Curriculum Vitae of Prof. Dr. Melanie Wilke

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1 Curriculum Vitae of Prof. Dr. Melanie Wilke Prof. Dr. Melanie Wilke studied from at the Ludwig Maximilian University (LMU) Psycholinguistics, Neuropsychology and Neurobiology. She graduated from the Max Planck Institute for Biological Cybernetics (Tübingen). From she worked as a postdoctoral fellow at the National Institutes of Mental Health (Bethesda, MD, USA) and at the California Institute of Technology (Pasadena, CA, USA). Since 4/2011 she is the head of the Department of Cognitive Neurology, established by the Schilling Foundation, at the University Medical Center Göttingen (UMG), and has been appointed a full professor there. She is also a co-investigator at the German Primate Center (DPZ, Göttingen), where she established the 'Decision and Awareness' research group. The focus of her research program is to understand the neural mechanisms underlying normal and impaired spatial awareness and decision making and to bridge the gap between basic and clinical research. She studies the influence of brain lesions in non-human primates and humans by means of brain inactivation and stimulation methods in combination with single cell physiology and functional imaging. Personal: Contact Department of Cognitive Neurology Medical School, Georg August University Göttingen Robert-Koch-Straße 40, Göttingen Phone: +49 (0) Fax: +49 (0) melanie.wilke@med.uni-goettingen.de Birth 1976 Education: PhD (Dr. rer. nat.) in Neural and Behavioral Sciences ('summa cum laude'), Max Planck Institute for Biological Cybernetics (Dept. Cognitive

2 Neurophysiology), Tübingen; Advisors: Prof. Dr. N.K. Logothetis and Dr. D.A. Leopold Topic: Neuronal underpinnings of perceptual suppression M.A. in Psycholinguistics, Neuropsychology and Neurobiology ( very good ), Ludwig-Maximilians-University, Munich Master Thesis at Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig; Advisor: Dr. E. Ferstl Topic: Effects of encoding perspective on recognition of textual information following damage of the frontal lobe Study of Political Sciences and Literature at the University of Leipzig and at the Ludwig-Maximilians-University, Munich Working experience: Since 04/2011. Schilling Foundation Professor (W3), Director of the Department of Cognitive Neurology, University Medical Center Göttingen (UMG), Georg August University, Göttingen Since 04/2011. Co-Investigator of the 'Decision and Awareness Group' (DAG) at the German Primate Center (DPZ), Göttingen Visiting Associate Faculty at the California Institute of Technology (Caltech), Pasadena Postdoctoral Fellow in the Division of Biology, California Institute of Technology (Caltech), Pasadena Advisor: Prof. R.A. Andersen Postdoctoral Fellow in the Laboratory of Neuropsychology, NIMH, Bethesda Advisor: Dr. D.A. Leopold

3 PhD student at the Max Planck Institute for Biological Cybernetics, Tübingen Scientific award: Fellows Award for Excellence in Biomedical Research, National Institutes of Health, 2008 Patent 09/2014. Wilke, M., Kagan, I., Andersen, R.A. Brain repair using electrical microstimulation of healthy nodes. DKT No US00/CIT-6260 (filed 07/2013) (granted 09/2014) Invited lectures/talks: Adrian Seminars in Neuroscience. University of Cambridge, Great Britain Symposium at the Meeting of the Association for the Scientific Study of Consciousness (ASSC), Paris, France Neuroscientific Seminar of the University Clinic RWTH, Aachen, Germany Keynote lecture at the 16 th Meeting of the Association for the Scientific Study of Consciousness (ASSC), Brisbane, Australia Computation Cognition Alliance Meeting, Osnarbrück, Germany Young Presidents Organization Meeting (YPO), Hannover, Germany Gordon Research Conference on Eye Movements, Easton, USA David Bodian Seminar in Neuroscience, John Hopkins University, USA University of Amsterdam, Netherlands Primate Neurobiology Meeting, Tübingen, Germany Attention Workshop, Tübingen, Germany BENEFRI Neuroscience Workshop, Fribourg, Switzerland Symposium at the International Winter Conference in Sölden, Austria Symposium from the Mind Science Foundation, Samoset, USA Minisymposium at the Society for Neuroscience Meeting, Washington, D.C., USA

