Urologische Tumoren. Frans Erdkamp Zuyderland
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1 Urologische Tumoren Frans Erdkamp Zuyderland
2 Disclosure ASCO 2017 travelgrant Pfizer Steering committee Pfizer
3 Onderwerpen Niercelcarcinoom Urotheelcelcarcinoom Prostaatcarcinoom
4 Niercelcarcinoom Adjuvant studies Risk score Immuno studie: Imotion 150
5 Reported TKI Adjuvant Trials Presented By Daniel Heng at 2017 ASCO Annual Meeting
6 PROTECT OS in ITT800mg and ITTAll Presented By Daniel Heng at 2017 ASCO Annual Meeting
7 Awaited Adjuvant Trials in Targeted Therapy Era Presented By Daniel Heng at 2017 ASCO Annual Meeting
8 Slide 14 Presented By Daniel Heng at 2017 ASCO Annual Meeting
9 Recurrence scores helpful only if there is adjuvant therapy Presented By Daniel Heng at 2017 ASCO Annual Meeting
10 Primary Objective: Prognostic Value<br />Association of RS with TTR in placebo arm Presented By Daniel Heng at 2017 ASCO Annual Meeting
11 Primary Objective: Predictive Value<br />Association of RS with TTR in placebo vs sunitinib<br /> Presented By Daniel Heng at 2017 ASCO Annual Meeting
12 16 Gene Recurrence Score (RS) Presented By Daniel Heng at 2017 ASCO Annual Meeting
13 Slide 24 Presented By Daniel Heng at 2017 ASCO Annual Meeting
14 Selected Adjuvant Immunoncology Trials Presented By Daniel Heng at 2017 ASCO Annual Meeting
15 Conclusions Presented By Daniel Heng at 2017 ASCO Annual Meeting
16 IMmotion150 (Phase II) Trial Design Presented By Michael Atkins at 2017 ASCO Annual Meeting
17 Shifting the Balance Toward Anti-Cancer Immunity <br />With Combined VEGF/PD-L1 Blockade Presented By Michael Atkins at 2017 ASCO Annual Meeting
18 1L Progression-Free Survival<br />ITT Presented By Michael Atkins at 2017 ASCO Annual Meeting
19 1L Progression-Free Survival<br /> 1% of IC Expressing PD-L1 Presented By Michael Atkins at 2017 ASCO Annual Meeting
20 Crossover Progression-Free Survival by 1L <br />Response Status Presented By Michael Atkins at 2017 ASCO Annual Meeting
21 Conclusions Presented By Michael Atkins at 2017 ASCO Annual Meeting
22 Urotheelcelcacinoom Relatief weinig echt nieuws Immuun studies
23 Metastatic urothelial carcinoma Presented By Jonathan Rosenberg at 2017 ASCO Annual Meeting
24 Abstract 4501: Survival analysis from phase 3, open-label study of pembrolizumab versus chemotherapy in advanced UC Presented By Jonathan Rosenberg at 2017 ASCO Annual Meeting
25 KEYNOTE-052 (NCT ): First-Line Pembrolizumab for Cisplatin-Ineligible Advanced Urothelial Cancer<br /> Presented By Peter O''Donnell at 2017 ASCO Annual Meeting
26 Confirmed Objective Response Rate: Validation Set Presented By Peter O''Donnell at 2017 ASCO Annual Meeting
27 Advanced Bladder Cancer Treatment Algorithm: June 2017 Presented By Jonathan Rosenberg at 2017 ASCO Annual Meeting
28 Prostaatcarcinoom Fase 2 studie Enza vs Abi laat geen verschil zien Doorgaan met Enza bij start Abi bij progressieve ziekte heeft geen toegevoegde waarde: PLATO studie Echter wat als Radium of docetaxel toevoegen? Duur ADT bij hoog risico patienten Risk score Stampede en Lattidu studies
29 Duration of Androgen Deprivation Therapy in High Risk Prostate Cancer:<br />Final Results of a Randomized Phase III Trial Presented By Abdenour Nabid at 2017 ASCO Annual Meeting
30 Slide 3 Presented By Abdenour Nabid at 2017 ASCO Annual Meeting
31 Randomization 10/2000 to 01/2008 Presented By Abdenour Nabid at 2017 ASCO Annual Meeting
32 Slide 10 Presented By Abdenour Nabid at 2017 ASCO Annual Meeting
33 Slide 4 Presented By Robert Bristow at 2017 ASCO Annual Meeting
34 Risk score verlaagt in 30% de risk groep Presented By Robert Bristow at 2017 ASCO Annual Meeting
35 Lattitude en Stampede studies OS DFS PCSM Time to radiographic progression Time to PSA rise
36 Lattitude OS Presented By Eric Small at 2017 ASCO Annual Meeting
37 Subsequent life-prolonging therapy for prostate cancer Presented By Eric Small at 2017 ASCO Annual Meeting
38 Slide 13 Presented By Eric Small at 2017 ASCO Annual Meeting
39 Slide 15 Presented By Eric Small at 2017 ASCO Annual Meeting
40 Comparing CHAARTED High Volume Patients and LATITUDE Patients Presented By Eric Small at 2017 ASCO Annual Meeting
41 Comparing LATITUDE and CHAARTED Patients Presented By Eric Small at 2017 ASCO Annual Meeting
42 Comparing Overall Survival Across Studies Presented By Eric Small at 2017 ASCO Annual Meeting
43 Slide 20 Presented By Eric Small at 2017 ASCO Annual Meeting
44 Slide 21 Presented By Eric Small at 2017 ASCO Annual Meeting
45 Slide 22 Presented By Eric Small at 2017 ASCO Annual Meeting
46 CONCLUSIONS: Comparing LATITUDE and CHAARTED Presented By Eric Small at 2017 ASCO Annual Meeting
47 Slide 26 Presented By Eric Small at 2017 ASCO Annual Meeting
48 Comparing Overall Survival Across Studies Presented By Eric Small at 2017 ASCO Annual Meeting
49 Unanswered Questions: Efficacy Presented By Eric Small at 2017 ASCO Annual Meeting
50 Implications: While there is much to celebrate Presented By Eric Small at 2017 ASCO Annual Meeting
51 Slide 36 Presented By Eric Small at 2017 ASCO Annual Meeting
52 Take Homes from Latitude Presented By Eric Small at 2017 ASCO Annual Meeting
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