Chelsea Kasten, PhD. Postdoctoral Fellow LSU Health Sciences Center New Orleans

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1 Chelsea Kasten, PhD Postdoctoral Fellow LSU Health Sciences Center New Orleans Department of Cell Biology & Anatomy 1901 Perdido St, Rm 6103 New Orleans, LA Phone: (724) EDUCATION Ph.D., Addiction Neuroscience, Indiana University Purdue University Indianapolis M.S., Addiction Neuroscience, Indiana University Purdue University Indianapolis B.A., Psychology, Gettysburg College RESEARCH EXPERIENCE Postdoctoral Fellow Dept. of Cell Biology & Anatomy, LSU Health Sciences Center New Orleans 2017-present Advisor: Dr. Tiffany Wills Research Focus: Sex-dependent regulation of glutamatergic signaling in the Bed Nucleus of the Stria Terminalis Skills: Research design; data analyses and management; oral presentations; grant and manuscript writing; mouse colony management; training and mentoring summer students. Techniques: Intra-cranial surgeries; alcohol vapor chamber; i.p. and subcutaneous mouse injections; contextual fear conditioning; elevated plus maze; novelty-induced hypophagia; brain harvesting, dissection, and sectioning; perfusions; slice electrophysiology. Graduate Student Department of Psychology, Indiana University Purdue University Indianapolis Advisor: Dr. Stephen L. Boehm II Research Focus: Pharmacological interventions and behavioral phenotypes associated with ethanol and cannabinoid exposure Skills: Research design; data analyses and management; manuscript writing; oral presentations; mouse colony breeding and record keeping; training new graduate students in lab techniques; training and mentoring undergraduate and high school students. Techniques: Intra-cranial surgeries and microinjections; preclinical drinking models; i.p. and subcutaneous mouse injections; brain harvesting, dissection, and sectioning; novel object recognition; elevated plus maze; open field locomotion; short-term selective breeding. Undergraduate Research Assistant Department of Psychology, Gettysburg College Advisor: Dr. Stephen Siviy Research Focus: Social interaction as a protective factor in behavioral phenotypes Skills: Research design; data analyses; oral presentations; scientific writing Techniques: Rat handling; preclinical drinking models; chronic mild stress; fear-potentiated startle; social interaction coding. Updated August,

2 RESEARCH SUPPORT NIH Institutional Postdoctoral Training Grant Biomedical Alcohol Research Training Program (AA007577), Dr. Patricia Molina August 2018 current NIH Institutional Predoctoral Training Grant August 2014 August 2017 Genetic Aspects of Alcoholism (AA007462), Dr. Cristine Czachowski PEER-REVIEWED PUBLICATIONS ORIGINAL RESEARCH 1. Kasten CR, Zhang Y, Boehm II SL (Submitted) Acute cannabinoids produce robust anxiety-like and locomotor effects in mice, but long-term consequences are age- and sex-dependent. Developmental Psychobiology. 2. Kasten CR, Zhang Y, Mackie K, Boehm II SL (2018) Short-term genetic selection for adolescent locomotor sedative sensitivity to Δ9-tetrahydrocannabinol (THC). Behav Genet, 48(3): doi: /s PMID: Kasten CR, Zhang Y, Boehm II SL (2017) Acute and Long-Term Effects of Δ9-tetrahydrocannabinol on Memory and Anxiety are Age- and Strain-Dependent in Mice. Pharmacol Biochem Behav, 163:9-19. doi: /j.pbb PMID: Kasten CR, Frazee AM, Boehm II SL (2016) Developing a model of binge-like nicotine consumption in C57Bl/6J mice. Pharmacol Biochem Behav, 148: doi: /j.pbb PMID: Fritz BM, Quoilin C, Kasten CR, Smoker MP, Boehm II SL (2016) Binge co-consumption of caffeine and ethanol increases ethanol intake in adolescent and adult mice and produces age-specific motor effects. Alcohol Clin Exp Res, 40(6): doi: /acer PMID: Kasten CR, Blasingame SN, Boehm II SL (2015) Bidirectional enantioselective effects of the GABAB agonist baclofen in two mouse models of ethanol consumption. Alcohol, 49(1): doi: /j.alcohol PMID: Kasten CR, Boehm II SL (2014) Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice. Behav Brain Res, 272: doi: /j.bbr PMID: Matson LM, Kasten CR, Boehm II SL, Grahame NJ (2014) Selectively bred crossed High Alcohol Preferring mice drink to intoxication and develop functional tolerance, but not locomotor sensitization during free-choice ethanol access. Alcohol Clin Exp Res, 38: doi: /acer PMID: Siviy SM, Deron LM, Kasten CR (2011) Serotonin, motivation, and playfulness in the juvenile rat. Dev Cogn Neurosci, 1: doi: /j.dcn PMID: REVIEW ARTICLES 1. Kasten CR, Boehm II SL (2016) Preclinical Medication Development: New Targets and New Drugs. Alcohol Clin Exp Res, 40(7): doi: /acer PMID: Kasten CR, Boehm II SL (2015) Identifying the role of pre- and postsynaptic GABAB receptors in behavior. Neurosci Biobehav Rev, 57: doi: /j.neubiorev PMID: POSTER PRESENTATIONS 1. Kasten CR, Carzoli KL, Lerner M, Sharfman NM, Wills TA (2018) Adolescent Alcohol and Adult Stress Exposure Results in Sex-Specific Disruption of Group 1 mglur-ltd in the BNST. Research Society on Alcoholism. Alcohol Clin Exp Res, 42: P0526. Updated August,

