Endovascular Therapy for Acute Ischaemic Stroke in Northern Ireland. Ian Rennie Interventional Neurologist On behalf of the Belfast trust stroke team
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1 Endovascular Therapy for Acute Ischaemic Stroke in Northern Ireland Ian Rennie Interventional Neurologist On behalf of the Belfast trust stroke team
2 Belfast Team
3 Evidence base we rely on ESCAPE trial Acute Ischemic Stroke (NIHSS>5) 12 Hour window No upper age limit Good functional status CT head: ASPECTS >5 (exclude large core) CTA: ICA+M1 or M1 or functional M1 (all M2s) CTA moderate to good collaterals
4 Result summary MRS 0-2 at 90 days 53.0% in the treatment arm 29.3% in the control arm NNT= 4 for independence We still stick fairly closely to the ESCAPE trail selection criteria
5 Demographics and Geography
6
7 Belfast City pop. = Belfast Metropolitan Area pop = (>33% of NI total) >1.2 million pop. within 30 miles of Belfast (>66% of NI total)
8 Famous for healthy Lifestyle
9 IV Thrombolysis rates
10 Extrapolation of numbers How ma ny i n real l ife? St Georges i n London offering s ervice to SW London and Surrey treat on a verage 2/month Just because somewhere else has little interest in stroke doesn t imply lack of need.?? how many treated in Calgary for similar population. I know Bern in Switzerland with a bout 1.8m population treat 2 per week If try to calculate those that might benefit Guess is better word than calculate Suitable for IV thrombolysis 12.6% according to RCP criteria We can treat patients not suitable for lysis. Prior Rankin 2 or less 81% Fa i r enough Arrive within 0-3 hours of onset symptoms 80% of thrombolysed Time is not relevant as ESCAPE was up to 12 hrs. As long as ASPECTS good. Don t respond to IV thrombolysis - 86% We don t wait to see if response Have proximal vessel occlusion a pprox. 25% unresponsive to IV tpa Most large vessel occlusions don t respond Reduces the percentage of potentially eligible to about 2% if the total. i.e. about 50/year for Northern Ireland. At best level of NNT that would be 12/yr who avoid disability We have treated about 50 patients in 1 st 4 months 2015 on 5/7 day basis. Simple maths on this would estimate about 210 patients per yr giving 50 who avoid disability. This fits with other other work presented here ESCAPE showed 50% mortality reduction by the way. Early IV trials were negative Recent presentation in Northern Ireland Took numbers from another hospital Guessed population catchments and did come maths Suggested the max need in Northern Ireland 12/yr
11 homework corrected Interventional cases to date is 38 Don t rely on guess work for estimates of numbers Try some local research that can be extrapolated
12 Method/ Premise IAT is likely to be beneficial for those with significant stroke secondary to proximal vessel occlusion and minimal early ischaemic change on CT. A list of all patients who received IV-tPA alone for acute ischaemic stroke in NI in 2012 and their initial National Institute of Health Stroke Scale (NIHSS) was obtained from the stroke service
13 Methods Three PACS systems covering all Northern Ireland hospitals were used to view the CT brain studies and calculate the Alberta Stroke Program Early CT score (ASPECTS) All patients who received IV-tPA alone for acute ischaemic stroke in NI in 2012 were assessed
14 Methods Ordinarily CT angiography is required to assess for proximal vessel occlusion CT angiography is not routinely performed outside the tertiary neuroradiology centre The presence of a significant proximal vessel occlusion was estimated using a combination of a hyperdense vessel (HDV) and NIHSS Patients with low ASPECT score excluded
15 Conclusion (2012 figures) Estimate referrals for IAT for acute ischaemic stroke per year in NI Approximately referrals per million population per year Our figures correlates with published estimates Cloft et al estimated likely be no more than 20,000 cases per year in the United States 1 (63 per million population per year) 1 Cloft HJ, Rabinstein A, Lanzino G, Kallmes DF. Intra-Arterial Stroke Therapy: An Assessment of Demand and Available Work Force. AJNR. 2009; 30:453-58
