Matthew Michael Churpek, MD, MPH, PhD Curriculum Vitae

Transcription

1 The University of Chicago Department of Medicine Section of Critical Care Medicine 5841 South Maryland Avenue MC 6076, M656 Chicago, IL Office: Fax: Matthew Michael Churpek, MD, MPH, PhD Curriculum Vitae ACADEMIC APPOINTMENTS AND EMPLOYMENT 1999 Researcher, Chester Summer Scholars Program, MetroHealth Medical Center, Cleveland, OH 2000 Researcher, National Science Foundation Summer Program, University of Notre Dame 2009 Chief Resident, Internal Medicine Residency Program, University of Chicago Instructor of Medicine, Section of Pulmonary and Critical Care, University of Chicago Medicine 2014 Assistant Professor of Medicine, Section of Pulmonary and Critical Care, University of Chicago Medicine ACADEMIC TRAINING B.A., Biochemistry. Ohio Wesleyan University, Delaware, OH M.D. Duke University School of Medicine, Durham, NC M.P.H. University of North Carolina at Chapel Hill, Chapel Hill, NC Internal Medicine Residency, University of Chicago Medicine, Chicago, IL Pulmonary and Critical Care Fellowship, University of Chicago Medicine, Chicago, IL Ph.D., Epidemiology. Department of Health Studies, University of Chicago, Chicago, IL LICENSING AND BOARD CERTIFICATION Internal Medicine Board Certified 8/2008 Pulmonary Disease Board Certified 10/2013 Critical Care Medicine Board Certified 11/2014 Illinois Medical License Illinois Controlled Substances License ACLS Certified PROFESSIONAL SOCIETIES American Thoracic Society American College of Chest Physicians American Heart Association Society of Critical Care Medicine HONORS, PRIZES, AND AWARDS Ohio Wesleyan University Presidential Scholar

2 Page The Timken Company Scholarship 1998 Phi Eta Sigma Honors Society 2000 NCAA Academic All-American, Outdoor Track and Field 2001 NCAA Academic All American, Outdoor Track and Field 2001 Summa Cum Laude, Ohio Wesleyan University 2001 Phi Beta Kappa Honors Society 2001 Chi Gamma Nu Honors Society (Chemistry) 2001 NCAA Post-Graduate Scholarship 2009 Quality Fair Poster Award Winner, Rapid Response Team Implementation Correlates with a Decrease in Cardiac Arrests on the Wards, University of Chicago 2012 American Thoracic Society International Meeting Travel Award 2012 CHEST annual meeting Young Investigator Award 2014 Department of Medicine Research Day: Best Clinical Research Award, Delayed Intensive Care Unit Transfer Is Associated With Increased Mortality In Ward Patients, University of Chicago 2014 The American Society for Clinical Investigation Young Physician-Scientist Award 2014 American Heart Association Young Investigator Award 2015 ATS Foundation Recognition Award for Early Career Investigators SCHOLARSHIP Peer-reviewed publications with original research 1. El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR. Use of serial analysis of gene expression to generate kidney expression libraries. Am J Physiol Renal Physiol Aug; 279(2):F PMID: Churpek MM, Yuen TC, Park SY, Hall JB, Edelson DP. Predicting cardiac arrest on the wards: a nested case-control study. Chest May;141(5): PMID: Churpek MM, Yuen TC, Park SY, Meltzer DO, Hall JB, Edelson DP. Derivation of a cardiac arrest prediction model using ward vital signs. Crit Care Med Jul;40(7): PMID: Churpek MM, Yuen TC, Edelson DP. Predicting clinical deterioration in the hospital: the impact of outcome selection. Resuscitation May;84(5): PMID: Churpek MM, Yuen TC, Edelson DP. Risk stratification of hospitalized patients on the wards. Chest Jun 1;143(6): PMID: Yoder JC, Yuen TC, Churpek MM, Arora VM, Edelson DP. A Prospective Study of Nighttime Vital Sign Monitoring Frequency and Risk of Clinical Deterioration. JAMA Intern Med Sep 9;173(16): PMID: Churpek MM, Yuen TC, Park SY, Gibbons RD, Edelson DP. Using electronic health record data to develop and validate a prediction model for adverse outcomes on the wards. Crit Care Med Apr;42(4): PMID: Town JA, Churpek MM, Yuen TC, Huber MT, Edelson DP. Relationship between ICU bed availability, ICU readmission, and cardiac arrest on the general wards. Crit Care Med Sep;42(9): PMID: Churpek MM, Yuen TC, Winslow C, Robicsek AA, Meltzer DO, Gibbons RD, Edelson DP. Multicenter Development and Validation of a Risk Stratification Tool for Ward Patients. Am J Respir Crit Care Med. Am J Respir Crit Care Med Sep 15;190(6): PMID:

