高醫肝膽胰內科創立 30 年國際研討會 日期 : 時間 : 13:00-18:10 地點 : 高雄醫學大學國際研究大樓 B2 300 人會議室

Transcription

1 高醫肝膽胰內科創立 30 年國際研討會 日期 : 時間 : 13:00-18:10 地點 : 高雄醫學大學國際研究大樓 B2 300 人會議室 主辦單位 : 高雄醫學大學附設中和紀念醫院肝膽胰內科高雄醫學大學附設中和紀念醫院肝炎防治中心高雄醫學大學醫學院肝炎學術研究中心財團法人台灣肝臟學術文教基金會 學分申請台灣內科醫學會學分申請中台灣消化系醫學會學分申請中台灣消化系內視鏡醫學會學分申請中中華民國醫用超音波學會學分申請中小兒消化系醫學會學分申請中高醫大教師訓練時數申請中

2 Time Topic Speaker Moderator 報到 Registration 台灣過去 30 年肝臟疾病演變 Introduction liver diseases in Taiwan 3 decades ago 全國全面施打 B 型肝炎疫苗成就及待解議題 Achievement and unmet needs of HBV control in Taiwan mass vaccination program 台灣 B 型肝炎控制成就及待解議題 類核苷酸治療 Achievement and unmet needs of HBV control in Taiwan NUC therapy 台灣 B 型肝炎控制成就及待解議題 干擾素治療 Achievement and unmet needs of HBV control in Taiwan IFN therapy 總評 ( 一 ) Commentary (I) 台灣 C 型肝炎控制成就及待解議題 初級預防 Achievement and unmet needs of HCV control in Taiwan primary prevention 台灣 C 型肝炎控制成就及待解議題 次級預防 Achievement and unmet needs of HCV control in Taiwan secondary prevention 台灣 C 型肝炎控制成就及待解議題 三級預防 Achievement and unmet needs of HCV control in Taiwan tertiary prevention 總評 ( 二 ) Commentary (II) 中場休息 Coffee break 張文宇教授 Prof. Wen Yu Chang 張美惠院士 Prof. Mei Hwei Chang 劉俊人教授 Prof. Chun Jen Liu 簡榮南教授 Prof. Rong Nan Chien 廖運範院士 Prof. Yun Fan Liaw 盧勝男教授 Prof. Sheng Nan Lu 余明隆教授 Prof. Ming Lung Yu 戴嘉言教授 Prof. Chia Yen Dai 陳定信院士 Prof. Ding Shinn Chen 張文宇教授 Prof. Wen Yu Chang 廖運範院士 Prof. Yun Fan Liaw 陳定信院士 Prof. Ding Shinn Chen

3 台灣非酒精性脂肪肝病變及肝炎趨勢 威脅及待解議題 The trend of NAFLD/NASH in Taiwan: threat and unmet needs 脂質代謝及其系統疾病 Lipid metabolism and systemic diseases 綜觀過去 30 年對高醫肝膽內科肝病貢獻 Overview of KMUH contributions in managing CLD in the past 3 decades 黃志富教授 Prof. Jee Fu Huang 陳珠璜教授 Prof. Chu Huang Chen 莊萬龍教授 Prof. Wan Long Chuang 陳培哲院士 Prof. Pei Jer Chen 總評 ( 三 ) Commentary (III) 未來肝臟醫學 Future Hepatology 非酒精性脂肪肝病變及肝炎治療策略新知 Therapeutic modalities for NAFLD/NASH 肝臟再生醫學進展 Recent advance in regenerative medicine of Hepatology 結論 Closing remarks 陳培哲院士 Prof. Pei Jer Chen Prof. Jacob George Prof. Takanori Takebe 張文宇教授 Prof. Wen Yu Chang 莊萬龍教授 Prof. Wan Long Chuang 余明隆教授 Prof. Ming Lung Yu

