A215- Urinary bladder cancer tissues

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1 A215- Urinary bladder cancer tissues (formalin fixed) For research use only Specifications: No. of cases: 45 Tissue type: Urinary bladder cancer tissues No. of spots: 2 spots from each cancer case (90 spots) Total spots: 94 4 non-neoplastic spots (4 spots) Corresponding normal tissues with cancers: Yes Diameter: 1. 0 mm Documents: Product specification: layout, summary of tissue spots H&E stained images Detailed pathological information Layout: A B C D E F G H I : Urothelial : Urothelial in situ : Adeno + other pathology : Squamous : Non-neoplastic

2 A215- Urinary bladder cancer tissues Summary of tissue spots (formalin fixed) For research use only No Coordinate Sex Age Key Word TNM Stage 1 1,2 m 64 Urothelial 2 3,4 m 49 Urothelial TaN0M0 ( 0a ) 3 5,6 m 56 Urothelial T1aN0M0 ( Ⅰ ) 4 A 7,8 m 41 Urothelial TaN0M0 ( 0a ) 5 9,10 m 48 Adeno signet ring cell T3aN0M0 ( Ⅲ ) 6 11 m 48 Non-neoplastic from A9,10 7 1,2 f 77 Papillary Urothelial 8 3,4 m 68 Urothelial TaN0M0 ( 0a ) 9 5,6 f 44 Urothelial T1aN0M0 ( Ⅰ ) 10 B 7,8 m 55 Urothelial T1aN0M0 ( Ⅰ ) 11 9,10 m 53 Transitional cell Adeno m 48 Non-neoplastic from A9, , 2 m 72 Urothelial T4aN0M0 ( Ⅲ ) 14 3, 4 m 63 Papillary Urothelial 15 5, 6 m 51 Urothelial TaN0M0 ( 0a ) 16 C Papillary 7, 8 m 75 Urothelial TaN0M0 ( 0a ) 17 9, 10 f 33 Adeno Mucinous adeno T3N0M0 ( Ⅲ ) f 33 Non-neoplastic from C9, , 2 m 60 Urothelial 20 3, 4 m 65 Urothelial T4aN0M0 ( Ⅲ ) 21 5, 6 m 68 Urothelial TaN0M0 ( 0a ) D 22 7, 8 m 58 Urothelial T1aN0M0 ( Ⅰ ) 23 9, 10 m 44 Adeno f 33 Non-neoplastic from C9, , 2 m 66 Urothelial T4aN0M0 ( Ⅲ ) 26 3, 4 f 74 Urothelial T1aN0M0 ( Ⅰ ) 27 5, 6 m 81 Urothelial T2N0M0 ( Ⅱ ) 28 E 7, 8 f 58 Urothelial T3bN1M0 ( Ⅳ ) 29 9, 10 m 44 Mucinous adeno Adeno Urachal adeno

3 A215- Urinary bladder cancer tissues Summary of tissue spots (formalin fixed) For research use only No Coordinate Sex Age Key Word TNM Stage 30 1, 2 f 79 Urothelial T2N0M0 ( Ⅱ ) 31 3, 4 f 75 Urothelial T1bN0M0 ( Ⅰ ) 32 F 5, 6 m 67 Urothelial T3bN0M0 ( Ⅲ ) 33 7, 8 m 67 Urothelial T3bN0M0 ( Ⅲ ) 34 9, 10 m 86 Squamous cell 35 1, 2 m 62 Urothelial T4aN0M1 ( Ⅳ ) 36 3, 4 m 86 Urothelial T4N1M1 ( Ⅳ ) 37 5, 6 m 76 Urothelial T2bN0M0 ( Ⅱ ) G 38 7, 8 m 64 Urothelial T1bN0M0 ( Ⅰ ) 39 9, 10 f 69 Urothelial Squamous cell T1bN0M0 ( Ⅰ ) 40 1, 2 m 67 Urothelial T2aN0M0 ( Ⅱ ) 41 3, 4 m 75 Urothelial T3bN0M0 ( Ⅲ ) 42 H 5, 6 f 66 Urothelial 43 7, 8 f 72 Urothelial T1aN0M0 ( Ⅰ ) 44 9, 10 f 59 Squamous cell T2bN0M0 ( Ⅱ ) 45 1, 2 m 87 Urothelial T2N0M0 ( Ⅱ ) 46 3, 4 m 52 Urothelial Carcinoma in situ TisN0M0 (0is ) 47 I 5, 6 f 59 Urothelial Carcinoma in situ TisN0M0 (0is ) 48 7, 8 m 64 Urothelial Carcinoma in situ TisN0M0 (0is ) 49 9, 10 m Squamous cell T2N0M0 ( Ⅱ )

