Composite Lymphocyte-Rich Hodgkin Lymphoma and Peripheral T-Cell Lymphoma Associated With Epstein-Barr Virus
|
|
- Kevin Thornton
- 6 years ago
- Views:
Transcription
1 Composite Lymphocyte-Rich Hodgkin Lymphoma and Peripheral T-Cell Lymphoma Associated ith Epstein-Barr Virus A Case Report and Review of the Literature Steven Sanchez, MD; Houston Holmes, MD; Nora Katabi, MD; Joe Newman, PhD; Rana Domiatti-Saad, PhD; Marvin Stone, MD; George Netto, MD e report a case of a 65-year-old black man with combined Hodgkin lymphoma and T-cell lymphoma. The patient presented with diffuse lymphadenopathy, fever, weight loss, and night sweats. Subsequent biopsy of an axillary lymph node revealed a composite lymphoma composed of classic Hodgkin lymphoma and a peripheral T-cell lymphoma. A needle biopsy of the liver also showed involvement by the composite lymphoma. In situ hybridization studies revealed positive Epstein-Barr virus in Reed- Sternberg cells. Development of T-cell lymphoma following chemotherapy for Hodgkin lymphoma has been reported, but synchronous composite occurrence of both lesions is very rare. Furthermore, this is the first report of such occurrence in a black patient. e present a review of the literature and a discussion of the potential pathophysiologic role of Epstein-Barr virus in the early stages of T-cell lymphomagenesis. (Arch Pathol Lab Med. 2006;130: ) Malignant lymphoma is the fifth most common form of malignancy in the United States. 1 Although more common in developed countries, areas of high incidence of lymphoma exist in parts of the Middle East and Africa. The incidence rates have increased during the last 20 years for non-hodgkin lymphoma (NHL), at least partly the result of improved diagnostic techniques and refined classification schemes. The incidence of Hodgkin lymphoma (HL) has fallen within the last 20 years. According to American Cancer Society estimates for 2005, of the new cases of lymphoma expected to be diagnosed, 11.5% would be HL and 88.5% NHL. 2 It has been estimated that approximately 80% of the NHL group are B-cell derived and only 7.6% are mature T-cell lymphomas. 3 Accepted for publication August 11, From the Departments of Pathology (Drs Sanchez, Katabi, Newman, Domiatti-Saad, and Netto) and Oncology (Drs Holmes and Stone) Sammons Cancer Center, Baylor University Medical Center, Dallas, Tex. The authors have no relevant financial interest in the products or companies described in this article. Corresponding author: George J. Netto, MD, Johns Hopkins Medical Institutions, Pathology and Laboratory Medicine, 401 N Broadway, Room 2242, Baltimore, MD ( gnetto1@jhmi.edu). Reprints not available from the authors. The term composite lymphoma was first proposed to denote the occurrence of more than one histological pattern of lymphoma in a single patient ; however, the term is now used to denote 2 distinct types of lymphoma occurring within a single organ or tissue. 4 Synchronous occurrence of 2 types of NHLs is more common than an NHL and HL. Reports of a B-cell NHL occurring in patients with HL is more common than a concurrent T-cell NHL. 5 The current case is unique in that, to our knowledge, it is the first case to describe lymphocyte-rich classic HL occurring in conjunction with peripheral T-cell lymphoma. In addition, all cases of composite lymphoma reported in the literature occurred in white patients, in contrast to our black male patient. 5 9 Additionally, this case is unusual in that the identical composite lymphoma is also found to involve the liver. REPORT OF A CASE The patient was a 65-year-old black man who presented with multiregional lymphadenopathy (cervical, axillary, and right groin), dysuria, fever, weight loss, and night sweats. The lowgrade fever, night sweats, and 30-lb weight loss had been present for 6 to 7 months. He had no history of major medical illness and he did not have a significant family medical history. He had quit smoking and heavy ethanol use more than 10 years prior to his presentation. He had a past history of heroin use. A complete blood count showed a white blood cell count of 2200/ L, hematocrit of 29.2%, and platelet count of / L. Results of a chemistry panel was normal. A computed tomographic scan confirmed the extensive lymphadenopathy throughout the abdomen and pelvis; the largest nodal mass measured 7 cm and was located in the aortocaval region. Lymphadenopathy was also demonstrated within the pelvic right common iliac chain. The spleen was enlarged to 15 cm in diameter. An open biopsy was performed on 3 axillary lymph nodes measuring up to 2.1 cm. A needle liver biopsy was also obtained. Following histopatholgic diagnosis, the patient received a combination of cyclophosphamide and prednisone followed by an additional course of C- MOPP (cyclophosphamide, vincristine, procarbazine, and prednisone). Despite an initial clinical improvement in the lymphadenopathy, his hepatic functions continued to worsen. The patient died 3 weeks following diagnosis as a result of sepsis and hepatic encephalopathy. An autopsy was not performed. MATERIALS AND METHODS Hematoxylin-esoin sections were obtained from formalin-fixed, paraffin-embedded lymph node and liver biopsies. Immunohis- Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al 107
