COLONIC DISEASES PROBLEMS AND PROGRESS

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THE EUROPEAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION (ESPGHAN) THE DEPARTMENT OF PEDIATRICS & THE EUROPEAN LABORATORY FOR THE INVESTIGATION OF FOOD INDUCED DISEASES, UNIVERSITY

The third Capri meeting will focus on the colon.

The meeting will attempt to bring scientists and clinicians together to discuss a somewhat-neglected organ an organ that has been well-studied by researchers but whose disorders are not often

The meeting s aim is to encourage better diagnosis and treatment of patients with colonic diseases.

1 THE EUROPEAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION (ESPGHAN) THE DEPARTMENT OF PEDIATRICS & THE EUROPEAN LABORATORY FOR THE INVESTIGATION OF FOOD INDUCED DISEASES, UNIVERSITY FEDERICO II, NAPLES, ITALY in association with THE ANEMGI ONLUS Associazione per la NeUroGastroenterologia e la Motilità Gastrointestinale Announce the THIRD ESPGHAN CAPRI MEETING COLONIC DISEASES The third Capri meeting will focus on the colon. The colon is a complex and multifunctional organ as well as the cause and the target of both functional and organic disorders that require an increased need of medical resources. The meeting will attempt to bring scientists and clinicians together to discuss a somewhat-neglected organ an organ that has been well-studied by researchers but whose disorders are not often discussed. Speakers are asked to prepare discussions on their research that are tailored to an audience primarily made up of clinicians. The meeting s aim is to encourage better diagnosis and treatment of patients with colonic diseases. Congenital abnormalities, motility disorders, colonic inflammatory diseases, features of colonic infection and inhabitation, and new approaches to evaluating the colon, including evaluation in the pre- and postoperative settings will be discussed along with other current topics. International Scientific Committee Salvatore Auricchio (ITALY) David Branski (ISRAEL) Enrico Corazziari (ITALY) Alfredo Guarino (ITALY) Olivier Goulet (FRANCE) Deirdre Kelly (UK) Carlo Di Lorenzo (USA) Michael J Lentze (GERMANY) Peter J Milla (UK) Annamaria Staiano (ITALY) Riccardo Troncone (ITALY) Local Scientific Committee R Auricchio, R Buonavolontà, P Coccorullo, E Miele Scientific Secretariat A Guarino, A Staiano, R Troncone - University Federico II Via S. Pansini, Naples Tel Fax April 2-4, 2009 Grand Hotel Quisisana Capri (Naples), Italy Organizing Secretariat MESSAGGI International srl Tel Fax info@messagginternational.org Website: For additional information p.t.o.

COLONIC DISEASES PROPOSED FACULTY S Auricchio University Federico II, Naples, Italy F Bäckhed Wallenberg Laboratory Sahlgrenska University Hospital, Göteborg, Sweden G Barbara Department of Internal

Gastroenterology and Nutrition Emma Children s Hospital, Academic Medical Center Amsterdam, The Netherlands D Branski Hadassah Medical Organization, Jerusalem, Israel M Camilleri Gastroenterology