4 2011. Satellite Meeting at the 15 th Meeting of the Association for the Scientific Study of Consciousness, Kyoto, Japan Symposium at the 14 th Meeting of the Association for the Scientific Study of Consciousness, Toronto, Canada Brain & Spine Institute (ICM)/ Hôpital Pitié-Salpêtrière, Paris, France Symposium at the workshop for "Scientific Studies of Consciousness" organized by National Institute for Physiological Sciences, Okazaki, Japan University of Southern California, Los Angeles, USA Okinawa Institute of Science and Technology (OIST), Okinawa, Japan Symposium at the 32 th Meeting of the Japanese Neuroscience Society, Nagoya, Japan California Institute of Technology, Pasadena, USA Salk Institute, La Jolla, USA Harvard Medical School, Boston, USA Vanderbilt University, Nashville, USA Tutorial at the 9 th Meeting of the Association for the Scientific Study of Consciousness, Pasadena, USA Professional services Head of the Primate Platform of the Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) at the German Primate Center (DPZ) Associate Editor: Neuroscience of Consciousness; Review editor for "Frontiers in Consciousness Research" Ad-hoc reviewer: Journal of Neuroscience, Journal of Vision, Vision Research, Nature Neuroscience, Neuron, Proceedings of the Royal Society (London), Journal of Cognitive Neuroscience, Cerebral Cortex Ad-hoc reviewer for funding sources: Geman Research Foundation, Hertie-Foundation, Mind Science Foundation (USA) Member of diverse UMG committees (Personalkommission, Habilitationskommission etc.)

5 Teaching and Supervision Lectures Medical School Göttingen M5.1 Module at the Medical School, "Higher Cognitive Functions" (1h/year) Summer School Neurology, (4h/year) Curriculum of the MSc/PhD Neuroscience Program of the International Max Planck Research School "Reward and Decision Making/Consciousness" (4x4h/year) Supervision (as main supervisor): Diploma and MSc Students (each supervised for 6-9 months) Kirsten Emmert (2012) (completed) Influence of body posture on spatial cognition Laura Geurts (2014) (completed) The role of the superior temporal gyrus and the intraparietal sulcus in auditory figure-ground segregation Kristina Miloserdov (2014) (completed) TACS modulation of fmri BOLD activity during resting state and visual contrast perception Eva Poland (2014) (completed) Effects of tacs on the perception of time Albert Lehr ( ongoing) No-report paradigm for visual suppression Yian Liao ( ongoing) Confidence in visual and auditory decision making Doctorate (PhD) Students (* co-supervised with Dr. Igor Kagan at DAG group/dpz) Yuranny Cabral-Calderin (2011-) Role of brain oscillations in bistable visual perception Danial Arabali* (2012-) Bilateral decision networks for eye and arm movements Adan-Ulises Dominguez-Vargas* (2012-) The role of thalamic pulvinar in eye-hand coordination for goal-directed actions Lukas Schneider* (2013-) The role of dorsal superior temporal areas in visuomotor decision making

