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1 Note: Page numbers of article titles are in boldface type. A Acalculous cholecystitis, postoperative, Acute cardiac failure, hypoxic liver injury and, in critically ill and postoperative patients, 185 Acute fatty liver of pregnancy (AFLP), 205 Acute intermittent porphyria, 75 Acute leukemia, Adrenal gland dysfunction of, liver disease and, excess from, liver disease and, 61 insufficiency of, liver disease and, Adult-onset Stills disease, liver and, 156 AFLP. See Acute fatty liver of pregnancy (AFLP). Alagille syndrome, dermatologic manifestations of, 175 Alanine aminotransferase, antiviral therapy related to, in HCV-HIV coinfection, 138 Androgen(s), liver disease and, 62 Anemia(s) hemolytic, See also Hemolytic anemias. sickle cell, 70 Anesthesia/anesthetics, liver dysfunction related to, Ankylosing sclerosis (AS), liver and, Anti-inflammatory drugs, nonsteroidal, in rheumatologic disease management, hepatotoxicity of, 158 a 1 -Antitrypsin deficiency, Anti tumor necrosis factor alpha (TNF-a), in rheumatologic disease management, 159 Antiviral therapy, in HCV-HIV coinfection management, alanine aminotransferase related to, 138 liver biopsy in selection of, Arthritis, rheumatoid, liver and, AS. See Ankylosing sclerosis (AS). Ascites, nephrogenic, Autoimmune hepatitis, celiac disease and, 97 Autoimmune liver diseases celiac disease related, dermatologic manifestations of, B Bacterial infections described, liver and, brucellosis, leptospirosis, Clin Liver Dis 15 (2011) doi: /s (10) /11/$ see front matter ª 2011 Elsevier Inc. All rights reserved. liver.theclinics.com
2 210 Bacterial (continued) Lyme disease, 120 mycobacterium TB, Q fever, 119 spirochetes, 120 syphilis, 120 typhoid fever, 116 PSC and, 91 Banti syndrome, Benign postoperative cholestasis, 190 Bilirubin, overproduction of, postoperative, 190 Birth weight, low, TPN associated liver disease related to, 100 Brucellosis, liver and, C Cancer(s), HCC, dermatologic manifestations of, 175 Candida spp., fungal infections associated with, liver and, Cardiovascular diseases, liver and, 1 20 congenital heart disease, 10 congestive hepatopathy, 5 10 heat stroke, hereditary hemorrhagic telangiectasia, ischemic hepatitis, 3 5 polyarteritis nodosa, vascular disorders, 12 Celiac disease autoimmune hepatitis and, 97 autoimmune liver disorders associated with, hepatobiliary manifestations of, clinical manifestations of, histologic findings in, 96 pathogenesis of, 95 prevalence of, 95 response to gluten-free diet, 96 in patients with chronic liver disorders, diagnosis of, liver disease and, prevalence of, 95 PBC and, PSC and, 97 viral hepatitis and, 97 CHF. See Congestive heart failure (CHF). Cholecystitis, acalculous, postoperative, Cholestasis benign postoperative, 190 in sepsis, intrahepatic, pregnancy-related, liver and, 43 Chronic lymphoid leukemia, 76 Cirrhosis(es) decompensated, HCV-HIV coinfection effects on, 135 liver, dermatologic manifestations of,
3 211 primary biliary, celiac disease and, CMV. See Cytomegalovirus (CMV). Congenital heart disease, liver and, 10 Congestive heart failure (CHF), hypoxic liver injury and, in critically ill and postoperative patients, 185 Congestive hepatopathy clinical features of, 6 8 described, 5 6 diagnosis of, 9 histopathology of, 8 9 incidence of, 6 prognosis of, 9 10 treatment of, 9 Critically ill patients, hepatobiliary manifestations in, hypoxic liver injury, sepsis, TPN related, 192 Cystic fibrosis, Cytomegalovirus (CMV), liver and, D Decompensated cirrhosis, HCV-HIV coinfection effects on, 135 Dengue, liver and, 115 Dengue hemorrhagic fever, liver and, 115 Dermatitis herpetiformis (DH), liver and, Dermatologic disorders liver and, described, 