4 A215- Urinary bladder cancer tissues (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 A11 B1 B2 B3 B4 B5 B6 B7 B8 B9 B10 B11 C1 C2

A215- Urinary bladder cancer tissues (formalin fixed) For research use only QC sheet_lot#122120412091

5 A215- Urinary bladder cancer tissues (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining C3 C4 C5 C6 C7 C8 C9 C10 C11 D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 E1 E2 E3 E4

6 A215- Urinary bladder cancer tissues (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining E5 E6 E7 E8 E9 E10 F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 G1 G2 G3 G4 G5 G6 G7 G8

7 A215- Urinary bladder cancer tissues (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining G9 G10 H1 H2 H3 H4 H5 H6 H7 H8 H9 H10 I1 I2 I3 I4 I5 I6 I7 I8 I9 I10

8 Urinary bladder, main mass, TURBT: low-grade papillary 1 A 1,2 m 64 Urinary bladder, deep biopsy: muscularis propria is free of neoplastic involvement Urinary bladder, dome, right lateral and left lateral wall, biopsy: free of tumor. 2 A 3,4 m 49 3 A 5,6 m 56 4 A 7,8 m 41 Urinary bladder, main mass, TURBT: low-grade papillary. Urinary bladder, deep, dome, right and left lateral wall, biopsy: free of tumor. Urinary bladder, TURBT: 1) right posterior wall: papillary, low grade, without stromal invasion 2) left bladder neck mass and deep biopsy and anterior wall mass: papillary, high grade, with superficial stromal invasion(pt1a). Urinary bladder, biopsy: 1) main mass and deep biopsy: papillary, low grade, without lamina propria invasion 2) posterior wall and right and left lateral walls: free of tumor. TaN0M0 ( 0a ) T1aN0M0 ( Ⅰ ) TaN0M0 ( 0a ) 5 A 9,10 m 48 adeno signet ring cell 6 A 11 m 48 non-neoplastic Non-neoplastic from A9,10 1.Urinary bladder, partial cystectomy: 1) adeno, with extensive mucin production and signet ring cell feature invading perivascular fat tissue. 2) resection margin: free of tumor, see note. 2. Skin, abdominal wall: free of tumor. Note: mucosal margins of urinary bladder are free of tumor. The tumor deeply extends beyond the deep muscle layer and is covered by peritoneum, which is involved, but not penetrated by neoplasm. T3aN0M0 ( Ⅲ )

9 7 B 1,2 f 77 8 B 3,4 m 68 9 B 5,6 f B 7,8 m B 9,10 m 53 papillary transitional cell adeno 12 B 11 m 48 non-neoplastic Non-neoplastic from A9,10 Urinary bladder, TURBT: 1) main mass(right dome): papillary, high grade (transitional cell, grade II) 2) deep biopsy: free of tumor 3) dome, right: papillary, high grade 4) posterior wall: papillary, high grade, with superficial laminar invasion 5) dome, right lateral and left lateral: free of tumor. 1) main mass: papillary, high grade (transitional cell grade 2) without stromal invasion (pta) 2) tumor bed: free of tumor 3) deep biopsy: free of tumor. 1) main mass dome, dome mass, bladder neck, bladder neck deep biopsy: papillary, high grade (transitional cell, grade II), with focally superficial stromal invasion and superficial lymphatic invasion (pt1a) 2) dome, right lateral, left lateral and tumor bed: free of tumor. 1) main mass and deep biopsy: papillary, low grade(transitional cell, grade II) with focally superficial lamina propria invasion(pt1a) 2) dome, right lateral and left lateral wall: free of tumor. Urinary bladder, partial cystectomy: 1) mixed (high grade transitional cell and well differentiated adeno). - with invasion in lamina propria(t1) - with no vascular invasion - with no perineural invasion - bladder mucosal margins: involvement of tumor(transitional cell in situ) 2) separately submitted specimen: transitional cell in situ. TaN0M0 ( 0a ) T1aN0M0 ( Ⅰ ) T1aN0M0 ( Ⅰ )