2 COLONIC DISEASES PROPOSED FACULTY S Auricchio University Federico II, Naples, Italy F Bäckhed Wallenberg Laboratory Sahlgrenska University Hospital, Göteborg, Sweden G Barbara Department of Internal Medicine and Gastroenterology University of Bologna, Bologna, Italy J Barnard Children s Hospital of Columbus The Ohio State University, Columbus, Ohio, USA M Benninga Department of Pediatric Gastroenterology and Nutrition Emma Children s Hospital, Academic Medical Center Amsterdam, The Netherlands D Branski Hadassah Medical Organization, Jerusalem, Israel M Camilleri Gastroenterology Research Unit Mayo Foundation, Rochester, Minnesota, USA M Cohen Cincinnati Children s Hospital Cincinnati, Ohio, USA E Corazziari Department of Clinical Science University La Sapienza, Rome, Italy S Cucchiara Pediatric Gastroenterology & Liver Unit University La Sapienza, Rome, Italy C Di Lorenzo Children s Hospital of Columbus The Ohio State University, Columbus, Ohio, USA O Goulet Service de Gastroenterologie et Nutrition Hopital Necker - Enfants Malades, Paris, France A Guarino University Federico II, Naples, Italy DW Hommes Department of Gastroenterology LUMC-Leiden University Medical Center Leiden, The Netherlands D Kelly The Liver Unit Birmingham Children s Hospital NHS Trust Birmingham, UK MJ Lentze Zentrum fuer Kinderheilkude Bonn, Germany TT Mc Donald Centre for Infectious Diseases Institute of Cell and Molecular Science Queen Mary s School of Medicine and Dentistry London, UK EA Mayer Center for Neurovisceral Sciences & Women s Health Division of Digestive Diseases David Geffen School of Medicine at UCLA Los Angeles, CA, USA PJ Milla Gastroenterology and Nutrition Institute of Child Health, London, UK RJ Rintala Children s Hospital, University of Helsinki Helsinki, Finland F Ruemmele Service de Gastroenterologie et Nutrition Hopital Necker - Enfants Malades, Paris, France R Shamir Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children s Medical Center of Israel Tel-Aviv University, Tel-Aviv, Israel A Staiano University Federico II, Naples, Italy N Thapar Gastroenterology and Nutrition Institute of Child Health, London, UK R Troncone University Federico II, Naples, Italy BW Warner Division of Pediatric Surgery St. Louis Children s Hospital St. Louis, Missouri, USA

Preliminary Programme COLONIC DISEASES Thursday, April 2, 2009 Friday, April 3, 2009 16.00-19.00 REGISTRATION 17.00-17.

3 Preliminary Programme COLONIC DISEASES Thursday, April 2, 2009 Friday, April 3, REGISTRATION Introductory Lecture Advances in understanding of colonic function: a mysterious organ no more? PJ Milla (London, UK) Satellite Symposium THE RAY CLOUSE LECTURES Evolving concepts on the pathogenesis of IBS: to treat the brain? EA Mayer (Los Angeles, USA) to treat the gut? M Camilleri (Rochester, USA) WELCOME RECEPTION AT THE GRAND HOTEL QUISISANA Session III THE PRE-OPERATIVE AND POST-OPERATIVE COLON The colon in short bowel syndrome and transplantation O Goulet (Paris, France) Short and long term complications of colectomy BW Warner (St Louis, USA) Coffee Break Colon polyps surveillance in children: following the new guidelines J Barnard (Columbus, USA) Congenital anorectal malformations: anything new? RJ Rintala (Helsinki, Finland) Friday, April 3, REGISTRATION WELCOME ADDRESSES Friday, April 3, 2009 Session I ADVANCES IN COLONIC INFLAMMATORY DISEASES Mechanisms of colonic inflammation TT McDonald (London, UK) Bacterial mucosa cross talk and pathophysiology of inflammation F Ruemmele (Paris, France) Risk and benefits of biologic therapy for IBD D Hommes (Amsterdam, The Netherlands) Intestinal mucus barrier in normal and inflamed colon E Corazziari (Rome, Italy) Coffee Break Friday, April 3, 2009 Session II COLONIC INHABITATION AND INFECTION: THE MICROFLORA IN HEALTH AND DISEASE Changes in intestinal microflora in the obese child: cause or consequence? F Backhed (Goteborg, Sweden) The colon in acute gastroenteritis A Guarino (Naples, Italy) Management dilemmas in Clostridium difficile infections M Cohen (Cincinnati, USA) ABSTRACT PRESENTATIONS Lunch Saturday, April 4, 2009 morning Session V NEUROGASTROENTEROLOGY AND THE COLON New frontiers in the treatment of Hirschsprung s disease N Thapar (London, UK) The pathologic basis of postinfectious IBS and options for prevention G Barbara (Bologna, Italy) Fecal incontinence in children: it is not always constipation! M Benninga (Amsterdam, The Netherland) Coffee Break Friday, April 3, 2009 Session IV NUTRITION AND THE COLON Nutritional challenge in pseudo-obstruction: the bridge between motility and nutrition S Cucchiara (Rome, Italy) Nutritional problems in patients with IBD R Shamir (Tel-Aviv, Israel) The colon in food allergy R Troncone (Naples, Italy) Pharmacotherapy for functional gastrointestinal disorders in children C Di Lorenzo (Columbus, USA) Novel and alternative therapies for childhood constipation A Staiano (Naples, Italy) ABSTRACT PRESENTATIONS

