MHC : Individual-Specific MHC-Restricted Acquired Immunity : A New Notion for the Development of HIV Vaccine

Transcription

1 ,**3 The Japanese Society for AIDS Research The Journal of AIDS Research CD+ MHC : Species-Specific CD+ -Restricted Innate Immunity and Individual-Specific MHC-Restricted Acquired Immunity : A New Notion for the Development of HIV Vaccine Hidemi TAKAHASHI Department of Microbiology and Immunology, Nippon Medical School T NKT gd T MHC T B MHC NK MHC NK + MHC MHC CD+ CD+ CD+ CD+ a, CD+ b, CD+ c CD+ CD+ d gd T +, CD+ c NKT CD+ d CD+ CD+ MHC MHC innate immunity HIV-+ nef CD+ CD+ a CD+ d - acquired immunity CD+ d. : ++-20*, + + / HIV,** ,3

2 H Takahashi : Species-Specific CD+ -Restricted Innate Immunity and Individual-Specific MHC-Restricted Acquired Immunity : A New Notion for the Development of HIV Vaccine +, SIV + CD+ CD+ CD+ MHC HIV-+,** -*

3 The Journal of AIDS Research Vol. ++ No. -,**3 - IgE. Cross-presentation * ++ IgE, IgE-FcR IgE IgE MHC Th, T B IgE B B - IgE IgE IgE IgE /,*+ -+

4 H Takahashi : Species-Specific CD+ -Restricted Innate Immunity and Individual-Specific MHC-Restricted Acquired Immunity : A New Notion for the Development of HIV Vaccine re-arrangement MHC MHC T gd T NKT MHC CD+ - T invariant chain CD+ MHC, individually-restricted cross-presentation MHC dsrna PolyI : C Toll-like receptor TLR - MHC CD2T MHC 0 MHC CD. 1 T MHC CD2 T cross-presentation cross-presentation 2 ISCOM CD+ immunostimulating complex 3 MHC CD+ CD2 T BCG. NKT gdt +* cross-presentation CD2 T MHC T re-arrangement - MHC CD+ :, T,*, -,

5 The Journal of AIDS Research Vol. ++ No. -,**3 crobial immunity. Curr Opin Immunol +- :.1+.12,,**+., Cohen NR, Garg S, Brenner MB : Antigen presentation ++ +, nef SHIV -,2,,**-. HAART HIV- + +* : 1+-1,*,,**3. by CD+ lipids, T cells, and NKT cells in microbial im- CD2 T munity. Adv Immunol +*, : + 3.,,**3. - Shinya E, Owaki A, Shimizu M, Takeuchi J, Kawashima T, Hidaka C, Satomi M, Watari E, Sugita M, Takahashi H : Endogenously expressed HIV-+ nef down-regulates antigen-presenting molecules, not only class I MHC but CD + also CD+ a, in immature dendritic cells. Virology -,0 : 13 23,,**.. MHC. Saito N, Takahashi M, Akahata W, Ido E, Hidaka C, Ibuki K, Miura T, Hayami M, Takahashi H : Analysis of evolutionary conservation in CD+ d molecules among primates. Tissue Antigens 00 : ,,,**/. / Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov HIV R : Basophils function as antigen-presenting cells for an allergen-induced T helper type, response. Nat Immunol 0 Fujimoto C, Nakagawa Y, Ohara K, Takahashi H : Poly- HIV-+ nef riboinosinic polyribocytidylic acid [poly(i : C)]/TLR- signaling allows class I processing of exogenous protein MHC CD+ and induction of HIV-specific CD2 cytotoxic T lymphocytes. Int Immunol +0 : // 0-,,**.. nef 1 Takahashi H : Antigen presentation in vaccine development. Comp Immunol Microbiol Infect Dis,0 : -*3 2 Wakabayashi A, Nakagawa Y, Shimizu M, Moriya K, Nishiyama Y, Takahashi H : Suppression of an already established tumor growing through activated mucosal CTLs induced by oral administration of tumor antigen with cholera toxin. J Immunol +2* :.***.*+*,,**2. Revised 3 Takahashi H, Takeshita T, Morein B, Putney S, Germain RN, Berzofsky JA : Induction of CD2 cytotoxic T cells cross-presentation by immunization with purified HIV-+ envelope protein in ISCOMs. Nature -.. : 21-21/, +33*. CD+ +* Higuchi T, Shimizu M, Owaki A, Takahashi M, Shinya CD+ E, Nishimura T, Takahashi H : A possible mechanism of intravesical BCG therapy for human bladder carcinoma : CD+ involvement of innate e# ector cells for the inhibition of tumor growth. Cancer Immunol Immunother /2 : +,./ +,//,,**3. ++ Takahashi H : Species-specific CD+ -restricted innate immunity for the development of HIV vaccine. Vaccine,,**3, in press. +, Satomi M, Shimizu M, Shinya E, Watari E, Owaki A, + Gumperz JE, Brenner MB : CD+ -specific T cells in mi- Hidaka C, Ichikawa M, Takeshita, T, Takahashi H :,*- --

6 H Takahashi : Species-Specific CD+ -Restricted Innate Immunity and Individual-Specific MHC-Restricted Acquired Immunity : A New Notion for the Development of HIV Vaccine +- Transmission of macrophage-tropic HIV-+ by breast- colonization enhancement. Biomed Res,0 : -/.,,,**/. milk macrophages via DC-SIGN. J Infect Dis +3+ : Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata +2+,,**/. T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami Shinya E, Hidaka C, Owaki A, Shimizu M, Li Y, Wata- M : Protection by intranasal immunization of a nefnabe K, Watari E, Hayami M, Klatzmann D, Takahashi deleted, nonpathogenic SHIV against intravaginal chal- H : Augmentation of Helicobacter pylori urease activity lenge with a heterologous pathogenic SHIV. Virology by its specific IgG antibody : implications for bacterial,32 : -*0-+0,,**,.,*. -.