4 Professor Mei-Hwei Chang CURRICULUM VITAE Current Position Distinguished Chair Professor, Department of Pediatrics, College of Medicine, National Taiwan University Chairperson, Hepatitis Research Center, National Taiwan University Hospital Place of Birth : Taipei, Taiwan Office Address : Department of Pediatrics, National Taiwan University Hospital, No.8, Chung-Shan S. Road, Taipei, Taiwan TEL: (02) , ext changmh@ntu.edu.tw Education and Postdoctoral Training M.D., Department of Medicine, College of Medicine, National Taiwan University Pediatric Residency, National Taiwan University Hospital Pediatric Chief Resident, National Taiwan University Hospital Adult Gastroenterology Fellowship, National Taiwan University Hospital Pediatric Gastroenterology Fellowship, UCLA School of Medicine, Los Angeles, California, U.S.A. Academic and Professional Appointments Attending Physician, Department of Pediatrics, National Taiwan University Hospital Lecturer, Department of Pediatrics, College of Medicine, National Taiwan University Chief, Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, National Taiwan University Hospital (1985- Present) Associate Professor, Department of Pediatrics, College of Medicine, National Taiwan University, Taipei ( ) Professor, Department of Pediatrics, College of Medicine, National Taiwan University (1990-Present) Chairman, Department of Pediatrics, College of Medicine, National Taiwan University ( ) Visiting Professor, laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institute of Health, U.S.A.(2004 April~June) Distinguished Professor, Department of Pediatrics, College of Medicine, National Taiwan University (2006- Present) Chairperson, Hepatitis Research Center, National Taiwan University Hospital (2009- Present) Distinguished Chair Professor, National Taiwan University (2013~Present) Academician, Academia Sinica, Taiwan (2014~Present) Major Research Interest and Field of Specialty Child Heath, Pediatric Hepatology, Cancer Prevention Awards and Honors Top-Ten Outstanding Female Youth of Taiwan

5 Professor Mei-Hwei Chang Professor Juei-Low Sung s Research Award 1989 Outstanding Research Award of the National Science Council (NSC) Green Apricot Foundation Research Award 1991 Outstanding Research Award of the NSC Min-Nin Wang s Research Contribution Award 1994 Out-standing Research Award of the NSC Harvard Combined Program in Pediatric Gastroenterology and 1997 Nutrition - The Marvin L. Dixon Memorial Visiting Professorship Out-standing Research Award of the NSC Hou Ching-Duei foundation Outstanding Research Award 1999 Special Contract Researcher Award of NSC ISI Citation Classic Award 2001 Jin-Yu Professorship Award of the National Taiwan University 2001 Sheila Sherlock Award of the International Association for the Study of 2002 the Liver Special Contract Researcher Award of NSC, Taiwan Research Award of the China Culture Foundation, NSC, Taiwan 2004 Taiwan Pediatric Association Award 2004 Outstanding Achievement Award in Science and Technology Award of 2005 the Executive Yuan, ROC Academic Award, National Department of Education, Taiwan 2006 Outstanding Asian Pediatrician Award 2006 National Chair Professor of Medicine, Ministry of Education, Taiwan Taiwan Outstanding Women in Science Award (2010) 2010 Health Promotion Contribution Award, Ministry of Heath and Welfare 2013 The World Academy of Sciences (TWAS)Prize in Medical Sciences 2013 Distinguished Achievement Award of the Phi Tau Phi Scholastic Honor 2014 Society Sass-Kortsak Award of the Canadian Association for the Study of the 2015 Liver/ Canadian Liver Foundation Patent Infant stool color card - ROC Patent number I (Filed august 1, 2008; Granted December 16, 2023) Major Society or Committee Assignments, and Professional Activities Global or International President, Federation of the International Societies of Pediatric Gastroenterology, Hepatology and Nutrition ( ) President, Asian-Pan Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition ( ) Council Member, Asian Pacific Pediatric Association ( ) Council Member, International Society of Cancer Prevention (2010- Present ) Secretary General ( ) and Council Member( ), Asian Society of Pediatric Research Program Evaluation Committee Member, American Association for the Study of Liver Disease (AASLD) ( ) Internal Medicine Topic Advisory Group (IM-TAG) for the 11th revision of the International Classification of Disease (ICD-11), WHO (2010~) 2