10 13 C 1, 2 m C 3, 4 m C 5, 6 m C 7, 8 m C 9, 10 f 33 papillary papillary adeno mucinous adeno 18 C 11 f 33 non-neoplastic Non-neoplastic from C9,10 Urinary bladder, TURBT: papillary, high grade(transitional cell, grade II) with squamous cell (mixed ) involving muscle proper. T4aN0M0 ( Ⅲ ) Urianry bladder, TURB: 1) main mass and deep biopsy: papillary, low grade (transitional cell grade 2), with superficial stromal invasion (pt1a) 2) dome, right and left lateral wall: free of tumor. Urinary bladder, TURBT and biopsy: 1) dome mass, dome mass-deep biopsy, neck mass, right posteriolateral mass, right posterolateral deep biopsy, left posterolateral main mass, and left posterolateral deep biopsy: papillary, low-grade (transitional cell, grade 2), without stromal invasion (pt20) 2) anterior wall: papillary tumor of low malignant potential(transitional cell, grade 1). 1) mass: papillary, low grade(transitional cell II) without stromal invasion 2) deep biopsy: free of tumor. Urinary bladder and umbilicus, partial cystectomy: 1) mucinous adeno mainly composed of signet ring cells of urachal origin, with penetrating the wall and extending to the serosal surface, and with lymphatic invasion 2) resection margins of bladder: free of tumor 3) lymph node, regional(0/1): free of tumor 4) umbilicus and urachus: Free of tumor without urachal tissue. TaN0M0 ( 0a ) TaN0M0 ( 0a ) T3N0M0 ( Ⅲ )

11 19 D 1, 2 m D 3, 4 m D 5, 6 m D 7, 8 m D 9, 10 m 44 adeno Bladder, TURBT: 1) main mass: mucinous adeno 2) anterior wall: free of tumor 3) right lateral wall:material insufficiency 4) left lateral wall: free of tumor 5) prostate urethra: free of tumor 6) dome: free of tumor 7) trigone: free of tumor. 24 D 11 f 33 non-neoplastic Non-neoplastic from C9,10 1) main mass: Urothelial, high grade (transitional cell, grade III/III), invading lamina propria 2) right lateral wall: free of tumor 3) left lateral wall: von Brunn's nest 4) left lateral: free of tumor 5) deep biopsy:, high grade (transitional cell, grade III/III) 6) dome: free of tumor. 1. Urethra and prostate, TURP:, high grade (transitional cell, grade III) 2. Urinary bladder, dome, biopsy:, high grade. 1. 1) main mass and B. Main mass, deep biopsy: papillary, high grade (transitional cell grade 3) without stromal invasion (Ta) 2) left posterior lateral wall mass: free of tumor 3) small mass of left posterior lateral wall mass : papillary, low grade 4) another mass of left lateral wall mass and left posterior lateral wall, deep biopsy: papillary, high grade (transitional cell, grade 2) without stromal invasion 5) right lateral wall: free of tumor 6) dome: free of tumor 7) left lateral wall: free of tumor 8) posterior urethra and bladder neck: free of tumor 2. Prostate, TURP: benign prostatic hyperplasia. Urinary bladder, prostate, seminal vesicles, radical cystectomy: 1) papillary, high grade (transitional cell, grade III), with superficial lamina invasion without extension into the muscularis mucosa 2) resection margins, separately submitted as bilateral ureters: free of tumor 3) resection margin, urethra: free of tumor 4) prostate gland: free of tumor 5) seminal vesicle, bilateral: free of tumor 6) lymph nodes, right iliac(0/11), left external iliac(0/5) and regional(0/1):(0/17): free of tumor 7) soft tissue, separately submitted as right and left obturator lymph node: free of tumor 8) appendix, appendectomy: no pathological diagnosis. T4aN0M0 ( Ⅲ ) TaN0M0 ( 0a ) T1aN0M0 ( Ⅰ )

