The how and why of Acute HIV Infection 1. How do we best diagnosis patients with acute HIV?
|
|
- Magdalene Hawkins
- 5 years ago
- Views:
Transcription
1 Acute HIV infection Eric Rosenberg, MD Associate Professor of Pathology Director, Clinical Microbiology Laboratory Massachusetts General Hospital Harvard Medical School
2 The how and why of Acute HIV Infection 1. How do we best diagnosis patients with acute HIV? Clinical presentation Differential diagnosis Laboratory markers 2. Why should we diagnosis patients with acute HIV? Transmission Treatment Treatment interuption
3 Diagnosis
4 How often do we see Acute HIV? 0.3% consecutive, unselected ED visits (Clark, JID 1994) 1% urgent care clinic patients with any symptom of a viral illness at BMC (Pincus, CID 2003) 1% of MGH patients tested for EBV mononucleosis with a negative heterophile (Rosenberg, NEJM 1999)
5 How do patients with acute HIV present?
6 Commonly reported signs and symptoms fever >80-90 % fatigue >70-90 % rash % myalgia/arthralgia % pharyngitis % Lymphadenopathy > 50% nightsweats 50 % n/v/d %
7 Less commonly reported signs and symptoms Leukopenia/thrombocytopenia % weight loss 25 % aseptic meningitis 24 % anorexia 21 % increased LFT s 20 % oral ulcers % genital ulcers 5-15 % cough/uri diagnosis very unlikely
8 Acute HIV Differential diagnosis EBV (1% of negative mono spots = ARS) CMV Streptococcal infection/pharyngitis HSV Influenza Acute Hepatitis A, B and C Toxoplasmosis (acute) Rubella/Measles Endocarditis
9 Which of the following patient s has acute HIV?
10 Patient 1: A 35 year old man with fever, rash, fatigue and nausea 35 year old man (IVDU) presents to the emergency room with: Fever to Rash Fatigue Nausea, anorexia, diarrhea WBC 7, HCT 42, PLT 290, Ast 478, Alt 509, Tb 2.3 Does this patient have acute HIV?
11 What is the diagnosis? 1. Acute HIV infection 2. Bacterial endocarditis 3. Acute Epstein-Barr virus infection 4. Acute Cytomegalovirus infection 5. Acute Hepatitis C infection
12 Patient 1 Rapid strept test negative HIV ELISA negative HIV RNA < 50 copies /ml plasma EBV heterophile negative CMV IgM negative, IgG positive HCV Ab negative HCV RNA > 700,000 copies/ml Dx= Acute Hepatitis C virus infection
13 Patient 2: A 20 year old man with fever, sore throat, lymphadenopathy and weight loss 20 year old MSM presents to MGH medical walk-in clinic complaining of: Fever X 2 weeks (103.2 on exam) Sore throat, Lymphadenopathy Fatigue, myalgia, arthralgia Nausea, vomiting, diarrhea and abdomen cramps. 8 lb weight loss WBC 1.5, 12% atypical lymphocytes, HCT 40, Plt 127, ALT 240, AST 280 Does this patient have acute HIV?
14 What is the diagnosis? 1. Acute HIV infection 2. Bacterial endocarditis 3. Acute Epstein-Barr virus infection 4. Acute Cytomegalovirus infection
15 Patient 2 HIV ELISA negative HIV RNA < 50 copies /ml plasma EBV heterophile negative CMV IgM 5 units, IgG Negative CMV DNA Positive HCV Ab negative HCV RNA undetectable Dx= Acute CMV infection
16 Patient 3: 47 year old male with fever, headache and photophobia Present to MGH ED with an 8 day history of : Fever to Headache Photophobia Myalgias and arthralgias Nausea and vomiting 3 rd visit to health care system
17 47 year old male Exam: Fever Oral ulcer Cervical lymphadenopathy Rash (started on torso spread to limbs and scalp) Data: WBC 7.6 (ALC 0.75) CSF 11 WBC s (70% lymphocytes)
18
19
20 Data: WBC 7.6 (ALC 0.75) 47 year old male EBV monospot negative CMV IgM negative, CMV IgG + CSF 11 WBC s (70% lymphocytes) HIV 4 th generation screening test (Ag/Ab) Positive HIV-1/2 differentiation assay Negative HIV RNA: 47,000,000 copies/ml
21 Diagnosis Acute HIV Infection
22 Diagnosis
23 Laboratory Markers and Terminology Branson, JAIDS 2010
24 Making the diagnosis of Acute HIV Must have a very high level of suspicion Risk factors Physical exam critical HIV ELISA 4 th generation (Ab/Ag) closes window ~7d HIV-1/HIV-2 Differentiation assay HIV RNA
25 Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations Branson et al, CDC/APHL