4 ABSTRACTS SCIENTIFIC SECRETARIAT SYMPOSIUM VENUE Selected abstracts will be presented as oral communications. Abstracts must be written in English. Selected abstracts will be published in an international pediatric journal. The Abstracts must be submitted electronically. A. Guarino, A. Staiano and R. Troncone University Federico II Via S. Pansini, Naples (Italy) Tel Fax Grand Hotel Quisisana Via Camerelle, Capri, Naples (Italy) Tel Fax REGISTRATION Registration deadline is September 30, 2008 The registration fee will cover costs for scientific sessions, welcome reception in April 2, 2009, congress kit, coffee breaks, working lunch on April 3, 2009, certificate of attendance, certificate of CME Credits for Italian participants. Registration for active participant is 480,00 VAT 20% included From October 1, 2008 to February 28, 2009 the cost for active participant is 600,00 VAT 20% included From March 1, 2009 the cost for active participant is 750,00 VAT 20% included Accepted Abstract fee is 480,00 VAT 20% included Registration by form enclosed to send completed by fax by form on line Payment by bank transfer (see details on the registration form) by credit card on line CANCELLATION Reimbursement of 50% of registration fees will be made 60 days after the meeting, if cancellation is received before December 31, No refunds after this date. ACCOMMODATION Accommodation request must be addressed to TRIAL TRAVEL srl Via Parroco Canale, Capri, Naples (Italy) Tel Fax gina@trialtravel.com PASSPORT, VISAS Check with the closest Italian Consulate or Embassy and your travel agent regarding appropriate documents for entry into Italy. REGISTRATION WITHOUT PAYMENT WILL BE NOT ACCEPTED SOCIAL PROGRAM Welcome cocktail and reception Dinner OFFICIAL LANGUAGE English is the official language of the congress. Simultaneous translation into Italian language will be provided. DINNER The Dinner will take place at the Grand Hotel Quisisana on Friday, April 3, Price 120,00 (VAT 20% included), for active participant and accompanying persons wishing to participate should be paid to the Organizing Secretariat by bank transfer or credit card on line. For registration and payment see Registration Form enclosed Form on line EXHIBITS Exhibitor stands of Pharmaceutical, Biomedical and Publishing Companies will be present. CERTIFICATE OF ATTENDANCE At the end of the Meeting, registered participants will receive an Attendance Certificate available at the Secretariat. ACCREDITATION - CME CREDITS CME Credits for Italian Medical Doctors ORGANIZING SECRETARIAT Please address any request for information to MESSAGGI International srl Tel Fax info@messagginternational.org For updating information

