Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells
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1 Chinese Journal of Tissue Engineering Research October 1, 2015 Vol.19, No.41 ( ) 1 2 3, PubMed(CNKI) Articular cartilage injury Bone marrow mesenchymal stem cells :R318 :A : (2015) [J] (41): doi: /j.issn Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells Hou Wei-yu, Cheng Yan-wei, Xiang Chuan (Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China) Abstract BACKGROUND: Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles have been confirmed in various tissue repairs, which are expected to become more effective and safe therapy for articular cartilage repair. OBJECTIVE: To overall understand the research progress in the use of induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles in articular cartilage repair. METHODS: A computer-based search of PubMed and CNKI was performed by the first author for articles related to stem cell treatment of osteoarthritis published from 2003 to The keywords were articular cartilage injury, bone marrow mesenchymal stem cells in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. RESULTS AND CONCLUSION: Articular cartilage injury is still a difficulty in the orthopedics. Many repair methods have been reported, but they all have limitations. Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles bring a new hope for patients with articular cartilage injury. However, there are still many problems to be solved, such as extracting and purifying a large amount of cells, proliferation and differentiation potentials, and mechanism underlying cartilage repair. Subject headings: Cartilage Diseases; Cartilage, Articular; Induced Pluripotent Stem Cells; Mesenchymal Stem Cells; Tissue Engineering Hou Wei-yu, Master, Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Corresponding author: Xiang Chuan, M.D., Associate professor, Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Accepted: P.O. Box 10002, Shenyang
2 . Hou WY, Cheng YW, Xiang C. Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(41): Introduction 5% 22% 50% [1] [2] 1 Data and methods 1.1 PubMed (CNKI) PubMed Articular cartilage injury, Bone marrow mesenchymal stem cellsand Results % 80% 10% 15% [3] [4] 2.2 ( ) ( 80% 90%) [5] [6] [7] [8] [9] Noble [10] 1995 [10-13] [14-15] [16-17] 2.3 (MSCs-MVs) () nm ISSN CN /R CODEN: ZLKHAH 6707
3 . [18] 1967 Wolf ( mrna sirna microrna ) [19] [20] P53 [19] [21] Bruno [22-23] 2009 SCID 2011 RNA [24] mrna Zhang [25] Zhu [26] Mokarizadeh [27] Wistar Strassburg [28] ( 1) Diao [29] 1 A 1 µm B T T [30] [31] [32] [33] [22] Takahashi [34] Oct4 Sox2 c-myc Klf4 4 [35] Hou [36] P.O. Box 10002, Shenyang
4 Zou [37] 2012 Diekman [38] [39-40] [41] Yamashita [42] 3 Conclusion ( ) ( ) 4 References [1] Piasecki DP, Spindler KP, Warren TA, et al. Intraarticular injuries associated with anterior cruciate ligament tear: findings at ligament reconstruction in high school and recreational athletes. An analysis of sex-based differences. Am J Sports Med. 2003;31(4): [2]. [J]., 2006,19(7): [3].[J].,1995,10(1): [4]. [J].,2008,10(3): ISSN CN /R CODEN: ZLKHAH 6709
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Origins of the tumor microenvironment: quantitative assessment of adiposederived and bone marrow-derived stroma. PLoS One. 2012; 7(2):e [18] Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics. 2008;8(19): [19] Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009;19(2): [20] Pap E, Pállinger E, Pásztói M, et al. Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm Res. 2009;58(1):1-8. [21],,,. [C]. 2013,2013. [22] Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol. 2009;20(5): [23] Bruno S, Grange C, Collino F, et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One. 2012;7(3):e [24],,. [J].,2012,18(13): [25] Zhang HC, Liu XB, Huang S, et al. Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev. 2012;21(18): [26] Zhu YG, Feng XM, Abbott J, et al. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxininduced acute lung injury in mice. Stem Cells. 2014; 32(1): [27] Mokarizadeh A, Rezvanfar MA, Dorostkar K, et al. Mesenchymal stem cell derived microvesicles: trophic shuttles for enhancement of sperm quality parameters. Reprod Toxicol. 2013;42: [28] Strassburg S, Hodson NW, Hill PI, et al. Bi-directional exchange of membrane components occurs during co-culture of mesenchymal stem cells and nucleus pulposus cells. PLoS One. 2012;7(3):e [29] Diao HJ, Yeung CW, Yan CH, et al. Bidirectional and mutually beneficial interactions between human mesenchymal stem cells and osteoarthritic chondrocytes in micromass co-cultures. Regen Med. 2013;8(3): [30] Mokarizadeh A, Delirezh N, Morshedi A, et al. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett. 2012;147 (1-2): [31] Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4(3): [32] Farsad K. Exosomes: novel organelles implicated in immunomodulation and apoptosis. Yale J Biol Med. 2002; 75(2): [33] Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8(9): [34] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4): [35] Boland MJ, Hazen JL, Nazor KL, et al. Adult mice generated from induced pluripotent stem cells. Nature. 2009;461(7260): [36] Hou P, Li Y, Zhang X, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013;341(6146): [37] Zou XH, Zhi YL, Chen X, et al. Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence. Biomaterials. 2010;31(18): [38] Diekman BO, Guilak F. Stem cell-based therapies for osteoarthritis: challenges and opportunities. Curr Opin Rheumatol. 2013;25(1): [39] Kim MJ, Son MJ, Son MY, et al. Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells. Arthritis Rheum. 2011;63(10): [40] Lee J, Kim Y, Yi H, et al. Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2014;16(1):R41. [41] Reardon S, Cyranoski D. Japan stem-cell trial stirs envy. Nature. 2014;513(7518): [42] Yamashita A, Morioka M, Kishi H, et al. Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. Nature. 2014; 513(7519): P.O. Box 10002, Shenyang
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