CURRENTLY ENROLLING ONCOLOGY TREATMENT STUDIES (as of )
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1 Leukemia AALL0932 closed after Induction CURRENTLY ENROLLING ONCOLOGY TREATMENT STUDIES (as of ) Treatment of Patients with Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-lineage Lymphoblastic Lymphoma (B-LLy) AALL1131 A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# ) in the Very High Risk Stratum AALL1231 A Phase III Randomized Trial Investigating Bortezomib (NSC# ; IND# 58443) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T- Lymphoblastic Leukemia (T-ALL) and T- Lymphoblastic Lymphoma (T-LLy) AALL1331 Risk-Stratified Randomized Phase III Testing of Blinatumomab (IND#117467, NSC#765986) in First Relapse of Childhood B- Lymphoblastic Leukemia AALL1521/Incyte A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitnib with Chemotherapy in Children with De Novo High-Risk CRLF2-Rearranged and /or JAK Pathway-Mutant Acute Lymphoblastic Leukemia AALL15P1 A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement AALL1621 A Phase 2 Study of Inotuzumab Ozogamicin (NSC# , IND# ) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia AALL1631 AAML1331 AAML1421 AAML1522/ Celgene AAML1531 POETIC International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Ph+ ALL Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones A Phase III Study for Patients with Newly Diagnosed Acute Promyelocytic Leukemia (APL) using Arsenic Trioxide and All-Trans Retinoic Acid A Phase 1/2 Study of CPX-351 (NSC# ; IND #129443) Alone Followed by Fludarabine, Cytarabine, and G-CSF (FLAG) for Children with Relapsed Acute Myeloid Leukemia A Phase II, Multi-Center, Single-Arm, Open-Label Study to Evaluate the Activity, Safety and Pharmacokinetics of Lenalidomide (Revlimid) in Pediatric Subjects From 1 to 18 Years of Age with Relapsed or Refractory Acute Myeloid Leukemia Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias Page 1 of 5
2 Brain ACNS0332 ACNS0831 ACNS1422 NMTRC ONC POETIC POETIC G Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients Phase I/II Study of Neratininb in children and Pediatric Patients with Relapsed or Refractory Solid Tumors or Hematologic Malignancies A Phase I/II Multicenter, Open Label, Dose Escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors Germ Cell Tumor AGCT1531 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors Liver AHEP0731 Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND#122782, NSC#683864) Added to High Risk Stratum Treatment Long Term Effects ALTE11C1 Longitudinal Assessment of Ovarian Reserve in Adolescents with Lymphoma Page 2 of 5
3 ALTE11C2 Lymphoma AALL0932 AALL1231 AHOD1331 ANHL12P1 C25004 Neuroblastoma ANBL1221 temporarily closed to accrual ANBL1232 NMTRC 010B NMTRC 011 NMTRC 012 NMTRC 014 NMTRC ONC Health Effects after Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-related Cardiomyopathy Treatment of Patients with Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-lineage Lymphoblastic Lymphoma (B-LLy) A Phase III Randomized Trial Investigating Bortezomib (NSC# ; IND# 58443) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T- Lymphoblastic Leukemia (T-ALL) and T- Lymphoblastic Lymphoma (T-LLy) A Randomized Phase III Study of Brentuximab Vedotin (SGN-35, IND #117117) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (chl) in Children and Adolescents A Randomized Phase II study of Brentuximab Vedotin (NSC# ) and Crizotinib (NSC# ) in Patients with Newly Diagnosed Anaplastic Large Cell Lymphoma (ALCL) IND # An Open-Label Study of Brentuximab Vedotin+Adriamycin, Vinblastine, and Dacarbazine in Pediatric Patients With Advanced Stage Newly Diagnosed Hodgkin Lymphoma A Phase II Randomized Trial of Irinotecan/Temozolomide with Temsirolimus (NSC# , IND# 61010) or Chimeric Antibody (ch14.18) (NSC# , IND# 4308) in Children with Refractory, Relapsed or Progressive Neuroblastoma Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma A Phase I/II Trial of DFMO in Combination with Bortezomib in Patients with Relapsed or Refractory Neuroblastoma A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma Pediatric Precision Laboratory Advanced Neuroblastoma Therapy A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy followed by maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma Neuroblastoma Maintenance Therapy Trial Using DFMO Page 3 of 5
4 Renal Sarcoma/Rhabdomyosaroma/Osteosarcoma/Ewing's Sarcoma AEWS1221 Randomized Phase II Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# , IND# ) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma AOST1321 Phase II Study of Denosumab, a RANK Ligand Antibody, for Recurrent or Refractory Osteosarcoma Temporarily Closed to Accrual AOST1421 Phase II Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 in Combination with Sargramostim (GM-CSF) in Patients with Recurrent Osteosarcoma ARST1321 Pazopanib Neoadjuvant Trial In Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# , IND# ) ARST1431 PI: Becton Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus in Patients with Intermediate Risk (IR) Rhabdomyosarcoma (RMS) Page 4 of 5
5 NMTRC ONC Solid Tumors ADVL1322/Novartis ADVL1622 POETIC G POETIC POETIC A Phase II Trial of Pazopanib NSC# , IND# in Children with Refractory Solid Tumors Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors A Phase I/II Multicenter, Open Label, Dose Escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias Phase I/II Study of Neratininb in children and Pediatric Patients with Relapsed or Refractory Solid Tumors or Hematologic Malignancies PEDIATRIC MATCH APEC1621SC NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol APEC1621A APEC1621C APEC1621D APEC1621E APEC1621F APEC1621G APEC1621H Phase 2 Subprotocol of LOXO-101 in Patients with Tumors Harboring Actionable NTRK Fusions. Phase 2 Subprotocol of Tazemetostat for Patients with Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex Phase 2 Subprotocol of LY in Solid Tumors Phase 2 Subprotocol of Selumetinib in Patients with Tumors Harboring Activating MAPK Pathway Mutations Phase 2 Subprotocol of Ensartinib in Patients with Tumors Harboring ALK or ROS1 Genomic Alterations Phase 2 Subprotocol of Vemurafenib in Patients with Tumors Harboring Actionable BRAF V600 Mutations Phase 2 Subprotocol of Olaparib in Patients with Tumors Harboring Defects in DNA Damage Repair Genes Page 5 of 5
CURRENTLY ENROLLING ONCOLOGY TREATMENT STUDIES (as of 4/27/2017)
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