Curriculum Vitae PERSONAL INFORMATION CONTACT. Job DESCRIPTION

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1 Curriculum Vitae PERSONAL INFORMATION Name Dr. Jörg Felix Hipp Date of Birth November 15th 1977 Place of Birth Hamburg (Germany) Nationality German Marital Status Married, 3 children (*2006, *2007, *2009) CONTACT Address Grenzacherstrasse 124, 4070 Basel, Switzerland Phone joerg.hipp@roche.com Job DESCRIPTION Responsible for biomarker delivery within individual projects and/or for a specific technology focus across projects in the Neuroscience department. Employ new approaches using electrophysiology (including EEG and MEG) to enable the discovery and validation of new biomarkers and pharmacological targets in humans based on disease pathophysiology understanding. Set clinical biomarker strategy for project teams within selected therapeutic areas and utilize specific technologies such as event related potentials (ERP), EEG, and MEG Contribute to the establishment of a sound biomarker & diagnostic strategy oriented to the delivery of Personalized Health Care for novel therapeutic assets Collaborate with senior internal, academic, and external industry based experts and providers who are focusing on translational and experimental medicine and the various relevant disease areas Lead experimental medicine studies and/or projects in collaboration with internal or external partners Leads/Contributes to scientific publications/co-authorships on scientific publications Perform specific tasks include implementation of agreed biomarker strategies, ongoing monitoring of biomarker activities, coordination of data collection, analysis, and interpretation as well as preparation of the results for informed decision making 1/8

2 PROFESSIONAL EXPERIENCE since 2015 Biomarker and Experimental Medicine Leader at F. Hoffmann-La Roche Ltd. Basel, Switzerland Build and implement EEG biomarker strategy within the Roche biomarker group Postdoctoral fellow at the Centre for Integrative Neuroscience (CIN) University of Tübingen, Germany Research focus on electrophysiological and hemodynamic signatures of neuronal interactions in the healthy and diseased human (EEG, MEG, fmri) Group leader MEG at the Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany Heading MEG research group including management of MEG facility (1 technical assistant, 1 biomedical engineer, 1 post-doc, and 5 PhD students). Research focus on electrophysiological and hemodynamic signatures of neuronal interactions in the healthy and diseased human (EEG, MEG, fmri) Postdoctoral fellow at the Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany Research focus on electrophysiological signatures (EEG) of neuronal interactions underlying flexible cognition Consulter for Mircro-Biolytics, Freiburg, Germany (part-time) Consulting for the development of infrared spectroscopy based biomarkers for bovine spongiform encephalopathy (BSE) Research visit at the California Institute of Technology (Caltech), USA (4 month) Building a model of the development and maintenance of the connection between olfactory sensory neurons and glomeruli in the olfactory bulb. since 2002 (part-time) Developer and consulter for Triple-In GmbH, Hamburg, Germany Development of novel technology for time-of-flight laser sensors (LIDAR sensors) and type specific tools (see patent) Intern at IBEO Lasertechnik GmbH, Hamburg, Germany (3 month) Internships in the departments for hardware and software development of LIDAR sensors. 2/8

3 EDUCATION PhD in Neurosciences (Dr. sc. nat.) Swiss Federal Institute of Technology (ETH) Zürich and Neuroscience Center Zürich, Switzerland Thesis: "Processing of natural stimuli in the somatosensory system" Institute for Neuroinformatics Supervisors: Prof. Peter König, Prof. Daniel Brandeis, Prof. Kevan Martin Diploma (M.S.) in Physics (Mag. rer. nat., with distinction) University of Innsbruck, Austria Thesis: "Simultan aktive Nervenzellen (Aktive Nervenmodelle)" Institute for Applied Physics Supervisors: Prof. Clemens Zierhofer, Prof. Erwin Hochmair Undergraduate studies in Physics University of Hamburg, Germany Certification as Chemical Technical Assistant Vocational school for CTA, Hamburg, Germany High school (Abitur, grade: 1.7) Gymnasium Hummelsbüttel, Hamburg, Germany LANGUAGE SKILLS German: Mother tongue English: Fluent, written and spoken French: Basic 3/8

4 INVITED TALKS IPEG (International Pharmaco EEG Society) Meeting 2016, Nijmegen, Netherlands (October 2016) Tübingen MEG Symposium, Tübingen, Germany (October 2014) Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (September 2014) F. Hoffmann-La Roche Ltd. Basel, Switzerland (September 2014) Center of Advanced European Studies and Research (caesar), Bonn, Germany (June 2014) CNS Annual Meeting, Boston, USA (April 2014) Center for Neural Science, NYU, New York, USA (April 2014) Colloquium at the University Medical Center Hamburg-Eppendorf, Germany (November 2013) Laboratoire de recherche en neuroimagerie (LREN), UNIL/CHUV. Lausanne, Switzerland (September 2013) Laboratory of Cognitive Neuroscience, Brain-Mind Institute, EPFL, Switzerland (September 2013) Workshop Disentangling the brainweb: A perspective from magnetoencephalography, Rovereto, Italy (June 2013) Ernst Struengmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany (Mai 2013) ERNI-HSF Workshop on Brain oscillations in health and disease 2012, Budapest, Hungary (November 2012) Ringberg Meeting 2012, organized by the Ernst Struengmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Ringberg, Germany (June 2012) SUPERVISION PhD*: David J. Hawellek (November 2008 July 2012, summa cum laude). I supervised the work but official advisor was Prof. Andreas K Engel; Supervision is documented by last-authorships. PhD*: Christine Carl (January 2008 February 2014, including maternal leave). I supervised the work but official advisor was Prof. Andreas K Engel; Supervision is documented by last-authorships. Post-doc: Pilar Garces (Since January 2015) RiSE student: Joel Frohlich (Since November 2016) 4/8