5 COLONIC DISEASES FORM FOR REGISTRATION Please type or print in block and return this form before September 30, 2008 by fax to MESSAGGI International srl Fax preferably please use the on line registration form Active Participant name Family Name REGISTRATION FEES (please check the appropriate item) Active Participant Before September 30, ,00 by Bank Transfer or by Credit Card on line (VAT 20% included) From October 1, 2008 to February 28, ,00 by Bank Transfer or by Credit Card on line (VAT 20% included) From March 1, ,00 by Bank Transfer or by Credit Card on line (VAT 20% included) Accepted Abstract fee by Bank Transfer or by Credit Card on line Given Name Title Date of birth VAT No FISCAL CODE PRIVATE ADDRESS (Absolutely necessary for all participants) Address (private) Postcode/Zip City Country State Phone Fax Portable INSTITUTION ADDRESS Department Hospital/University/Institution Address (institution) Postcode/Zip City Country State Phone Fax Portable INVOICE DETAILS (Absolutely necessary for Italian participants) Name Address Postcode/Zip City Country State Phone Fax Portable VAT No. Fiscal Code I authorize MESSAGGI International srl for the general treatment of my personal datas (see reference Italian Law No. 675, 31/12/1996). Date Capri NA (Italy), April 2-4, Grand Hotel Quisisana - Via Camerelle, Capri - Tel Signature 480,00 (VAT 20% included) Active Participant registration fee includes: welcome reception on April 2, 2009, participation to the scientific sessions, congress kit, coffee breaks, working lunch on April 3, 2009, certificate of attendance, certificate of CME Credits for Italian participants. Dinner on Friday evening April 3, ,00 not included in the registration fees (VAT 20% included) PAYMENT by (please check the appropriate item) TOTAL AMOUNT PAID BANK TRANSFER payable to MESSAGGI International srl - Fiscal code and VAT number Bank Credito Artigiano SpA, Agenzia 22 di Milano, Italy account n CAB ABI CIN W IBAN IT 92 W BIC SWIFT ARTI IT M 2 CREDIT CARDS on line see information REGISTRATION WITHOUT PAYMENT WILL BE NOT ACCEPTED

6 Please fill in this form and send it to the Organizing Secretariat MESSAGGI International srl by Fax or preferably please use the registration form on line

7 Deadline: December 20, If successful your abstract will be printed in an International Journal to be available to delegates attending the Meeting. Authors will be notified if their abstracts have been accepted by January 20, NOD MICE ON A GLUTEN-CONTAINING DIET SHOW HIGHER INCIDENCE OF DIABETES AND SIGNS OF SMALL INTESTINAL ENTEROPATHY F. Maurano 1, G. Mazzarella 1, R. Stefanile 1, R. D Arienzo 1, D. Luongo 1, S.Auricchio 2, R.Troncone 2, M.Rossi 1 1 Institute of Food Science and Technology, CNR, Avellino, Italy, 2 Dept Paediatrics and ELFID, University Federico II, Naples, Italy. Background. Several evidence suggest that the mucosal immune response plays a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Methods. 3- to 4-week-old female NOD mice were maintained under strict pathogen-free conditions on a standard diet (SD) or on a gluten-free diet (GFD). Small intestine intraepithelial lymphocyte (IEL) density and villus and crypt length were assessed; the MHC class II expression was also evaluated by immunohistochemistry, as well as the message for proinflammatory cytokines by semiquantitative. Results: The GFD group developed diabetes significantly later than the SD group: after 43 weeks diabetes incidence was 95% (n= 22) in SD mice compared to 67% (n=23) in GFD mice (P< 0.05). A decreased villous length ( vs ; P< 0.001), and higher IEL number ( vs ; P< 0.001) were also detected in the SD group. Only in the latter group epithelial expression of MHC class II molecules was present, as well as the message for gamma-interferon is more strong. Conclusions. Signs of intestinal inflammation are present in NOD mice, apparently related to the presence of gluten in their diet. In NOD mice an abnormal mucosal immune response to gluten may contribute to the pathogenesis of IDDM. Principal Author s Name Title: Mr/Mrs/Dr/Prof/Ms/Miss Family Name Institution Address City Country Telephone including country code THIRD ESPGHAN CAPRI MEETING COLONIC DISEASES April 2-4, 2009 Grand Hotel Quisisana Capri (Naples), Italy Abstract Form TO BE SUBMITTED ELECTRONICALLY EXAMPLE Given Name Postcode/Zip State Fax including country code Important (For office use) The principal author affirms that the material here in: 1) will not have been published as an article by December 20, 2008 or have been presented at a national meeting of a national society, or abroad at a major foreign or international meeting; 2) that if human subjects were exposed to risks not required by their medical needs, the study was approved by an appropriate committee or, if no such committee was available and informed consent was needed, it was obtained in accordance with the principles enunciated in The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research, U.S. Government Printing Office: :3205, or 3) any animal studies conform with the Guiding Principle in the Care and Use of Animals of the American Physiological Society. Agreed of Principal Authors Instructions for authors THEABSTRACT MUST BE SUBMITTED ELECTRONICALLY 1. Abstract must be in English. 2. Deadline: December 20, Typed (arial 12 point with single line spacing - do not use a smaller font), can only be sent electronically by using the abstract template. The Abstract is not to exceed 250 words. 4. Leave no top or left margins within the rectangle. Short abstracts should NOT be centered in the typing space. 5. CAPITALIZE the entire TITLE. Begin underlined authors names on a new line. Initials or names precede last name. Institutional name and location are required. 6. Begin body of abstract on a new line. 7. The title should be as brief as possible but long enough to indicate clearly the nature of the study. Omit degrees and titles of authors. Specify name and location of institution where the work was done. 8. The body of the abstract should be organized as follows a. A sentence stating the purpose of the study, unless stated in the title. b. A brief statement of methods, if pertinent. c. A summary of the results obtained. d. A statement of conclusions reached. It is not satisfactory to state that The results will be discussed. 9. Abbreviations. Avoid abbreviations in the title. Avoid excessive abbreviation in the body of the text. 10. Attachments, slides or any reference materials cannot be submitted with the abstract. 11. Nonproprietary (generic) names of drugs should be given when a drug is first mentioned. Capitalize the first letter of proprietary drugs. 12. It is the author s responsibility to submit a correct abstract; any errors in spelling, grammar or scientific fact may be reproduced as typed by the author. 13. Selected Abstracts will be published in an International Journal. Once the abstract has been checked and is ready for submission it must be sent to staiano@unina.it Any queries with reference to the abstract please direct to A. Staiano M.D. at the address staiano@unina.it or telephone

