Trichofolliculoma of the Guinea Pig 1,2
|
|
- Stephen Dean
- 5 years ago
- Views:
Transcription
1 Trichofolliculoma of the Guinea Pig 1,2 Raymond D. Ediger, Garrett S. Dill, Jr., and Robert M. Kovatch, Aerobiology and Evaluation Laboratories and Medical Sciences Laboratories, Fort Detrick, Frederick, Maryland SUMMARY-Trichofolliculoma, a spontaneously occurring skin tumor, was found in 21 Hartley strain guinea pigs. Except for 2, these benign neoplasms were located in the hypodermis and were collected during 7,670 necropsy examinations performed on guinea pigs over a 41!2-year period. They were characterized by: formation of either medullary or cortical hair components (or both), well-differentiated follicular structures, the presence of sebaceous glands, 1 large cyst accompanied by smaller cysts, and loose connective tissue stroma.-j Nat Cancer Inst 46: ,1971. ONLY 5 spontaneous skin tumors have been reported in the guinea pig. One was described and called an epithelioma adenoides cysticum by Haranghy et al. (1). One sebaceous adenoma each has been reported by Murray (2) and Mosinger (3), and two sebaceous adenomas have been reported by Lombard (4). This report concerns a series of 21 cutaneous tumors classified as trichofolliculoma, which were found during 7,670 necropsy examinations performed on guinea pigs in the Fort Detrick colony from January 1965 to July These necropsies included a large number of discarded breeders and surplus animals, all animals that died spontaneously, and all animals with grossly visible lesions. This guinea pig colony was derived from a group of Dunkin-Hartley strain breeders imported from England in No other stock has been added since that time, and the colony has been randombred. HISTORY AND GROSS FINDINGS AT NECROPSY The data compiled on these 21 neoplasms revealed that all the tumors clinically appeared as solitary nodules elevating the skin. The largest lesion was 4.5 cm in diameter and the smallest, 1 X 1 X 0.5 cm. Seventeen of these skin tumors were in the dorsal lumbar region; three were in the lateral femoral area, and the other was at the cranial aspect of the shoulder. The tumors were observed in animals 6 weeks to 32 months of age (mean age, 17.6 months). Nine of the tumors were found in male and twelve in female animals. 1 Received August 10, 1970; accepted November 6, In conducting the research reported herein, we adhered to the Guide for Laboratory Animal Facilities and Care established by a special committee appointed by the Institute of Laboratory Animal Resources, National Academy of Sciences, National Research Council
2 518 EDIGER, DILL, AND KOVATCH On cut section, the tumors were found to be nonencapsulated and consisted of a central cyst surrounded by smaller cysts divided by an apparent stromal network (fig. 1). These cysts were filled with a caseous, white-to-yellow material, sometimes containing hair. All but 2 were located entirely in the hypodermis. These 2 neoplasms penetrated the epidermis; one was a papillary projection and the other had a central pore connecting the cyst to the skin surface. HISTOPATHOLOGY The tumors were usually multiloculated, cystic, and epithelial (fig. 2). The walls of the cysts were composed of stratified squamous epithelium, abortive hair follicles, and sebaceous glands scattered throughout a stroma of loose connective tissue. The smaller cysts were generally filled with keratinous debris, and some had birefringent hair shafts. Several tumors were more cellular and contained fewer smaller cysts. The hair follicle and keratin production varied morphologically. One type of hair follicle, morphologically similar to a normal follicle although arranged haphazardly, produced birefringent hair shafts (fig. 3). Another type was made up of stratified squamous epithelium, in crescentic, semicircular, and circular shapes (figs. 4 and 5). The stratum granulosum of this epithelium had prominent trichohyalin granules (fig. 6) and formed keratin, which was contained in a small cyst or streamed away in ribbons into larger cysts. The tumors with follicles producing birefringent hair structures (5 of the 21) also contained many follicles of the other type. The sebaceous glands generally were scattered haphazardly throughout the stroma, but occasionally they were in the usual histological position when