26 Why is it important to make the diagnosis of Acute HIV infection?
27 Transmission Making the diagnosis of acute HIV infection help may stop unknowing transmission of HIV
28 Transmission of HIV is greatest during acute and early HIV infection 12 times more likely to transmit Wawer et al, JID 2005:191 Time after seroconversion
29 Treatment Should individuals with Acute HIV-1 infection be treated with antiretroviral therapy?
30 Advantages Preservation of HIV-specific cellular immune responses Opportunity for structured treatment interruption Lowering of HIV-1 set point Limitation of viral evolution and diversity Decreased transmission Mitigation of acute retroviral symptoms Disadvantages Toxicities and unknown long-term risks Short- and long-term clinical benefits are not well-defined Resistance acquisition Limitation of future antiretroviral therapy options Quality of life impact Cost Kassutto et al, Clinical Infectious Diseases 2006
31 SPARTAC trial Short Pulse Antiretroviral Therapy at Seroconversion 48 weeks course of therapy delayed disease progression although not much longer than the course of treatment NEJM, January 17, 2013
32 Primo-SHM Trial: No Treatment versus 24 or 60 weeks of Antiretroviral Treatment during Primary HIV infection Strongest evidence to date that early therapy may delay need for therapy in chronic infection Grijsen et al, PLOS Medicine, March 2012
33 Conclusions The early events in acute HIV infection may represent a unique window of opportunity for treatment It is not known whether treatment during acute infection is the right thing to do Making the diagnosis of Acute HIV infection is the correct thing to do Treatment followed by discontinuation of therapy may have a role in management of acute infection but optimal approach not known.
Didactic Series. Primary HIV Infection. Greg Melcher, M.D. UC Davis AETC 8 Nov 2012
Didactic Series Primary HIV Infection Greg Melcher, M.D. UC Davis AETC 8 Nov 2012 ACCREDITATION STATEMENT: University of California, San Diego School of Medicine is accredited by the Accreditation Council
More informationDiagnosing HIV Infection AMNERIS E. LUQUE, M.D. PROFESSOR OF MEDICINE/INFECTIOUS DISEASES MEDICAL DIRECTOR, PARKLAND HIV SERVICES
Diagnosing HIV Infection AMNERIS E. LUQUE, M.D. PROFESSOR OF MEDICINE/INFECTIOUS DISEASES MEDICAL DIRECTOR, PARKLAND HIV SERVICES Disclosures None Objectives 1. Outline the CDC recommendations for HIV
More informationLisa K. Fitzpatrick, MD, MPH Associate Professor of Medicine Howard University School of Medicine
Lisa K. Fitzpatrick, MD, MPH Associate Professor of Medicine Howard University School of Medicine HIV Testing Missed Opportunities Acute Retroviral Syndrome Opportunistic Infections Treatment Reminders
More informationHIV 101: Overview of the Physiologic Impact of HIV and Its Diagnosis Part 2: Immunologic Impact of HIV and its Effects on the Body
HIV 101: Overview of the Physiologic Impact of HIV and Its Diagnosis Part 2: Immunologic Impact of HIV and its Effects on the Body Melissa Badowski, PharmD, BCPS, AAHIVP Clinical Assistant Professor University
More informationGeneral Medical Concerns
General Medical Concerns General Medical Concerns Fred Reifsteck MD Head Team Physician University of Georgia Missed Time: school, work, practice, games Decreased Performance Physical/ Mental stress: New
More informationHepatitis B (Part 1 - intro)
Hepatitis B (Part 1 - intro) The Hepatitis B virus (HBV) l Virology Discovered in 1966 double-stranded DNA virus l family of hepadnaviruses l HBV unique to Humans (Primates too in laboratory studies) no
More informationHIV Basics: Pathogenesis
