ASCO Annual Meeting Peter Paul Yu, MD, FACP, FASCO Hartford HealthCare Cancer Institute Memorial Sloan Kettering Cancer Center
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1 ASCO Annual Meeting 2017 Peter Paul Yu, MD, FACP, FASCO Hartford HealthCare Cancer Institute Memorial Sloan Kettering Cancer Center
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3 Prospective Pooled Analysis of Six Phase III Trials Investigating Duration of Adjuvant Oxaliplatin-based therapy (3 vs. 6 months) for Patients with Stage III Colon Cancer: <br />The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration Presented By Qian Shi at 2017 ASCO Annual Meeting
4 Study Overview Presented By Qian Shi at 2017 ASCO Annual Meeting
5 IDEA Trials Summary Presented By Qian Shi at 2017 ASCO Annual Meeting
6
7 Treatment Compliance Presented By Qian Shi at 2017 ASCO Annual Meeting
8 Adverse Events Presented By Qian Shi at 2017 ASCO Annual Meeting
9 Non-inferiority Hypothesis Testing Presented By Qian Shi at 2017 ASCO Annual Meeting
10 Primary DFS Analysis (mitt), cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
11 DFS Comparison by Regimen, cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
12 DFS Comparison by Risk Groups, cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
13 Summary Presented By Qian Shi at 2017 ASCO Annual Meeting
14 LATITUDE: A phase 3, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos <br />in newly diagnosed high-risk metastatic hormone-naïve prostate cancer patients Presented By Karim Fizazi at 2017 ASCO Annual Meeting
15 De novo metastatic prostate cancer Presented By Karim Fizazi at 2017 ASCO Annual Meeting
16 ADT + docetaxel: a new standard of care for men with mcnpc and high metastatic burden (2015) Presented By Karim Fizazi at 2017 ASCO Annual Meeting
17 Abiraterone mechanism of action: <br />androgen biosynthesis inhibitor Presented By Karim Fizazi at 2017 ASCO Annual Meeting
18 Objective Presented By Karim Fizazi at 2017 ASCO Annual Meeting
19 Overall study design of LATITUDE Presented By Karim Fizazi at 2017 ASCO Annual Meeting
20 Statistically significant 38% risk reduction of death Presented By Karim Fizazi at 2017 ASCO Annual Meeting
21 Statistically significant improvement in all secondary end points Presented By Karim Fizazi at 2017 ASCO Annual Meeting
22 Statistically significant 58% risk reduction of time to subsequent <br />PC therapy Presented By Karim Fizazi at 2017 ASCO Annual Meeting
23 Adverse events of special interest Presented By Karim Fizazi at 2017 ASCO Annual Meeting
24 Safety Presented By Karim Fizazi at 2017 ASCO Annual Meeting
25 Conclusions Presented By Karim Fizazi at 2017 ASCO Annual Meeting
26 OlympiAD: Phase III trial of olaparib monotherapy versus chemotherapy for patients with HER2-negative metastatic breast cancer and a germline BRCA mutation Presented By Mark Robson at 2017 ASCO Annual Meeting
27 Poly(ADP-ribose) polymerase (PARP) inhibition as a therapeutic strategy Presented By Mark Robson at 2017 ASCO Annual Meeting
28 OlympiAD study design Presented By Mark Robson at 2017 ASCO Annual Meeting
29 Primary endpoint: progression-free survival by BICR Presented By Mark Robson at 2017 ASCO Annual Meeting
30 Overall survival (interim analysis; 46% data maturity) Presented By Mark Robson at 2017 ASCO Annual Meeting
31 Adverse events (any grade) in 15% of patients Presented By Mark Robson at 2017 ASCO Annual Meeting
32 Grade 3 adverse events in 2% patients in either arm Presented By Mark Robson at 2017 ASCO Annual Meeting
33 Conclusions Presented By Mark Robson at 2017 ASCO Annual Meeting
34 Slide 3 Presented By Suzanne Topalian at 2015 ASCO Annual Meeting
35 Slide 8 Presented By Suzanne Topalian at 2015 ASCO Annual Meeting
36 Slide 9 Presented By Suzanne Topalian at 2015 ASCO Annual Meeting
37 Slide 10 Presented By Suzanne Topalian at 2015 ASCO Annual Meeting