associated with normally structured follicles (fig. 7). In all cases, the sebaceous glands appeared mature and frequently seemed to be contributing to the cyst content. Two neoplasms, in addition to the components described, contained masses and cords of compactly arranged basal cells with small compact nuclei and scant cytoplasm. These cells did not appear to be related to the follicular structures. In all tumors, mitotic figures were infrequent, and no nuclear abnormalities were seen. None of the neoplasms appeared locally invasive, and an inflammatory reaction was not a morphologic feature. DISCUSSION The trichofolliculoma in man was described by Gray and Helwig (5) as a harmartoma showing a definite differentiation toward hair structures. Histologically, the epithelial proliferation of these guinea pig tumors showed all stages of pilar formation. Leblond (6) discussed soft keratin, which makes up the medulla and inner root sheath, and hard keratin, which composes the cortex and cuticle of hair. Normal guinea pig hair has both a cortex and medulla. The brightly birefringent hair structures seen in some of the follicles in these tumors had only a cortex. The soft keratin, formed from the epithelium with trichohyalin granules, was the medullary portion or inner root sheath of the hair. In this tumor, both of the principal hair components were being formed separately, but complete hair was not being formed. When it is present, the birefringent cortex makes differentiation from the trichoepithelioma obvious. We believe the soft keratin component, when recognized as such, is equally distinctive. There are, however, minor differences between the tumor in the guinea pig and the tumor described in man. In the latter, an umbilicated area opening to the surface is often present, but a pore connecting the cyst to the surface was seen in only one of our tumors. The tumor in man occasionally extends from the corium into the hypodermis (5); however, in the guinea pig all but two of the tumors were confined to the hypodermis. In addition, the human tumor is encapsulated, but the trichofolliculoma in guinea pigs was not. Although sebaceous glands were described by Gray and Helwig (5) in 16% of 32 human cases, they were found in all trichofolliculomas of the guinea pig. JOURNAL OF THE NATIONAL CANCER INSTITUTE
3 TRICHOFOLLICULOMA OF THE GUINEA PIG 519 Gray and Helwig (5) adequately described the differential diagnosis of trichofolliculoma from multiple or solitary trichoepithelioma, basal cell carcinoma, and the dilated pore of Winer. In the tumors reported here, the maturity of the abortive hair follicle, the central cyst, the consistent preduction of hair components, and the general absence of islands of basal cells classify this group as trichofolliculomas. Other authors reported that spontaneous tumgrs rarely occur in guinea pigs that do not survive to senility (7); however, these supposedly rare tumors occurred in Hartley strain guinea pigs as early as six weeks of age. This suggests that either these tumors are more common in this colony or have been encountered elsewhere but not reported. REFERENCES (1) HARANGHY L, GYERGYAY F, ANTALFFY A, et al: Meerschweinchentumoren. Acta Morphol 4: , 1954 (2) MURRAY JA: A transplantable sarcoma of the guinea pig. J Path Bact 20: ,1916 (3) MOSINGER M: On the carcinoresistance of the guinea pig. I. Spontaneous guinea-pig tumors. Bull Assoc Franc Cancer 48 : , 1961 (4) LOMBARD C: La cancero-resistance du cobaye. Bull Assoc Franc Cancer 47: ,1960 (5) GRAY HR, HELWIG EB: Trichofolliculoma. Arch Derm (Cbicago) 86 : , 1962 (6) LEBLOND CP: Histological structure of hair, with a brief comparison to other epithelial appendages and epidermis itself. Ann NY Acad Sci 53 : , 1951 (7) ROGER JB, BLUMENTHAL HT: Studies of guinea pig tumors. I. Report of fourteen spontaneous guinea pig tumors, with a review of the literature. Cancer Res 20: , 1960 VOL. 46, NO.3, MARCH 1971
4 FIGURE I.-Two small cut sections (left.) and one larger section (right) represent neoplasms from 2 animals and show the central cyst surrounded by smaller cysts. FIGURE 2.-Neoplasm in the hypodermis, showing the multiloculated, cystic, and epithelial features. Hematoxylin and eosin. X EDIGER, DILL, AND KOVATCH