HIV Basics: Pathogenesis Michael Saag, MD, FIDSA University of Alabama, Birmingham Director, Center for AIDS Research ACTHIV 2011: A State-of-the-Science Conference for Frontline Health Professionals Learning
More informationClinical Manifestations of HIV
HIV Symptoms Diane Havlir, MD Professor of Medicine and Chief, HIV/AIDS Division University of California, San Francisco (UCSF) WorldMedSchool; July 2, 2013 1 Clinical Manifestations of HIV! Result from
More informationInfectious Mononucleosis The Virus Pathophysiology: Age: History: Fever. Lymphadenopathy
Infectious Mononucleosis The Virus A member of the Herpesvirus family Infects human B lymphocytes Herpes viruses contain double-stranded DNA, and they have an icosahedral capsid and a glycoprotein-containing
More informationPrimary Human Immunodeficiency Virus Infection Presenting as Elevated Aminotransferases
Also available online http://www.e-jmii.com ISSN 1684-1182 Volume 43 Number 3 June 2010 Indexed in MEDLINE/Medicus, SCIE, BIOSIS, EMBASE, Aidsline, CancerLit, Chemical Abstracts, HealthSTAR The official
More informationHIV Basics: Clinical Tests and Guidelines
HIV Basics: Clinical Tests and Guidelines ACTHIV 2010 Zelalem Temesgen MD Mayo Clinic Topics Baseline laboratory evaluation Laboratory monitoring through the continuum of care Patients not on antiretroviral
More informationViral hepatitis. Supervised by: Dr.Gaith. presented by: Shaima a & Anas & Ala a
Viral hepatitis Supervised by: Dr.Gaith presented by: Shaima a & Anas & Ala a Etiology Common: Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E Less common: Cytomegalovirus EBV Rare: Herpes
More informationHerpes virus co-factors in HIV infection
Herpes virus co-factors in HIV infection Dr Jane Deayton Barts and the London Queen Mary School of Medicine Introduction Herpes viruses very common and often coexist with HIV Establish life-long latent
More informationINTEGRATING HIV INTO PRIMARY CARE
INTEGRATING HIV INTO PRIMARY CARE ADELERO ADEBAJO, MD, MPH, AAHIVS, FACP NO DISCLOSURE 1.2 million people in the United States are living with HIV infection and 1 in 5 are unaware of their infection.
More informationObjectives. HIV in the Trenches HIV Update for the Primary Care Provider, An Overview The HIV Continuum of Care.
1:30 2:30pm HIV Update SPEAKER Gordon Dickinson, MD Presenter Disclosure Information The following relationships exist related to this presentation: Gordon Dickinson, MD, has no financial relationships
More informationThe Dubbo Infection Outcomes Study
The Dubbo Infection Outcomes Study Determinants of protracted illness after acute infection Dubbo Infection Outcomes Study Three parallel cohorts Epstein-Barr virus: - infectious mononucleosis - established
More informationEBV and Infectious Mononucleosis. Infectious Disease Definitions. Infectious Diseases
Infectious Disease Definitions Infection when a microorganism invades a host and multiplies enough to disrupt normal function by causing signs and symptoms Pathogencity ability of an organism to cause
More informationHEALTH SERVICES POLICY & PROCEDURE MANUAL
PAGE 1 of 5 PURPOSE To provide guidelines on the treatment and care of patients with Hepatitis. POLICY Hepatitis is an injury to hepatic cells and an inflammatory process in the liver. The major causes
More informationOther Diagnostic Tests
Other Diagnostic Tests APTIMA HIV-1 RNA Qualitative Assay (approved in Oct 2006) Confirmation test (like Western Blot) Detects RNA of the HIV-1 virus (Nucleic Acid Amplification Test/ NAAT) First test
More informationSome medical conditions require exclusion from school or child care to prevent the spread of infectious diseases among staff and children.