6 Lydia Gibson* (2013-) Pulvinar-cortical interactions for spatial perception and goal-directed actions in non-human primates Ahmad Nazzal (2013-) Dissociating spatial decision and awareness components in patients with spatial neglect Kathleen Williams (2014-) Towards a non-invasive approach to evaluate abnormal network oscillations in Parkinson's Disease: combined tacs and fmri studies Kristina Miloserdov (2014-) Visual perception in hallucinating and non-hallucinating Parkinson-Patients Eva Poland (2015-) Neural variability in electrical field potentials and BOLD signals underlying conscious perception. Apart from the students working in our department, I am currently member of 9 PhD Advisory Boards of the GAUSS Programs in Göttingen Publications: Journal Articles: Cabral-Calderin, Y*., Weinrich, C.*, Schmidt-Samoa, C., Poland, E., Dechent, P., Bähr, M., Wilke, M. Transcranial alternating current stimulation affects the BOLD signal in a frequency and task-dependent manner Human Brain Mapping Oct 27. Tsuchiya, N., Wilke, M., Frässle, S., Lamme, V. No-report paradigms: Towards the true neural correlates of consciousness (Trends in Cognitive Sciences, in press). Paschke, K., Kagan, I., Wüstenberg, T., Bähr, M., Wilke, M. Trunk rotation affects temporal order judgments with direct saccades: influence of handedness Neuropsychologia Oct 27. pii: S (15) Cabral-Calderin, Y., Schmidt-Samoa, C., Wilke, M. Rhythmic gamma stimulation affects bistable perception. Journal of Cognitive Neuroscience :1-10. Hwang, E., Hauschild, M., Wilke, M., Andersen, R.A. Spatial and Temporal Eye-Hand Coordination Relies on the Parietal Reach Region. Journal of Neuroscience :

7 Wilke, M., Kagan, I., Andersen, R.A. Effects of pulvinar inactivation on spatial decision making between equal and asymmetric reward options. Journal of Cognitive Neuroscience (8), Helms, G., Garea-Rodriguez, E., Schlumbohm, C., König, J., Dechent, P., Fuchs, E., Wilke, M. Structural and quantitative neuroimaging of the common marmoset monkey using a clinical MRI system. Journal of Neuroscience Methods (1): Hwang, E.J., Hauschild, M., Wilke, M., Andersen, R.A. Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades. Neuron (5): Wilke, M.*, Kagan, I.*, Andersen R.A. Functional Imaging Reveals Rapid Reorganization of Cortical Activity after Parietal Inactivation in Monkeys. PNAS : Schmid, M.C., Mrowka, S., Turchi, J., Saunders, R., Wilke, M., Ye, F., Leopold, D.A. Blindsight functions depend on the lateral geniculate nucleus. Nature (7304): Wilke, M., Turchi, J., Smith, K., Mishkin, M., Leopold, D.A. Pulvinar inactivation disrupts selection of movement plans. Journal of Neuroscience : Wilke, M, Mueller, K.M., Leopold, D.A. Visibility related modulation of neural responses in visual thalamic nuclei. PNAS (23): Mueller, K.M., Wilke, M., Leopold, D.A. Neural responses in monkey area V4 following visual shape adaptation. Neuroscience (2): Cui, J., Wilke, M., Logothetis, N.K., Leopold, D.A, Liang, H. Visibility states modulate microsaccade rate and direction. Vision Research (2): Maier, A., Wilke, M., Aura, C., Zhu, C., Ye, F.Q., Leopold, D.A. Divergence of electrical and fmri signals in primary visual cortex during perceptual suppression. Nature Neuroscience (10): Wilke, M., Logothetis, N.K., Leopold, D.A. Local field potentials reflect perceptual suppression in monkey visual cortex. PNAS (46): Wilke, M., Logothetis, N.K., Leopold, D.A. Generalized flash suppression of salient visual targets. Neuron (6): Maier, A., Wilke, M., Logothetis, N.K., Leopold, D.A. Perception of temporally interleaved ambiguous patterns. Current Biology (13):