2 Table 1. Immunohistochemistry and In Situ Hybridization (ISH) Markers and Source* Antibody Dilution Manufacturer CD3 CD20 CD30 CD15 EMA ALK1 CD45 CD5 EBER (ISH) 1:200 1:150 1:20 1:40 1:200 1:25 1:100 1:40 RTU Cell Marque, Hot Springs, Ark DakoCytomation, Carpinteria, Calif DakoCytomation Biocare, Concord, Calif Cell Marque Novocastra Laboratories, Newcastle upon Tyne, United Kingdom DakoCytomation Novocastra Ventana * EMA indicates epithelial membrane antigen; EBER, Epstein-Barr virus encoded RNA; and RTU, ready to use. tochemistry and in situ hybridization studies (Epstein-Barr virusencoded RNA [EBER]) were performed using standard avidinbiotin-peroxidase procedures and a Ventana autostainer (Ventana Medical Systems, Inc, Tucson, Ariz). Appropriate controls were used (Table 1). Flow cytometry analysis was performed using staining panels that included 3 color combinations consisting of CD3, CD5, CD10, CD14, CD19, CD45, and and light chains. Stained cells were run on a FACScaliber (Becton Dickinson, San Jose, Calif) capturing at least cells within the general gated area of interest. Cells were analyzed in CellQuest (BD Biosciences, San Jose, Calif) employing backgating techniques to find particular cell populations of interest and isotypic controls to separate out positive staining cells from negative cells. Gene rearrangement studies were performed using commercial kits (T-cell and B-cell clonality assays, InVivoScribe Technologies, San Diego, Calif). The DNA was extracted from archival formalin-fixed, paraffin-embedded tissue using the QIAamp DNA Mini Kit (Qiagen, Valencia, Calif) according to manufacturer s recommendation. For immunoglobulin heavy-chain gene rearrangement, 3 separate master mixes were used that target all 3 of the conserved framework regions and the joining region within the immunoglobulin heavy gene. For the T-cell receptor chain gene rearrangement, 2 master mixes were used that target multiple variable and joining exon regions within the T-cell receptor chain locus. The polymerase chain reaction (PCR) was performed in a final volume of 50 L in a GeneAmp PCR System 9700 thermocycler (Applied Biosystems, Foster City, Calif). Five microliters of DNA was added to each master mix containing 1.25 U of AmpliTaq Gold polymerase (Applied Biosystems). The amplification reactions were initially heated at 95 C for 10 minutes, then subjected to 35 cycles of 94 C for 30 seconds, 55 C for 30 seconds, and 72 C for 1 minute. The PCR products were extended at 72 C for 10 minutes. The amplification products were resolved by capillary electrophoresis in an ABI 3100 Genetic Analyzer (Applied Biosystems). For this, 1 L of PCR product was mixed with 30 L of deionized formamide containing GeneScan (ROX) size standards (Applied Biosystems). The GeneScan software was used to determine the size of the amplified products. HISTOPATHOLOGIC FINDINGS Axillary Lymph Nodes The lymph node demonstrated effacement of normal architecture by multiple darker nodules separated by lighter diffuse areas (Figure 1, A). On high-power microscopic examination, the darker nodules were composed of small lymphocytes with interspersed large mononuclear Hodgkin cells and classic Reed-Sternberg cells (Figure 1, B). Only rare plasma cells, eosinophils, or neutrophils were present. The overall morphologic features in these areas are those of lymphocyte-rich type of HL. The lighter, diffuse areas separating the described nodules showed infiltration by large lymphocytes with clumped chromatin and inconspicuous nucleoli (Figure 1, C and D). The latter demonstrate increased mitotic activity. Immunohistochemical studies in the nodular areas revealed the expected phenotype of Reed-Sternberg cells (CD30-positive, CD15-positive, and negative reaction to epithelial membrane antigen, ALK1, CD20, and CD45) (Figure 1, E through G). The Reed-Sternberg cells were strongly positive for Epstein-Barr virus (EBV) by in situ hybridization (Figure 1, H). Variable numbers of CD3-positive small lymphocytes were seen surrounding Reed-Sternberg cells in a rosette pattern. However, most of the small lymphocytes within the nodules were CD20-positive. In the diffuse areas separating the nodules, the large lymphocytes were CD3-positive. Flow cytometry analysis demonstrated an abnormal population of CD3 T cells with loss of pan T-cell marker CD5 (Figure 2). No light-chain restriction in B-cell population was detected by flow cytometry. Gamma T-cell receptor gene rearrangement studies revealed a clonal population of T cells (Figure 3). No evidence of immunoglobulin heavy-chain gene rearrangement was on clonality assay. Liver Portal areas of the liver biopsy showed 2 distinct populations of neoplastic cells. Their morphologic and immunophenotypic features support involvement by composite lymphoma identical to that described in the axillary lymph node (Figure 4, A and B). The cells with Reed- Sternberg cell features were positive for CD30 (Figure 4, C) and weakly positive for CD15, and they were negative for CD20 and CD45. The large cell (T-cell) population was positive for CD3 (Figure 4, D) and lacked CD5 positivity. The EBER in situ hybridization for EBV was again positive in the Reed-Sternberg cells. Gene rearrangement studies performed on paraffin tissue of the liver biopsy revealed a clonal T-cell population with an identical size of PCR product of the T-cell receptor gene in both axillary and Figure 1. A, Section of lymph node showing the interface between darker nodular area (lower left) and lighter diffuse area (upper right) representing the Hodgkin lymphoma (HL) and the peripheral T-cell lymphoma (PTL), respectively. Arrowheads point to Reed-Sternberg (HRS) cells (hematoxylin-eosin, original magnification 100). B, Lymph node section demonstrating the HL component containing Reed-Sternberg cells (hematoxylin-eosin, original magnification 400). C, Hematoxylin-eosin section of lymph node demonstrating the PTL component composed of a diffuse population of large cells (original magnification 400). D, Diffuse CD3-positive staining in PTL component (original magnification 400). E and F, The HRS cells demonstrating membranous and Golgi pattern of staining with anti-cd30 and anti-cd15, respectively (original magnifications 400). G, The CD20-negative HRS cells in a background of CD20-positive small B-lymphocytes (immunohistochemistry, original magnification 400). H, The HRS cells showing positive nuclear reactivity for Epstein-Barr virus encoded RNA (EBER) (in situ hybridization for Epstein- Barr virus, original magnification 400). 108 Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al
3 Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al 109