16 Assessment of the Potential Unmet Need For Intra-arterial Stroke Therapy Presented to BSNR in 2014 We now think the estimate is slightly conservative (longer time windows /posterior circulation stroke / fluctuating NIHSS etc) in Northern Ireland 36 patients in 7 months on a 5 day service would equate to 86 patients per year with just an increase to working day time Saturday and Sunday 100 patients for IA therapy per 1 million population is pretty close
17 Scotland Population 5.2 million Estimates of 500+ IA stroke treatments per year Similar issues to N I concerning patient access
18 Hub and Spoke Model Currently the most common business model Probably started by airlines Our current evolving model
19 Distance: 70 miles Journey Time: 1 hour, 27 minutes Total number of thrombolysed strokes = 22 Number meeting eligibility criteria for thrombectomy = 13 (59.1%) Out of office hours = 9/13
20 Distance: 84 miles Journey Time: 1 hour 37 minutes Total number of thrombolysed strokes = 18 Number meeting eligibility criteria for thrombectomy = 7 (38.9%) Out of office hours = 3/7
21
22 How to make this work 3 hospitals have regular visiting neuroradiology sessions (1 further hospital has a trained diagnostic Nrad ) Regular stroke network meetings CTA for all eligible stroke with initial CT Calls all directed by stroke physicians Transfer patients met in CT by stroke team Repeat imaging carried out in RVH Rapid transfer to angio room
23 Team getting faster 2014 CTA to groin was a mean of 26.2 minutes Groin to Recan was a mean of 48.6 minutes 2015 CTA to groin was a mean of minutes Groin to Recan was a mean of 38.1 minutes
24 How to get faster Avoid anaesthesia (always contacted ) No gown etc for patient All members of team know their role Neuroradiologist doesn t leave patient and will push from CT Stroke consultant talks to family
25 Case examples Cases selected to show our learning points Learn from where we did it well Where we got lucky Where we got it wrong
26 Case 1 Good 74 yr old high NIHSS CT at 15:54 CTA at 16:01 Repeat after transfer at 17:20 CTA at 17:27 TICA 2a only but NIHSS drop to 4 next day
27 Initial Imaging
28 Repeat in RVH
29 Angio
30 Lessons Get diagnosis of occlusive clot at base hospital Repeat imaging always Quick assessment and transfer to angiosuite This case worked well as list in peripheral hospital was covered by a new consultant who was our trainee the previous week!
31 Lucky 44 yr old female High NIHSS Wake up presentation ( last well within 12 hrs) Wednesday morning CT at 09:17 CTA at 09:30 Decided to leave alone as a wake up stroke
32 Neuroradiology meeting in DGH 10 am Neuroradiologist arrives a bit early Imaging reviewed Discucssed with RVH team Transfer ASAP CT repeat in RVH 11:35 at our 12hr from well cut off
33 ASPECTS 8 on transfer
34 Perfusion still good
35 Complete occlusion at origin of carotid and multiple Intracranial M1,A1,P2 occlusions
36
37
38 NHISS from 20+ to 1 next day Final Diagnosis of Takayasu arteritis Home on dual antiplatlets for stent and immunosupression for underlying disease
39 Lessons Don t hope for luck Educate DGH stroke teams and radiologists
40 Bad 52 yr old male High NIHSS CT at 14:32 Repeat CT, CTA, CTP at 16:44 No procedure performed
41 ASPECTS good at base hospital
42
43 Lessons Patients are transferred for assessment but not always treatment Avoid treating patients who are no longer in a position to benefit
44 Summary Get good reliable data to estimate numbers Very rigid patient selection based on imaging Work as a team All members should be willing to meet patient at hospital door Occasional cases are easy but some are the most challenging in neuroradiology especially given time pressure
45 Summary The evidence relates to high volume Neuroradiology centers with well established pathways and experienced operators We cannot afford a learning curve or the treatment will be discredited Don t reinvent the wheel copy best practice
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