8 Leopold, D.A., Wilke, M., Maier, A., Logothetis, N.K. Stable perception of visually ambiguous patterns. Nature Neuroscience (6): Reviews/Book chapter: Boly, M., Seth, A., Wilke, M., Igmundson, P., Baars, D., Laureys, S., Edelman, D., Tsuchiya, N. Consciousness in humans and non-human animals: recent outstanding advances, and possible future directions. Frontiers in Consciousness Research Wilke, M., Dechent, P., Schmidt-Samoa, C. Experimentelle Modelle für räumlichen Neglect (Studien in humanen und nicht-humanen Primaten). Neuroforum : Leopold, D.A., Wilke, M., Neuroimaging: seeing the trees for the forest. Current Biology (18): Leopold, D.A., Maier, A., Wilke, M., Logothetis, N.K. Binocular rivalry and the illusion of monocular vision. Binocular rivalry and perceptual ambiguity (Eds.) David Alais and Randoph Blake, MIT Press, Cambridge, MA. Selected recent conference abstracts from the department: Poland, E., Donner, T., Leopold, D.A., Müller, K-M., Wilke, M. (2015). Variability of spiking responses varies with perceptual visibility in V4, but not in pulvinar. Society for Neuroscience Meeting (upcoming in Washington, DC., USA). Domínguez-Vargas, A.U., Schneider, L., Kagan, I.*, Wilke, M.* (2014) Time-dependent effects of pulvinar microstimulation on visually-guided saccades and target selection. Society for Neuroscience Meeting (Washington, DC., USA). Gibson, L., Spanou, E., Wilke, M., Kagan, I. (2014) The effects of pulvinar microstimulation on cortical BOLD activity in behaving monkey. Society for Neuroscience Meeting (upcoming in Washington, DC., USA). Paschke, K., Bähr, M., Kagan, I., Wilke, M. (2013) Trunk orientation and saccadic choice behavior: Effects of egocentric midline shift. In: Society for Neuroscience Meeting, San Diego, USA.

9 Neef, E.N., Schmidt-Samoa, C., Wilke, M. (2013) TMS-induced changes of brain circuits involved in stimulus-driven auditory figure-ground segregation. In: Society for Neuroscience Meeting, San Diego, USA. Wilke, M., Schmidt-Samoa, C., Cabral-Calderin, Y. (2013) Causal role of gamma oscillations in bistable perception revealed by transcranial alternating current stimulation. Meeting of the Association for the Scientific Study of Consciousness, San Diego, USA Dechent, P., Schmidt-Samoa, C., Wilke, M. (2012) Transcranial Direct Current Stimulation (tdcs) Modulates Connectivity in Human Attention Networks. In: Society for Neuroscience Meeting, New Orleans, USA. Domínguez-Vargas, A.U., Graß, A., Wilke, M., Kagan, I. (2012) High reward and risk modulate effort-based spatial decisions in monkeys. In: Society for Neuroscience Meeting, New Orleans, USA. Schmidt-Samoa, C., Wilke, M., Dechent, P., Andersen, R.A., Kagan, I. (2012) Spatial decision differently activates frontoparietal network in humans and in monkeys. In: Society for Neuroscience Meeting, New Orleans, USA. Weinrich, C., Schmidt-Samoa, C., Dechent, P., Bähr, M., Wilke, M. (2012) Task-dependent activation of thalamo-cortical networks with tacs. In: Society for Neuroscience Meeting, New Orleans, USA.

10 Grant Support DFG RU Primate Systems Neuroscience (FOR 1847/KA 3726/2-1). The Physiology of Distributed Computing Underlying Higher Brain Functions in Non-Human Primates. Topic: "Bilateral decision networks for eye and arm movements". Principle Investigators: I. Kagan & M. Wilke Euro for 36 months DFG Einzelantrag (WI 406/1-1). Topic: "Neural basis of spatial neglect symptoms in thalamo-cortical circuits." Principle Investigators: M. Wilke, Co-Investigator: I. Kagan Euro for 36 months ENC Network project - cycle 4. Topic: "Towards a non-invasive approach to evaluate abnormal network oscillations in Parkinson's disease: combined tacs and fmri studies." Principle Investigators: M. Wilke & M. Bähr, Co-Investigators: P. Achermann, H. Berendse Euro for 36 months "Nanoscale Microscopy and Molecular Physiology of the Brain" (CNMPB) Pool-grant for the platform Primate Models (D3). Main topic: "Combined deep brain stimulation and fmri in non-human primates" Euro per 12 months.

Curriculum Vitae of Prof. Dr. Melanie Wilke

Curriculum Vitae of Prof. Dr. Melanie Wilke Personal: Contact Department of Cognitive Neurology Medical School, Georg August University Göttingen Robert-Koch-Straße 40, 37075 Göttingen Phone: +49 (0) 551