3 2. Kasten CR, Carzoli KL, Lerner M, Sharfman NM, Wills TA (2018) Adolescent Alcohol Exposure in Female Mice Disrupts Group 1 mglur-ltd in the BNST. Gordon Research Conference on Alcohol and the Nervous System. 3. Kasten CR, Zhang Y, Boehm II SL (2017). Ethanol-related behaviors in mice selectively bred for adolescent sedation-response to Δ9-tetrahydrocannabinol (THC). Research Society on Alcoholism. Alcohol Clin Exp Res, 41: P Kasten CR, Zhang Y, Vigil D, O Neal W, Yoder K, Mackie K, Boehm II SL (2017). Short-term selective breeding for adolescent sensitivity to Δ9-tetrahydrocannabinol- (THC-) induced locomotor sedation in mice. International Behavioural and Neural Genetics Society. 5. Kasten CR, Zhang Y, Yoder K, Mackie K, Boehm II SL (2016). Short-term selective breeding for adolescent sensitivity to Δ9-tetrahydrocannabinol- (THC-) induced locomotor sedation in mice. NIDA Genetics Consortium. 6. Kasten CR, Blasingame SN, Boehm II SL (2016). The GABAB positive allosteric modulator GS39783 modulates binge-like, but not chronic, ethanol intake. Research Society on Alcoholism. Alcohol Clin Exp Res, 40: P Boehm II SL, Zhang Y, Kasten CR (2016). Short-term selective breeding for adolescent sensitivity to tetrahydrocannabinol- (THC-) induced locomotor sedation in mice. International Behavioural and Neural Genetics Society. 8. Kasten CR, Frazee AM, Fritz BM, Boehm II SL (2015). The GABAB receptor agonist R(+)-baclofen attenuates both nicotine and alcohol intake in C57Bl/6J mice using the Drinking-in-the-Dark model. Research Society on Alcoholism. Alcohol Clin Exp Res, 39: P Boehm II SL, Fritz BM, Kasten CR, Smoker MP, Quoilin C (2015) Development of a mouse model of adolescent binge caffeinated alcohol consumption. International Behavioural and Neural Genetics Society. 10. Kasten CR, Boehm II SL (2014) Intra-accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice. Research Society on Alcoholism. Alcohol Clin Exp Res, 38: P Kasten CR, Boehm II SL (2014) Enantioselective effects of baclofen on ethanol intake in High Alcohol Preferring Line 1 mice. International Behavioural and Neural Genetics Society. 12. Matson LM, Kasten CR, Buckingham A, Tombers E, Boehm SL II, Grahame N (2013) Crossed High Alcohol Preferring (chap) mice exhibit stimulation and ataxia during early ethanol access, and develop functional tolerance during free-choice ethanol access. Research Society on Alcoholism. Alcohol Clin Exp Res, Kasten CR, Boehm II SL (2013) R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol intake in C57Bl/6J mice. Research Society on Alcoholism. Alcohol Clin Exp Res, 37: P Kasten CR, Boehm II SL (2013) R(+)- baclofen attenuates ethanol intake in High Alcohol Preferring Line 1 mice. International Behavioural and Neural Genetics Society. 15. Kasten CR, Vore AS, Linsenbardt DN, Melon LC, Boehm II SL (2012) Free-choice ethanol access and daily ethanol injections do not alter locomotor response in crossed high-alcohol preferring mice. Research Society on Alcoholism. Alcohol Clin Exp Res, 36: P Kasten CR, Siviy SM (2011) Comparing the effects of social vs isolated housing during adolescence on ethanol consumption in adulthood in Wistar rats. Gettysburg College Celebration. 17. Kasten CR, Henning A, Siviy SM (2010) Chronic mild stress does not alter ethanol consumption in Sprague-Dawley rats. Gettysburg College Celebration. ORAL PRESENTATIONS INVITED TALKS 1. Adolescent Alcohol Exposure in Female Mice Disrupts Group 1 mglur-ltd in the BNST. ADACE 9 th Scientific Retreat. New Orleans, LA. May SEMINAR PRESENTATIONS Updated August,