5 FIGURE 3.-Abortive hair follicles producing the cortical component of hair. Hematoxylin and eosin. X 40 FIGURE 4.-Abortive hair follicles producing the soft keratin component of hair. Hematoxylin and eosin. X 40 EDIGER, DILL, AND KOVATCH 521
6 FIGURE 5.-Abortive hair follicles producing the soft keratin component of hair. Hematoxylin and eosin. X 125 FIGURE 5.-Numerous trichohyalin granules which stain brightly eosinophilic in soft keratin structures. Hematoxylin and eosin. X EDIGER, DILL, AND KOVATCH
7 FIGURE 7.-Sebaceous glands scattered haphazardly throughout the stroma. Hematoxylin and eosin. X 125 EDIGER, DILL, AND KOVATCH 523
INTEGUMENTARY 1-Epidermis, 2-Dermis, Structure of thick and thin skin I- Epidermis . Stratum basale
INTEGUMENTARY The skin (integument, cutis ) and its derivatives constitute the integumentary system. It form the external covering of the body and is the largest organ of the body. The skin consists of
More informationSkin and Body Membranes
4 Skin and Body Membranes PowerPoint Lecture Slide Presentation by Jerry L. Cook, Sam Houston University ESSENTIALS OF HUMAN ANATOMY & PHYSIOLOGY EIGHTH EDITION ELAINE N. MARIEB Skin and Body Membranes
More informationSkin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs
Skin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs Classification of Body Membranes Epithelial membranes Cutaneous
More informationPowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes 4 Body Membranes Function of body membranes Cover body surfaces Line body cavities
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article A Clinicopathological Study of Adnexal Tumors of Skin in a Tertiary Care Research Hospital
More informationDisorders of Cell Growth & Neoplasia. Histopathology Lab
Disorders of Cell Growth & Neoplasia Histopathology Lab Paul Hanna April 2010 Case #84 Clinical History: 5 yr-old, West Highland White terrier. skin mass from axillary region. has been present for the
More informationIntegumentary System. Integumentary System
1. General aspects a. The integumentary system consists of several organs major organ of the system is the skin other organs are relatively small and they can be considered as specialized structures of
More informationLab 7: Integumentary System Hamilton ANSWERS TO PRE- LAB ASSIGNMENTS
Lab 7: Integumentary System Hamilton ANSWERS TO PRE- LAB ASSIGNMENTS Pre-Lab Activity 1: 1. a. epidermis b. dermis c. hypodermis d. adipose tissue e. hair f. sebaceous gland g. sweat gland 2. a Pre-Lab
More informationUnit 4 - The Skin and Body Membranes 1
Unit 4 - The Skin and Body Membranes 1 I. Unit 4: Skin and Body Membranes A. Body Membranes 1. Function of body membranes a) Cover body surfaces b) Line body cavities c) Form protective sheets around organs
More informationIntroduction. Skin and Body Membranes. Cutaneous Membranes Skin 9/14/2017. Classification of Body Membranes. Classification of Body Membranes
Introduction Skin and Body Membranes Body membranes Cover surfaces Line body cavities Form protective and lubricating sheets around organs Classified in 5 categories Epithelial membranes 3 types- cutaneous,
More informationAnatomy and Physiology Homework: Chapters 3-4
Anatomy and Physiology Homework: Chapters 3-4 CHAPTER 3: Cells and Tissues 1. The smallest unit of living tissue is called a. All living organisms are composed of these basic units where all life processes
More informationEx. 7: Integumentary
Collin County Community College BIOL. 2401 Ex. 7: Integumentary. Skin or Integument Consists of three major regions Epidermis outermost superficial region Dermis middle region Hypodermis (superficial fascia)
More informationCHAPTER 5 INTEGUMENTARY
CHAPTER 5 INTEGUMENTARY skin under the skin other stuff cutaneous layer hypodermis (subcutaneous) accessory structures Cutaneous layer = skin epithelial layers = connective tissue layer = dermis Subcutaneous
More informationSkin and Body Membranes
Essentials of Human Anatomy & Physiology Elaine N. Marieb Seventh Edition Chapter 4 Skin and Body Membranes Slides 4.1 4.32 Lecture Slides in PowerPoint by Jerry L. Cook Skin and Body Membranes Function
More informationCh. 4: Skin and Body Membranes
Ch. 4: Skin and Body Membranes I. Body Membranes A. Function of body membranes 1. Cover body surfaces 2. Line body cavities 3. Form protective sheets around organs II. Classification of Body Membranes
More informationSkin. Kristine Krafts, M.D.
