Mathieu E. Wimmer, Ph.D.

Transcription

1 Mathieu E. Wimmer, Ph.D. Assistant Professor Department of Psychology, Temple University 823 Weiss Hall, 1701 North 13 th Street Philadelphia PA Education Ph.D Neuroscience, University of, Philadelphia, PA B.A Biological Basis of Behavior and French, University of, Philadelphia, PA Professional Experience Assistant Professor, Department of Psychology, Temple University 2016 Research Associate, Department of Psychiatry, University of Postdoctoral Researcher, Department of Psychiatry, University of, Dr. R. Chris Pierce, advisor Graduate Studies, Neuroscience Graduate Group, University of, Dr. Ted Abel, advisor Research Technician, Department of Psychiatry, University of, Dr. Gary Aston-Jones, advisor Honors 2015 Best Poster Presentation, Society for Neuroscience Philadelphia Chapter Symposium 2011 Dorothea Jameson and Leo M. Hurvich Behavioral Neuroscience Travel Award Research Support Ongoing K01 DA039308, Mathieu E Wimmer (PI) NIH/NIDA Mechanisms underlying learning deficits caused by paternal cocaine taking Completed 2T32 DA NIDA Translational Addiction Research Fellowship Program Principal Investigators: R. Chris Pierce and Anna Rose-Childress Role: Postdoctoral Trainee. 2T32 HL NHLBI Training program in Sleep and Neurobiology training grant Principal Investigator: Allan Pack Role: Pre-doctoral Trainee. Publications Tudor JC, Davis E, Peixoto L, Wimmer ME, Van Tilborg E, Park AJ, Poplawski SG, Chung CW, Havekes R, Gatti E, Pierre P, Abel T (2016) Sleep deprivation impairs memory by attenuating mtorc1-dependent protein synthesis. Science Signaling. 9:425: ra41. PMCID PMC Schmidt HD, Mietlicki-Baase EG, Ige K, Guerio LA, Wimmer ME, Olivos DR, Reiner D, De Jonghe BC, Hayes MR (2016) Activation of glucagon-like peptide-1 receptors in the ventral tegmental area decreases the reinforcing efficacy of cocaine. Neuropsychopharmacology. 41(7): PMCID PMC White SL, Vassoler FM, Schmidt HD, Pierce RC, Wimmer ME (2015) Enhanced anxiety in male offspring of sires that self-administered cocaine. Addiction Biology. 21(4): PMCID PMC

2 Peixoto L, Risso D, Poplawski SG, Wimmer ME, Speed TP, Wood MA, Abel T (2015) How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets. Nucleic Acids Research. 18:43(16): PMCID PMC Peixoto LL, Wimmer ME, Poplawski SG, Tudor JC, Kenworthy CA, Liu S, Mizuno K, Garcia BA, Zhang NR, Giese K, Abel T (2015) Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression. BMC Genomics. Doi: / S5-S5. PMCID: PMC Poplawski SG, Schoch H, Wimmer ME, Hawk JD, Walsh JL, Giese KP, Abel T (2014) Object-location training elicits an overlapping but temporally distinct transcriptional profile from contextual fear conditioning. Neurobiology of Learning and Memory. 116: PMCID: PMC Prince T, Wimmer M, Choi J, Havekes R, Aton S, Abel T (2014) Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory. Neurobiology of Learning and Memory. 109: PMCID: PMC Wimmer M, Rising J, Galante RJ, Wyner A, Pack AI, Abel T (2013) Aging in mice reduces the ability to sustain sleep/wake states. PLoS ONE 8(12): e doi: /journal.pone PMCID: PMC Wimmer M*, Vecsey CG*, Havekes R, Park AJ, Perron IJ, Meerlo P, and Abel T (2013) Daily acclimation handling does not affect hippocampal long-term potentiation or cause chronic sleep deprivation in mice. Sleep. 36(4): PMCID: PMC * Authors contributed equally Vecsey CG, Peixoto L, Choi JH, Wimmer M, Jaganath D, Hernandez, PJ, Blackwell J, Meda K, Park A, Hannenhalli S, and Abel T (2012) Genomic analysis of sleep deprivation reveals translational inhibition in the hippocampus. Physiological Genomics. 44(20): PMCID: PMC Wimmer M, Hernandez P, Blackwell J, and Abel T (2012) Aging impairs hippocampus-dependent longterm memory for object location in mice. Neurobiology of Aging. 33(9): PMCID: PMC Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, and Abel T (2009) Sleep deprivation impairs camp signalling in the hippocampus. Nature. 461(7267): PMCID: PMC Harris GC, Wimmer M, Randall-Thompson JF, and Aston-Jones G (2007) Lateral hypothalamic orexin neurons are critically involved in learning to associate and environment with morphine reward. Behav. Brain Res. 183(1): PMCID: PMC Harris GC, Hummel M, Wimmer M, Mague SD, and Aston-Jones G (2007) Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. Neuroscience. 147(3): PMCID: PMC Harris GC, Wimmer M, and Aston-Jones G (2005) A role for lateral hypothalamic orexin neurons in reward seeking. Nature. 437(7058): Harris GC, Wimmer M, Byrne R, and Aston-Jones G (2004) Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine. Neuroscience. 129(3):841-7.

