T-9 GC-MS. Solid Science Creative Ideas Innovative Products

Transcription

1 T-9 GC-MS Solid Science Creative Ideas Innovative Products

2 Torion develops novel sampling devices and miniaturized instrumentation for on-site, field analysis of chemical and biological threats, contaminants, and pollutants, using chromatography and mass spectrometry.

3 T-9

4 I have met the enemy.. and he is us

5 Motivation for Field Analysis Immediate Results to Make Timely Decisions and Solve Problems Laboratory Quality Data Rapid Results Save Time and Money Do it all at the Sample s Location

6 Why GC-MS? GC/MS is the legal and laboratory standard for chemical identification GC separates complex mixtures High sensitivity and high selectivity High Sensitivity Low false negative rates High Selectivity Low false positive rates 6

7 TRIDION GC-MS Features Helium Cartridge & Battery External helium connection Universal Injection Port Gas Chromatograph Touch Pad Interface Key Pad Toroidal Ion Trap MS Person Portable Case

8 TRIDION -9 Specifications No Handle 17.5 With Handle 15 Dimensions: 38 cm x 39 cm x 23 cm Weight: <14.5 kg or 32 lbs (including battery) Power: Peak ~120 W; Average ~ 60 W Sample introduction: SPME or direct liquid GC: MXT-5, 5 m x 0.1 mm x 0.4 mm Temperature programmable GC Electronic pressure control Ion trap: Toroidal ion trap MS Electron ionization: Internal Vacuum: Turbo molecular/diaphragm pump Ion trap heater: 150 C 180 C Mass range: 45 to 500 da. Resolution: Amplitude scanning 0.43 at m/z 134 (n-butylbenzene) 0.53 at m/z 284/286 (hexachlorobenzene)

9 TRIDION GC-MS Features GC Technical Specifications: Temperature range: C Analyze volatiles & semi-volatiles in a single analysis (under 5 min) MS Technical Specifications: Mass range: amu Internal 2 stage pumping system Operational Conditions: Temperature: 5-40 C Humidity: up to 100% relative, non-condensing

10 Mass Analyzer Scan speed ~10 scans/s ~1 s Resolution < 1 amu FWHM across mass range

11 Miniaturizing the GC GC column Injection port Cooling fan Electronics Conventional Laboratory GC TRIDION -9 GC

12 Low Thermal Mass Capillary GC Cooling fan LTM column Injection port EPC module Typical GC Conditions Column: MXT-5 (5 m x 0.1 mm x 0.4 mm) Mobile Phase: Helium Head Pressure: 25 psig Column Max Flow: ~ o C Split-splitless Injection: Selectable split ratios: 0, 10, 50, and 60 to 1 Program: 50 o C (hold 10 s) to 300 o C (hold o C/min GC-TMS run time: <5 min (including GC cooling cycle and data processing)

13 Resistively Heated Column Technology

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15 Solid Phase Microextraction (SPME) Sample Collection Sampling Techniques Headspace Direct Immersion Direct Contact Must be easy to use!

16 Sampling Options SPME General purpose mid level to high concentration rapid screening and identification of threats > 100 ppm 1 5 second sample ppm second sample 1 10 ppm 1 minute to 5 minute sample < 1 ppm minute sample SPME can be used to sample Air Liquids

17 Easy-to-Use Onboard Software

18 Active Real-time Display Post-run Showing Library Hits 1100 Compounds in T-9 Library NIST 2014 on Computer (laptop)

19 Rapid Results Cold start = 5 10 min Run-to-run cycle time = 5 min Shut down = 5 min

20 Autocalibration in the Field CALION Performance validation Valve cap Retention Time (seconds) Glass wool PDMS Absorbed calibration compounds

21 PV Insures instrument is operating correctly

22 Drug Adulterants: Law Enforcement and Public Health Implications IDEC-Lima April 2016

23 Law Enforcement Programs Eradication Interdiction Immobilize Illicit Drug Labs Money Laundering Investigations Arrest Kingpins Precursor Chemical Controls

24 Some Contemporary Drug Adulterants PHENACETIN: pain reliever / fever reducer PARACETAMOL: a pain reliever AMINOPYRINE: analgesic, anti-inflammatory BENZOCAINA: a local anesthetic XYLAZINE: a veterinary tranquilizer LIDOCAINA: a local anesthetic LEVAMISOLE: used to expel parasitic worms ACETAMINOPHEN: pain reliever / fever reducer METAMIZOLE: pain reliever / fever reducer

25 During the last decade, many shipments of cocaine seized by U.S. drug authorities have been found to be adulterated with levamisole (a veterinary anti-worming medicine) and Phenacetin (a painkiller). Why is cocaine adulterated with an animal dewormer? 1. It s easy to mix with cocaine 2. It appears like high quality cocaine 3. It may enhance the effects of cocaine 4. It s relatively Cheap 5. It s easy to obtain

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27 Levamisole skin toxicity

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30 Drug Checking Technologies Result Report Portable Raman Spectroscopy Portable GC-MS Reagents and Test Targets (Color check)

31 Welcome to Lima

32 Buying Street Drugs

33 Checking out the Score

34 Field Testing

35 Catch the First Cab to Safety

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38 Cocaine Sample (Peru)

39 Cocaine cut with Phenacetin (Peru)

40 Hydrocarbons in Cocaine sample (Peru)

41 Evidence Locker in Mexico

42 Meth Analysis in Mexico

43 Methamphetamine in Mexico Methamphetamine

44 Drug Testing in Vancouver BC

45 Case Studies

46 Cocaine & Benzocaine

47 MDEA

48 Allopseudococaine

49 Phenacetin

50 Caffeine

51 Welcome to Maine The Benefits of a Portable Gas Chromatograph Ion Trap Mass Spectrometer for the Identification of Controlled Substances in Seized Street Drugs Heather Dyer 1, Jamie Foss 2, Bill Hahn 2, Charlie Schmidt 2, Frank Kero 2 1. Maine Health and Environmental Testing Laboratory, 221 State St., Augusta, ME PerkinElmer, 710 Bridgeport Ave., Shelton, CT Acetylfentanyl Cocaine Furanylfentanyl Methamphetamine PCP W-15 Acetaminophen Cocaine Base Heroin Methaqualone Phenacetin W-18 AH-7921 Cocaine HCl Hydroxyzine Methylphenidate Phentermine Xylazine Amphetamine Codeine Levamisole Morphine Procaine 4-ANPP Benzocaine Desomorphine Lidocaine MT-45 Pseudoephedrine 4-methoxyamphetamine Butyrylfentanyl Diltiazem MDEA Norfentanyl Theophylline Caffeine Ephedrine Metamizole Noscapine Valerylfentanyl Clenbuterol Fentanyl Methadone Papaverine U-47700

52 Thank You! Questions? Reliable Sampling, Reliable Analysis, Reliable Identification

53 TRIDION -9 GC-MS Introduction Solid Science Creative Ideas Innovative Products The world s fastest and most portable GC-MS