Corynebacterium striatum
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1 小児感染免疫 Vol. 26 No Corynebacterium striatum 1 Corynebacterium striatum 1 0 C. striatum 1 Stage Corynebacterium striatum 1 Corynebacterium C. striatum Cefotiam hexetil cefditoren pivoxil 300 mgday ,258 g Apgar NICU 49 cm 3,258 g WBC CRP 2.8 mgdl IgM 14 mgdlapr ph 7.174pCO Key wordscorynebacterium striatum
2 360 WBC 23,100l Myelo 1 Metamyelo 6 Stab 14 Segment 32 RBC l Hb 18.7 gdl Plt l ph pco 2 50 mmhg HCO meql BE 6.1 meql Lactic acid 32.4 mgdl 1 TP 6.1 gdl Alb 3.9 gdl AST 56 IUl HP ALT 14 IUl CRP LDH 524 IUl IgM CPK 125 IUl IgG T. Bil 2.7 mgdl BUN 10 mgdl Cr 0.64 mgdl Na 137 meql K 5.4 meql Ca 10.2 mgdl CRP 2.8 mgdl Glucose 59 mgdl APR score Alpha1AG 14 mgdl 1,049 mgdl ph pco mmhg HCO meql BE 8.6 meql Lactic acid 48.7 mgdl T. Biltotal bilirubinapracute phase reactantshphaptoglobin l l l 1 ABPCSBTampicillinsulbactam l mmhgbe 8.6 meql ph 7.252pCO 2 50 mmhgbe 6.1 meql X 1 30 ampicillinabpc sulbactamsbt150 mgkgday 2 2 Corynebacterium Corynebacterium API coryne C. striatum C. striatum C. striatum Staphylococcus C. striatum 1 2 WBC 25,900l 84 4 CRP 7 ABPCSBT ABPC MICmin-imum inhibitory concentration 2 gml resistance ABPCSBT MIC 8 gdl susceptible 2 MRI 13 Stage 2 Wharton s jelly Stage 3
3 小児感染免疫 Vol. 26 No MICgml Antibiotics MICgml PCG 2 ABPC 2 CEZ 8 CTM 8 FMOX 4 IPMCS 1 GM 1 EM 0.5 CLDM 0.5 MINO 2 VCM 0.5 FOM 32 LVFX 0.5 ABPCSBT 8 PCGbenzylpenicillin ABPCampicillin CEZcefazolin CTMcefotiam FMOXflomoxef IPMCSimipenemcilastin GMgentamicin EMerythromicin CLDMclindamycin MINOminocyclin VCMvancomycin FOMfosfomycin LVFXlevofloxacin ABPCSBTampicillinsulbactam MICminimum inhibitory concentration Corynebacterium 1 C. striatum 1918 Eberson 2 AIDS C. striatum 2 C. striatum Stage 3 Whartons jelly Stage C. striatum 14 C. striatum PubMed C. striatum C. striatum vancomycin gentamicin
4 362 6 C. striatum 7 C. striatum Corynebacterium Stage C. striatum C. striatum 1 C. striatum 8 C. striatum C. striatum 1 NICU Gram positive rods Corynebacterium 1 1 Corynebacterium Adderson EE, et alinfections caused by coryneform bacteria in pediatric oncology patients. Pediatr Infect Dis J , VP Corynebacterium striatum Babay HA, et alisolation of coryneform bacteria from blood cultures of patients at a University Hospital in Saudi Arabia. Saudi Med J , Feliu R, et alnosocomial outbreak of Corynebacterium striatum infection in patients with chronic obstructive pulmonary disease. J Clin Microbiol , Verroken A, et alepidemiological investigation of a nosocomial outbreak of multidrugresistant Corynebacterium striatum at one Belgian university hospital. Clin Microbiol Infect , 7Lee PP, et alcorynebacterium striatuman underappreciated community and nosocomial pathogen. J Infect , Otsuka Y, et alemergence of multidrugresistant Corynebacterium striatum as a nosocomial pathogen in longterm hospitalized patients with underlying diseases. Diagn Microbio Infect Dis , 2006 C. striatum
5 小児感染免疫 Vol. 26 No A case of term neonate developed early sepsis caused by Corynebacterium striatum Toru WATANABE Department of Pediatrics, Iwata City Hospital This study reports the first case of neonatal sepsis caused by Corynebacterium striatum in neonates. The weight of the male patient at birth was at 3,258 g after 38 weeks and 5 days gestation. He had neonatal asphyxia, and ampicillinsulbactam was administered for 7 days due to elevated CRP. On day 2, C. striatum was detected in his blood, and on his skin and pharynx, as well as vaginal cultures from his mother. Clinical improvement was achieved after intravenous antibiotics. The patient was discharged on day 13 without clinical sequelae on MRI investigation. Histhopathology of the placenta and cord showed chorioamnionitis and funisitisstage. Nondiphtheria Corynebacterium species were regarded as having little pathogenicity until recent reports indicated that this group of organisms may be an important cause of nosocomial infections, such as pneumonia and catheter related infections. This report highlights the growing need to consider the possibility of Corynebacterium species as a causative organism for neonates
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