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1 STCYPCNG List of chemotherapy regimens Day Localised Unresectable neuroblastoma (CCLG guidelines) Carbo-Etoposide Etoposide CADO Doxorubin, Vincristine Irinotecan, Irinotecan-TMZ temozolomide Localised Unresectable neuroblastoma - relapsed Cisplatin-Etoposide Cisplatin, etoposide cyclo-topotecan topotecan High risk Neuroblastoma HR-NBL trial Rapid COJEC D0 and 40 Carboplatin etoposide Rapid COJEC D10,30,50,70 Cisplatin Rapid COJEC 20,60 TVD Cyclophosphamide Etoposide Topotecan, Vincristine Pe-Neuroblast Carbo Etop Sep-02 Pe-Neuroblastoma Cado 1 08-Apr-02 Pe-Neuroblastoma- Cisplatin And Etoposide Oct-07 Pe-Neuroblastoma- Siopen-Cojec-Day 1 & May-08 Pe-Neuroblastoma- Siopen-Cojec-Day May-08 Pe-Neuroblastoma- Siopen-Cojec-Day 20 & May-08 Doxorubicin Pe-Tvd-Neuroblastoma Jul-05 Bu-Mel Busulfan, Melphalan Pe-Hd-Siopen- Busulf+Melphalan Jun-09 Prepared By: J Mycroft Date of Review: January 2012
2 STCYPCNG List of chemotherapy regimens isotretinoin isotretinoin anti GD2+ IL2 anti GD2 Neuroblastoma - Refractory after HR-NBL and 2nd line therapies TVD Irinotecan-TMZ cyclo-topotecan Topotecan, Vincristine Pe-Neuroblastoma- Hrnbl1-Isotretinoin 1 26-Sep-08 Doxorubicin Pe-Tvd-Neuroblastoma Jul-05 Irinotecan, temozolomide topotecan Cyclophosphamide Cyclo-Etoposide oral Etoposide Neuroblastoma - 3rd line Topotecan with mibg therapy Topotecan Pe- Temozolomide+Oral Irinotecan 1 17-Apr-07 Pe-Combined-Etop- Cyclophos Oral 1 18-Aug-03 Pe-Neuro-Hd- Topotecan-Mibg 1 27-Apr-04 Prepared By: J Mycroft Date of Review: January 2012
3 VIDE VAI ME-ME VAC Bu-Mel COG AEWS 0031 VCD COG AEWS 0031 VC COG AEWS 0031 IE Etoposide, Day Doxorubicin Pe-Ewings-Euro99-Vide Mar-04 actinomycin D melphalan etoposide phosphate Vincristine. Actinomycin D Pe-Ewings-Euro99-Vai Consolidation Aug-03 Pe-Hd-Melphalan- Etoposide Phosphate Aug-06 Cyclophosphamide Pe-Ewings-Euro99-Vac Sep-03 busulfan orally, melphalan Doxorubicin Cyclophosphamide Etoposide Ewings sarcoma - relapsed TMZ-IRINO Ewings Sarcoma (Euro-Ewings trial) Ewings Sarcoma - metastatic Temozolomide, Irinotecan Pe-Ewings-Sarcoma- Temozol+Irinotecan May-07 Date of Review: January 2012
4 Day Rhabdomyosarcoma - EpSSG RMS 2005 trial Actinomycin D, IVADO Doxorubicin Ivado Jan-06 IVA VA Actinomycin D, Iva 1 05-Mar-07 actinomycin D Va 1 30-Jan-06 Vincristine Vinorelbine-Cyclo rhabdomyosarcoma - second line therapy Topo-Cyclo Topo-Carbo Etop-Carbo Dox- Carbo Topotecan, cyclophosphamide Topotecan, carboplatin Etoposide, Carboplatin Carboplatin Dox- Cyclo Cyclophosphamide rhabdomyosarcoma - metastatic follow EpSSG RMS 2005 Vincristine 1 30-Jan-06 Maintenance-Vin+Cyclo 1 30-Jan-06 Topotecan+Cyclo 1 27-Feb-07 Topotecan+Carbo 1 30-Jan-06 Etoposide+Carbo 1 30-Jan-06 Dox+Carbo 1 27-Feb-07 Doxorubicin+Cyclo 1 30-Jan-06 Date of review: January 2012