4 Figure 2. Histogram demonstrating flow cytometry analysis. A predominant CD3-positive/CD5-negative population is found in the R2 region of intermediate-sized cells. Intermed indicates intermediate; FSC, forward scatter; Per CP, peridinin chlorophyll protein; UL, upper left; UR, upper right; LL, lower left; LR, lower right; PE, phycoerythrin; and FITC, fluorescein isothiocyanate. Figure 3. T-cell receptor (TCR) gene rearrangement assay results. From top to bottom: Lines 1 and 2 show the polyclonal and monoclonal controls of the assay. Lines 3 and 4 demonstrate the presence of a clonal T-cell population in paraffin tissue from the axillary lymph node and liver, respectively. Note the identical size of T-cell receptor (TCR) gene polymerase chain reaction (PCR) product, suggesting a clonal relation of the monoclonal populations in both samples. hepatic biopsies, strongly suggesting clonal relation among the 2 T-cell lymphomas (Figure 3). COMMENT The term composite lymphoma was first proposed to denote the occurrence of more than 1 lymphoma in a single patient; however, the term is now reserved to denote the rare concurrent occurrence of 2 distinct types of lymphoma within a single organ or tissue. 4 The occurrence of 2 NHLs is more common than that of an NHL and an HL. 1 Reports of a B-cell NHL occurring in patients with HL is more common than a concurrent T-cell NHL. 5 Composite HL and T-cell lymphoma is an entity that has been rarely reported. Our review of the literature found only 6 previous cases of composite lymphoma composed of HL and T-cell lymphoma (Table 2). 5 8 Many cases of patients with both T-cell lymphoma and HL reported in the literature do not fit the strict definition currently being used to define a composite lymphoma because they describe a T-cell lymphoma that occurred at separate sites and/or at different points in time. Three of the 6 previously described cases of composite lymphoma harbor the nodular lymphocyte-predominant type of HL. 5 The remaining 3 cases describe the HL component belonging to the classic type. 6 8 Specifically, our case has lymphocyterich classic HL. To our knowledge, this case is the first report of a composite classic HL and peripheral T-cell lymphoma developing in a black patient. An interesting observation described by Quintanilla- Martinez et al 9 is the presence of the so-called Reed-Sternberg-like cells that may occur in T-cell lymphoma. These Reed-Sternberg-like cells have the typical morphologic features of prominent eosinophilic nucleoli and abundant cytoplasm. They are reportedly negative for all T-cell markers and in some cases positive for CD20. In all cases, the Reed-Sternberg-like cells were positive for CD30, CD15, EBV-latent membrane protein 1, and EBER. It is important to recognize this mimicker of HL so as not to diagnose such lesions as a composite Hodgkin and T-cell lymphoma. In our case, this did not pose difficulty because in the lymphocyte-rich classic HL, the Reed-Sternberg cells occurred in separate, scattered nodules consisting mostly of small B cells in which scattered Reed-Sternberg cells were found. Another interesting aspect of the current case was the simultaneous presence of both elements of the composite neoplasm in the liver tissue as well as in the axillary lymph nodes. As illustrated here, we were able to demonstrate an identical-sized PCR product of the T-cell receptor gene in both axillary and hepatic biopsies, strongly 110 Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al
5 Figure 4. A, Liver biopsy showing involvement of portal tract by the composite lymphoma (hematoxylin-eosin, original magnification 100). B, Reed-Sternberg cells in a portal tract. Note peripheral T-cell lymphoma (PTL) cells in background (hematoxylin-eosin, original magnification 400). C, Portal tract showing Reed-Sternberg cells with positive CD30 reactivity (original magnifications 400). D, Portal tract showing background PTL cells with CD3-positive reactivity (immunohistochemistry, original magnification 200). Table 2. Prior and Current Reported Cases of Composite T-Cell and Hodgkin Lymphoma* Age, y/sex Race HL Type T-Cell Lymphoma Source, y 31/M 51/M 26/M 65/M 88/F 81/F 65/M? B NLP NLP NLP 4 y posttreatment for HL Delabie et al, Delabie et al, Delabie et al, Niedobitek et al, Bee et al, Steinhoff et al, Current case, 2005 * HL indicates Hodgkin lymphoma; NLP, nodular lymphocyte-predominant Hodgkin lymphoma; and, classic Hodgkin lymphoma. suggesting a clonal relation among the T-cell lymphoma components. The pathogenesis of composite lymphomas is more difficult to explain in cases of an HL and a T-cell lymphoma as opposed to an HL and a B-cell lymphoma or 2 different types of B-cell lymphomas. Common explanation of the latter occurrence is clonal progression of malignant B cells through mutational accumulation, and progression into a more aggressive, higher grade neoplastic B-cell process. An example would be Richter syndrome of B-cell small lymphocytic lymphoma transforming into a high-grade, diffuse, large B-cell lymphoma with coexistence of both processes. Because neoplastic Reed-Sternberg cells are, in most cases, a type of B-lymphocyte, a similar logic of progression among an HL and a coexisting B-cell NHL would be conceivable. On the other hand, the development of a T-cell lymphoma in the setting an HL or a B-cell lymphoma raises the possibility of some cooperative process between T-lymphocytes and B-lymphocytes that favored neoplasia. In a case such as our current report, in which an infectious agent (EBV) is identified, the theory of multilineage, Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al 111