165 DH, DHS, 170 liver cirrhosis, mastocytosis, 171 primary skin disorders, psoriasis, sarcoidosis, 169 scleroderma, 168 SLE, 167 SS, systemic disorders, toxic epidermal necrolysis, 170 treatment of, hepatotoxicity of, malignant, liver and, DH. See Dermatitis herpetiformis (DH). DHS. See Drug-induced hypersensitivity (DHS). Diabetes mellitus, in patients with chronic renal diseases, 42 Dialysis liver and, treatment of chronic liver diseases in patients undergoing, 47 DIC. See Disseminated intravascular coagulation (DIC). Disseminated intravascular coagulation (DIC), liver and, 71 72
4 212 Drug(s) for HCV-HIV coinfection, hepatotoxicity of, for patients with chronic renal diseases, toxicity of, 42 for rheumatologic disease, hepatotoxicity of, thyrotoxic effects of, in liver disease, Drug-induced hypersensitivity (DHS), liver and skin effects of, 170 Drug-induced liver injury, E EBV. See Epstein-Barr virus (EBV). Endocrine diseases, liver and, adrenal dysfunction, growth hormone, metabolic syndrome, sex hormones, thyroid dysfunction, drugs and, systemic conditions causing, 60 Enteral nutrition, lack of, TPN associated liver disease related to, 100 Epstein-Barr virus (EBV), liver and, Erythropoietic protoporphyria, Estrogen(s), liver disease and, F Felty syndrome, liver and, 156 Fibrosis(es) cystic, hepatic, in HCV-HIV coinfected patients, Fungal infections, liver and, Candida spp., G Gastrointestinal disorders, hepatobiliary manifestations of, See also specific diseases. Genetic(s), in PSC, 90 Genetic disorders, liver and, a 1 -antitrypsin deficiency, cystic fibrosis, Gluten-free diet, in celiac disease management, response to, 96 Granulomatous diseases, liver and, sarcoidosis, TB, Growth hormone, liver disease and, H HAART. See Highly active antiretroviral therapy (HAART). Hairy cell leukemia, 76
5 HCC. See Hepatocellular carcinoma (HCC). HCV-HIV coinfection CD4 cell count effects on progression of HCV-related liver disease in patients with, 134 described, epidemiology of, HCV treatment for patients with, selection of, impact on progression of hepatic fibrosis in patients with, significance of, treatment of, antiviral therapy in, alanine aminotransferase related to, 138 liver biopsy in selection of, barriers to, HAART in, hepatotoxicity of, medications in, hepatotoxicity of, OLT in, ribavirin in, SVR related to, Heart disease, congenital, liver and, 10 Heart failure acute, hypoxic liver injury and, in critically ill and postoperative patients, 185 congestive, hypoxic liver injury and, in critically ill and postoperative patients, 185 Heat stroke clinical features of, 11 described, 10 histopathology of, 11 incidence of, liver and, prognosis of, 12 treatment of, HELLP syndrome, pregnancy-related, Hematologic diseases liver and, malignant, liver and, chronic MPDs, leukemia, lymphomas, solid tumors with hepatic metastases, nonmalignant, liver and, DIC, hemolytic anemias, hypersplenism, porphyrias, Hemolytic anemias, background of, 69 malaria, 71 PNH, 70 sickle cell anemia, 70 TTP-HUS, 71 Hemophagocytic syndrome, Hepatic fibrosis, in HCV-HIV coinfected patients,
6 214 Hepatitis autoimmune, celiac disease and, 97 B chronic renal disease and, dermatologic manifestations of, C acute, treatment of, in HIV patients, 141 chronic renal disease and, dermatologic manifestations of, HIV infection with, See also HCV-HIV coinfection. progression of, HIV treatment effects on, treatment of antiviral therapy in, 136 goal of, 136 infective lesions of, dermatologic manifestations of, 172 ischemic, 305. See also Ischemic hepatitis. viral, celiac disease and, 97 Hepatocellular carcinoma (HCC) dermatologic manifestations of, 175 HCV-HIV coinfection effects on, Hepatopathy, congestive, See also Congestive