Skin Kristine Krafts, M.D. Skin Lecture Objectives Describe the functions of skin. Describe the structure, location and function of the cell types found in epidermis: keratinocytes, melanocytes, Langerhans
More informationMalignant transformation in benign cystic teratomas, dermoids of the ovary
European JournalofObstetrics& Gynecology andreproductivebiology, 29 (1988) 197-206 197 Elsevier EJO 00716 Malignant transformation in benign cystic teratomas, dermoids of the ovary S. Chadha 1 and A. Schaberg
More informationThe Integumentary System: An Overview
The Integumentary System: An Overview Functions: Protective covering Helps regulate body temperature Retards water loss from deeper tissues Houses sensory receptors Synthesizes biochemicals Excretes small
More informationSkin Adnexal Tumors - A Histopathological Spectrum at a Tertiary Care Hospital
Original Article GCSMC J Med Sci Vol (VI) No (I) January-June 2017 Skin Adnexal Tumors - A Histopathological Spectrum at a Tertiary Care Hospital Neeraja Barve*, Hansa Goswami**, Urvi Parikh *** Abstract
More informationHistopathology: Cervical HPV and neoplasia
Histopathology: Cervical HPV and neoplasia These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need to learn about
More informationIntegumentary System. Packet #12
Integumentary System Packet #12 Introduction Skin/Integument Skin, considered an organ, is the major component of the integumentary system. The integumentary system is also composed of other accessory
More informationSUPPLEMENTARY FIG. S2. Teratoma. Portion of a teratoma composed of neural tissue. The large cells in the central part correspond to ganglion cells.
Supplementary Data SUPPLEMENTARY FIG. S1. Teratoma. The tumor is composed predominantly of keratinizing squamous epithelium (Sq), which forms cysts filled with keratin (arrows). The tumor also contains
More informationAppendageal skin tumors
Appendageal skin tumors Ibrahim Khalifeh, M.D. Associate Professor Department of Pathology American University of Beirut Medical Center Beirut, Lebanon Appendageal tumors Neoplasms whose differentiation
More informationCase Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationThe Integumentary System
The Integumentary System Integument is skin Skin and its appendages make up the integumentary system A fatty layer (hypodermis) lies deep to it Two distinct regions Epidermis Dermis PHL 212 1 Function
More information3. Histopathology. 1. Introduction. 2. Case History. Volume 6 Issue 4, April Licensed Under Creative Commons Attribution CC BY
Spiradenocylindroma with Trichoepithelioma A Collision Tumor with Multiple Differentiation R. Lavanya 1, S. K. Sridevi 2, P. Viswanathan 3, P. V. S.Prasad 4 1 II nd Year Post Graduate, Department of Pathology,
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation
More informationCornell Notes Name: Date: Topic: CH 4
*We are revisiting Ch 3B on body tissues (Connective) prior to our study of Ch 4 Integumentary. Start on p.90 I. Connective Tissue A. Functions of Connective 1. Protection 2. Support 3. Binding Together
More informationA 5 Year Histopathological Study of Skin Adnexal Tumors at a Tertiary Care Hospital
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 14, Issue 4 Ver. VII (Apr. 2015), PP 01-05 www.iosrjournals.org A 5 Year Histopathological Study of Skin
More informationObservations on the Pathology of Lesions Associated with Stephanofilaria dinniki Round, 1964 from the Black Rhinoceros (Diceros bicornis)
Journal of Helminthology, ~ol. XXXVIII, Nos. 1/2, 1964, pp. 171-174. Observations on the Pathology of Lesions Associated with Stephanofilaria dinniki Round, 1964 from the Black Rhinoceros (Diceros bicornis)
More informationIntegumentary System and Body Membranes
Integumentary System and Body Membranes The Skin and its appendages hair, nails, and skin glands Anatomy/Physiology NHS http://www.lab.anhb.uwa.edu.au/mb140/corepages/integumentary/integum.htm I. System
More informationChapter 4 Opener Pearson Education, Inc.