6 Chun-Jen Liu ( 劉俊人 ) EDUCATION: M.D., Medicine, National Taiwan University Ph.D., Graduate Institute of Clinical Medicine, National Taiwan University POSITIONS HELD: Professor, Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine Visiting staff, Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital HONORS: 1. An award from Liver Disease Prevention and Treatment Research Foundation in Research scholarship from the Acadamia Sinica, Taiwan, from 2000 to A research award from Prof JL Sung s Research Foundation in Graduate Student Research Award, National Taiwan University College of Medicine in A paper award from Liver Disease Prevention and Treatment Research Foundation in Shanghai-Hong Kong International Liver Congress 2006: Poster Presentation Award th Annual Meeting of the American Association for the Study of Liver Diseases, 2007, Boston, USA: Poster of President s Choice. 8. AGD shortlisted Prize, 3rd Ditan International Conference on Infectious Diseases, 2009, Beijing. 9. Y. Z. Hsu Scientific Paper Award in JGH Foundation Emerging Leader Lecture in APDW 2013, Shanghai. RESEARCH INTERESTS: He is interested in the filed of chronic hepatitis B and C, and nonalcoholic fatty liver disease. His studies focus on the role of viral and host factors in the pathogenesis and natural/treatment outcomes of chronic hepatitis B and C, particularly the mechanism of hepatitis B acute exacerbation, the genotypes and phenotypes of HBV viral mutants, and the mechanism of HBsAg seroclearance. Besides, he has been actively involved in the clinical trials on the treatment of chronic hepatitis C, chronic hepatitis B, dual chronic hepatitis C and B, and HCC. He has published more than 190 peer-reviewed papers. EDITOR: PLoS One ASSOCIATE EDITOR: Liver International EDITORIAL BOARD: Gut and Liver, Journal of Gastroenterology and Hepatology REVIEWER: Liver International, Journal of Viral Hepatitis, Journal of Gastroenterology and Hepatology, Journal of Formosan Medical Association, Nephrology, Journal of Microbiology Immunology and Infection, Journal of Medical Virology, Epidemiology and Infection, Hepatology International, Preventive Medicine, The Kaohsiung Journal of Medical Sciences, Oncogene, Journal of Hepatology, Lipids in Health and Disease, Hepatitis Research and Treatment, Gastroenterological Journal of Taiwan, the Lancet Infectious Diseases, Hepatology. SELECTED PUBLICATIONS: 1. Liu CJ, Chen PJ, Lai MY, Kao JH, Chen DS. Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full-length viral sequences. Hepatology 2001;34:583-9.