6 cooperative, reactive processes driving progression to lymphoma becomes even more conceivable. Although EBV preferentially infects B cells, it may also infect T cells. Infection of T cells is through the C3d (CR2/CD21) receptor found on developing T cells, but not mature circulating T cells. 10 InareportbyHoetal, 11 EBV-infected cells were found in 52% of peripheral T-cell lymphomas. However, in the majority of EBV-positive cases (77%), only a few of the tumor cells were infected. In their remaining peripheral T-cell lymphoma cases, more than half of tumor cells were infected. Double-staining was used to evaluate lineage in the infected cells. The EBV-positive cells were shown to be CD20-positive more often than CD3-positive. The CD3-posivitve/EBER-positive cells were 1% of the total EBER-positive cells. In the same cases, CD20-positive/EBER-positive cells comprised 10% or more, and in 6 of the 11 cases, they comprised 50% or more of all EBERpositive cells. Curiously, in 5 of the 11 successfully doublestained cases, 50% of the EBER-positive cells expressed neither CD20, CD3, nor CD45RO reactivity. The latter may be caused by downregulation of cellular markers related to the viral infection. Subsequent studies have confirmed by double-labeling immunohistochemistry that most of the EBV-positive cells in HL and T-cell lymphoma are CD20-positive. 11 The occurrence of combined HL and T-cell lymphoma could be a totally coincidental existence of 2 independent de novo neoplastic processes of 2 separate cases of histogenesis. However, it is possible that 1 of the 2 processes could have existed first and had a role in the oncogenesis of the second type of lymphoma. At this point, one can only theorize on the different pathogenic possibilities for the development of such composite lymphomas. In our case, one possible scenario would be malignant transformation of a preexisting reactive T-cell population. Such reactive T-cell population/clone could have developed in response to a preexisting B-cell infectious or neoplastic process, for example, neoplastic EBV-positive Reed-Sternberg cells. Such theory is evidently supported by the fact that infected as well as neoplastic B-lymphocytes are capable of altering T-cell growth through the production of cytokines and by expressing T-cell directed growth stimulatory molecules. 10,12 A second possibility that could explain a combined HL/peripheral T-cell lymphoma such as ours may be the occurrence of a T-cell neoplasm first that, in turn, recruited a host B-cell response. The latter, potentially with a pathogenic role for EBV, 10 could have undergone a neoplastic transformation and led to the formation of the HL component. Future studies examining the clonal evolution of such combined lymphomas are needed to further shed light on these intriguing rare entities. References 1. Ioachim HL, Ratech H. Ioachim s Lymph Node Pathology. 3rd ed. Philadelphia, Pa: Lippincott illiams & ilkins; 2002: American Cancer Society. Cancer Facts and Figures Atlanta, Ga: American Cancer Society; Stewart B, Kleihues P. orld Cancer Report. Lyon, France: IARC Press; 2003: Thirumala S, Esposito M, Fuchs A. An unusual variant of composite lymphoma. Arch Pathol Lab Med. 2000;124: Delabie J, Greiner TC, Chan C, et al. lymphocyte predominance Hodgkin s disease and T-cell lymphoma. A report of three cases. Am J Surg Pathol. 1996;20: Niedobitek G, Baumann I, Brabletz T, et al. Hodgkin s disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection. J Pathol. 2000;191: Bee CS, Blaise YP, Dunphy. Composite lymphoma of Hodgkin lymphoma and mycosis fungoides: previously undescribed in the same extracutaneous site. Leuk Lymphoma. 2001;42: Steinhoff M, Hummel M, Orfanos CE, et al. Cutaneous T cell lymphoma and classic Hodgkin lymphoma of the B cell type within a single lymph node: composite lymphoma. J Clin Pathol. 2004;57: Quintanilla-Martinez L, Fend F, Jaffe ES, et al. Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. Am J Surg Pathol. 1999;23: Jones JF, Shurin S, Sklar J, et al. T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. New Engl J Med. 1988;313: Ho J, Ho F, Chan A, et al. Frequent detection of Epstein-Barr virus-infected B cells in peripheral T-cell lymphomas. J Pathol. 1998;185: Bishop GA, Hostager BS. The CD40-CD154 interaction in B cell-t cell lesions. Cytokine Growth Factor Rev. 2003;14: Arch Pathol Lab Med Vol 130, January 2006 Composite Hodgkin and T-Cell Lymphoma Sanchez et al
Case Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent
Int J Clin Exp Med 2014;7(1):307-311 www.ijcem.com /ISSN:1940-5901/IJCEM1311029 Case Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent Qilin Ao 2, Ying Wang 1, Sanpeng Xu 2,
More informationLymphoma: What You Need to Know. Richard van der Jagt MD, FRCPC
Lymphoma: What You Need to Know Richard van der Jagt MD, FRCPC Overview Concepts, classification, biology Epidemiology Clinical presentation Diagnosis Staging Three important types of lymphoma Conceptualizing
More informationNon-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL)
Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL) Lymphoid Neoplasms: 1- non-hodgkin lymphomas (NHLs) 2- Hodgkin lymphoma 3- plasma cell neoplasms Non-Hodgkin lymphomas (NHLs) Acute Lymphoblastic Leukemia/Lymphoma
More informationGastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR
Gastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR Pages with reference to book, From 305 To 307 Irshad N. Soomro,Samina Noorali,Syed Abdul Aziz,Suhail Muzaffar,Shahid
More informationIncidence. Bimodal age incidence 15-40, >55 years Childhood form (0-14) more common in developing countries M:F=1.5:1; in all subtypes except NS
Hodgkin Lymphoma Hodgkin Lymphoma 30% of all lymphomas Absolute incidence unchanged Arise in lymph node, cervical region Neoplastic tissues usually contain a small number of tumor cells Incidence Bimodal
More informationT cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma
T cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma Sylvia Hartmann Dr. Senckenberg Institute of Pathology Goethe University Frankfurt Overview Borderline ALCL classical HL Borderline
More information, , 2011 HODGKIN LYMPHOMA
European Federation of Cytology Societies 4tu Annual Tutorial in Cytopathology Trieste, June 6-10, 2011 HODGKIN LYMPHOMA Classification The World Health Organization Classification of Lymphomas (2001)
More informationMECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA. April 16, 2008
MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA April 16, 2008 FACULTY COPY GOAL: Learn the appearance of normal peripheral blood elements and lymph nodes. Recognize abnormal peripheral blood
More informationCase 3. Ann T. Moriarty,MD
Case 3 Ann T. Moriarty,MD Case 3 59 year old male with asymptomatic cervical lymphadenopathy. These images are from a fine needle biopsy of a left cervical lymph node. Image 1 Papanicolaou Stained smear,100x.