hepatopathy. Hereditary hemorrhagic telangiectasia, clinical manifestations of, 13 described, 12 diagnosis of, 13 incidence of, 12 treatment of, Herpes simplex virus (HSV), liver and, HG. See Hyperemesis gravidarum (HG). Highly active antiretroviral therapy (HAART), for HCV-HIV coinfection, hepatotoxicity of, HIV infection acute HCV treatment in patients with, 141 HCV with, See also HCV-HIV coinfection. liver and, treatment of, effects on progression of HCV-related liver disease, Hodgkin s lymphoma, 77 Hormone(s), sex, liver disease and, HSV. See Herpes simplex virus (HSV). Hyperemesis gravidarum (HG), Hypersplenism, background of, 72 Banti syndrome, left-sided portal hypertension, 73 noncirrhotic portal hypertension, Hypertension, portal left-sided, 73 noncirrhotic, Hyperthyroidism, liver disease and, Hypothyroidism, liver disease and, 59 Hypoxic liver injury, in critically ill and postoperative patients,
7 215 acute cardiac failure and, 185 CHF and, 185 respiratory failure and, I ICP. See Intrahepatic cholestasis (ICP). ICU. See Intensive care unit (ICU). Immunology, in PSC, Infection(s). See specific types. Infectious diseases, liver and, bacterial infections, fungal infections, parasitic infections, viruses, Inflammatory bowel disease, hepatobiliary manifestations of, See also specific types. PSC, Intensive care unit (ICU), liver dysfunction in, 183 Intestinal anatomy, TPN associated liver disease related to, 100 Intrahepatic cholestasis (ICP), pregnancy-related, Ischemic hepatitis clinical features of, 4 described, 3 histopathology of, 5 incidence of, 4 prognosis of, 5 treatment of, 5 Ischemic injury, postoperative, J Jaundice, liver cirrhosis and, 166 L Left-sided portal hypertension, 73 Leptospirosis, liver and, Leukemia(s), acute, background of, chronic lymphoid, 76 hairy cell, 76 Hodgkin s lymphoma, 77 Liver as protective organ in sepsis, as target of sepsis, 187 cardiovascular diseases and, See also specific diseases and Cardiovascular diseases, liver and. dermatologic disorders and, See also specific disorders and Dermatologic disorders, liver and. dialysis and, 46 47
8 216 Liver (continued) DIC and, diseases of. See Liver diseases. dysfunction of anesthetic-related, in ICU, 183 in sepsis, endocrine diseases and, See also Endocrine diseases, liver and. heat-related disorders of, hematologic diseases of, infectious diseases and, See also Infectious diseases, liver and. macrocirculation of, 1 3 microcirculation of, 1 3 oncologic diseases of, See also Hematologic diseases. pulmonary diseases and, See also specific diseases and Pulmonary diseases, liver and. renal diseases and, See also specific diseases and Renal diseases. renal transplant effects on, respiratory failure effects on, rheumatologic diseases and, See also Rheumatologic diseases, liver and. tumors of, metastatic, vascular disorders of, 12 Liver cirrhosis, dermatologic manifestations of, jaundice, 166 palmar erythema, 166 spider nevi, white nails, 167 Liver diseases adrenal dysfunction and, adrenal excess and, 61 adrenal insufficiency and, autoimmune celiac disease related, dermatologic manifestations of, chronic celiac disease in patients with, diagnosis of, dialysis in patients with, treatment of, in patients undergoing dialysis, 47 cutaneous manifestations of, developmental, dermatologic manifestations of, 175 growth hormone and, hereditary, dermatologic manifestations of, 175 pregnancy-related, See also specific diseases and Pregnancy, liver diseases related to. sex hormones and, skin effects of, See also specific disorders and Dermatologic disorders, liver and. Liver injury drug-induced, hypoxic, in critically ill and postoperative patients, See also Hypoxic liver injury, in critically ill and postoperative patients.