Chapter 4 Opener Introduction The integumentary system is composed of: Skin Hair Nails Sweat glands Oil glands Mammary glands The skin is the most visible organ of the body Clinicians can tell a lot about
More informationPowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes 4 Body Membranes Function of body membranes Cover body surfaces Line body cavities
More informationBSD 2015 Case 19. Female 21. Nodule on forehead. The best diagnosis is:
BSD 2015 Case 19 Female 21. Nodule on forehead. The best diagnosis is: A. mixed tumour of skin B. porocarcinoma C. nodular hidradenoma D. metastatic adenocarcinoma BSD 2015 Case 19 Female 21 Nodule on
More informationThe Integumentary System
The Integumentary System The Integumentary System Integument is skin Skin and its appendages make up the integumentary system (See if you can name some appendages) A fatty layer (hypodermis) lies deep
More informationResearch Article Histopathological Study of Skin Adnexal Tumours Institutional Study in South India
Skin Cancer, Article ID 543756, 4 pages http://dx.doi.org/10.1155/2014/543756 Research Article Histopathological Study of Skin Adnexal Tumours Institutional Study in South India Ankit Sharma, 1 Deepak
More informationDiseases of the breast (1 of 2)
Diseases of the breast (1 of 2) Introduction A histology introduction Normal ducts and lobules of the breast are lined by two layers of cells a layer of luminal cells overlying a second layer of myoepithelial
More informationEpidermoid Cyst of the Ovary
Epidermoid Cyst of the Ovary A eport of Three Cases with Comments on Histogenesis OBET H. YOUNG, M.B., JAIME PAT, M.D., AND OBET E. SCUY, M.D. Young, obert H., Prat, Jaime, and Scully, obert E.: Epidermoid
More informationDiagnostic Cytology of Cancer Cases
Diagnostic Cytology of Cancer Cases Somporn Techangamsuwan Companion Animal Cancer Research Unit (CAC-RU) Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University 1 Tumor or Non-tumor
More informationMy Journey into the World of Salivary Gland Sebaceous Neoplasms
My Journey into the World of Salivary Gland Sebaceous Neoplasms Douglas R. Gnepp Warren Alpert Medical School at Brown University Rhode Island Hospital Pathology Department Providence RI Asked to present
More informationHistopathological Study of Skin Adnexal Tumors - A Ten Years Study
Original Research Article Histopathological Study of Skin Adnexal Tumors - A Ten Years Study V. Srinivas Kumar 1, V. Geeta 1*, Nikhil Kumar Voruganti 2, O. Shravan Kumar 3, Tamilarasi 4 1 Associate Professor
More informationNormal thyroid tissue
Thyroid Pathology Overview Normal thyroid tissue Normal thyroid tissue with follicles filled with colloid. Thyroid cells form follicles, spheres of epithelial cells (always single layered in health, usually
More informationKidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
More informationDr Narmeen S. Ahmad. Lab 1
Dr Narmeen S. Ahmad Lab 1 1 Tissues are groups of cells with a common structure (form) and function (job). There are (4) types of tissue: 1. Epithelial 2. Connective 3. Muscle 4. Nervous 2 Epithelial cells
More informationPLEOMORPHIC ADENOMA ( BENIGN MIXED TUMOR )
( BENIGN MIXED TUMOR ) Grossly, the tumor is freely movable, solid, sometimes lobulated and occasionally cystic. If recurrent, multinodular masses are common. Histologically, within a fibrous capsule,
More information11/8/2012. Chapter 6 Part 1 Objectives: Skin = Integument = Cutaneous Membrane. The Structure of Skin. Epidermis
Chapter 6 Part 1 Objectives: Define organ, and associate the skin as an organ of the integumentary system. List the general functions of the skin. Describe the structure of the layers of the skin. Summarize
More informationNeoplasia literally means "new growth.
NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the
More informationMammary Nodular Hyperplasia in Intact R hesus Monkeys
Vet. Path. 10: 130-134 (1973) Mammary Nodular Hyperplasia in Intact R hesus Monkeys L. W NELSON and L. D. SHOTT Department of Pathology and Toxicology, Mead Johnson Research Center, Evansville, Ind., and
More information3. Dense connective tissue is found in skin, & surrounding blood vessels, nerves, and organs.
Ch.4&5 Group Quiz True/False Indicate whether the statement is true or false. 1. There are 4 basic types of tissue in the human body. 2. Cartilage is also known as osseous tissue. 3. Dense connective tissue
More informationALL PHOTOS ARE IDENTIFIED IN THE LOWER RIGHT CORNER WITH THE MAGNIFICATION POWER THAT THE PHOTO WAS TAKEN WITH. SCAN - THIS IS A VERY LOW POWER IMAGE
ALL PHOTOS ARE IDENTIFIED IN THE LOWER RIGHT CORNER WITH THE MAGNIFICATION POWER THAT THE PHOTO WAS TAKEN WITH. SCAN - THIS IS A VERY LOW POWER IMAGE THAT WE USE WHEN A SAMPLE IS SO BIG THAT YOU CAN T
More informationGross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of
Tiền liệt tuyến Tiền liệt tuyến Gross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of solid and microcystic areas.