Policies - Time Out - Department of Health Exclusion Periods Some medical conditions require exclusion from school or child care to prevent the spread of infectious diseases among staff and children. This
More informationHuman Herpes Viruses (HHV) Mazin Barry, MD, FRCPC, FACP, DTM&H Assistant Professor and Consultant Infectious Diseases KSU
Human Herpes Viruses (HHV) Mazin Barry, MD, FRCPC, FACP, DTM&H Assistant Professor and Consultant Infectious Diseases KSU HERPES VIRUS INFECTIONS objectives: ØTo know the clinically important HHVs. ØTo
More informationHuman Immunodeficiency Virus. Acquired Immune Deficiency Syndrome AIDS
Human Immunodeficiency Virus Acquired Immune Deficiency Syndrome AIDS Sudden outbreak in USA of opportunistic infections and cancers in young men in 1981 Pneumocystis carinii pneumonia (PCP), Kaposi s
More informationVAERS Cases of Pancreatitis and Pancreatitis Acute
Freda Birrell, Scotland S.A.N.E. Vax, Inc. July 2010 VAERS Cases of Pancreatitis and Pancreatitis Acute Life Threatening Reporter considered symptoms were possibly related to therapy with Gardasil Details
More informationCleaning for Additional Precautions Table symptom based
for Additional Precautions Table symptom based The need to wear personal protective equipment () for Routine Practices is dependent on the risk of contact or contamination with blood or body fluids. should
More informationHepatitis and Herpes Viruses. These two virus groups are very diverse, but cause much human morbidity and mortality
Hepatitis and Herpes Viruses These two virus groups are very diverse, but cause much human morbidity and mortality Liver Functions Performs 3 major functions: Regulation: of blood composition glucose levels,
More information0% 0% 0% Parasite. 2. RNA-virus. RNA-virus
HIV/AIDS and Treatment Manado, Indonesia 16 november HIV [e] EDUCATION HIV is a 1. DNA-virus 2. RNA-virus 3. Parasite 0% 0% 0% DNA-virus RNA-virus Parasite HIV HIV is a RNA-virus. HIV is an RNA virus which
More informationStudents. Exhibit - Reporting and Exclusion Requirements for Common Communicable Disease. Reporting Mandated to Local Health Authority
August 2003 7:280-E2 Students Exhibit - Reporting and Exclusion Requirements for Common Communicable s Animal Bites (potential for rabies) Bacterial Vaginosis Chancroid As soon as possible, but within
More informationHow is it transferred?
STI s What is a STI? It is a contagious infection that is transferred from one person to another through sexual intercourse or other sexually- related behaviors. How is it transferred? The organisms live
More informationA case of acute liver failure in HIV/HBV co-infection
A case of acute liver failure in HIV/HBV co-infection Lukun zhang Department of Infectious Disease The Third People s Hospital of Shenzhen May 12th,2017 History of present illness Patient basic information
More informationClinical presentations and virologic characteristics of primary human immunodeficiency virus type-1 infection in a university hospital in Taiwan
J Microbiol Immunol Infect 2004;37:271-275 Clinical presentations and virologic characteristics of primary human immunodeficiency virus type-1 infection in a university hospital in Taiwan Hsin-Yun Sun
More informationImmunodeficiencies HIV/AIDS
Immunodeficiencies HIV/AIDS Immunodeficiencies Due to impaired function of one or more components of the immune or inflammatory responses. Problem may be with: B cells T cells phagocytes or complement
More informationNASRONUDIN 4/17/2013. DENVs of each type are grouped into several genotypes.
NASRONUDIN Institute of Tropical Disease, Airlangga University-Tropical and Infectious Diseases Division, Department of Internal Medicine Medical Faculty-Dr. Soetomo Hospital Disampaikan pada 14 th Jakarta
More informationBLOCK 12 Viruses of the ENT
BLOCK 12 Viruses of the ENT Acute infections Introduction Pharyngitis, Common cold, Sinusitis, Otitis media Recurrent infections Herpes zoster oticus Chronic infections HIV and ENT manifestations Neoplasms
More informationInfectious diseases Dr n. med. Agnieszka Topczewska-Cabanek
Infectious diseases Dr n. med. Agnieszka Topczewska-Cabanek Viral: Exanthema subitum (Roseaola infantum) Herpetic stomatitis Measles Rubella Chickenpox Erythema infectious (5th Disease, Slapped cheec disease)
More informationThe Kinder Garden. Aim. Legislative Requirements. Who is affected by this policy? Implementation. Infectious Diseases Policy
Infectious Diseases Policy Aim The Kinder Garden The Kinder Garden will minimise the spread of potentially infectious diseases between children, and the Service, by excluding children, educators/staff,
More informationManagement of Severe Primary HIV Infection
Management of Severe Primary HIV Infection Martin Fisher Brighton and Sussex University Hospitals Outline What is severe PHI? How frequent is severe PHI? Is this occurring more frequently? Is severe PHI
More informationDiseases of Absence. Disclosures
Diseases of Absence Meg Fisher, MD Medical Director, The Unterberg Children s Hospital Long Branch, NJ Disclosures I have no disclosures I do not intend to mention off label uses of drugs I have way too