12 25 E 1, 2 m 66 Urinary bladder, radical cystectomy: 1) papillary, high grade (transitional cell, grade III), with extension to the muscle proper(pt2) and prostate, with vascular(probably venous) invasion 2) leiomyoma 3) resection margins, ureters and urethra: free of tumor 4) lymph nodes, perivesical(0/1), right obturator(0/7), left obturator (0/3), right external iliac(0/3), left external iliac(0/15), and right common iliac(0/10): Free of tumor metastasis in all 39 nodes 5) appendix, incidental appendectomy: no pathological diagnosis. 6) small intestine: free of tumor. <Additional and revised report> Urinary bladder, radical cystectomy: 1) papillary, high grade (transitional cell, grade III), with extension to the muscle proper(pt2) and prostate, with vascular(probably venous) invasion. 2) post-operative spindle cell nodule. Note: result of immunohistochemistry: Actin(-), Cytokeratin(-), MIB-1(+). T4aN0M0 ( Ⅲ ) 26 E 3, 4 f E 5, 6 m E 7, 8 f E 9, 10 m 44 mucinous adeno adeno urachal adeno papillary, high grade (transitional cell, grade III), with superficial lamina invasion without muscular mucosa(t1a). 1) main mass and deep biopsy: invasive papillary, high grade (transitional cell, grade III), with extension to the proper muscle 2) dome, right and left lateral wall: free of tumor. 1) main mass and deep biopsy: invasive, high grade (transitional cell, grade III), with invasion to the proper muscle layer 2) left lateral wall: chronic nonspecific inflammation without tumor. Urinary bladder, radical cystectomy and appendectomy: 1) urachal mucinous adeno with invasion to the muscle layer but confined to the urachus, stage II by Sheldon system, see note. 2) ileum segmental resection: free of tumor 3) prostate: free of tumor 4) seminal vesicles, both: free of tumor 5) ureters, both: free of tumor 6) vas deferens, both: free of tumor 7) appendix: no pathological diagnosis. 8) regional lymph nodes, perivesical(0/4), common iliac, right(0/8), left(0/4), obturator, right(0/3), left(0/3), left femoral(0/0): (0/22): free of tumor in all 22 lymph nodes. Note: Sheldon staging system: Stage I: cancer is confined to the urachal mucosa Stage II: cancer is invasive but confined to the urachus Stage III: local extension to the bladder(iiia), abdominal wall(iiib), peritoneum(iiic) or visceral other than bladder(iiid) Stage IV: metastasis to regional lymph nodes(iva) or distant sites(ivb). T1aN0M0 ( Ⅰ ) T2N0M0 ( Ⅱ ) T3bN1M0 ( Ⅳ )

13 , high grade(transitional cell, grade III) 30 F 1, 2 f 79 with invasion to the proper muscle layer. T2N0M0 ( Ⅱ ) 31 F 3, 4 f F 5, 6 m F 7, 8 m F 9, 10 m 86 squamous cell Urinary bladder, biopsy: 1) main mass: papillary, high grade(transitional cell grade 3) with superficial laminar invasion 2) deep biopsy: papillary, high grade, with invasion to the muscularis mucosa(pt1b) 3) bladder neck deep biopsy: papillary, low grade, without stromal invasion. Urinary bladder, seminal vesicles and prostate, radical cystectomy: 1) invasive, high grade(transitional cell grade III) with extension to the perivesical fat tissue and with extensive lymphovascular invasion 2) resection margins, ureteral and urethral: free of tumor 3) prostate: free of tumor 4) seminal vesicles, bilateral: free of tumor 5) lymph nodes, right internal iliac(0/2), left internal iliac(0/2), left obturator(0/2) and left external iliac(0/0): free of tumor in all 6 nodes 6) appendix, incidental appendectomy: fatty obliteration. Urinary bladder, ureters, seminal vesicls, prostate gland, raidial cystectomy: 1) urinary bladder: Invasive, high grade, with extension to the perivesical fat tissue. 2) prostate: Adeno (Gleason's score: 3+3:6) involving1 lobe(size:1.0x0.6cm) 3) seminal vesicles, both: free of tumor 4) resection margins, urethra and both ureter: free of tumor 5) lymph nodes, pelvic, dissection: right common iliac(0/7), right external iliac(0/10), right obturator(0/7), left common iliac(0/4), left external iliac(0/5) and left obturoator(0/6):(0/39): free of tumor 6) soft tissue, separately submitted as paraaortic lymph ndoe: fat necrosis. 1) labelled as "mass": poorly differentiated squamous infiltrating diffusely into the fibromuscular wall 2) llabelled as "anterior wall mass": poorly differentiated squamous infiltrating diffusely into the fibromuscular wall. T1bN0M0 ( Ⅰ ) T3bN0M0 ( Ⅲ ) T3bN0M0 ( Ⅲ )