9 217 Liver transplantation for PSC, 94 in TPN associated liver disease management, 103 Low birth weight, TPN associated liver disease related to, 100 Lyme disease, liver and, 120 Lymphoma(s) Hodgkin s, 77 liver and, non-hodgkin s, M Macrocirculation, of liver, 1 3 Malaria, 71 liver and, Mastocytosis, liver and, 171 Metabolic syndrome, NAFLD and, Methotrexate hepatoxicity related to, 95 in rheumatologic disease management, hepatotoxicity of, 159 Microcirculation, of liver, 1 3 MPDs. See Myeloproliferative disorders (MPDs). Mycobacterium tuberculosis, liver and, Myeloproliferative disorders (MPDs) chronic, hepatic manifestations of, N NAFLD. See Nonalcoholic fatty liver disease (NAFLD). Neoplasia, PSC and, Nephrogenic ascites, Nephrogenic hepatic dysfunction, Nevus(i), spider, liver cirrhosis and, Nonalcoholic fatty liver disease (NAFLD) in patients with chronic renal diseases, 42 metabolic syndrome and, Noncirrhotic portal hypertension, Non-Hodgkin s lymphoma, Nutrient(s) deficiency of, lack of, TPN associated liver disease related to, toxicity of, TPN associated liver disease related to, 101 Nutrition, enteral, lack of, TPN associated liver disease related to, 100 Nutritional disorders, hepatobiliary manifestations of, See also specific diseases. celiac disease, TPN, See also Total parenteral nutrition (PTN). O OLT. See Orthotopic liver transplantation (OLT). Oncologic diseases, liver and, See also Hematologic diseases.
10 218 Orthotopic liver transplantation (OLT), in HCV-HIV coinfection management, Osler-Weber-Rendu disease, See also Hereditary hemorrhagic telangiectasia. P Palmar erythema, liver cirrhosis and, 166 Parasitic infections described, 120 liver and, malaria, schistosomiasis, Paroxysmal nocturnal hemoglobinuria (PNH), 70 PBC. See Primary biliary cirrhosis (PBC). Penicillamine, in rheumatologic disease management, hepatotoxicity of, 158 PNH. See Paroxysmal nocturnal hemoglobinuria (PNH). Polyarteritis nodosa, clinical manifestations of, 14 described, 14 incidence of, 14 treatment of, 15 Porphyria(s), acute intermittent, 75 background of, 73 erythropoietic protoporphyria, porphyria cutanea tarde, 75 Porphyria cutanea tarde, 75 Portal hypertension left-sided, 73 noncirrhotic, Postoperative patients hepatobiliary manifestations in, acalculous cholecystitis, anesthetic-related, benign postoperative cholestasis, 190 bilirubin overproduction, 190 hypoxic liver injury, ischemic injury, TPN related, 192 liver dysfunction in, 183 Preeclampsia, liver dysfunction related to, Pregnancy, liver diseases related to, AFLP, 205 described, HELLP syndrome, HG, ICP, preeclampsia-related, Prematurity, TPN associated liver disease related to, 100 Primary biliary cirrhosis (PBC), celiac disease and, Primary sclerosing cholangitis (PSC), bacterial infection and, 91
11 219 causes of, celiac disease and, 97 clinical features of, complications of, described, epidemiology of, 90 genetic factors in, 90 IBD drug-induced hepatotoxicity related to, imaging of, 92 immunologic factors in, laboratory findings in, 92 natural history of, 91 pathogenesis of, pathology of, 93 prognostic models of, 91 treatment of, 94 vascular injury and, 91 Primary skin disorders, liver and, Progressive systemic sclerosis/scleroderma, liver and, 157 PSC. See Primary sclerosing cholangitis (PSC). Psoriasis, liver and, Pulmonary diseases, liver and, See also specific diseases. genetic disorders, granulomatous diseases, Q Q fever, liver and, 119 R RA. See Rheumatoid arthritis (RA). Renal diseases abnormal liver tests in patients with, 39 chronic, liver conditions in patients with, diabetes mellitus, 42 drug toxicity, 42 hepatitis B, C, NAFLD, 42 steatohepatitis, 42 liver and, cholestasis, 43 nephrogenic ascites, nephrogenic hepatic dysfunction, renal transplant, renal tubular disorders, 43 Renal transplantation, liver and, Renal tubular disorders, liver and, 43 Respiratory failure
