DEGREE (if applicable)

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1 NAME: Joseph Jasper Locascio OMB No and (Rev. 11/16 Approved Through 10/31/2018) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. (updated 02/28/2017) era COMMONS USER NAME (credential, e.g., agency login):jlocascio POSITION TITLE: Assistant Professor of Neurology EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE (if applicable) Completion Date MM/YYYY FIELD OF STUDY Loyola University, Chicago, IL B.S Psychology University of Kansas, Lawrence, KS M.A Psychology/Statistics Northwestern University, Evanston, IL Ph.D Psychology/Statistics University of Illinois at Champaign-Urbana Postdoctoral 1983 Statistics A. Personal Statement I have had a research appointment as a senior Bio-Statistician for the Alzheimer's Disease Research Center and Memory/Movement Disorders Units, Department of Neurology at Massachusetts General Hospital (MGH), Boston, since 1992, and am an Assistant Professor of Neurology at Harvard Medical School as well as a Collaborating Statistician in the Neurology Dept. at Brigham and Women s Hospital. I had a dual appointment as research statistician in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT) from 1992 to 2009 where I also taught formal data analysis courses for four years. I am a Consulting Statistician for the Harvard Catalyst Bio-Statistical Consulting Group of Harvard Medical School, and a member of the Statistical Advisory Board for the journal PLOS One (Public Library of Science). I have also taught statistics at Northwestern University (1982) and worked as a statistician in psychiatric research at the University of Chicago ( ) and Bellevue Hospital/New York University Medical Center ( ) and was Research Coordinator for the Mental Health Division of the Chicago Dept. of Health ( ). I have over 100 publications in prestigious medical, scientific, and scholarly journals, magazines, and books. B. Positions and Honors Positions and Employment Coordinator of Research and Evaluation, Mental Health Division, Chicago Dept. of Health, Chicago, IL Teacher and Teaching Assistant, Northwestern University, Evanston, IL Research Associate, Dept. of Psychiatry, University of Chicago, Pritzker School of Medicine, Illinois State Psychiatric Institute, Chicago, IL Assistant Professor and Director of Data Management and Analysis Unit, Mental Health Clinical Research Center, Dept. of Psychiatry, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH Associate Research Scientist, New York University Medical Center/Bellevue Hospital, Dept. of Psychiatry, New York, NY Instructor, Introductory Statistics Course, Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA.

2 Statistician, Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA Biostatistician, Dept. of Neurology, Massachusetts General Hospital (MGH), Boston, MA Instructor in Neurology, Faculty, Harvard Medical School Consulting Statistician for the Harvard Catalyst Statistical Consulting Group of Harvard Medical School Formal Member of Statistical Advisory Board for PLOS ONE (Public Library of Science) journal Assistant Professor of Neurology, Harvard Medical School Collaborating Biostatistician, Dept. of Neurology, Brigham and Women s Hospital. Other Experience and Professional Memberships Member, American Psychological Association Member, American Statistical Association Member, Society for Neuroscience Member, American Humanist Association Honors May, 2011: Invited by the Journal of Computational and Graphical Statistics to contribute an editorial/letter to their forum discussion on graphical methods. In 2012, I received an honorary medallion for 20+ years continued service at Massachusetts General Hospital. C. Contributions to Science 1. I have worked in medical and behavioral science research for over 35 years, primarily in Neurology, Neuroscience, Adult Biological Psychiatry, and Child Psychiatry. My role has primarily been that of a statistician, especially in consulting and working as the statistical collaborator on research projects. I have over 100 publications, some as senior or sole author, in medical/social science research journals, books, and magazines. 2. I have taught data analysis formally and informally at Northwestern University, New York University, the Dept.of Brain and Cognitive Sciences at the Massachusetts Institute of Technology, and in the Neurology Dept. at Massachusetts General Hospital. 3. I have also advanced statistical science methodology by publishing numerous data analysis methods papers and editorials. Examples are below: Locascio, J. J., Jennings, P.J., Moore, C.I., and Corkin, S. Time series analysis in the time domain and resampling methods for studies of functional magnetic resonance brain imaging. Human Brain Mapping, 1997, 5(3), Locascio, J. J. and Atri, A. An overview of longitudinal data analysis methods for neurological research. Dementia and Geriatric Cognitive Disorders Extra, Oct, 2011, Vol. 1, PMCID: PMC Locascio, Joseph J. A Statistical Suggestion. Scientific American, Letters, Vol 305, No. 6, December, 2011, pgs Locascio, Joseph J. Psychology and statistics: Readers respond to the BASP ban on p-values. Significance Magazine, June, 2015, pages I have been a member of the PLOS-ONE journal s statistical advisory board since 2013 and in that role, I review the data analysis methods of manuscripts submitted for publication, about one or two manuscripts a month. The manuscripts involve studies in many different areas of medical and behavioral science. I have to date provided detailed statistical and methodological reviews of more than 60 manuscripts.