14 35 G 1, 2 m G 3, 4 m G 5, 6 m G 7, 8 m Urinary bladder, prostate, seminal vesicle and ureter, radical mastectomy: diffuse infiltrative, high grade with 1) size: approximately 6x5cm 2) penetration of bladder wall and invasion to prostate and seminal vesicle 3) perineural invasion 4) intact resection margins including right and left ureter 5) no lymph node metastasis (0/54), external iliac right(0/6) and left(0/10), common iliac, right(0/13) and left(0/5), obturator, right(0/15) and left(0/3), perivascular(0/2) 2. Appendix, appendectomy: free from tumor extension. 1) papillary, high grade, with squamous and glandular differentiation and sarcomatoid differentiation, consistent with sarcomatoid 2) urinary bladder, "deep biopsy", TURB: with invasion to the muscle proper and lymphatic invasion. 1) main mass:, high grade 2) left posterior wall mass: with extensive proper muscle invasion 3) dome mass:, high grade 4) not specified specimen: several fragments of proper muscle bundles without evidence of tumor. 1) right lateral wall: -, high grade, with invasion to the muscularis mucosa(pt1b) - in situ 2) right posterolateral wall: papillary, high grade, without stromal invasion 3) right lateral, left lateral and dome: free of tumor. T4aN0M1 ( Ⅳ ) T4N1M1 ( Ⅳ ) T2bN0M0 ( Ⅱ ) T1bN0M0 ( Ⅰ ) 39 G 9, 10 f 69 squamous cell 1), high grade, with squamous differentiation, with invasion to the muscularis mucosa (pt1b) 2) urinary bladder, deep biopsy: with invasion limited in superficial lamina propria 3) urinary bladder, dome, right and left lateral wall, TURB: free from tumor extension. T1bN0M0 ( Ⅰ )

15 40 H 1, 2 m H 3, 4 m H 5, 6 f H 7, 8 f H 9, 10 f I 1, 2 m I 3, 4 m I 5, 6 f I 7, 8 m I 9, 10 m squamous cell in situ in situ Urinary bladder: 1) main mass, TURBT: high-grade with involvement of muscularis propria 2) urinary bladder, deep, biopsy: high-grade 3) urinary bladder, dome, and right lateral wall, biopsy: in-situ 4) urinary bladder, left lateral wall, biopsy: free of tumor. Urinary bladder, TURBT: 1) main mass and deep biopsy: papillary, high grade, with invasion to the proper muscle layer(pt1c) 2) dome: in situ 3) left lateral wall mass: papillary, high grade 4) right and left lateral wall: free of tumor. Urinary bladder, TURBT: 1) main mass and deep biopsy: papillary, high grade, without stromal invasion 2) random, right and left lateral wall: chronic nonspecific inflammation without tumor. T2aN0M0 ( Ⅱ ) T3bN0M0 ( Ⅲ ) Urinary bladder, TURBT:, high grade, focally squamous differentiation, with invasion to the muscularis mucosa(pt1b). T1aN0M0 ( Ⅰ ) Urinary bladder, TURBT: invasive squamous cell, well differentiated, with marked necrosis and extension to the muscle proper and probably to perivesical soft tissue, see note. Note: This tumor is probably metaplastic from previous. But the possibility T2bN0M0 ( Ⅱ ) of metastatic squamous cell of uterine cervix cannot be excluded. Urinary bladder, TURBT: main mass and deep biopsy:, high grade, with invasion to the muscle T2N0M0 ( Ⅱ ) proper(pt2). Urinary bladder, TURBT: posterior wall mass, anterior wall mass, right lateral wall mass, and right side posterior wall mass: TisN0M0 (0is ) 1) papillary, high grade, without stromal invasion 2) in situ. 1) main mass and deep biopsy: papillary, high grade(transitional cell, grade III) with invasion beyond muscularis mucosa but not to the muscle proper (pt1c) 2) dome, right and left lateral walls: free of tumor 3) posterior wall: in situ with Pagetoid spread of. main mass and deep biopsy: 1) papillary, high grade (transitional cell, grade III), with in situ superficial stromal invasion(pt1a) 2) in situ. squamous cell TisN0M0 (0is ) TisN0M0 (0is ) Urinary bladder, TURBT: papillary, high grade(transitional cell, grade II) with squamous cell (mixed ) involving muscle proper. T2N0M0 ( Ⅱ ) comment TURBT : Trans urethral resection of bladder tumor

Bladder Case 1 SURGICAL PATHOLOGY REPORT. Procedure: Cystoscopy, transurethral resection of bladder tumor (TURBT)

Bladder Case 1 SURGICAL PATHOLOGY REPORT. Procedure: Cystoscopy, transurethral resection of bladder tumor (TURBT) Bladder Case 1 February 17, 2007 Specimen (s) received: Bladder Tumor Pre-operative Diagnosis: Bladder Cancer Post operative Diagnosis: Bladder Cancer Procedure: Cystoscopy, transurethral resection of