More information*with blood clot. Microscopically, the tumor was made up of papillary. Krompecher,2 Bloodgood,8 and Hazen I also have clinical and histologic
THE HISTOGENESIS OF CLEAR CELL PAPILLARY CARCINOMA OF THE SKIN * Y. Lru, M.D. (From the Department of Pathology, Peiping Union Medical Colege, Peiping, China) Clear cell papillary carcinoma, so designated
More informationPathology Slides. [Pathology]
Pathology Slides MedicoNotes provides real laboratory pathological slides to aid you to differentiate between different pathological structures under microscope. www.mediconotes.com Histology slides example
More informationPrinciples of Anatomy and Physiology
Principles of Anatomy and Physiology 14 th Edition CHAPTER 5 The Integumentary System Introduction The organs of the integumentary system include the skin and its accessory structures including hair, nails,
More informationIntegumentary System. 2/20/02 S. Davenport 1
Integumentary System 2/20/02 S. Davenport 1 Functions of Skin Protection Temperature regulation Sensation Excretion Vitamin D production 2/20/02 S. Davenport 2 Protection A Barrier Three types of barriers:
More informationEpithelia will be discussed according to the following scheme: Type Number of layers Shape Line drawing. Squamous Cuboidal Columnar
Epithelia Epithelia will be discussed according to the following scheme: Type Number of layers Shape Line drawing Simple Squamous Cuboidal Columnar Covering and Lining epithelium Pseudostratified Stratified
More informationAPOCRINE SWEAT GLAND CARCINOMA OF THE VULVA* JOHN R. McDONALD, M.D. Section on Surgical Pathology, The Mayo Clinic, Rochester, Minnesota
APOCRINE SWEAT GLAND CARCINOMA OF THE VULVA* JOHN R. McDONALD, M.D. Section on Surgical Pathology, The Mayo Clinic, Rochester, Minnesota The wide variety of neoplasms, both benign and malignant, originates
More informationSkin (Integumentary System) Wheater, Chap. 9
Skin (Integumentary System) Wheater, Chap. 9 Skin (Integument) Consists of skin and associated derivatives Largest organ of body (21 ft 2 ; 9 lbs.; has 11 miles of blood vessels) Functions: Protection
More informationDescribe the functions of the vertebrate integumentary system. Discuss the structure of the skin and how it relates to function.
Chapter 5 Describe the functions of the vertebrate integumentary system. Discuss the structure of the skin and how it relates to function. Explain the basis for different skin colors. Describe the structure
More informationChapter 6 Skin and the Integumentary System. Skin Cells. Layers of Skin. Epidermis Dermis Subcutaneous layer beneath dermis not part of skin
Chapter 6 Skin and the Integumentary System Composed of several tissues Maintains homeostasis Protective covering Retards water loss Regulates body temperature Houses sensory receptors Contains immune
More informationSamer Ghosn, MD Associate professor, Derpartment of Dermatology American University of Beirut Medical Center. Follicular lesions
Samer Ghosn, MD Associate professor, Derpartment of Dermatology American University of Beirut Medical Center Follicular lesions Introduction Follicular lesions are important to recognize: For proper management
More informationSynonyms. Nephrogenic metaplasia Mesonephric adenoma
Nephrogenic Adenoma Synonyms Nephrogenic metaplasia Mesonephric adenoma Definition Benign epithelial lesion of urinary tract with tubular, glandular, papillary growth pattern Most frequently in the urinary
More informationHistogenesis of medullary carcinoma of the thyroid
J. clin. Path., (1966), 19, 114 E. D. WILLIAMS1 From the Institute ofpathology, The London Hospital SYNOPSIS Thirty-one dog thyroid tumours and 28 spontaneous rat thyroid tumours were studied histologically
More informationCh 4. Skin and Body Membranes
Ch 4 Skin and Body Membranes TITLE HISTOLOGY SLIDES & NOTES ESSENTIAL QUESTION What tissues compose the integumentary system? Stratified Squamous Epithelium Stratified = several layers; Squamous = shape
More informationSalivary Glands 3/7/2017
Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationAnatomy Ch 6: Integumentary System
Anatomy Ch 6: Integumentary System Introduction: A. Organs are body structures composed of two or more different tissues. B. The skin and its accessory organs make up the integumentary system. Types of
More informationThe Integementary System. The Skin & Its Parts