3 Invited Talks 2016 University of Epigenetics Program Seminar, Philadelphia, PA Paternal cocaine exposure elicits learning deficits in progeny 2015 American College of Neuropsychopharmacology Annual Meeting (ACNP) Data Blitz, Hollywood, FL Paternal cocaine exposure elicits learning deficits in male progeny 2015 Temple University Brain and Cognitive Sciences seminar series, Philadelphia PA Paternal cocaine taking elicits learning deficits in male progeny 2015 Rudolf Magnus Brain Center, University Medical Center Utrecht, Netherlands Paternal cocaine exposure causes increased anxiety and learning deficits in progeny 2015 Psychiatry Addiction Didactic Seminar, University of Epigenetics and vulnerability to addiction, 2015 NIDA IRP Behavioral Neuroscience Branch Seminar Series Paternal cocaine exposure causes increased anxiety and learning deficits in progeny 2013 Beyond Genetics, News Conference, Society for Neuroscience 43 d Annual Meeting (SD, CA) Paternal cocaine use impairs cocaine-induced neuronal and behavioral plasticity Neuroscience Boot Camp, Center for Neuroscience and Society, University of Brain development and aging breakout session 2011 NIDA IRP Behavioral Neuroscience Branch Molecular mechanisms of sleep/wake regulation and memory in young and aged mice 2011 University of Student Retreat Neuroscience Graduate Group Aging causes deterioration of sleep and memory impairments in mice Teaching and Mentoring 2016 Guest Lecturer, Serotonin, Neurotransmitter Signaling & Pharmacology (NGG 510), University of 2015 Guest Lecturer, Synaptic Plasticity: LTP, LTD, Molecular and Cellular Neurobiology (BIBB 251), University of 2015 Teaching Assistant, Molecular and Cellular Neurobiology (BIBB 251), University of 2015 Guest Lecturer, Epigenetics and Vulnerability to Addiction, Advanced Topics in Neuropsychopharmacology (NGG 576), University of 2015 Co-mentor, Undergraduate Independent Study (BIBB 499), University of, Alexander Testino 2014 Co-mentor, Undergraduate Independent Study (BIBB 499), University of, Jordan Karsch 2013 Co-mentor, Undergraduate Independent Study (BIBB 499), University of, Kelsey Ige Guest Lecturer, Animal Circadian Rhythms, Human Chronobiology and Sleep (BIBB 240), University of 2010 Guest Lecturer, 2 lectures: Animal Circadian Rhythms; Animal Models of Sleep/Wake Neurobiology, Human Chronobiology and Sleep (BIBB 240), University of 2010 Teaching Assistant, Human Chronobiology and Sleep (BIBB 240), University of 2009 Teaching Assistant, Cellular Neurobiology (BIBB 251), University of 2009 Co-mentor, Summer Undergraduate Internship Program, University of, Lyl Tomlinson 2011 Co-director, Summer Neuroscience Course, Upward Bound Program, University of Instructor, Sleep; Learning & Memory, Neuroscience Course, Upward Bound Program Professional Societies & Public Advisory Roles Invited review for Physiology & Behavior Invited review for Brain Research