5 AD-HOC REVIEWER FOR Brain, Journal of Neuroscience, Cerebral Cortex, Human Brain Mapping, Neuropsychologia, PLoS One, Journal of Vision, Frontiers in Human Neuroscience, Brain Topography, Brain Connectivity 5/8

6 PUBLICATION IMPACT SUMMARY Publications (peer reviewed) 21 Researcher ID PUBLICATIONS Charman T, Loth E., Tillmann J, Crawley D, Wooldridge C, Goyard D, Ahmad J, Auyeung B, Ambrosino S, Banaschewski T, et al. (2017). The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation. Molecular Autism 8, 27. Loth E, Charman T, Mason L, Tillmann J, Jones EJH, Wooldridge C, Ahmad J, Auyeung B, Brogna C, Ambrosino S, et al. (2017). The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders. Molecular Autism 8, 24. Noury N, Hipp JF, and Siegel M (2016). Physiological processes non-linearly affect electrophysiological recordings during transcranial electric stimulation. NeuroImage 140, Klinzing JG, Mölle M, Weber F, Supp G, Hipp JF, Engel AK, and Born J (2016). Spindle activity phase-locked to sleep slow oscillations. NeuroImage 134, Siems M, Pape A-A, Hipp JF, and Siegel M (2016). Measuring the cortical correlation structure of spontaneous oscillatory activity with EEG and MEG. NeuroImage 129, Hipp JF, and Siegel M (2015). BOLD fmri Correlation Reflects Frequency-Specific Neuronal Correlation. Current Biology 25, Hipp JF, and Siegel M (2015). Accounting for Linear Transformations of EEG and MEG Data in Source Analysis. PLOS ONE 10, e Carl C, Hipp JF, König P, and Engel AK (2016). Spectral Signatures of Saccade Target Selection. Brain Topogr 29, Hawellek DJ, Schepers IM, Röder B, Engel AK, Siegel M, and Hipp JF (2013). Altered intrinsic neuronal interactions in the visual cortex of the blind. Journal of Neuroscience. 33, Hipp JF, and Siegel M (2013). Dissociating neuronal gamma-band activity from cranial and ocular muscle activity in EEG. Frontiers in Human Neuroscience 7, Schepers IM, Schneider TR, Hipp JF, Engel AK, and Senkowski D (2013). Noise alters betaband activity in superior temporal cortex during audiovisual speech processing. Neuroimage 70, /8

7 Hipp JF, Hawellek DJ, Corbetta M, Siegel M, and Engel AK (2012). Large-scale cortical correlation structure of spontaneous oscillatory activity. Nature Neuroscience 15, Schepers IM*, Hipp JF*, Schneider TR, Röder B, and Engel AK (2012). Functionally specific oscillatory activity correlates between visual and auditory cortex in the blind. Brain 135, Carl C, Açik A, König P, Engel AK, and Hipp JF (2012). The saccadic spike artifact in MEG. Neuroimage 59, Friese U, Supp GG, Hipp JF, Engel AK, and Gruber T (2012). Oscillatory MEG gamma band activity dissociates perceptual and conceptual aspects of visual object processing: a combined repetition/conceptual priming study. Neuroimage 59, Supp GG, Siegel M, Hipp JF, and Engel AK (2011). Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness. Current Biology 21, Hawellek DJ, Hipp JF, Lewis CM, Corbetta M, and Engel AK (2011). Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis. Proc Natl Acad Sci USA 108, Hipp JF, Engel AK, and Siegel M. (2011). Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception. Neuron 69, Hipp J, Arabzadeh E, Zorzin E, Conradt J, Kayser C, Diamond ME, and König P (2006). Texture signals in whisker vibrations. Journal of Neurophysiology 95, Hipp J, Einhäuser W, Conradt J, and König P (2005). Learning of somatosensory representations for texture discrimination using a temporal coherence principle. Network 16, Einhäuser W, Hipp J, Eggert J, Körner E, and König P (2005). Learning viewpoint invariant object representations using a temporal coherence principle. Biological Cybernetics 93, * indicates equal 1 st author contribution, underlined when corresponding author BOOK CHAPTERS Hipp, J.F. (2015). Time-Frequency Analysis. In Encyclopedia of Computational Neuroscience, D. Jaeger, and R. Jung, eds. (Springer New York), pp PATENTS Hipp JF. Device and System for Determining Brain Activities. PCT application filed. (PCT/EP2012/076854, WO A1) (Priority ) 7/8

8 Hipp JF, Hipp J. Distance measurement. EP B1 / US B2. (Priority ) 8/8

TULLIA PADOVANI, PH.D. CURRICULUM VITAE

TULLIA PADOVANI, PH.D. CURRICULUM VITAE Citizenship: Swiss, Italian Civil status: Married, two children (2000, 2003) Address: Sempachstr.11, CH-3014 Bern Tel. 031/ 331 56 57 (private) 031/ 631 54 36 (office)