More informationPlasma cell myeloma (multiple myeloma)
Plasma cell myeloma (multiple myeloma) Common lymphoid neoplasm, present at old age (70 years average) Remember: plasma cells are terminally differentiated B-lymphocytes that produces antibodies. B-cells
More informationPrimary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders
Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual
More informationHepatic Lymphoma Diagnosis An Algorithmic Approach
Hepatic Lymphoma Diagnosis An Algorithmic Approach Ryan M. Gill, M.D., Ph.D. University of California, San Francisco PLEASE TURN OFF YOUR CELL PHONES Disclosure of Relevant Financial Relationships USCAP
More information7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour
7 Omar Abu Reesh Dr. Ahmad Mansour Dr. Ahmad Mansour -Leukemia: neoplastic leukocytes circulating in the peripheral bloodstream. -Lymphoma: a neoplastic process in the lymph nodes, spleen or other lymphatic
More informationComposite mantle cell and follicular lymphoma. A case report
Human Pathology (2009) 40, 259 263 www.elsevier.com/locate/humpath Case study Composite mantle cell and follicular lymphoma. A case report Raquel B. Ilgenfritz MD a,, Agnès Le Tourneau MD a, Michel Arborio
More informationDifferential diagnosis of hematolymphoid tumors composed of medium-sized cells. Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital
Differential diagnosis of hematolymphoid tumors composed of medium-sized cells Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital Lymphoma classification Lymphoma diagnosis starts with morphologic
More informationMimics of Lymphoma in Routine Biopsies. I have nothing to disclose regarding the information to be reported in this talk.
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco I have nothing to disclose regarding the information to be reported in this
More informationEpstein-Barr Virus Associated High-Grade B-Cell Lymphoma of Mucosal-Associated Lymphoid Tissue in a 9-Year-Old Boy
Epstein-Barr Virus Associated High-Grade B-Cell Lymphoma of Mucosal-Associated Lymphoid Tissue in a 9-Year-Old Boy We report an unusual case of Epstein-Barr virus (EBV)- associated mucosal-associated lymphoid
More informationMimics of Lymphoma in Routine Biopsies. Mixed follicular and paracortical hyperplasia. Types of Lymphoid Hyperplasia
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco Types of Lymphoid Hyperplasia Follicular hyperplasia (B-cells) Paracortical
More informationBurkitt lymphoma. Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8
Heme 8 Burkitt lymphoma Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8 Most common is t(8;14) Believed to be the fastest growing tumor in humans!!!! Morphology
More informationAnaplastic Large Cell Lymphoma (of T cell lineage)
Anaplastic Large Cell Lymphoma (of T cell lineage) Definition T-cell lymphoma comprised of large cells with abundant cytoplasm and pleomorphic, often horseshoe-shaped nuclei CD30+ Most express cytotoxic
More informationComposite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma A Case Report and Review of the Literature
Hematopathology / COMPOSITE T- AND B-CELL LYMPHOMA Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma A Case Report and Review of the Literature Yin Xu, MD, PhD, 1 Robert W.
More informationInstructions for Chronic Lymphocytic Leukemia Post-HSCT Data (Form 2113)
Instructions for Chronic Lymphocytic Leukemia Post-HSCT Data (Form 2113) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the CLL Post-HSCT Data Form. E-mail
More informationHIV and Malignancy Alaka Deshpande, Himanshu Soni
HIV and Malignancy Alaka Deshpande, Himanshu Soni Emergence of new infectious disease was documented in 1981. Within a short span of time it became a pandemic. It was Acquired Immunodeficiency Syndrome
More informationCorrigenda. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition): corrections made in second print run
Corrigenda WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition): corrections made in second print run In addition to corrections of minor typographical errors, corrections
More informationImmunopathology of Lymphoma
Immunopathology of Lymphoma Noraidah Masir MBBCh, M.Med (Pathology), D.Phil. Department of Pathology Faculty of Medicine Universiti Kebangsaan Malaysia Lymphoma classification has been challenging to pathologists.
More informationNodular lymphocyte predominant Hodgkin lymphoma. Lymphoma Tumor Board. January 5, 2018
Nodular lymphocyte predominant Hodgkin lymphoma Lymphoma Tumor Board January 5, 2018 Etiology Subtypes of Classical Hodgkin Lymphoma (chl)* Nodular sclerosing HL Most common subtype Composed of large tumor
More informationPearls and pitfalls in interpretation of lymphoid lesions in needle biopsies
Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies Megan S. Lim MD PhD University of Pennsylvania October 8, 2018 Objectives To understand how the trend toward less invasive lymph
More informationThe development of clonality testing for lymphomas in the Bristol Genetics Laboratory. Dr Paula Waits Bristol Genetics Laboratory
The development of clonality testing for lymphomas in the Bristol Genetics Laboratory Dr Paula Waits Bristol Genetics Laboratory Introduction The majority of lymphoid malignancies belong to the B cell
More informationVDx: Unlocking Complex Diagnostics
VDx: Unlocking Complex Diagnostics VDx now offers PARR testing in-house on formalin-fixed tissue Complicated Case? Is this cat s chronic lymphocytic enteritis really chronic IBD or is this early small
More informationHODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO
HODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO HODGKIN LYMPHOMA CLASSIFICATION Lukes & Butler Rye WHO-2016 Linphocytic and/or histiocytic Nodular & diffuse Nodular Sclerosis Lymphocyte
More informationMolecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU
Molecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU Lecture outline Time 10:00 11:00 11:15 12:10 12:20 13:15 Content Introduction to lymphoma Review of lymphocyte biology
More informationClassification of Hematologic Malignancies. Patricia Aoun MD MPH
Classification of Hematologic Malignancies Patricia Aoun MD MPH Objectives Know the basic principles of the current classification system for hematopoietic and lymphoid malignancies Understand the differences
More informationCase Report Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern
Case Reports in Hematology Volume 23, Article ID 84253, 6 pages http://dx.doi.org/.55/23/84253 Case Report Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern Rowan L.