More informationMohammed El-Khateeb MSVL-4 Nov 26 th 2013
Mohammed El-Khateeb MSVL-4 Nov 26 th 2013 The respiratory system is the most commonly infected system. Health care providers will see more respiratory infections than any other type. Geography of the
More informationExclusion Periods for Infectious Diseases
Exclusion Periods for Infectious Diseases Amoebiasis (Entamoeba Histolytica) Campylobacter Candidiasis Chickenpox (Varicella) CMV (Cytomegalovirus Infection) Conjunctivitis Cryptosporidium Infection Diarrhoea
More informationClinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA
Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection Masoud Mardani M.D,FIDSA Shahidhid Bh BeheshtiMdi Medical lui Universityit Cytomegalovirus (CMV), Epstein Barr Virus(EBV), Herpes
More informationPresented by: Melissa Egan, Regional Health Education Coordinator, CATIE Date: Tuesday October 8th, 2013, 1 2pm EST
Presented by: Melissa Egan, Regional Health Education Coordinator, CATIE Date: Tuesday October 8th, 2013, 1 2pm EST Agenda 1. HIV and the immune system 2. The progression of untreated HIV 3. Monitoring
More informationBlood Borne Pathogens. November 2010
Blood Borne Pathogens November 2010 Objectives Meet requirements of OSHA Standard 29 CFR 1910.1030 OSHA Blood Borne Pathogens Post Test Routes of Transmission Types of Pathogens BSI / PPE Common Diseases
More informationJoanne Stekler, MD, MPH Assistant Professor of Medicine Deputy Director, Public Health Seattle & King County HIV/STD Program
NORTHWEST AIDS EDUCATION AND TRAINING CENTER HIV Testing Joanne Stekler, MD, MPH Assistant Professor of Medicine Deputy Director, Public Health Seattle & King County HIV/STD Program Presentation prepared
More informationPost-Exposure Prophylaxis Review for International Visitors
Post-Exposure Prophylaxis Review for International Visitors Case Presentation 27 yo nurse presents to Urgent Care for a needlestick 2 days ago from a diabetic lancet. Source patient (SP): 35 yo male known
More informationA rash case Infection control management of measles
A rash case Infection control management of measles 23 th June 2013 PanCeltic Meeting Dr Jo Hargreaves Microbiology SpR University Hospital of Wales, Cardiff Acknowledgements Dr Harriet Hughes Nicola Bevan,
More informationHepatitis A Virus: Old Things Made New
Hepatitis A Virus: Old Things Made New Cody A. Chastain, MD Assistant Professor of Medicine Viral Hepatitis Program Division of Infectious Diseases Vanderbilt University Medical Center Cody.A.Chastain@VUMC.org
More informationMemo No: Date: 25-Nov NEW Serology and Virology Testing
Memo No: 2014-61 Date: 25-Nov-2014 www.hicl.on.ca Re: NEW Serology and Virology Testing In Common Laboratories has been working hard to expand our test menu. We are pleased to announce the availability
More informationClass 10. DNA viruses. I. Seminar: General properties, pathogenesis and clinial features of DNA viruses from Herpesviridae family
English Division, 6-year programme Class 10 DNA viruses I. Seminar: General properties, pathogenesis and clinial features of DNA viruses from Herpesviridae family II. Assays to be performed: 1. Paul-Bunnel-Davidsohn
More informationPrEP in the Real World: Clinical Case Studies
PrEP in the Real World: Clinical Case Studies Kevin L. Ard, MD, MPH April 30, 2015 Massachusetts General Hospital, National LGBT Health Education Center Continuing Medical Education Disclosure Program
More informationWest Nile Virus. Syndrome. (Family: Flaviviridae) Severe Manifestations (Typically >50 years of age) NEUROLOGICAL (Meningoencephalitis >Meningitis)
Severe Manifestations (Typically >50 years of age) Syndrome NEUROLOGICAL (Meningoencephalitis >Meningitis) CSF WBC Protein Glucose-WNL Confusion Change in Sensorium Stupor Seizures Ataxia Cranial Nerve
More informationChapters 21-26: Selected Viral Pathogens
Chapters 21-26: Selected Viral Pathogens 1. DNA Viral Pathogens 2. RNA Viral Pathogens 1. DNA Viral Pathogens Smallpox (pp. 623-4) Caused by variola virus (dsdna, enveloped): portal of entry is the respiratory
More informationMorning Report. Thursday, April 9, 2015 Danielle Eggie
Morning Report Thursday, April 9, 2015 Danielle Eggie It s finally here! Chief complaint: 18 year old male with vomiting and aches H: E: A: D: D: S: S: Lives in LSU dorms during school, and at home with
More informationVZV, EBV, and HHV-6-8
VZV, EBV, and HHV-6-8 Anne Gershon Common Features of Herpesviruses Morphology Basic mode of replication Primary infection followed by latency Ubiquitous Ability to cause recurrent infections (reactivation
More informationMultiple Choice Questions - Paper 1
Multiple Choice Questions - Paper 1 Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could
More informationHIV/AIDS Definition: CDC Classification of HIV Infection Stage 1: Stage 2: Stage 3: Risk Factors
HIV/AIDS Definition: Acquired immune deficiency syndrome (AIDS) is a progressive, incurable disease caused by the human immunodeficiency virus (HIV). Aids destroys the CD4+ T cells, impairing the immune
More informationHuman Herpesviruses. Medical Virology, 27 Nov 2015.