3 5. I have also been a member of the Harvard Catalyst Biostatistics Group since 2012 and in that capacity, I have so far consulted on about 75 different research projects with substantive researchers throughout the Boston area in many fields of medicine regarding appropriate data analysis methods for their projects and often perform the data analysis for them myself or oversee it. My assistance has been acknowledged in many manuscripts and grant applications, and so far I am a co-author on two publications I worked on in my role at Harvard Catalyst: Oreskovic, N.M., Perrin,J.M., Robinson, A.I., Locascio, J.J., Blossom, J., Chen, M.,L., Winickoff, J. P., Field, A. E., Green, C., Goodman, E. Adolescents' use of the built environment for physical activity. BioMedCentral (BMC) Public Health, 2015, 15:251. Mukerji, S. S, Locascio, J.J., Misra V., Lorenz, D.R., Holman, A., Dutta, A., Penugonda, S., Wolinsky, S.M., Gabuzda, D. Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy. Clinical Infectious Diseases, 2016, in press. List of My Published Work (Includes my publications in PubMed, which is about 80% of all my career publications; excludes certain editorials and letters in science magazines and journals, essays in philosophy journals, and chapters in books.) : D. Research Support (updated by Gala Laffey, Grants Administrator 02/28/2017) ACTIVE 5P50AG (Hyman) 05/01/09-03/31/19 NIH/NIA: Core C Massachusetts Alzheimer s Disease Research Center The Data Management and Statistics Core provides the database and statistical support for research conducted in conjunction with the ADRC, including local projects and collaborative efforts with other ADCs and with national AD research initiatives. The Marshall Pilot project goal is to optimize and validate a new performance-based ADL instrument and subjective ADL scale, which tap the high level tasks that challenge seniors in daily life. 1U01NS A1 (Scherzer) 09/01/13-8/31/17 (No Cost Extension) NIH/NINDS A Next Generation of Biomarkers for Incipient Huntington Disease This study will establish a national bio-bank resource and develop bio-fluid markers useful for tracking disease processes prior to the onset of clinical symptoms. P01AG (Sperling) 07/15/15 03/31/20 NIH/NIA Impact of Amyloid on the Aging Brain, Core D The overall goals of the Program Project application are to elucidate the biological and clinical significance of amyloid deposition in clinically normal older individuals and to determine age-related functional and cognitive change in the absence of amyloid. R01AG (PI - R. Sperling/K. Johnson) 04/01/12-03/31/17 NIH/NIA Evolution of memory-related fmri activation over the course of MCI and AD

4 The major goal of this study is to develop functional MRI as a biomarker for clinical trials and longitudinal studies of disease progression in MCI and AD. Role: Co-investigator Harvard Catalyst Statistical Consulting/Analysis 10/01/13-4/30/18 CTSA Design & Biostatistics Statistical consulting and data analysis for Harvard Medical School researchers, under supervision of Rebecca Betensky, Biostatistician, Harvard Medical School. 5U01NS (Scherzer) 09/01/12-08/31/17 NIH/NINDS Biomarkers for Early Intervention in Parkinson Disease No cures exist, but the number of Parkinson's patients is expected to nearly double to 9.3 million in 2030 posing an increasing threat to public health with annual costs estimated at $10.8 billion in the US alone. We propose a specific and a general strategy to overcome two critical roadblocks that impede progress on developing disease-modifying therapeutics. Harvard Neurodiscovery Center (Hyman, Blacker) 01/01/13 06/30/17 (No Cost Extension) Clinical Innovations Core The goals of this project are to: provide investigators with state-of-the-art instrumentation for assessing clinical state, and to develop a better understanding of the heterogeneity of patient populations to better predict the rate of disease progression in the setting of clinical trials.. 1R21AG A1 (Culley) 08/01/15-04/30/17 Subcontract to BWH (Blacker Site PI) Preoperative Cognitive Screening in Elderly Surgical Patients The purpose of this work is to determine whether preoperative cognitive screening of patients over the age of 65 can be used to predictor postoperative outcomes in patients undergoing lower extremity surgical procedures. Role:Statistician CDC (Taveras/Land Co-PIs) 08/08/ /29/2018 CDC Clinical-Community Approaches to Pediatric Weight Management: MA CORD 2.0 The overall goals of this study are to implement a new clinical-community intervention, theoretically grounded in the Integrated Clinical and Community Systems of Care Model, to address obesity through optimized screening and management known to be effective in STAR, e-referrals developed by MDPH, Healthy Weight Clinics tested in MA CORD, and the YMCA s Healthy Weight and Your Child weight management program (originally known as MEND). Completed W81XWH (Scherzer) 02/15/15/-02/14/17 U.S. Army Medical Research Acquisition Activity The PD Brain Map: From Genome to Function As a trained quantitative psychologist, Dr. Locascio has particular expertise in longitudinal data analyses. Dr. Locascio assists Dr. Scherzer with statistical data analysis and interpretation, and manuscript editing.. New England School of Acupuncture (Conboy) 06/1/14-12/31/16 DOD; Subcontract to MGH Bench to Bedside: Understanding Symptom Response to Acupuncture Treatment and Designing a Successful Acupuncture Treatment Program

5 The goal of this study is to help identify whether acupuncture is an effective treatment for Gulf War Syndrome.. MJ Fox Fdn for Parkinson s Research (Growdon) 05/08/ /07/2014 Neuroimaging Markers Predict Cognitive Decline in PD $84,175 This project seeks to determine whether these cognitive impairments signal the onset of a dementing process and whether brain scans that display anatomy, measure brain energy and detect excessive deposits of a protein called amyloid that is toxic to neurons will identify those PD patients who will eventually develop dementia. Paracelsus-Elena-Klinik (Dr. Brit Mollenhauer) 1/1/ /31/2014 DeNoPa project Dr. Locascio provides statistical support for this study including measurements of proteins in cerebrospinal fluid and blood as potential biomarker for the disease state and disease rate.. W81XWH DOD NETRP(Scherzer) 5/15/13-11/14/14 The Parkinson Transcriptome Project: Roadmap to Personalized Care $245,908 The specific aims of this project are to delineate the genetic variability controlling the expression of non-coding RNAs in human brain dopamine neurons and to translate these insights into personalized biomarkers..

DEGREE (if applicable) NOTE: The Biographical Sketch may not exceed five pages. Follow the formats and instructions below.

DEGREE (if applicable) NOTE: The Biographical Sketch may not exceed five pages. Follow the formats and instructions below. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format