12 220 Respiratory (continued) hepatic dysfunction related to, hypoxic liver injury and, in critically ill and postoperative patients, Rheumatoid arthritis (RA), liver and, Rheumatologic diseases described, 153 liver and, adult-onset Stills disease, 156 AS, felty syndrome, 156 progressive systemic sclerosis/scleroderma, 157 RA, SLE, SS, treatment of anti TNF-a in, 159 medication hepatotoxicity in, methotrexate, 159 penicillamine in, 158 sulfasalazine, 158 Ribavirin, in HCV-HIV coinfection management, S Sarcoidosis, liver and skin effects of, 169 Schistosomiasis, liver and, Scleroderma, liver and skin effects of, 168 Sclerosis(es) ankylosing, liver and, systemic, liver and, 157 Sepsis cholestasis in, liver as protective organ in, liver as target of, 187 liver dysfunction in, TPN associated liver disease related to, 100 Sex hormones, liver disease and, Sickle cell anemia, 70 Sjögren syndrome (SS) dermatologic effects of, liver and, , Skin, liver diseases effects on, See also specific disorders and Dermatologic disorders, liver and. SLE. See Systemic lupus erythematosus (SLE). Small intestine transplantation, in TPN associated liver disease management, 103 Spider nevi, liver cirrhosis and, Spirochetes, liver and, 120 SS. See Sjo gren syndrome (SS). SSc. See Systemic sclerosis (SSc). Steatohepatitis, in patients with chronic renal diseases, 42
13 221 Stills disease, adult-onset, liver and, 156 Sulfasalazine, in rheumatologic disease management, hepatotoxicity of, 159 Syphilis, liver and, 120 Systemic lupus erythematosus (SLE) liver and, , 167 skin effects of, 167 Systemic sclerosis (SSc), liver and, 157 T TB. See Tuberculosis (TB). Terry nails, liver cirrhosis and, 167 Thiopurines, hepatoxicity related to, Thrombotic thrombocytopenic purpura hemolytic uremic syndrome (TTP-HUS), 71 Thyroid dysfunction, liver disease and, hyperthyroidism, hypothyroidism, 59 systemic conditions causing, 60 thyrotoxic effects of drugs, TNF-a. See Tumor necrosis factor alpha (TNF-a). Total parenteral nutrition (TPN) described, 98 hepatobiliary manifestations of, clinical spectrum of, 99 histopathologic findings, 99 management of, prevalence of, 99 risk factors for, in critically ill and postoperative patients, 192 Toxic epidermal necrolysis, liver and skin effects of, 170 Transplantation(s) liver for PSC, 94 in TPN associated liver disease management, 103 orthotopic liver, in HCV-HIV coinfection management, renal, liver and, small intestine, in TPN associated liver disease management, 103 TTP-HUS. See Thrombotic thrombocytopenic purpura hemolytic uremic syndrome (TTP-HUS). Tuberculosis (TB), mycobacterium, liver and, Typhoid fever, liver and, 116 V Vascular disorders, of liver, 12 Vascular injury, PSC due to, 91 Viral hepatitis, celiac disease and, 97 Virus(es), liver and, CMV, dengue, 115
14 222 Virus(es) (continued) dengue hemorrhagic fever, 115 EBV, HSV, yellow fever, W Whipple s disease, hepatobiliary manifestations of, 98 White nails, liver cirrhosis and, 167 Y Yellow fever, liver and,
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