Human Herpesviruses Assoc.Prof. Murat Sayan Kocaeli Üniversitesi, Rutin PCR Lab. Sorumlu Öğt.Üyesi Yakın Doğu Üniversitesi, DESAM Kurucu Öğrt. Üyesi sayanmurat@hotmail.com 0533 6479020 Medical Virology,
More informationPretreatment Evaluation
Pretreatment Evaluation Objective At the end of this lecture, the learner will be able to: Outline the appropriate evaluation of a person infected with HCV in order to assess the benefits and risks of
More informationImportant Safety Information About TRUVADA for a Pre-exposure Prophylaxis (PrEP) Indication. For Healthcare Providers
Important Safety Information About TRUVADA for a Pre-exposure Prophylaxis (PrEP) Indication For Healthcare Providers About TRUVADA for a PrEP Indication INDICATION AND PRESCRIBING CONSIDERATIONS TRUVADA,
More informationOpportunistic infections in the era of cart, still a problem in resource-limited settings
Opportunistic infections in the era of cart, still a problem in resource-limited settings Cristiana Oprea Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania Assessment
More informationCase Studies in PrEP Management. Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016
Case Studies in PrEP Management Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016 Continuing Medical Education Disclosure Program Faculty: Kevin
More informationGOALS AND OBJECTIVES INFECTIOUS DISEASE
GOALS AND OBJECTIVES INFECTIOUS DISEASE Infectious Disease and HIV Overview: The Infectious Diseases Program at the University of Southern California prepares trainees for the management of problems in
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Royal Liverpool & Broadgreen University Hospitals NHS Trust Department of Virology Liverpool Clinical Laboratories Royal Liverpool and Broadgreen
More informationINFECTIOUS DISEASES PROCEDURE
INFECTIOUS DISEASES PROCEDURE Policy Hierarchy link Responsible Officer Contact Officer Superseded Documents Associated Documents Children (Education and Care Services National Law Application) Act 2010
More informationPet Pigs and Pyrexia
Pet Pigs and Pyrexia 7 th Annual SHM Iowa Chapter Conference Dianna Edwards, MD Hospitalist UnityPoint Health- St. Luke s Cedar Rapids No disclosures 10/29/2016 HPI: 6/2016 45 yo male with OSH ED with
More informationObjectives. Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions. Case 1. Dengue Introduction 10/15/2018
Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions Wayne Ghesquiere MD FRCPC Infectious Diseases Consultant Clinical Assistant Prof, UBC Victoria, BC Objectives Discuss common Arbovirus
More informationWherever possible it is recommended that a child receive their vaccination on a day when they will not be attending the centre..
Policy Hierarchy link Responsible Officer Contact Officer Superseded Documents Children (Education and Care Services National Law Application) Act 2010 Education and Care Services National Regulations
More informationCurrent Infectious Disease Screening for the Live Organ Donor
2013 Public Health and Safety Guidelines for reducing HIV, HBV and HCV Transmission Though Organ Transplantation: Implications for Counseling and Disclosure Dianne LaPointe Rudow DNP, ANP-BC, CCTC Director
More informationQuick Study: Sexually Transmitted Infections
Quick Study: Sexually Transmitted Infections Gonorrhea What is it: A bacterial infection of the genitals, anus, or throat. How common: The CDC estimates 820,000 people in the United States get Gonorrhea
More informationHepatitis. Dr. Mohamed. A. Mahdi 5/2/2019. Mob:
Hepatitis Dr. Mohamed. A. Mahdi Mob: 0123002800 5/2/2019 Hepatitis Hepatitis means the inflammation of the liver. May cause by viruses or bacteria, parasites, radiation, drugs, chemical and toxins (alcohol).