7 2. Liu CJ, Chen PJ, Lai MY, et al. A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation. Gastroenterology 2003;124: Liu CJ, Chen PJ, Lai MY, Kao JH, Chen DS. Ribavirin and interferon is effective for hepatitis C virus clearance in hepatitis B and C dually infected patients. Hepatology 2003;37: Liu CJ, Kao JH, Wang HY, Lai MY, Chen TC, Chen PJ, Chen DS. Origin of serum hepatitis B virus in acute exacerbation: Comparison with HBV in the liver and from other exacerbation. Hepatology 2004;40: Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B virus precore/core promoter mutations and serum viral load on non-cirrhotic hepatocellular carcinoma: A case control study. J Infect Dis 2006;194: Liu CJ, Chen PJ, Jeng YM, et al. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J Hepatol 2005;43: Liu CJ, Lo SC, Kao JH, Tseng PT, Lai MY, Ni YH, Yeh SH, Chen PJ, Chen DS. Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan. J Hepatol 2006;44: Liu CJ, Lai MY, Chao YC, et al. Interferon alfa-2b with and without ribavirin for hepatitis B e antigen-positive chronic hepatitis B: A Randomized Study. Hepatology 2006;43: Liu CJ, Chuang WL, Lee CM, et al. Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis C and B viruses. Gastroenterology 2009;136: Yu ML, Lee CM, Chuang WL, et al. HBsAg profiles in patients receiving peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. J Infect Dis 2010:202: (corresponding author) 11. Liu CJ, Lee PH, Lin DY, et al. Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and dose-finding. J Hepatol 2009;50: Liu CJ, Jeng YM, Chen CL, et al. Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in chronic hepatitis B patients. J Infect Dis 2009;199: Tseng TC, Liu CJ, Su TH, et al. Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters. Gastroenterology 2011;141: Tseng TC, Liu CJ, Yang HC, et al. Determinants of spontaneous surface antigen loss in HBeAg-negative patients with a low viral load. Hepatology 2012;55: Tseng TC, Liu CJ, Yang HC, et al. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology 2012;142: Tseng TC, Liu CJ, Yang HC, et al. Serum hepatitis B surface antigen levels help predict disease progression in patients with low HBV loads. Hepatology 2013;57: Yu ML, Lee CM, Chen CL, Chuang WL, Lu SN, Liu CH, Wu SS, Liao LY, Kuo HT, Chao YC, Tung SY, Yang SS, Kao JH, Su WW, Lin CL, Yang HC, Chen PJ, Chen DS, Liu CJ, Taiwan Liver-Net Consortium. Sustained HCV clearance and increased HBsAg seroclearance in patients with dual chronic hepatitis C and B during post-treatment follow-up. Hepatology 2013 Jan Tseng TC, Liu CJ, Su TH, et al. Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation. J Infect Dis 2012;206: Liu CJ, Chu YT, Shau WY, Kuo RNC, Chen PJ, Lai MS. Treatment of patients with dual hepatitis C and B by peginterferon alfa and ribavirin reduced risk of hepatocellular carcinoma and mortality. Gut 2014;63: Liu CJ, Kao JH. Global Perspective on the natural history of chronic hepatitis B: Role of hepatitis B virus genotypes A to J. Semin Liver Dis 2013:33: Liu CJ, Chen PJ. Updates in the treatment and outcomes of dual chronic hepatitis C and B virus infection. World J Gastroenterol 2014;20: Liu CJ. Treatment of patients with dual HCV and HBV infection: Resolved and unresolved issues. J Gastroenterol Hepatol 2014;29: Chen MY, Liu CH, Chen TC, Su TH, Chen PJ, Chen DS, Kao JH, Liu CJ. Value of interleukin 28B genetic polymorphism on retreatment outcomes of chronic hepatitis C genotype 1 relapsers by peginterferon alfa plus ribavirin. J Gastroenterol Hepatol 2014;29: Wu HL, Kao JH, Chen TC, Wu WH, Liu CH, Su TH, Yang HC, Chen DS, Chen PJ, Liu CJ. Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: Clinical and mechanistic implications. J Gastroenterol Hepatol (in press) 25. Su TH, Kao JH, Liu CJ. Molecular mechanism and treatment of viral hepatitis related-liver fibrosis. Int J Mol Sci 2014;15:

8 26. Liu CJ, Chang J, Lee PH, Lin DY, Wu CC, Jeng LB, Lin YJ, Mok KT, Lee WC, Yeh HZ, Ho MC, Yang SS, Yang MD, Yu MC, Hu RH, Peng CY, Lai KL, Chang SS, Chen PJ. Adjuvant PI-88 for prevention of post-resection HCC recurrence: 3-year follow-up. World J Gastroenterol 2014;20: Liu CJ, Chen TC, Chen PJ, Wang H, Tseng TC, Cheng HR, Liu CH, Chen DS, Kao JH. Microevolution of the hepatitis B virus genome in hepatitis B e-antigen-positive carriers: Comparison of genotypes B and C at various immune stages. J Gastroenterol Hepatol 2014 Jul 6. doi: /jgh [Epub ahead of print]

9 Rong Nan Chien, MD, Professor of medicine at the Chang Gung University College of Medicine, is now the deputy superintendent of the Keelung Chang Gung Memorial Hospital. He graduated from the college of medicine at the China Medical University in Taiwan in He undertook postgraduate training at the Linkou Chang Gung Memorial Hospital between 1986 and 1991 and has been an attending physician in the department of internal medicine and division of Gastroenterology since Professor Chien has received more than 20 awards and honors, including research awards from the national science council, academic award of Prof. JL Sung s research foundation, emerging leadership award of APDW and excellently teaching attending physician award several times at Chang Gung Memorial Hospital. Professor Chien is an executive council member and president ( ) of the Taiwan Association for the Study of Liver Disease. He was the vice editor in chief of the Gastroenterological Journal of Taiwan ( ) and the editor of Hepatology International and Biomedical Journal. In addition, he contributes to peer review for a further 30 journals, including Hepatology, Journal of Hepatology, American Journal of Gastroenterology, Journal of Viral Hepatitis, Journal of Gastroenterology and Hepatology, and Hepatology International. Professor Chien has published more than 130 articles in the fields of viral hepatitis as well as toxic hepatitis, and his work has appeared in many leading journals including the New England Journal of Medicine, Hepatology, Journal of Hepatology, American Journal of Gastroenterology, Antiviral Therapy, Journal of Viral Hepatitis and Journal of Gastroenterology and Hepatology.