More informationBlastic NK-Cell Leukemia / Lymphoma
* * Blastic NK-Cell Leukemia / Lymphoma A Case Report Chun-Ming Lin Shu-Hui Wang Tseng-tong Kuo* Ching-Chi Chi Hsin-Chun Ho Hong-Shang Hong Blastic natural killer (NK) cell lymphoma / leukemia is a rare
More informationLymphoma/CLL 101: Know your Subtype. Dr. David Macdonald Hematologist, The Ottawa Hospital
Lymphoma/CLL 101: Know your Subtype Dr. David Macdonald Hematologist, The Ottawa Hospital Function of the Lymph System Lymph Node Lymphocytes B-cells develop in the bone marrow and influence the immune
More informationFrom Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology. Songlin Zhang, MD, PhD LSUHSC-Shreveport
From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology Songlin Zhang, MD, PhD LSUHSC-Shreveport I have no Conflict of Interest. FNA on Lymphoproliferative
More information88-year-old Female with Lymphadenopathy. Faizi Ali, MD
88-year-old Female with Lymphadenopathy Faizi Ali, MD Clinical History A 88-year-old caucasian female presented to our hospital with the complaints of nausea, vomiting,diarrhea, shortness of breath and
More informationLarge cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s
Non Hodgkin s Lymphoma Introduction 6th most common cause of cancer death in United States. Increasing in incidence and mortality. Since 1970, the incidence of has almost doubled. Overview The types of
More informationECP meeting, Lisbon, september 2012 Slide seminar New and old challenges in the diagnosis of peripheral T-cell lymphomas
ECP meeting, Lisbon, september 2012 Slide seminar New and old challenges in the diagnosis of peripheral T-cell lymphomas Philippe Gaulard, Dept of Pathology, INSERM U955, Hôpital Henri Mondor, 94010 -
More informationCase Report PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature
Hindawi Case Reports in Hematology Volume 2017, Article ID 7531729, 4 pages https://doi.org/10.1155/2017/7531729 Case Report PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and
More informationMethods used to diagnose lymphomas
Institut für Pathologie Institut für Pathologie Methods used to diagnose lymphomas Prof. Dr.Med. Leticia Quintanilla-Fend Molecular techniques NGS histology Cytology AS-PCR Sanger seq. MYC Immunohistochemistry
More information2012 by American Society of Hematology
2012 by American Society of Hematology Common Types of HIV-Associated Lymphomas DLBCL includes primary CNS lymphoma (PCNSL) Burkitt Lymphoma HIV-positive patients have a 60-200 fold increased incidence
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationGranulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma
Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma Alexandra Papoudou-Bai 1, Eleni Kapsali 2, Ioannis Kostas-Agnantis
More informationEpstein Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature
J Hematopathol (2009) 2:127 131 DOI 10.1007/s12308-009-0030-3 CASE REPORT Epstein Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature Lizabeth
More informationPair-fed % inkt cells 0.5. EtOH 0.0
MATERIALS AND METHODS Histopathological analysis Liver tissue was collected 9 h post-gavage, and the tissue samples were fixed in 1% formalin and paraffin-embedded following a standard procedure. The embedded
More informationA Report of a Rare Case of Anaplastic Large Cell Lymphoma of the Oral Cavity
AJMS Al Ameen J Med Sci (2 0 1 2 )5 (1 ):9 8-1 0 2 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G CASE REPORT A Report of a Rare Case of Anaplastic
More informationContents. vii. Preface... Acknowledgments... v xiii
Contents Preface... Acknowledgments... v xiii SECTION I 1. Introduction... 3 Knowledge-Based Diagnosis... 4 Systematic Examination of the Lymph Node... 7 Cell Type Identification... 9 Cell Size and Cellularity...
More informationNeoplastic proliferation arising from white blood cells. Introductory remarks. Classification
Neoplastic proliferation arising from white blood cells Lymphoproliferative and myeloproliferative diseases and syndromes Oliver Rácz, 2012-2017 1 Introductory remarks Leukemia and lymphoma are old descriptive
More informationLymphoma co existing with Tuberculosis granulomatous
Available online at www.worldscientificnews.com WSN 90 (2017) 265-270 EISSN 2392-2192 SHORT COMMUNICATION Lymphoma co existing with Tuberculosis granulomatous Madeeha Subhan 1, *, Waleed Sadiq 2 1 Ayub
More informationCase: The patient is a 62 year old woman with a history of renal cell carcinoma that was removed years ago. A 2.4 cm liver mass was found on CT
Case: The patient is a 62 year old woman with a history of renal cell carcinoma that was removed years ago. A 2.4 cm liver mass was found on CT during follow- up. ALT, AST, Alk Phos and bilirubin were
More informationImmunohistochemical and Immunogenetic Analyses of Ocular Adnexal Lymphoid Proliferation
Immunohistochemical and Immunogenetic Analyses of Ocular Adnexal Lymphoid Proliferation Toshinobu Kubota, Yasushi Yatabe, Shinobu Awaya, Junpei Asai and Naoyoshi Mori Department of Ophthalmology and Pathology,
More informationLymphoma Case Scenario 1
Lymphoma Case Scenario 1 HISTORY: A 23-year-old healthy female presented with a month-long history of persistent headache of increasing severity. She noted episodic nausea and vomiting in association with
More informationLYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center
LYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center Lymphoma is cancer of the lymphatic system. The lymphatic system is made up of organs all over the body that make up and store cells
More informationPrimary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report Pages with reference to book, From 148 To 149 Suhail Muzaffar,Irshad Nabi Soomro,Naila Kayani,Shahid Siddiqui ( Departments of Pathology, The Aga
More informationNuclear morphometric study of Non- Hodgkin's Lymphoma (NHL)
Original Research Article Nuclear morphometric study of Non- Hodgkin's Lymphoma (NHL) Sridhar Reddy Erugula 1, P. Sujatha 2, Ayesha Sameera 3, B. Suresh Reddy 4, Jesudass Govada 5, G. Sudhakar 6, Kandukuri