More informationViruses. CLS 212: Medical Microbiology Miss Zeina Alkudmani
Viruses CLS 212: Medical Microbiology Miss Zeina Alkudmani History Through the 1800s, many scientists discovered that something smaller than bacteria could cause disease and they called it virion (Latin
More informationAcute respiratory illness This is a disease that typically affects the airways in the nose and throat (the upper respiratory tract).
Influenza glossary Adapted from the Centers for Disease Control and Prevention, US https://www.cdc.gov/flu/glossary/index.htm and the World Health Organization http://www.wpro.who.int/emerging_diseases/glossary_rev_sept28.pdf?ua=1
More informationHIV/AIDS. Communication and Prevention. Davison Community Schools Grade Six June 2018
HIV/AIDS Communication and Prevention Davison Community Schools Grade Six June 2018 Discussing Sensitive Matters with Your Parents Parents: A child s first and most important teacher Parent s role is to
More informationINFECTIOUS DISEASES POLICY
Purpose The purpose of this policy is to ensure that the control of infectious diseases and contagious conditions are effectively addressed through both preventative and management strategies. Scope This
More informationHepatitis A Hepatitis D Hepatitis E HSV CMV EBV
Ammar Hassan PGY-4 Hepatotropic Viruses Nominal Viruses Hepatitis A Hepatitis D Hepatitis E HSV CMV EBV HEPATITIS A *Non-enveloped, single-stranded RNA virus. *Only one known serotype. *The primary route
More informationDiagnosis of Acute HCV Infection
Hepatitis C Online PDF created December 20, 2017, 7:54 pm Diagnosis of Acute HCV Infection This is a PDF version of the following document: Module 1: Screening and Diagnosis of Hepatitis C Infection Lesson
More informationHuman Herpesviruses. VZV, EBV, and HHV-6-8. The rash of VZV is vesicular. MID 34
VZV, EBV, and HHV-6-8 Anne Gershon Human Herpesviruses Replication (lytic infection) occurs in a cascade Latency occurs when the cascade is interrupted Transcription of viral genome and protein synthesis
More informationMathematical-Statistical Modeling to Inform the Design of HIV Treatment Strategies and Clinical Trials
Mathematical-Statistical Modeling to Inform the Design of HIV Treatment Strategies and Clinical Trials Marie Davidian and H.T. Banks North Carolina State University Eric S. Rosenberg Massachusetts General
More informationViral Diseases. T Bamdad, PhD, Tarbiat Modares University
Viral Diseases 1 Categorizing viral infections by the organ system most commonly affected (eg, lungs, GI tract, skin, liver, CNS, mucous membranes) can be clinically useful, although certain viral disorders
More informationWhat Does HIV Do to You?
What Does HIV Do to You? HIV and the immune system Your immune system is supposed to protect you from viruses and other infections. Why, then, doesn t it protect you from HIV? The answer is complicated,
More informationIncrease in Locally-Acquired Cyclosporiasis Cases in Ontario
Increase in Locally-Acquired Cyclosporiasis Cases in Ontario Update to York Region health care providers as of July 31, 2018 Ontario is experiencing an increase in the number of Cyclospora infections.
More informationCASE STUDY. Adverse Events in treatment chronic hepatitis C patients with PegInterferon and Ribavirin What would your management decision be?