4 1. Sex-Dependent Glutamatergic Regulation of Relapse in the BNST: A Work in Progress. Department of Physiology, LSU Health Sciences Center, New Orleans, LA. April, Pair Housing May Alter Sensitivity to Behavioral Effects Induced by Δ9-tetrahydrocannabinol (THC). Department of Physiology, LSU Health Sciences Center, New Orleans, LA. March, Acute and Long-Term Effects of Cannabinoids on Object Memory and Anxiety-Like Behavior. Department of Psychology, Indiana University Purdue University Indianapolis, IN. January, Age-Dependent Effects of Cannabinoids on Unconditioned Anxiety and Object Memory. Department of Psychology, Indiana University Purdue University Indianapolis IN. March, Nicotine Drinking-in-the-Dark. Department of Psychology, Indiana University Purdue University Indianapolis, IN. January, Evaluating the Role of GABAB Receptors in Modulating Chronic Ethanol Intake in HAP Mice. HAP- LAP Conference, Indianapolis, IN. August, Enantioselective Effects of Baclofen on Binge-Like Drinking in C57Bl/6J Mice. Department of Psychological Sciences, Purdue University, West Lafayette, IN. March, Baclofen Administration Alters Ethanol and Saccharin Consumption in HAP1 Mice. Department of Psychology, Indiana University Purdue University Indianapolis, IN. April, R(+)- and S(-)- Baclofen Bidirectionally Alter Binge-Like Ethanol Intake in C57Bl/6J Mice. Department of Psychology, Indiana University Purdue University Indianapolis, IN. January, TEACHING AND MENTORING INSTRUCTOR PSY-B 311 Research Methods in Psychology Lab Instructor, IUPUI TEACHING ASSISTANT PSY-B 110 Introduction to Psychology, IUPUI PSY-B 307 Tests and Measurements, IUPUI PSY-B 311 Research Methods in Psychology, IUPUI PSY-B 320 Behavioral Neuroscience, IUPUI PSY-B 344 Learning, IUPUI PSY-B 365 Health Psychology, IUPUI MENTORING UNDER DR. WILLS Thor Henderson, NSF REU Summer Research Program, 2018 MENTORING UNDER DR. BOEHM Robert Altamirano, Post-Baccalaureate Research Education Program (PREP), Zoe Zalesak, High School Summer Research Assistant, 2016 Ashley Frazee, Undergraduate Research Assistant, Shelby Blasingame, Undergraduate Research Assistant, AWARDS AND HONORS Research Society on Alcoholism Travel Grant; annually, Craig Andler Memorial Travel Scholarship, $750; 2017 Paul J. McKinley Award; 2017 International Behavioral and Neural Genetics Society Travel Grant, $ ; 2013, 2014 School of Science Graduate Student Council Travel Grant, $600; 2013 Updated August,

5 PROFESSIONAL AFFILIATIONS AND CONTRIBUTIONS MEMBERSHIPS Research Society on Marijuana, International Behavioral Neuroscience Society, International Behavioral and Neural Genetics Society, Research Society on Alcoholism, 2011-Present Psi Chi International Honor Society in Psychology, 2009-Present SCIENTIFC CONTRIBUTIONS Ad hoc reviewer, Psychopharmacology, 2018-present Ad hoc reviewer, Alcoholism: Clinical and Experiment Research, 2016-present Ad hoc reviewer, Frontiers in Psychiatry, 2016-present COMMUNITY OUTREACH Mentor, Sci-Fly Speed Mentoring Event; 2018 Volunteer, Girl Scouts Believe in Girls; 2017 Grad School is for You Panelist, IUPUI School of Science Diversity Council; 2015, 2017 Women in STEM Poster Session Participant, IUPUI; 2015, 2016 Science Fair Judge, Center for Inquiry at IPS No. 2; 2014 REFERENCES Tiffany A. Wills, Ph.D. Assistant Professor Cell Biology & Anatomy LSU Health Sciences Center New Orleans 1901 Perdido St, Rm 6110 New Orleans, LA Phone: Stephen L. Boehm II, Ph.D. Professor of Psychology Addiction Neuroscience Graduate Program and Director, Undergraduate Neuroscience Program Indiana University Purdue University Indianapolis 402 N Blackford St, LD124 Indianapolis, IN Phone: slboehm@iupui.edu Cristine L. Czachowski, Ph.D. Associate Professor Addiction Neuroscience Graduate Program Department of Psychology, IUPUI 402 N. Blackford St., LD 124 Indianapolis, IN Phone: cczachow@iupui.edu Updated August,