38 Slide 2 Presented By Cassian Yee at 2017 ASCO Annual Meeting
39 Slide 39 Presented By Suzanne Topalian at 2015 ASCO Annual Meeting
40 Spectrum of PD-1/PD-L1 Antagonist Activity Presented By Mario Sznol at 2017 ASCO Annual Meeting
41 Epacadostat Plus Nivolumab in Patients With Advanced Solid Tumors: Preliminary Phase 1/2 Results of ECHO-204 Presented By Karl Lewis at 2017 ASCO Annual Meeting
42 IDO1 Enzyme and Epacadostat Presented By Karl Lewis at 2017 ASCO Annual Meeting
43 Objective Presented By Karl Lewis at 2017 ASCO Annual Meeting
44 Study Design Presented By Karl Lewis at 2017 ASCO Annual Meeting
45 Phase 2 Treatment-Related AEs* ( 10%; All Tumor Cohorts)<br />Epacadostat 100 or 300 mg BID in combination with nivolumab 240 mg IV Q2W Presented By Karl Lewis at 2017 ASCO Annual Meeting
46 Treatment-Naive MEL: Best Objective Response<br />Epacadostat 100 or 300 mg BID in combination with nivolumab 240 mg IV Q2W (phase 2; mrecist) Presented By Karl Lewis at 2017 ASCO Annual Meeting
47 Treatment-Naive MEL: Percentage Change From Baseline in Target Lesions <br />Epacadostat 100 or 300 mg BID in combination with nivolumab 240 mg IV Q2W (phase 2; mrecist) Presented By Karl Lewis at 2017 ASCO Annual Meeting
48 SCCHN: Percentage Change From Baseline in Target Lesions <br />Epacadostat 100 or 300 mg BID in combination with nivolumab 240 mg IV Q2W (phase 2; mrecist) Presented By Karl Lewis at 2017 ASCO Annual Meeting
49 OC and CRC Efficacy<br />Epacadostat 100 or 300 mg BID in combination with nivolumab 240 mg IV Q2W (phase 2; mrecist) Presented By Karl Lewis at 2017 ASCO Annual Meeting
50 Conclusions Presented By Karl Lewis at 2017 ASCO Annual Meeting
51 Phase I studies of the novel carcinoembryonic antigen CD3 T-cell bispecific (CEA-TCB) antibody as a single agent and in combination with atezolizumab: preliminary efficacy and safety in patients with metastatic colorectal cancer (mcrc)<br /> Presented By Josep Tabernero at 2017 ASCO Annual Meeting
52 CEA-TCB is the first T-cell bispecific antibody with a novel <br />2-to-1 format, optimized for efficacy and safety Presented By Josep Tabernero at 2017 ASCO Annual Meeting
53 Design of ongoing Phase I studiesa Presented By Josep Tabernero at 2017 ASCO Annual Meeting
54 Patient characteristics: heavily pre-treated mcrc, majority 3L+ MSS Presented By Josep Tabernero at 2017 ASCO Annual Meeting
55 Safety profile of CEA-TCB was manageable as monotherapy and <br />in combination with atezolizumab Presented By Josep Tabernero at 2017 ASCO Annual Meeting
56 CEA-TCB at doses of 60 mga demonstrated clinical activity in mcrc as monotherapy and in combination with atezolizumab Presented By Josep Tabernero at 2017 ASCO Annual Meeting
57 CEA-TCB + atezolizumab demonstrated promising clinical activity in mcrc Presented By Josep Tabernero at 2017 ASCO Annual Meeting
58 CEA-TCB at doses 60 mg + atezolizumab demonstrated promising clinical activity in 3L+ patients with MSS mcrc Presented By Josep Tabernero at 2017 ASCO Annual Meeting
59 Conclusions Presented By Josep Tabernero at 2017 ASCO Annual Meeting
60 Durable remissions with BCMA specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
61 Slide 17 Presented By Mario Sznol at 2017 ASCO Annual Meeting
62 Slide 5 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
63 Slide 10 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
64 Slide 12 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
65 Slide 13 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
66 Slide 16 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
67 Slide 17 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
68 Slide 18 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting
69 Slide 21 Presented By Cassian Yee at 2017 ASCO Annual Meeting
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