3 Page Cao H, Churpek MM, Zeng Z, Fine JP. Analysis of the Proportional Hazards Model with Sparse Longitudinal Covariates. J Am Stat Assoc. 2015;110(511): PMID: Churpek JE, Walsh T, Zheng Y, Moton Z, Thornton AM, Lee MK, Casadei S, Watts A, Neistadt B, Churpek MM, Huo D, Zvosec C, Liu F, Niu Q, Marquez R, Zhang J, Fackenthal J, King MC, Olopade OI. Inherited predisposition to breast cancer among African American women. Breast Cancer Res Treat Jan;149(1):31-9. PMID: Patel AR, Zadravecz FJ, Young RS, Williams MV, Churpek MM, Edelson DP. The Value of Clinical Judgment in Detection of Clinical Deterioration. JAMA Intern Med Mar;175(3): PMID: Razi R, Churpek MM, Yuen TC, Peek ME, Fisher T, Edelson DP. Racial disparities in outcomes following PEA and asystole in-hospital cardiac arrests. Resuscitation Feb;87:69-74 PMID: Shah T, Churpek MM, Perraillon MC, Konetzka RT. Understanding Why COPD Patients Get Readmitted: A Large National Study to Delineate the Medicare Population for the Upcoming Readmissions Penalty Expansion. Chest May;147(5): PMID: Churpek MM, Yuen TC, Winslow C, Hall JH, Edelson DP. Differences in vital signs between elderly and non-elderly patients prior to ward cardiac arrest. Crit Care Med Apr;43(4): PMID: Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek, MM. Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards. J Hosp Med Sep;10(9): PMID: Zadravecz FJ, Tien L, Robertson-Dick BJ, Yuen TC, Twu NM, Churpek MM, Edelson DP. Comparison of mental-status scales for predicting mortality on the general wards. J Hosp Med Oct;10(10): PMID: Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RA. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer Jan 15;122(2): PMID: Churpek MM, Zadravecz FJ, Winslow C, Howell M, Edelson DP. Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med Oct 15;192(8): PMID: Churpek MM, Winslow CJ, Meltzer DO, Kattan M, Edelson DP. Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards. Crit Care Med Feb;44(2): PMID: Churpek MM, Adhikari R, Edelson DP. The value of vital sign trends for detecting clinical deterioration on the wards. Resuscitation May;102:1-5. PMID: Churpek MM, Wendlandt B, Zadravecz FJ, Adhikari R, Winslow C, Edelson DP. Association between intensive care unit transfer delay and hospital mortality: A multicenter investigation. J Hosp Med Jun 28. PMID: Hamilton DE, Press VG, Twu NM, Yuen TC, Azu CN, Churpek MM, Edelson DP. Testing the functional assessment of mentation: A mobile application based assessment of mental status. J Hosp Med Jul;11(7): PMID: Kang MA, Churpek MM, Zadravecz FJ, Adhikari R, Twu NM, Edelson DP. Real- Time Risk Prediction on the Wards: A Feasibility Study. Crit Care Med Aug;44(8): PMID:

4 Page Greenberg JA, David MZ, Churpek MM, Pitrak DL, Hall JB, Kress JP. Sequential Organ Failure Assessment Score Modified for Recent Infection in Patients With Hematologic Malignant Tumors and Severe Sepsis. Am J Crit Care Sep;25(5): PMID: Koyner JL, Adhikari R, Edelson DP, Churpek MM. Development of a Multicenter Ward Based AKI Prediction Model. Clin J Am Soc Nephrol Sep 15. pii: CJN [Epub ahead of print] PMID: Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP. qsofa, SIRS, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the ICU. Am J Respir Crit Care Med Sep 20. [Epub ahead of print] PMID: Kipnis P, Turk BJ, Wulf DA, Carlos LaGuardia J, XLiu V, Churpek MM, Romero- Brufau S, Escobar GJ. Development and validation of an electronic medical record-based alert score for detection of inpatient deterioration outside the ICU. J Biomed Inform Sep 19. pii: S (16) doi: /j.jbi [Epub ahead of print] PMID: Perman SM, Stanton E, Soar J, Berg RA, Donnino MW, Mikkelsen ME, Edelson DP, Churpek MM, Yang L, Merchant RM; American Heart Association's Get With the Guidelines Resuscitation (formerly the National Registry of Cardiopulmonary Resuscitation) Investigators. Location of In-Hospital Cardiac Arrest in the United States-Variability in Event Rate and Outcomes. J Am Heart Assoc Sep 29;5(10). PMID: Bhattacharjee P, Churpek MM, Snyder A, Howell MD, Edelson DP. Detecting Sepsis: Are Two Opinions Better Than One? J Hosp Med. In press. 31. Churpek MM, Edelson DP. Moving Beyond Single-Parameter Early Warning Scores for Rapid Response System Activation. Crit Care Med Dec;44(12): PMID: Volchenboum SL, Mayampurath A, Göksu-Gürsoy G, Edelson DP, Howell MD, Churpek MM. Association Between In-Hospital Critical Illness Events and Outcomes in Patients on the Same Ward. JAMA Dec 27;316(24): PMID: Reviews, commentaries, and editorials 1. Patterson K, McShane PJ, Churpek MM, Verhoef P. Recommended Reading from the University of Chicago Pulmonary and Critical Care Fellows. Am J Respir Crit Care Med. 2010; 182: PMCID: PMC Churpek, MM, Hall, JB. Measuring quality in the ICU: The yardstick isn t as straight as we d like. Am J Respir Crit Care Med Jan 1;185(1):3-4. PMID: Edelson, DP, Churpek, MM. Sifting through the heterogeneity of the Rapid Response Team literature. Resuscitation Dec;83(12): PMID: Churpek MM, Edelson DP. In search of the optimal rapid response system bundle. J Hosp Med. In Press. PMID: Churpek MM, Edelson DP. Moving Beyond Single Parameter Early Warning Scores For Rapid Response Team Activation. Crit Care Med. In press. 6. Bhattacharjee P, Edelson DP, Churpek MM. Identifying Patients with Sepsis on the Hospital Wards. Chest. In press. PMID: Book chapters 1. Sanchez-Pinto LN, Churpek MM. Predictive Analytics and Machine Learning in Medicine. Actionable Intelligence in HealthCare. Taylor & Francis. In press.

5 Page 5 FUNDING Current K08 HL NIH/NHLBI Churpek (PI) 1/1/14 12/31/18 Career Development Award The aims of this grant proposal are to develop and validate prediction models to detect inhospital cardiac arrest and then to perform simulation studies to determine the optimal method for implementation of the model in order to plan for future clinical trials. Role: Principal Investigator ATS Foundation Churpek (PI) 1/15/16 1/14/17 Recognition Award for Early Career Investigators The aims of this grant proposal are to compare methods of identifying high-risk patients with sepsis on the wards, and to determine which interventions are most likely to benefit these patients using data from a single center. Role: Principal Investigator Completed UL1 RR Pilot Grant Solway (PI) 8/15/11 08/15/12 Pilot and Collaborative Translational and Clinical Studies Awards The purpose of this award was to promote collaboration between the University of Chicago and NorthShore University Health Systems in order to collect a multicenter electronic health record database for future studies developing prediction models for in-hospital cardiac arrest. Role: Co-Investigator T32 HL NIH/NHLBI Solway (PI) 10/01/11 09/30/12 Fellowship Research Training Grant The purpose of the Training Program in Pulmonary and Critical Care at the University of Chicago is to provide outstanding scientific training for postdoctoral trainees in order to prepare them for careers as independent investigators in academic medicine. Role: Research post-doctoral Fellow INVITED SPEAKING 2009 Grand Rounds Speaker, Rapid response teams: The earlier the better? Department of Medicine Grand Rounds, University of Chicago, Chicago, IL Oral Presentation, Derivation of a cardiac arrest prediction model using ward vital signs. American Heart Association 2011 Annual Meeting Oral Presentation, Using Electronic Health Record Data to Develop and Validate a Prediction Model for Adverse Outcomes on the Wards. CHEST 2012 Annual Meeting Grand Rounds Speaker, Predicting cardiac arrest on the wards: Past, present, and future. St. Joseph Hospital, Chicago, IL Grand Rounds Speaker, Predicting cardiac arrest on the wards: Past, present, and future. Cleveland Clinic Foundation, Cleveland, OH Moderator of Scientific Mini-Symposium, Predictions and Outcomes in the ICU. American Thoracic Society 2014 International Conference Invited Speaker, Risk Stratification of Patients on the Wards: Past, Present and Future. American Thoracic Society 2014 International Conference Oral Presentation, Multicenter Development and Validation of a Risk Stratification Tool for Ward Patients. American Thoracic Society 2014 International Conference.

6 Page Co-Chair of Scientific Symposium, Building Bridges Not Walls: Critical Care Outside the ICU. American Thoracic Society 2014 International Conference Invited Speaker, MAPping a course for success: Should we really aim for a target? American Thoracic Society 2015 International Conference Oral Presentation, Multicenter Comparison of Conventional Regression and Machine Learning Methods for Predicting Clinical Deterioration on the Wards. American Thoracic Society 2015 International Conference Invited Speaker, Is "Big Data" the Canary in the Coal Mine? Using Electronic Health Record Data to Detect Critical Illness. American Thoracic Society 2015 International Conference Co-Chair of Scientific Symposium, Can we answer Big Questions in Critical Care with Big Data? American Thoracic Society 2015 International Conference Co-Chair of Scientific Symposium, Titrating Therapy to Prevent Iatrogenocide: When Enough is Enough. American Thoracic Society 2015 International Conference Grand Rounds Speaker, Risk Stratification of Patients on the Wards: Past, Present, and Future. University of Arizona, Tucson, AZ Grand Rounds Speaker, Using Big Data to Detect Clinical Deterioration. University of Arizona, Tucson, AZ Invited Speaker, Using Big Data to Detect Clinical Deterioration. CHEST 2015 International Conference Invited Speaker, Early Warning Systems to Predict Clinical Deterioration: Do They Work? American Thoracic Society 2016 International Conference Co-Chair of Scientific Symposium, Critical Care Meets Silicon Valley: Tech Solutions for Research and Practice. American Thoracic Society 2016 International Conference Invited Speaker, Mapping Real-Time Alerts to Identify Critical Illness. American Thoracic Society 2016 International Conference Invited Speaker (Expert panel), Using Big Data for Real-time Decision Support. ANESTHESIOLOGY 2016 Conference Invited Speaker (Featured Critical Care Network Speaker), Using Big Data to Detect Clinical Deterioration. CHEST 2016 International Conference. INVITED, ELECTED, OR APPOINTED EXTRAMURAL SERVICE Member, American Thoracic Society Annual Meeting Program Committee Member, Adult Research Task Force, American Heart Association Member, Critical Care NetWork Steering Committee, CHEST TEACHING For Graduate programs (Ph.D.): 2011 Teacher, Stata sessions for Epidemiologic Methods (HSTD 31001) For Pritzker School of Medicine (M.D.): 2011 Moderator, Clinical Pathophysiology & Therapeutics course Teacher, Introduction to Medical Evidence (MEDC 30020) For Graduate medical education (residency and clinical fellowships): Presenter, Fellows Clinical Case Conference

7 Page Moderator, Resident Clinical Case Conference 2009 Lecturer, Medicine Resident Procedure Curriculum 2009 Teacher, Medicine Resident Code Simulation Training CLINICAL 2009 General Medicine Attending Physician (2 months) Pulmonary Medicine Clinic Attending Physician (one half-day clinic per week) Procedure Service Attending Physician (2 weeks per year) ICU Attending Physician (6-8 weeks per year) COMMITTEE MEMBERSHIP Member, Infection Control Committee, Veteran Affairs Hospital, Durham, NC 2009 Member, Clinical Operations Task Force, University of Chicago 2009 Member, Cardiopulmonary Resuscitation Committee, University of Chicago Member, Dept. of Medicine Research Day Committee, University of Chicago