More informationHematopathology Service Memorial Sloan Kettering Cancer Center, New York
SH2017-0334 t(14;18) Negative Follicular Lymphoma with 1p36 abnormality associated with In Situ Follicular Neoplasia with t(14;18) translocation Pallavi Khattar MD, Jennifer Maerki MD, Alexander Chan MD,
More information3/24/2017 DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS. Disclosure of Relevant Financial Relationships
DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason L. Hornick, M.D., Ph.D. Director of Surgical Pathology and Immunohistochemistry Brigham and Women s Hospital Professor
More informationLymphoid Neoplasms Associated With IgM Paraprotein A Study of 382 Patients
Hematopathology / LYMPHOMAS WITH IGM PARAPROTEIN Lymphoid Neoplasms Associated With IgM Paraprotein A Study of 382 Patients Pei Lin, MD, 1 Suyang Hao, MD, 1* Beverly C. Handy, MD, 2 Carlos E. Bueso-Ramos,
More informationThomas Hodgkin and Hodgkin lymphoma
J Hematopathol (2014) 7:123 138 DOI 10.1007/s12308-014-0214-3 REVIEW ARTICLE Thomas Hodgkin and Hodgkin lymphoma Judith A. Ferry Received: 26 June 2014 /Accepted: 31 July 2014 /Published online: 12 August
More informationHemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma
Hemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma Katherine Devitt, M.D., Benjamin Chen, M.D., Ph.D., Hongbo Yu, M.D., Ph.D., Bruce Woda, M.D. 1 1 Department
More informationPathology #07. Hussein Al-Sa di. Dr. Sohaib Al-Khatib. Mature B-Cell Neoplasm. 0 P a g e
Pathology #07 Mature B-Cell Neoplasm Hussein Al-Sa di Dr. Sohaib Al-Khatib 0 P a g e Thursday 18/2/2016 Our lecture today (with the next 2 lectures) will be about lymphoid tumors This is a little bit long
More informationWBCs Disorders 1. Dr. Nabila Hamdi MD, PhD
WBCs Disorders 1 Dr. Nabila Hamdi MD, PhD ILOs Compare and contrast ALL, AML, CLL, CML in terms of age distribution, cytogenetics, morphology, immunophenotyping, laboratory diagnosis clinical features
More informationMolecular Probes Introducing 14 new probes
Molecular Probes Introducing 14 new probes Gene and Chromosome Probes Dual Colour ISH INFORM HER2 Dual ISH DNA Probe Cocktail Assay Product Part Number INFORM HER2 Dual ISH DNA Probe Cocktail 800-4422
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationLymphatic system component
Introduction Lymphatic system component Statistics Overview Lymphoma Non Hodgkin s Lymphoma Non- Hodgkin's is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most
More information3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:
Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position
More informationPeripheral blood Pleural effusion in a cat
Tools for the Diagnosis of Lymphoproliferative Diseases When is it difficult to diagnose lymphoproliferative disease? Persistent lymphocytosis consisting of small Lymph node aspirates containing an excess
More informationLearn more about diffuse large B-cell lymphoma (DLBCL), the most common aggressive form of B-cell non-hodgkin s lymphoma 1
Learn more about diffuse large B-cell lymphoma (DLBCL), the most common aggressive form of B-cell non-hodgkin s lymphoma 1 Expression of B-cell surface antigens drives several non-hodgkin s lymphomas (NHLs)
More informationCase Report Precursor B Lymphoblastic Lymphoma Involving the Stomach
Volume 2013, Article ID 930918, 4 pages http://dx.doi.org/10.1155/2013/930918 Case Report Precursor B Lymphoblastic Lymphoma Involving the Stomach Masaya Iwamuro, 1,2 Yoshinari Kawai, 1 Yasuhide Yamawaki,
More informationUnknown Case 6. Ann T. Moriarty, MD
Unknown Case 6 Ann T. Moriarty, MD Unknown Case 6 61 year old male with an enlarged cervical lymph node. He has a history of lung carcinoma, renal cell carcinoma and lymphoma. Case 6 Image 1: Fine needle
More informationHENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD. Parts 2 and 3
HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD Parts 2 and 3 NEOPLASTIC LYMPHOID DISEASES Introduction o The bone marrow is the source of all cells in the
More informationCase Report Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab
Case Reports in Hematology, Article ID 641483, 4 pages http://dx.doi.org/10.1155/2014/641483 Case Report Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with
More informationHAEMATOLOGICAL MALIGNANCY
HAEMATOLOGICAL MALIGNANCY Reference Compulsory reading Haematology at Glance 2 nd ed. Atul Mehta & Victor Hoffbrand Chapters: 20 to 31 Pages: 46 to 69 Pathogenesis of Haematological Malignancy Figure (a)
More informationLack of Surface Immunoglobulin Light Chain Expression by Flow Cytometric Immunophenotyping Can Help Diagnose Peripheral B-Cell Lymphoma
Hematopathology / SURFACE IMMUNOGLOBULIN LIGHT CHAIN NEGATIVE PERIPHERAL B-CELL LYMPHOMA Lack of Surface Immunoglobulin Light Chain Expression by Flow Cytometric Immunophenotyping Can Help Diagnose Peripheral
More informationDifferential cell counts in the histiocytic variant of lymphocytic predominance subtype of Hodgkin's
Journal of Clinical Pathology, 1978, 31, 1234-1238 Differential cell counts in the histiocytic variant of lymphocytic predominance subtype of Hodgkin's disease FIONA I. SUTHERLAND, J. B. MAcGILLIVRAY,
More informationHematopathology Lab. Third year medical students
Hematopathology Lab Third year medical students Objectives Identify the lesion Know the specific name of the lesion Know associated disease Know relevant pathologic background Spherocytes: appear small,
More informationThe Lymphomas. An overview..
The Lymphomas An overview.. Peter Anglin MD, FRCPC, MBA Stronach Regional Cancer Centre Newmarket, ON The lymphomas are an important part of the history of medicine 1666 Magpighi publishes first recorded
More informationVENTANA hematopathology solutions. Deliver diagnostic confidence
VENTANA hematopathology solutions Deliver diagnostic confidence 2 Hematopathology diagnostic solutions Contents VENTANA hematopathology assays 3 Detecting and subtyping hematological cancers 4 The importance
More informationDepartment of Pathology, University of California San Diego Health Sciences, 3855 Health Sciences Drive, San Diego, CA 92093, USA.
