Online data supplement

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1 Online data supplement Predicting Survival after Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure: the Respiratory ECMO Survival Prediction (RESP)-Score. Matthieu Schmidt 1,2, Michael Bailey 1,3, Jayne Sheldrake 3, Carol Hodgson 1,3, Cecile Aubron 1, Peter T. Rycus 4, Carlos Scheinkestel 3, D. Jamie Cooper 1,3, Daniel Brodie 4-5, Vincent Pellegrino 1,3, Alain Combes 2, David Pilcher 1,3. 1 Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health, Monash University, Melbourne, Australia; 2 Medical-Surgical Intensive Care Unit, ican, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France; 3 Intensive Care Department, Alfred Hospital, Melbourne, Australia; 4 Extracorporeal Life Support Organization, Ann Arbor, MI, USA; 5 Division of Pulmonary & Critical Care Medicine, Columbia College of Physicians and Surgeons, New York, USA.

2 Table E1 : Pre-ECMO factors independently associated with hospital survival after identified continuous variables in the final logistic regression model transformed into categorical variables using a bootstrap technique. OR (95% CI) p-value Age (years) ( ) < ( ) < Immunocompromised 0.38 ( ) Mechanical ventilation prior to initiation of ECMO < 48 hours 2.10 ( ) < h 7 days 1.44 ( ) Acute respiratory failure diagnosis group Viral pneumonia 2.24 ( ) < Bacterial pneumonia 2.08 ( ) < Asthma ( ) < Trauma/burn 1.99 ( ) Aspiration pneumonitis 3.42 ( ) < Others acute respiratory diagnoses 1.32 ( ) Central nervous system dysfunction * 0.14 ( ) < Acute associated (non-pulmonary) infection 0.44 ( ) Neuro-muscular blockade agents 1.45 ( ) < Nitric oxide 0.72 ( ) 0.05 Bicarbonate infusion 0.63 ( ) < Cardiac arrest 0.61 ( ) < PCO 2 75 mmhg 0.77 ( ) Peak inspiratory pressure 42 cmh 2 O 0.72 ( ) Continuous variables (PCO 2, Peak Inspiratory Pressure, Duration of Mechanical Ventilation and Age) have been transformed into categorical variables. Immunocompromised is defined as hematologic malignancies, solid tumor, solid organ transplantation, human immunodeficiency virus and cirrhosis. * Central nervous system dysfunction diagnosis combined neurotrauma, stroke, encephalopathy, cerebral embolism, as well as seizure and epileptic syndrome. Acute associated infection is defined as bacterial, viral, parasitic or fungal infection which did not involve the lung.. E2

3 Figure E1 : Number of patients and their respective survival per year included in the RESP-score cohort Figure E2: Survival between early period cohort (n=891) and late period cohort (n=1464) according to the RESP-score class. Predicted survival is expressed as mean and standard deviation. The area under the receiver operating characteristics (ROC) curve of the RESP score in the early period cohort and in the late period cohort were 0.75 (95%CI ) and 0.73 (95%CI ) respectively. Hosmer-Lemeshow C-statistic in the early period cohort and in the late period cohort were 12.7 (p=0.12) and 9.4 (p=0.30) respectively. Figure E3: Survival between patients with viral pneumonitis and patients with others diagnoses according to the RESP-score class. Predicted survival is expressed as mean and standard deviation. Figure E4: Graphic representation of the RESP-score, the SAPS II and the SOFA performances in the external validation on a dataset of 140 patients (1). The area under the receiver operating characteristics (ROC) curve of the RESP was 0.92 (95%CI ) while it were 0.60 (95%CI ) and 0.58 (95%CI ) for the simplified acute physiology score (SAPS) II and the sepsis-related organ failure assessment (SOFA) score, respectively. E3

4 References E1. Schmidt M, Zogheib E, Roze H, Repesse X, Lebreton G, Luyt CE, Trouillet JL, Brechot N, Nieszkowska A, Dupont H, Ouattara A, Leprince P, Chastre J, Combes A. The preserve mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive care medicine 2013;39: E4

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