Laser and Ultrasound Co-Analyzer for thyroid nodules (LUCA) GA No:
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1 Laser and Ultrasound Co-Analyzer for thyroid nodules (LUCA) GA No:
2 Motivation: Thyroid cancer is a major and growing health challenge. Chances of survival and full recovery heavily depend on an early and fast diagnosis and an effective treatment. CHARACTERISTICS - Low cost - Non-invasive device - Enhanced information people with thyroid nodules SCREENING TECHNIQUES - Ultrasound SOCIAL IMPACT Better and more specific results in thyroid nodule screening FNAB s /year false positives or non-diagnosis in EU - Fine Needle Aspiration Biopsy Benign vs Malignant - Psychological complications - Work-day absences - Further healthcare COST IMPACT Millions /y Better diagnosis Socio-economical impact: reduced number of thyroidectomies, associated comorbidities and improved quality of life of the patients unnecessary surgeries / surgery could be saved!
3 The LUCA Vision Overview of the LUCA vision starting at the present clinical practice in thyroid screening and our current research followed by the proposed innovations during the LUCA period, for the short- and long-term following the end of LUCA. The goal of LUCA is to start at a technology readiness level (TRL) of TRL 5 and move to TRL 7. US: Ultrasound FNAB: Fine Needle Aspiration Biopsy TRS: Time Result Spectroscopy DCS: Diffuse correlation Spectroscopy
4 Objectives»To develop a novel low-cost tool for the screening of thyroid nodules for malignant cancers»to develop an innovative probe that combines diffuse optics and clinical ultrasound for simultaneous multi parametric ultrasound imaging and optical measurement of tissue hemodynamics and composition of the thyroid nodules»to develop a multi-modal, point-of care device which integrates with the probe developed and a portable, low-cost ultrasound system»to establish the clinical usability of the LUCA device
5 The LUCA System Combination of Photonics and Ultrasound + Blood Flow Oxygenation Water Structure Local Non-invasive»Device Illuminates the tissue with near-infrared light (non-invasive + local)»combination of different diffuse optical techniques (TRS + DCS): Light incident on tissue Photon scattering and absorption depend on tissue structure and content»algorithms for diffuse optics The output of TRS and DCS is processed to give information on hemodynamics, metabolism and structure of the thyroid
6 TRS Time Resolved Spectroscopy Absorption spectrum of principal tissue components»trs Method Pico-second laser pulses illuminate the tissue measurement of the absorption and scattering coefficient of the tissue by analyzing the deformation of the detected laser pulse Use of 8 different wavelengths in the near infrared (~ nm) the absorption spectrum gives information on the concentrations of different components»output Quantification of the concentrations of oxyhemoglobin (HbO 2 ), deoxyhemoglobin (Hb), lipid, collagen and water, i.e. structure & function
7 DCS Diffuse Correlation Spectroscopy Speckle pattern P. Farzam, PhD Thesis, ICFO»DCS Method Laser light goes into tissue photons scattered by moving red blood cells generate a moving interference pattern (speckle pattern) Measurement of the decay of the electric field autocorrelation function of a single speckle»output Quantification of micro-vascular blood flow, i.e. function
8 Expected Impact»Improvement in the specificity of the thyroid screening process compared to the conventional ultrasound-based workflow»earlier and faster diagnosis for an effective treatment and management and reduction of the number of surgeries»potential application of the LUCA device in other types of cancer diagnosis, screening and therapy monitoring (in areas of the body accessible to both techniques )»Reduction of socio-economic cost related to thyroid cancer»wide-market introduction of the LUCA technology LUCA IP generation and market monitoring After LUCA Within LUCA Clinical research sales Clinical trial Clinical market sales
9 CONSORTIUM Optics, opto-electronics & Biophotonics Industrial: product developer End-users Researcher & Clinics The Institute of Photonic Sciences Vermon S.A. European Institute for Biomedical Imaging Research Politecnico di Milano Hemophotonics S.A. University of Birmingham Echo Control Medical Consorci Institut D Investigacions Biomediques August Pi Sunyer University of Birmingham
10 Consortium s Expertise ICFO - Medical Optics group PI: Turgut Durduran, LUCA coordinator Diffuse Correlation Spectroscopy Knowledge & Technology Transfer POLIMI: Davide Contini, Dipartimento di Fisica Time resolved Spectroscopy IDIBAPS: Ramon Gomis, Endocrinology Department HEMO: Udo Weigel, VERMON, An Nguyen-Dinh, Technology & Research Clinical Endocrinology and Radiology Biomedical optical device development Commercialization Ultrasound Probes ECM, Sixte de Fraguier, R&D Ultrasound device software UoB, Hamid Dehghani, School of Computer Science EIBIR, Gabriel Krestin, Radiology Physical modelling and data fusion Biomedical imaging research project management
11 Work Plan»Phase I (M1-M18): Development and construction of device components»phase II (M12-M36): Testing of components and validation of device in laboratory settings»phase III (M30-M48): Demonstration in real settings, feedback, upgrades and final tests
12 Work Packages
13 Work Packages: Objectives»WP1 Project Management To achieve excellence in project management in technical and administrative terms»wp2 Development of components and sub-systems To utilize innovative components for new sub systems and to develop an innovative, multi modal probe that combines diffuse optics and clinical ultrasound»wp3 Development of a demonstrator To develop a low cost, portable, point of care, robust LUCA demonstrator that integrates with the probe developed in WP2 and with a portable, low cost ultrasound system»wp4 Ex vivo, phantom validation and standardization To develop ex vivo phantoms and standards for validation and quality control
14 Work Packages: Objectives»WP5 Validation in real-settings To evaluate the clinical usability and validate the system in real-settings»wp6 Dissemination To disseminate project results broadly as well as directly to stakeholders and endusers»wp7 Exploitation To exploit the project results at all levels from know how and intellectual property generation to business plan development in order to commercialize the probe and the LUCA device
15 Governance Structure
16 Governance Structure: Consortium Bodies»Consortium General Assembly (CGA) Overall decision-making body Decides on legal, contractual, ethical and financial issues»steering Committee (SC) Executive operational body Monitors the effective and efficient implementation of the project and is responsible for the proper execution and implementation of the decisions of the CGA»Medical Advisory Board (MAB) External MAB members advise the consortium on the performance and progress of the project as well as the appropriate resolution of potential conflicts and deviations»innovation and Exploitation Committee (IEC) Monitors the strategic and commercial gains as well as the overall impact of the project
17 Key Information»LUCA runs from February 1st 2016 to January 31st 2020»Grant amount: EUR 3,628,845.75»
DELIVERABLE REPORT. Grant Agreement number:
Laser and Ultrasound Co-Analyzer for thyroid nodules DELIVERABLE REPORT Grant Agreement number: 688303 Project acronym: LUCA Project title: Laser and Ultrasound Co-Analyzer for thyroid nodules Funding
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