The Integementary System The Skin & Its Parts General Structure 2. Accessory structures: hair, nails, exocrine glands 1. Cutaneous membrane: various layers Major Functions 1. Protection 2. Temperature
More informationFORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT
I: 2047-2051 ISSN: 2277 4998 FORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT ABEDI G 1, HESARAKI S 2, ASGHARI A 1* 1: Department of Clinical Science, Science and Research branch, Islamic Azad University,
More informationABCD rule. apocrine glands. arrector pili. ceruminous glands. contact dermatitis
ABCD rule assessing moles: asymmetric, broder irregularity, color, diameter (larger than 6mm) apocrine glands arrector pili sweat glands in the pubic and underarm areas that secrete thicker sweat, that
More information2/5/2019. Organ System: Skin or Integumentary System. Hypodermis (or superficial fascia) Integumentary System - Learn and Understand
Integumentary System - Learn and Understand Skin is an organ comprised of all four tissues Each layer of the skin contributes to one or more of its numerous functions Skin is both strong and flexible Keratinization
More informationJournal of International Academy of Forensic Science & Pathology (JIAFP)
Journal of International Academy of Forensic Science & Pathology (JIAFP) ISSN 2395-0722 MICROCYSTIC ADNEXAL CARCINOMA-A CASE REPORT WITH REVIEW OF LITERATURE Case Report Sulakshana M S 1,Natarajan M 2
More informationIntegumentary System (Script) Slide 1: Integumentary System. Slide 2: An overview of the integumentary system
Integumentary System (Script) Slide 1: Integumentary System Slide 2: An overview of the integumentary system Skin is the body s largest and heaviest organ making up 15% of body weight. Most skin is 1 to
More informationSinusoids and venous sinuses
LYMPHOID SYSTEM General aspects Consists of organs that are made of lymphoid tissue; Immune defense Breakdown of red blood cells. 1 Sinusoids In place of capillaries Endothelium; often fenestrated More
More informationWhat is new on adnexal neoplasms. Omar P. Sangueza, MD. Professor and Director of Dermatopathology. Wake Forest University School of Medicine
What is new on adnexal neoplasms Omar P. Sangueza, MD Professor and Director of Dermatopathology Wake Forest University School of Medicine Winston Salem, North Carolina Carney complex is an autosomal dominant
More information(CYLINDROMA) ATLAS OF HEAD AND NECK PATHOLOGY ADENOID CYSTIC CARCINOMA
(CYLINDROMA) This malignant tumor is poorly encapsulated and while seemingly well defined within the affected gland, there is usually infiltration of surrounding tissue on closer examination. The cut surface
More informationSalivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches
Salivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches Christopher C. Griffith, MD, PhD Raja R. Seethala, MD 1. Salivary gland tumor cytology: A
More informationLymphoid Organs. Dr. Sami Zaqout. Dr. Sami Zaqout IUG Faculty of Medicine
Lymphoid Organs Dr. Sami Zaqout Cells of the Immune System Lymphocytes Plasma cells Mast cells Neutrophils Eosinophils Cells of the mononuclear phagocyte system Distribution of cells of the immune system
More informationTHE INTEGUMENTARY SYSTEM. Body Membranes & Skin
THE INTEGUMENTARY SYSTEM Body Membranes & Skin TYPES OF MEMBRANES Epithelial Membranes includes layer of epithelial cells and connective tissue Serous Cutaneous Mucous Connective Tissue Membranes solely
More informationThe Integumentary System
The Integumentary System The Integumentary System Integument is skin Skin and its appendages make up the integumentary system A fatty layer (hypodermis) lies deep to it Two distinct regions Epidermis Dermis
More informationCase Report Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases
SAGE-Hindawi Access to Research Pathology Research International Volume 2011, Article ID 105973, 4 pages doi:10.4061/2011/105973 Case Report Nevus Lipomatosus Superficialis with a Folliculosebaceous Component:
More informationthe urinary system pathology Dr. Fairoz A Eltorgman
the urinary system pathology Dr. Fairoz A Eltorgman Tumors of the renal pelvis & kidney Benign tumors of the renal pelvis: Hemangioma Leiomyoma Malignant tumors: Transitional cell carcinoma Squamous cell
More informationSynchronous squamous cell carcinoma of the breast. and invasive lobular carcinoma
Sentani K et al. 1 Letter to the editor Synchronous squamous cell carcinoma of the breast and invasive lobular carcinoma Kazuhiro Sentani, 1 Takashi Tashiro, 2 Naohide Oue, 1 Wataru Yasui 1 1 Department
