610 AGX710 (Diameter) AxoGuard Nerve Connector: 1.5mm AxoGuard Nerve Connector: 2mm AxoGuard Nerve Connector: 3mm AxoGuard Nerve Connector: 4mm AxoGuard Nerve Connector: 5mm AxoGuard Nerve Connector: 6mm AxoGuard Nerve Connector: 7mm AxoGuard Nerve Connector 64 65

34 Through our valued partners Innomed, Inc. and Symmetry Surgical, Hospital Innovations offer an expansive portfolio of orthopaedic and arthroscopic instruments, including: Forceps Gouges Graspers Rasps Probes Punches Retractors Spreaders Curettes Osteotomes Patient Positioners Hospital Innovations full range of instrumentation covers hip, knee, spine, small bone and trauma procedures and full catalogues can be provided upon request. Tibial Component Extractor Femoral Component Extractor Cup X Acetabular Cup Extraction System Symmetry Arthroscopic Handheld Stulberg Hip Positioner

35 Hospital Innovations Limited Concept House Talbot Green Business Park Pontyclun CF72 9FG T: E: