The evox System. A medical device to measure and train the brain evox System
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1 The A medical device to measure and train the brain
2 What Is evox? The medical device to MEASURE & TRAIN brain function. Measure clinically-proven biomarkers Objectively track treatment success Offer biofeedback treatment options Measure clinically-proven biomarkers. Identify the cause of stress-related conditions. Train the brain with personalized interventions. CONFIDENTIAL 2
3 Intended Use evox, [noun]: A medical device for physicians that enables the collection of patients electrophysiological biomarkers, which profile neurological function and provide clinical information to facilitate more informed patient management decisions. Train. Easy to use biofeedback treatment modalities Identify. Brain electrophysiology biomarkers Target. Biomarkers guide personalized interventions CONFIDENTIAL 3
4 Key Facts FDA Registered. FDA Registered Class II Medical Device. ISO Certified. ISO Certification obtained in Inc 500 Honoree. One of America s fastest growing private companies two years running. Founded in evox commercialized in Well Established. Over 300 customers in the United States. HQ in NYC. With offices in California and North Carolina. CONFIDENTIAL 4
5 evox Patients The root cause of your patients symptoms may be in the brain. evox can help you discover what the brain is hiding. CONFIDENTIAL 5
6 The evox Assessment evox collects, analyzes, and reports brain-based metrics: Brain health EEG and LORETA imaging Brain processing speed Event Related Potentials Heart and autonomic nervous system health ECG metrics Mental health neuropsychological screeners Behavior reaction time task all in less than 45 minutes. CONFIDENTIAL 6
7 EEG Database Comparison Revealing suboptimal brain function Research & Validity EEG analysis identifies sensitive biomarkers of physiological aging and memory performance 1-3. These reflect cognitive capacity and allow for early detection of mild cognitive decline 4-5. Event-Related Potentials Measuring brain processing speed ERPs reflect real-time cognitive processing abilities like decision making, organization, attention, and memory 6-7. ERP testing can reveal early risk measures of dementia 8. Power (uv) Time (ms) Heart Rate Variability Autonomic nervous system health HRV metrics are linked to anxiety & stress-related conditions 9. Low HRV predicts heart disease incidence and is correlated with cognitive impairment Sympathetic Balanced Parasympathetic 1. Dujardin K, et al. (1995) Electroencephalog Clin Neurophysiol, 96(2), Klass DW, Brenner RP. (1995) J Clin Neurophysio, 12(2), Klimesch W. (1999) Brain Res Rev, 29(2-3), Terry JR, et al. (2004) Human Brain Mapping, 23(2), Babiloni C, et al. (2006) Human Brain Mapping, 27(2), Polich J, Corey-Bloom J. (2005) Curr Alzheimer Res, 2(5), Polich J. (2007) Clin Neurophysiol, 118, Pfurtscheller G, Lopes da Silva FH (1999) Clin Neurophysiol, 110(11), p CONFIDENTIAL 7 9. Jasvant S, et. al. (2011) Psychosomatic Med, 73(6), Liao D, et. al. (1997) Amer J Epidemiol, 145, Zulli, R, et al. (2005) J American Geriatrics Society, 53, 12, Babiloni C, et al. (2006) Human Brain Mapping, 27(2),
8 evox Reports Comprehensive Report A detailed report of all assessment domains Summary Report One-page overview, great for a patient handout Memory Report Focused on assessment domains relevant for patients with memory loss NeuroRead Report 3 rd party opinion report with clinical intervention considerations How We Do It Algorithms for digital analysis and artifact removal Automated report generation, delivered within 48 hours of data collection Cloud-based data storage with HIPAA compliant web portal Quality assurance review by Evoke Neuroscience Second opinion service by NeuroRead Complementary ongoing technical support and continuing education CONFIDENTIAL 8
9 evox Biofeedback Treating the underlying problem is easy with evox Neurofeedback Surface training Neurofeedback 4D Source training Biofeedback Heart Rate Variability Easily executed by office staff Objective evox assessment helps guide individualized biofeedback Z-score based training teaches the brain to function optimally Use the most intuitive feedback stimulus, the green circle, to retrain dysregulated EEG patterns. Get started after only 2 hours of webbased product training CONFIDENTIAL 13
10 Why evox? Easy to use Easily executed by technicians and office staff Clinically valuable Assessment and treatment bundled into one system Fast In-office assessment completed in less than 45 minutes Secure Automated & secure data collection, analysis, and report generation Convenient Complementary and unlimited one-on-one, web-based training Dedicated Ongoing customer service with dedicated account management CONFIDENTIAL 15
11 evox In Your Practice Complete payment and paperwork Shipment of evox System to Client Shipment Training Web-based training for physician and key healthcare staff Technicians: How to use the evox System How to assess the web portal Physicians: How to interpret evox Reports Second opinion report reviews as needed Retraining as needed Ongoing Support CONFIDENTIAL 17
12 A Patient s Journey with evox Experience symptoms. Research symptoms online at evoxbrainmap.com Visit doctor s office. Complete the Check Your Head patient screener in waiting room Learn about evox. See evox Poster in exam room and receive About evox trifold Complete the assessment. Noninvasive, pain free, and less than 45 minutes Get the evox Report. Discuss results with physician and receive Summary Report and Report Guide trifold to take home CONFIDENTIAL 18
13 evox System Opportunity Comprehensive. One system approach to measure & train the brain Clinically Valuable. Identify and treat the underlying cause of stress-related conditions Convenient. Easy to use, in-office medical device Identify. Target. Train. CONFIDENTIAL 19
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