COLONIC DISEASES Capri NA (Italy), April 2nd - 4th, 2009 - Grand Hotel Quisisana - Via Camerelle, 2-80073 Capri - Tel.

8 COLONIC DISEASES Capri NA (Italy), April 2nd - 4th, Grand Hotel Quisisana - Via Camerelle, Capri - Tel Please fill in this form and send it to: HOTEL ACCOMMODATION Form Trial Travel srl Via Parroco Canale, Capri, NA (Italy) Tel Fax gina@trialtravel.com Deadline: February 16th, 2009 Family Name... Name... Name of Institution... Street... Postal Code and City... Phone... Please book n...rooms/s Country... Fax Hotel L Hotel Hotel Hotel Hotel double double single use Min./Max. Min./Max CAPRI L 290,00-490,00 270,00-490,00 ANACAPRI 200,00-275,00 160,00-275,00 150,00-210,00 140,00-170,00 120,00-140,00 100,00-120,00 150,00-170,00 130,00-150,00 Lodging in the hotels will be done according to the avaibility of the hotel chosen; this will be done keeping in mind the order in which the requests are received as well as respecting the category chosen where possible. The daily rates are in Euro for Bed and breakfast and include Vat. Arrival Date... Departure Date... Accommodation procedure payment: The accommodation form must be filled out including a credit card number and expiring date or a bank cheque in favour of Trial Travel srl and sent before February 16th, To avoid a penalty, cancellation must reach us before March 1st, Type of Credit Card...Number...Exp. date... Date... Signature...

9 Please fill in this form and send it to Trial Travel srl Via Parroco Canale, Capri, NA (Italy)

COLONIC DISEASES PROBLEMS AND PROGRESS

COLONIC DISEASES PROBLEMS AND PROGRESS THE EUROPEAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION (ESPGHAN) THE DEPARTMENT OF PEDIATRICS & THE EUROPEAN LABORATORY FOR THE INVESTIGATION OF FOOD INDUCED DISEASES, UNIVERSITY FEDERICO