Adverse Events in treatment chronic hepatitis C patients with PegInterferon and Ribavirin What would your management decision be? CASE STUDY Pham Thi Thu Thuy MD, PhD Ho Chi Minh City Vietnam Serious Adverse
More informationTRUVADA for a Pre-exposure Prophylaxis (PrEP) Indication. Training Guide for Healthcare Providers
TRUVADA for a Pre-exposure Prophylaxis (PrEP) Indication Training Guide for Healthcare Providers About TRUVADA for a PrEP indication to reduce the risk of sexually acquired HIV-1 infection in high-risk
More informationRepetitorium of selected human viruses HIV
Repetitorium of selected human viruses HIV Chair and Department of Medical Microbiology Poznan University of Medical Sciences Chairman: prof. dr hab. Andrzej Szkaradkiewicz Wieniawskiego Street 3, 61-712
More informationVirology Serology Diagnostics Infection Training Dr Alison Watt
Virology Serology Diagnostics Infection Training 2016 Dr Alison Watt Total testing Pathway Lundberg (1981): Brain to Brain loop concept for laboratory testing: Pre-Analytical Pre Post Post Post Analytical
More informationImportant Safety Information About Emtricitabine/Tenofovir Disoproxil Fumarate 200 mg/300 mg for HIV-1 Pre-exposure Prophylaxis (PrEP)
Important Safety Information About Emtricitabine/Tenofovir Disoproxil Fumarate 200 mg/300 mg for HIV-1 Pre-exposure Prophylaxis (PrEP) For Healthcare Providers About Emtricitabine/Tenofovir Disoproxil
More informationCASE-BASED SMALL GROUP DISCUSSION
MHD II, Session XII, STUDENT Copy Page 1 CASE-BASED SMALL GROUP DISCUSSION Session XII MHD II April 21, 2014 STUDENT COPY Helpful Resource: ACP Medicine online available through LUHS Library Infectious
More informationEpstein-Barr Virus 1
Epstein-Barr Virus 1 Herpesviruses dsdna, linear, enveloped, 180-200 nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV HSV-2 virus particle. Note that
More informationViral hepatitis Blood Born hepatitis. Dr. MONA BADR Assistant Professor College of Medicine & KKUH
Viral hepatitis Blood Born hepatitis Dr. MONA BADR Assistant Professor College of Medicine & KKUH Outline Introduction to hepatitis Characteristics of viral hepatitis Mode of transmission Markers of hepatitis
More informationالحترمونا من خري الدعاء
الحترمونا من خري الدعاء Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or
More informationDisease Transmission( Spread) Symptoms Infectious Period/ Exclusion. Should see physician as antibiotic treatment may be required
Management of Communicable Diseases Adopted April 26, 05 These guidelines, based on those developed by With the assistance of the Canadian Pediatric Society, these Guidelines have been developed to assist
More informationRESPIRATORY TRACT INFECTIONS. CLS 212: Medical Microbiology Zeina Alkudmani
RESPIRATORY TRACT INFECTIONS CLS 212: Medical Microbiology Zeina Alkudmani Lower Respiratory Tract Upper Respiratory Tract Anatomy of the Respiratory System Nasopharynx Oropharynx Respiratory Tract Infections
More informationCASE-BASED SMALL GROUP DISCUSSION MHD II
MHD II, Session 11, Student Copy Page 1 CASE-BASED SMALL GROUP DISCUSSION MHD II Session 11 April 11, 2016 STUDENT COPY MHD II, Session 11, Student Copy Page 2 CASE HISTORY 1 Chief complaint: Our baby
More informationEpstein-Barr Virus in a Toddler. Elaine Bullock, MD Pediatrics LSU Health Shreveport Louisiana Chapter AAP Pediatric Potpourri on the Bayou
Epstein-Barr Virus in a Toddler Elaine Bullock, MD Pediatrics LSU Health Shreveport Louisiana Chapter AAP Pediatric Potpourri on the Bayou Disclosure Presenter: Elaine Bullock, MD I have nothing to disclose
More informationBRAINZ POLICY AND PROCEDURE ON COMMUNICABLE DISEASES
BRAINZ POLICY AND PROCEDURE ON COMMUNICABLE DISEASES PURPOSE: To prevent the spread of communicable diseases to client and staff of Brainz Home care Agency from staff with contagious illnesses. POLICY:
More informationA summary of guidance related to viral rash in pregnancy
A summary of guidance related to viral rash in pregnancy Wednesday 12 th July 2017 Dr Rukhsana Hussain Introduction Viral exanthema can cause rash in pregnant women and should be considered even in countries
More informationA challenging neurological complication in a young HIV-infected woman
A challenging neurological complication in a young HIV-infected woman Ianache Irina-Cristiana Vi tor Ba es Clini al Hospital for Infectious and Tropical Diseases Bucharest - HIV/AIDS department Assessment
More informationPreventing Sexual Transmitted Diseases
Preventing Sexual Transmitted Diseases Chapter 12 Card game Lie Sexually Transmitted Diseases Sexuality is an intrinsic part of human nature and affects many things People are not always honest about their
More informationClinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) virus infection in China
Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) virus infection in China Naim Mahroum, MD Internal Medicine B Sheba Medical Center NEJM December 24, 2009 H1N1 Pandemic April
More information