4 Co-chair, Biomedical Postdoctoral Council Diversity Committee, University of National Postdoctoral Association (NPA) Advocacy Committee, Active Member Mentor ( scienteer ), 6 th graders, ipraxis 2011 Instructor, Philadelphia Science Festival, Penn s Chapter of the National Honor Society in Neuroscience Instructor, Kids Judge Neuroscience, University of Associated Professional Sleep Societies Member Society for Neuroscience Member Poster Presentations Wimmer M, Briand LA, Guercio LA, Arreola AC, Schmidt HD, Pierce RC (2015) Paternal cocaine exposure elicits learning deficits in male progeny. ACNP annual meeting, Hollywood FL Wimmer M, Briand LA, Craige CP, Guercio LA, Arreola AC, Schmidt HD, Pierce RC (2014) Paternal cocaine exposure elicits transgenerational learning deficits. Society for Neuroscience 44 th Annual Meeting, Washington, DC Wimmer M, Vassoler FM, Ortinski PI, White SL, Schmidt HD, Sadri-Vakili G, Pierce RC (2013) Cocaineinduced plasticity deficits in the male offspring of cocaine-experienced sires. Society for Neuroscience 43 d Annual Meeting, San Diego, CA. Schmidt HD, Mietlicki-Baase EG, Ige K, Guercio LA, Wimmer M, Pierce C, Hayes MR (2013) Intra-VTA administration of the glucagon-like peptide-1 receptor agonist exendin-4 attenuates cocaine taking and seeking in rats. Society for Neuroscience 43 d Annual Meeting, San Diego, CA. Choi JH, Davis EJ, Peixoto L, Wimmer M, Hernandez PJ, Havekes R, Pierre P, Abel T (2013) Sleep deprivation impairs hippocampal translation that is mediated specifically via the mtorc1 signaling pathway. Society for Neuroscience 43 d Annual Meeting, San Diego, CA. Peixoto L, Wimmer M, Poplawski S, Zhang NR, Abel T (2013) Transcriptome analysis reveals differences in processes that regulate gene expression during memory consolidation and retrieval. Society for Neuroscience 43 d Annual Meeting, San Diego, CA. Wimmer M, Blackwell J, Abel T (2012) The phosphodiesterase 4 (PDE 4) inhibitor rolipram rescues agedrelated spatial memory deficits in mice. Society for Neuroscience 42 d Annual Meeting, New Orleans, LA. Prince T, Wimmer M, Aton S, Choi J, Havekes R, Abel T (2012) Identifying the time course of sleep deprivation in modulating memory and hippocampal synaptic plasticity. Society for Neuroscience 42 d Annual Meeting, New Orleans, LA. Wimmer M, Rising J, Galante R, Wyner A, Pack A, Abel T (2011) A novel approach to analyze age-related deterioration of sleep/wake in C57BL/6 mice. Society for Neuroscience 41 st Annual Meeting, Washington, DC Hernandez P, Wimmer M, Abel T (2011) The GABA-B agonist baclofen differentially effects fear responding in aged and young adult mice. Society for Neuroscience 41 st Annual Meeting, Washington, DC Peixoto L, Wimmer M, Poplawski S, Kenworthy C, Abel T (2011) The transcriptomic landscape of learning and memory formation. Society for Neuroscience 41 st Annual Meeting, Washington, DC Wimmer M, Rising J, Galante R, Wyner A, Pack A, Abel T (2011) Aging reduces the ability to sustain sleep/wake states in mice. 6 th NIH National Graduate Student Research Conference, Bethesda, MD

5 Wimmer M, Cui R, Abel T (2010) CREB is required in the forebrain to maintain wakefulness. Sleep 2010, 24 th Annual Meeting of the Associated Professional Sleep Societies, LLC, Seattle, WA Wimmer M, Cui R, Abel T (2009) Forebrain-specific CREB deletion decreases wakefulness and increases NREM sleep. Society for Neuroscience 40 th Annual Meeting, Chicago, IL Wimmer M, Harris GC, Aston-Jones G (2006) Innervation of the ventral tegmental area from lateral hypothalamic orexin neurons is necessary for acquisition of morphine-conditioned place preference. Society for Neuroscience 36 th Annual Meeting, Atlanta, GA Wimmer M, Harris GC, Aston-Jones G (2005) Activation of lateral hypothalamic orexin neurons reinstates morphine-seeking behavior. Society for Neuroscience 35 h Annual Meeting, Washington, DC Harris GC, Wimmer M, Aston-Jones G (2004) Activity of orexin/hypocretin neurons corresponds with reward value of food- or morphine-paired stimuli. Society for Neuroscience 34 th Annual Meeting, San Diego, CA References Dr. R. Christopher Pierce, University of, rcpierce@mail.med.upenn.edu, Dr. Ted Abel, University of, abele@sas.upenn.edu, Dr. Julie Blendy, University of, blendy@mail.med.upenn.edu, Dr. David Dinges, University of, dinges@mail.med.upenn.edu, Dr. Gary Aston-Jones, Rutgers University, aston.jones@rutgers.edu