10 CURRICULUM VITAE NAME: Yun-Fan Liaw EDUCATION: , College of Medicine, National Taiwan University, Taipei ACADEMIC APPOINTMENT: Distinguished Chair Professor, Chang Gung University EMPLOYMENT: Senior advisor and physician, Chang Gung Memorial Hospital AWARD: 1. Distinguished Scientist Award, Executive Yuan, Academic Award, Ministry of Education, Executive Yuan, Distinguished Research Award, National Science Council, Executive Yuan 4. Elected member, Academia Sinica, 2000~ 5. Thomson Scientific Citation Laureate Awards, The European Association for the Study of Liver (EASL) International Recognition Award, 2013 Professor Liaw is Distinguished Chair Professor of Medicine at Medical College, Chang Gung University, Taipei, Taiwan. After graduation from the College of Medicine National Taiwan University, Professor Liaw went on to specialize in internal medicine and then gastroenterology, becoming Director of the Department of Hepatogastroenterology, a position he held from 1976 to During this time, Professor Liaw was also the Director of the Liver Research Unit of Chang Gung Memorial Hospital, where he is now an Advisor. Professor Liaw has professional affiliations with all major organizations in his field. He served as president of Taiwan Association for the Study of the Liver (TASL) from 1994 to 1995 and of Asian-Pacific Association for the Study of the Liver (APASL) from 2000 to Professor Liaw has devoted in hepatology, especially clinical and research in HBV related liver diseases since Having published extensively in these areas, for which he was awarded Thomson Scientific Citation Laureate Awards, He has also served as a reviewer for many prestigious international journals, was the editor of J Gastroenterol Hepatology ( ), Hepatol Int ( ), an associate Editor of J Hepatol ( ) and is currently on the editorial board of Journal of Viral Hepatitis and Antiviral Therapy. Among the awards he has received are the Distinguished Research Award from the National Science Council, the Academic Award from the Ministry of Education and Distinguished Scientist Award from the Prime Minister of Taiwan. Professor Liaw has also been elected Academician of the Academia Sinica, Taiwan since year He won the 2013 EASL International Recognition Award.

11 Curriculum Vitae Name: Position: Institution: Sheng-Nan Lu MD, MPH, PhD Professor and Attending Physician, Department of Hepatogastroenterology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan. Sheng-Nan Lu graduated from Kaohsiung Medical University (KMU) in 1984, and then he completed a two-year Master s course of Public Health (MPH) at National Taiwan University in Following this, He received complete training of Internal Medicine and Gastroenterology in KMU Hospital and became an attending physician in 1990, and was awarded a PhD degree from KMU in In 1997, he moved to Kaohsiung Chang Gung Memorial Hospital (KCGMH). At present, he is a professor of hepatology and epidemiology of CGMH and Chang Gung University. Dr. Lu has published more than 300 international papers with most of them being clinical and epidemiological studies of hepatitis and hepatocellular carcinoma. He is an Academic Editor of PLOS One and a member of editorial board of Journal of Gastroenterology and Hepatology. He is also serving as a journal referee of about 50 peer-review journals. He is a member of council in the Gastroenterology Society of Taiwan (GEST), the Taiwan Liver Cancer Association (TLCA) and the Taiwan Academy of Tumor Ablation (TATA). He is also a member of Committee for Liver Cancer and Hepatitis Prevention and Control, Minister of Health and Welfare, Taiwan. Research Interesting: Hepatology, Intervention ultrasonography, Epidemiology, Preventive Medicine.