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationSkin Histology. Dr. Heba Kalbouneh Associate Professor of Anatomy and Histology
Skin Histology Dr. Heba Kalbouneh Associate Professor of Anatomy and Histology Integumentary system The skin is considered the largest organ of the body Basic Skin Histology The skin is composed of two
More informationEpithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev
Epithelial tumors Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Tumors from the epithelium are the most frequent among tumors. There are 2 group features of these tumors: The presence in most
More informationAnatomy Fall Semester Set 1: Organization and Tissues
. 1. Which of the following describes anatomy? a. using devices to investigate parameters such as heart rate and blood pressure b. investigating human structure via dissections and other methods c. studying
More informationAN OBSERVATION OF PRIMARY TUMORS OF THE PITUITARY, OVARIES, AND MAMMARY GLANDS IN A MOUSE
AN OBSERVATION OF PRIMARY TUMORS OF THE PITUITARY, OVARIES, AND MAMMARY GLANDS IN A MOUSE W. U. GARDNER,' L. C. STRONG,' AND G. M. SMITH (Front the Department of Anatomy, Yale Univerdy School of Medicine)
More informationIn the third part of the present study tumours which previous were described as basal cell tumours but now have been reclassified as trichoblastomas
170 6. SUMMARY Immunhistochemical investigations for identifying the histogenesis of basaloid neoplasias and hyperplasias in the mamma parenchyma of the bitch, for the use of the human nuclear protein
More informationFigure 4.1. Using Figure 4.1, identify the following: 1) The region that contains adipose tissue is indicated by letter. Diff: 2 Page Ref: 115
Essentials of Anatomy and Physiology, 9e (Marieb) Chapter 4 Skin and Body Membranes Short Answer Figure 4.1 Using Figure 4.1, identify the following: 1) The region that contains adipose tissue is indicated
More informationXX. Tumours of the nasal cavity *
XX. Tumours of the nasal cavity * H. STONZI 1 & B. HAUSER2 Tumours of the nasal cavity are rare in domestic animals, most cases occurring in the dog. Epithelial tumours are the most common type in carnivores
More informationA clinicopathologic study of skin appendageal tumors
Net Study A clinicopathologic study of skin appendageal tumors Pradeep S. Nair Department of Dermatology and Venereology, Medical College Hospital, Trivandrum- 695 011, Kerala, India Address for correspondence:
More informationA neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after
NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a
More informationEMBRYONAL NEPHROMA IN THE CHICKEN: REPORT OF TWO CASES
EMBRYONAL NEPHROMA IN THE CHICKEN: REPORT OF TWO CASES FRANK D. McKENNEY, V.M.D. (Di1!ision of Experimental Surgery and Pathology, The Mayo Foundation, Rochester, Minnesota) Few data have been collected
More informationXIII. Tumours of the liver and biliary system
XIII. Tumours of the liver and biliary system V. PONOMARKOV 1 & L. J. MACKEY 2 In this histological classification of liver and gall bladder tumours the tumour types largely correspond to those found in
More informationFigure 6.1 Transparency Master 37
Pore Hair shaft Epidermis Dermal papillae (papillary layer of dermis) Meissner s corpuscle Dermis Free nerve ending Reticular layer of dermis Sebaceous (oil) gland Arrector pili muscle Sensory nerve fiber
More informationBI 121 LAB. WEEK 2: Tissues (continued); Integumentary System
BI 121 LAB 2-1 WEEK 2: Tissues (continued); Integumentary System This week you will 1) Review the four major tissue types 2) Review the characteristics of epithelial tissues. 3) Learn the major characteristics
More informationEXPERIMENTAL THERMAL BURNS I. A study of the immediate and delayed histopathological changes of the skin.
EXPERIMENTAL THERMAL BURNS I A study of the immediate and delayed histopathological changes of the skin. RJ Brennan, M.D. and B. Rovatti M.D. The purpose of this study was to determine the progressive
More informationBASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY Divvya B 1, Rehana Tippoo 2, P. Viswanathan 3, B. Krishnaswamy 4, A.
BASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY Divvya B 1, Rehana Tippoo 2, P. Viswanathan 3, B. Krishnaswamy 4, A. Anvar Ali 5 HOW TO CITE THIS ARTICLE: Divvya B, Rehana Tippoo, P. Viswanathan,
More information