Int J Clin Exp Pathol 2011;4(2):190-196 www.ijcep.com /IJCEP1012012 Case Report Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma presenting as an isolated nasopharyngeal mass: a case report
More informationAmong the benign intraepithelial melanocytic proliferations, Inflamed Conjunctival Nevi. Histopathological Criteria. Resident Short Reviews
Resident Short Reviews Inflamed conjunctival nevi (ICN) may suggest malignancy because of their rapid growth and atypical histology. The objective of this study was to characterize the diagnostic features
More informationLymphoma (Lymphosarcoma) by Pamela A. Davol
Lymphoma (Lymphosarcoma) by Pamela A. Davol Cells derived from the bone marrow that mature and take part in cellular immune reactions are called lymphocytes. When lymphocytes undergo transformation and
More informationSupplemental materials
Supplemental materials 1 Supplemental Fig. 1 Immunogram This immunogram summarizes patient clinical data and immune parameters at corresponding time points for Patient IMF-32. The top panel illustrates
More informationLymphoma. Types of Lymphoma. Clinical signs
Lymphoma Lymphoma is a tumour originating from lymphoid tissue, either nodal (lymph ) or extranodal (thymus, spleen, mucosa, conjunctiva, or skin-associated lymphoid tissue). It is one of the most common
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationAbstracting Hematopoietic Neoplasms
CASE 1: LYMPHOMA PHYSICAL EXAMINATION 43yo male with a history of lower gastrointestinal bleeding and melena undergoing colonoscopy and biopsy to rule out neoplasm versus inflammation. Patient had no other
More informationMantle Cell Lymphoma
HEMATOPATHOLOGY Original Article Mantle Cell Lymphoma Morphologic Findings in Bone Marrow Involvement JAY WASMAN, MD, 1 NANCY S. ROSENTHAL, MD,' AND DIANE C. FARHI, MD 2 Although mantle cell lymphoma (MCL),
More informationCase Report A Case of p63 Positive Diffuse Large B Cell Lymphoma of the Bladder
Case Reports in Hematology Volume 2016, Article ID 4348208, 4 pages http://dx.doi.org/10.1155/2016/4348208 Case Report A Case of p63 Positive Diffuse Large B Cell Lymphoma of the Bladder Chelsey D. Deel,
More informationCase Report Synchronous Pulmonary Squamous Cell Carcinoma and Mantle Cell Lymphoma of the Lymph Node
Case Reports in Genetics Volume 2011, Article ID 945181, 5 pages doi:10.1155/2011/945181 Case Report Synchronous Pulmonary Squamous Cell Carcinoma and Mantle Cell Lymphoma of the Lymph Node Yu Sun, 1 Yun-Fei
More informationThe patient had a mild splenomegaly but no obvious lymph node enlargement. The consensus phenotype obtained from part one of the exercise was:
Case History An 86 year old male was admitted to hospital with chest infection. Haematological examination subsequently revealed the following: Hb- 11.0 g/dl; WBC- 67.1 x 10^9/l; PLT- 99 x10^9/l; RBC-
More informationIntegrated Diagnostic Approach to the Classification of Myeloid Neoplasms. Daniel A. Arber, MD Stanford University
Integrated Diagnostic Approach to the Classification of Myeloid Neoplasms Daniel A. Arber, MD Stanford University What is an integrated approach? What is an integrated approach? Incorporating all diagnostic
More informationCME/SAM. Olga Pozdnyakova, MD, PhD, 1 Svetlana Kondtratiev, MD, 1,2 Betty Li, MS, 1 Karry Charest, 1 and David M. Dorfman, MD, PhD 1.
Hematopathology / New Mastocytosis Flow Cytometry Approach High-Sensitivity Flow Cytometric Analysis for the Evaluation of Systemic Mastocytosis Including the Identification of a New Flow Cytometric Criterion
More informationHISTOPATHOLOGY. Shannon Martinson
HISTOPATHOLOGY Shannon Martinson March 2013 Case #1 History: 8 year old beagle Neck pain for the past couple of weeks Paresis, followed by paralysis developed over the past few days Gross Description courtesy
More informationLow grade High grade , immune suppression chronic persistent inflammation viruses B-symptoms
We've one category for lymphoid neoplasm which is the lymphoma in contrast to that of myeloid which has three categories; acute myeloid leukemias, myeloproliferative & myelodysplastic disorders. Lymphoma
More informationCancers of unknown primary : Knowing the unknown. Prof. Ahmed Hossain Professor of Medicine SSMC
Cancers of unknown primary : Knowing the unknown Prof. Ahmed Hossain Professor of Medicine SSMC Definition Cancers of unknown primary site (CUPs) Represent a heterogeneous group of metastatic tumours,
More informationCase Report Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Diagnostic Challenge
Case Reports in Pathology, Article ID 956217, 5 pages http://dx.doi.org/10.1155/2014/956217 Case Report Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma:
More informationConcurrent malignant melanoma and cutaneous involvement by classical hodgkin lymphoma (CHL) in a 63 year-old man
Gru and Lu Diagnostic Pathology 2013, 8:135 CASE REPORT Open Access Concurrent malignant melanoma and cutaneous involvement by classical hodgkin lymphoma (CHL) in a 63 year-old man Alejandro A Gru 1* and
More informationHematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall
Hematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall Tesha Guillory, MD, 1 Shiyong Li, MD, PhD, 1 Daniel J. Bergsagel, MD, 2 Elizabeth
More informationMany of the hematolymphoid disorders are derived
REVIEW ARTICLE Practical Immunohistochemistry in Hematopathology: A Review of Useful Antibodies for Diagnosis Ji Lu, MD and Karen L. Chang, MD Abstract: This review article offers some useful panels of
More informationClinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA
Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection Masoud Mardani M.D,FIDSA Shahidhid Bh BeheshtiMdi Medical lui Universityit Cytomegalovirus (CMV), Epstein Barr Virus(EBV), Herpes
More information