5 AVD AV-1 AV-2 Actinomycin D, Vincristine Day Doxorubicin Actinomycin D, Vincristine Actinomycin D, Vincristine V vincristine etop-carb Etoposide, Carboplatin cyclophospamide, cyclo-dox doxorubicin Wilms tumour relapsed - CCLG guidelines Group B - Course 1 Group B - Course 2 Group C- Course 1 Group C - Course 2 Wilms tumour WT 2001 trial cyclophospamide, etoposide cyclophospamide, doxorubicin Etoposide Etoposide Melphalan-PBSC Melphalan ICE Etoposide Avd Jan-08 Av Jan-08 Av Jan-08 Vincristine Jan-08 Etop-Carbo Jan-08 Cyclo-Dox Jan-08 Pe-Wilms-Ccsk-Ukwr- Gp B-Course Apr-02 Pe-Wilms-Ccsk-Ukwr- Grp B Course Mar-02 Pe-Wilms-Ccsk-Ukwr- Gp C-Course Apr-02 Pe-Wilms-Ccsk-Ukwr- Gp C-Course Apr-02 Pe-High Dose Melphalan Aug-07 Pe-Ice-Poor Risk Wilms & Other Rhabdoid 1 17-Dec-03 Topotecan Topotecan Pe-Wilms-Topotecan 1 28-Jul-06 Clear cell Sarcoma of Kidney (CCSK) - see recommendations in WT 2001 Approved by: Prof A pearson Date prepared: January 2011 Date of review: January 2012
6 Stage I-III AVA Actinomycin D, Vincristine Pe-Ccsk-Ava- Vinc+Actinomycin+Dox 1 16-Jun-05 Stage I-III V Vincristine Pe-Ccsk-Ava-Vinc Only 1 16-Jun-05 Stage IV - see high risk post-op arm of Wilms Approved by: Prof A pearson Date prepared: January 2011 Date of review: January 2012
7 Solid Tumour Day Osteogenic sarcoma (euramos 1 trial) AP Cisplatin M Methotrexate IE AI Etoposide Doxorubicin A Dox +Dexra AP+ Dexraz dexrazoxane Cisplatin, Dexrazoxane Pegylated Interferon Pegylated Interferon Osteogenic sarcoma - metastatic disease Osteogenic sarcoma - relapsed and refractory Pe-Euramos 1-Ap- Rmh Modified May-07 Pe-Euramos 1- Methotrexate May-08 Pe-Euramos 1- Ifosfamide+Etoposide- Ie Pe-Euramos May-07 Doxorubicin+Ifosfamid e-ai May-07 Pe-Euramos 1- Doxorubicin-A May-07 Pe-Euramos 1- Doxorubicin+Dexrazox ane May-07 Pe-Euramos 1- Ap+Dexrazoxane 1 16-Sep-08 Date of Review: January 2012
8 Hepatoblastoma - Standard risk (SIOPEL 6 trial) Cisplatin Cisplatin Cisplatin + Thiosulphate Cisplatin, Sodium Thiosulpate Hepatoblastoma - High risk (SIOPEL 4 guidelines) Block A1- Day 1 Cisplatin Block A1 - day 8-9 Cisplatin, Doxorubicin Block A1- day 15 Cisplatin Block A2 - day 29 Cisplatin Cisplatin, Block A2 - day Doxorubicin Block A2 - day 43 Cisplatin Cisplatin, Block A3 - day Doxorubicin Block A3 - day 64 Cisplatin Block B Day Doxorubicin Block C Doxorubicin Hepatocellular Carcinoma - (SIOPEL 5 guidelines ) Cisplatin- Dox A1-Day 1-Cisplatin 1 23-Mar-07 A1-Day 8+9-Cisp+Dox 1 23-Mar-07 A1-Day 15-Cisplatin 1 20-Feb-07 Pe-Hepatoblastoma-Siopel 4 - A2-Day 29-Cisplatin 1 23-Mar-07 A2-Day Cisp+Dox 1 23-Mar-07 A2-Day 43-Cisplatin 1 23-Mar-07 A3-Day Cisp+Dox 1 23-Mar-07 A3-Day 64-Cisplatin 1 23-Mar-07 B-Carbo+Doxo 1 29-May-07 C-Carbo+Doxo 1 29-May-07 Cisplatin, Doxorubicin Pe-Hcc-Siopel 5-Cisp+Dox 1 22-May-08 Date prepared: January 2011 Date of Review January 2012
9 Thalidomide- Cyclo Thalidomide, oral cyclophosphamide Hepatoblastoma - relapsed and refractory Date prepared: January 2011 Date of Review January 2012
10 Day Soft Tissue Sarcoma - EpSSG NRSTS trial Ifos-Dox Doxorubicin Vin- Cyclo oral Vinorelbine, Cyclophosphamide Vinorelbine oral Vinorelbine Extracranial rhabdoid tumours - EpSSG NRSTS VDCy Cy*CE Etoposide Aggressive fibromatosis - EpSSG NRSTS vinblastine, methotrexate Pe-Epssg-Nrsts Ifos+Dox 1 02-Aug-07 Pe-Epssg-Nrsts Oral Vin+Cyclo May-07 Pe-Epssg-Nrsts Oral Vinorelbine May-07 Pe-Epssg-Nrsts- Fibramotosis-Vinb+Mtx 1 21-Dec-09 IVA Actinomycin D, Iva 1 05-Mar-07 VA actinomycin D Va 1 30-Jan-06 tamoxifen Tamoxifen Chair JPOC Version:2 Date of Review: January 2012
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