12 Ding-Shinn Chen, MD, FAASLD Affiliation: Title: National Taiwan University College of Medicine & National Taiwan University Hospital; Genomics Research Center, Academia Sinica (Taiwan) Distinguished Chair Professor; Distinguished Visiting Fellow Specialty: Hepatology, Gastroenterology Address: Hepatitis Research Center 7 Chung-Shan South Road Taipei 10002, Taiwan Education: Bachelor of Medicine, National Taiwan University School of Medicine Taipei, Taiwan Postgraduate Training: Resident, Department of Internal Medicine, National Taiwan University Hospital Taipei, Taiwan Research interest: Basic and clinical aspects of viral hepatitis and liver diseases, from prevention to management Experience: 1975 Visiting Fellow, National Cancer Center Research Institute, Tokyo, Japan Associate Professor, National Taiwan University College of Medicine, Taipei, Taiwan Visiting Scientist, National Institutes of Health, Bethesda, USA Member, Hepatitis Control Committee, Department of Health, Taiwan (Chairman, ) Professor of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Founding Director, Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan President, Taiwan Association for the Study of the Liver President, Gastroenterological Society of Taiwan President, Formosan Medical Association Dean, National Taiwan University College of Medicine, Taipei, Taiwan - 1 -

13 President, the International Association for the Study of the Liver (IASL), Munich, Germany Honors: 1984 National Outstanding Science and Technology Award of the Republic of China, Executive Yuan, Taiwan 1986 Abbott Laboratories Research Award, Abbott Laboratories, USA Outstanding Research Award in Biology and Medicine, National Science Council, Taiwan 1989 Outstanding Academic Award (Medicine), Ministry of Education, Taiwan 1992~ Academician, Academia Sinica, Taiwan 1993 Grand Award, Society of Chinese Bioscientists in America (SCBA), USA 1994 Hou Jin-Duei Outstanding Contribution Award in Basic Science, Taiwan Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan National Chair-Professor of Medicine, Ministry of Education, Taiwan 2004~ Lifetime National Chair-Professor of Medicine, Ministry of Education, Taiwan 2001~ Fellow, The Third World Academy of Sciences (TWAS), Italy 2002 Doctor of Philosophy (honoris causa), Kaohsiung Medical University, Taiwan 2005~ Foreign Associate, National Academy of Sciences, USA 2005 Caring Physicians of the World, World Medical Association, France 2005 Outstanding Achievement Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan 2006 Trieste Science Prize, TWAS, Italy 2007 Presidential Science Prize of Taiwan, Taiwan 2009 EASL International Recognition Award, Denmark 2009 Okuda Lectureship Award, JGH Foundation, Australia 2010 Nikkei Asia Prize, Japan 2011 Distinguished Clinician Educator/Mentor Award, AASLD, San Francisco 2014 President s Award, Chung-Hwa Rotary Educational Foundation, Taichung 2014 Doctor of Philosophy (honoris causa), China Medical University, Taichung Publications: As of May 2015, 710 original articles were published, together with 44 book chapters

14 Chen, Chu-Huang BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME Chen, Chu-Huang POSITION TITLE Director Vascular and Medicinal Research era COMMONS USER NAME chchen1 EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY Kaohsiung Medical College, Kaohsiung, Taiwan M.D Medicine Chang-Gung Memorial Hospital, Taipei, Taiwan Resident Pathology Texas Tech University, Lubbock, Texas Ph.D Physiology Maryland General Hospital & Univ. of Maryland Resident Internal Medicine Baylor College of Medicine, Houston, Texas Fellow Cardiology A. Positions and Honors Professional Experience Postdoctoral Associate, Section of Atherosclerosis/Medicine, Baylor College of Medicine Instructor of Medicine, Baylor College of Medicine, Houston, Texas Assistant Professor of Medicine, Baylor College of Medicine, Houston, Texas 2004-present Associate Professor of Medicine, Baylor College of Medicine, Houston, Texas 2006-present Clinical Director, Behavioral Medicine Research Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 2009-present Professor and Director, Vascular and Medicinal Research, Houston, Texas Heart Institute, Houston, Texas Visiting Professor and Director of L5 Research Center, China Medical University, Taichung, Taiwan 2012-present Visiting Professor and Director of Center for Lipid Biosciences, Kaohsiung Medical University, Kaohsiung, Taiwan 2013-present Chairman, Research Advisory Committee, New York Heart Research Foundation, New York 1

15 Chen, Chu-Huang 2014-present Chair Professor, Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2015-present Adjunct Professor, Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan Honors and Awards 1) Tar box Fellowship, Texas Tech University, ) The Methodist Hospital Foundation Award, ) The Virginia and Ernest Cockrell Jar Award, ) Zeneca Pharmaceuticals Research Award, ) AHA, Texas Affiliate, Grant-In-Aid, ) Texas Medical Center/NASA Cooperative Research Grant, ) AHA, National, Scientist Development Award, ) The Atorvastatin Research Award, ) American Diabetes Association Research Award, ) Pfizer Independent Medical Grant, ) American Diabetes Association Research Award, ) Pfizer Independent Medical Grant, ) Philip Morris Research Award, ) AHA grant reviewer, Western Review Consortium, ; ) Associate Editor, Journal of Alzheimer s Disease, ) 12 th Generation Chen Style Tai Chi Selected Disciple, 2013 life time 17) Editorial board, Biomedical Journal 2013 present 18) Outstanding Alumni Award, Kaohsiung Medical University, Taiwan, life time Honors as a Mentor 1) Postdoctoral Fellow, Jeffrey P. Walterscheid, PhD, AHA Fellowship, ) Postdoctoral Fellow, Daming Tang, MD PhD, NIH Training Grant, 2007 Memberships in Professional Societies 1) American Diabetes Association 2) AHA, Atherosclerosis Council 3) International Atherosclerosis Society 4) American Association for the Advancement of Science 5) The Angiogenesis Society 2

16 PHOTO Please send us a High Resoulution File by Name: Position: Institution: BIOGRAPHY Jacob George Robert W. Storr Professor of Hepatic Medicine Storr Liver Centre, Westmead Millennium Institute, University of Sydney and Westmead Hospital BRIEF INTRODUCTION Education and Career Background: (within 300 words) Jacob George is the Robert W. Storr Professor of Hepatic Medicine at the Storr Liver Centre, Westmead Millennium Institute, University of Sydney and Head of the Department of Gastroenterology and Hepatology at Westmead Hospital and Director of Gastroenterology and Hepatology Services for the Western Sydney Local Health District. He undertakes basic and clinical research on NASH, hepatitis C, liver cancer and hepatic fibrosis. He is an Associate Editor for the Journal of Hepatology, and is or has been on the Editorial Board of Hepatology, Liver international, Hepatology International and the World Journal of Gastroenterology. He was a past Executive Council member of the Asian Pacific Association for the Study of the Liver and is on the council of the Gastroenterological society of Australia. Clinical and Research Interest: He undertakes basic and clinical research on NASH, hepatitis C, liver cancer and hepatic fibrosis. Five Representative Publications: 1.Suppiah V, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nature Genetics 2009;41: Editorial: O Brien TR. (IF 35.2). Major impact on understanding the role of host genetics on hepatitis C outcomes; 2. Jacobson I, et al. Telaprevir for Previously Untreated Chronic Hepatitis C Infection. NEJM 2011;364: Editorial: Rosen H (IF 51.55). Heralded direct acting antivirals for treatment of hepatitis C; 3. Chitturi S, et al. NASH and insulin resistance:insulin hypersecretion and specific association with insulin resistance syndrome. Hepatology 2002; 35: Editorial: Giulio Marchesini and Gabriele Forlani. (IF 11.19). Showed for the first time that fatty liver and NASH are caused by insulin resistance; 4. Suppiah V, et al. IL28B, HLA-C and KIR variants additively predict response to therapy in chronic hepatitis C. PLoS Medicine 20118:e Editorial Klenerman P. (IF 15.2). Major impact on undersanding the role of host genetics on hepatitis C outcomes; 5. Hui JM, et al. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression. Gastroenterology 2003; 125: Editorial: Sanyal AJ. Identified that HCV is an infectious cause of insulin resistance/type 2 diabetes. (IF 13.9).