Tests recently added to the NMS Labs test menu. New Tests are effective immediately.
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1 Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed below are the types of changes that may be included in this notification, effective New Tests - Tests recently added to the NMS Labs test menu. New Tests are effective immediately. Test Changes - Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements. Discontinued Tests - Tests being discontinued with alternate testing suggestions. Please use this information to update your computer systems/records. These changes are important to ensure standardization of our mutual laboratory databases. If you have any questions about the information contained in this notification, please call our Client Support Department at (866) Thank you for your continued support of NMS Labs and your assistance in implementing these changes. The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. NMS Labs does not assume responsibility for billing errors due to reliance on the CPT Codes listed in this document. Page 1 of 9
2 Test Code Test Name New Test Test Name Method / CPT Code Specimen Req. Stability Scope Units Reference Comments Discontinue 2089B Fluconazole, Blood 2089SP Fluconazole, Serum/Plasma 2460B Itraconazole, Blood 2460SP Itraconazole, Serum/Plasma 2485B Ketoconazole, Blood 2485SP Ketoconazole, Serum/Plasma 3790B Posaconazole, Blood 3790SP Posaconazole, Serum/Plasma 9560B Synthetic Cannabinoids Screen, Blood (Forensic) 4782B Voriconazole, Blood Page 2 of 9
3 New Tests 2089B Fluconazole, Blood Effective Immediately Method(s): Purpose: Category: Minimum Volume: Fluconazole [LC-MS/MS] High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Therapuetic Drug Monitoring Antifungal 0.22 ml Room Temperature: 30 day(s) : 30 day(s) Method: High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Set-Up Days / TAT: Monday Wednesday Friday 2 days (after set-up) CPT Code: Compound Name / Alias Units RL Reference Comment Fluconazole Diflucan mcg/ml 0.5 Single oral doses of 50 or 150 mg fluconazole resulted in peak plasma concentrations of / mcg/ml and 2.7 +/- 0.4 mcg/ml respectively. Peak plasma concentrations were 6.7 mcg/ml (range mcg/ml) approximately 1 to 2 hours after a single 400 mg oral dose of fluconazole. The blood to plasma ratio is not known for this compound. 2089SP Fluconazole, Serum/Plasma Effective Immediately Method(s): Purpose: Category: Minimum Volume: Fluconazole [LC-MS/MS] High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Therapuetic Drug Monitoring Antifungal 1 ml Serum or Plasma 0.22 ml Serum: Collect sample in Red top tube Plasma: Collect sample in or Pink top tube. Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. Plastic container (preservative-free) Polymer gel separation tube (SST or PST). Room Temperature: 30 day(s) : 30 day(s) Page 3 of 9
4 New Tests Method: High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Set-Up Days / TAT: CPT Code: Monday Wednesday Friday 2 days (after set-up) Compound Name / Alias Units RL Reference Comment Fluconazole Diflucan mcg/ml 0.5 Single oral doses of 50 or 150 mg fluconazole resulted in peak plasma concentrations of / mcg/ml and 2.7 +/- 0.4 mcg/ml respectively. Peak plasma concentrations were 6.7 mcg/ml (range mcg/ml) approximately 1 to 2 hours after a single 400 mg oral dose of fluconazole. 3790B Posaconazole, Blood Effective Immediately Method(s): Purpose: Category: Minimum Volume: Posaconazole [LC-MS/MS] High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Therapuetic Drug Monitoring Triazole Antifungal 0.4 ml Room Temperature: 30 day(s) : 30 day(s) Method: High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Set-Up Days / TAT: Monday Wednesday Friday 2 days (after set-up) CPT Code: Compound Name / Alias Units RL Reference Comment Posaconazole Noxafil mcg/ml Effective Date: 0.05 The average peak plasma concentration of posaconazole was 0.51 mcg/ml (range ) five hours after a single 200 mg oral dose administered with a high-fat meal. Steady state plasma concentrations averaged 0.72 mcg/ml (range ) after ten days of twice daily administration of 400 mg posaconazole. The blood to plasma ratio is not known for this compound. 3790SP Posaconazole, Serum/Plasma Effective Immediately Method(s): Purpose: Category: Minimum Volume: Posaconazole [LC-MS/MS] High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Therapuetic Drug Monitoring Triazole Antifungal 1 ml Serum or Plasma 0.4 ml Page 4 of 9
5 New Tests Serum: Collect sample in Red top tube Plasma: Collect sample in or Pink top tube. Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. Plastic container (preservative-free) Polymer gel separation tube (SST or PST). Room Temperature: 30 day(s) : 30 day(s) Method: High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Set-Up Days / TAT: Monday Wednesday Friday 2 days (after set-up) CPT Code: Compound Name / Alias Units RL Reference Comment Posaconazole Noxafil mcg/ml Effective Date: 0.05 The average peak plasma concentration of posaconazole was 0.51 mcg/ml (range ) five hours after a single 200 mg oral dose administered with a high-fat meal. Steady state plasma concentrations averaged 0.72 mcg/ml (range ) after ten days of twice daily administration of 400 mg posaconazole. Page 5 of 9
6 Test Changes 2460B Itraconazole, Blood Specimen Requirements were changed. Reference Comment was changed. Methods/CPT Codes were changed [LC-MS/MS (83789)] Room Temperature: 14 day(s) : 30 day(s) LC-MS/MS (83789): Itraconazole Compound Name Units Reference Comment Itraconazole mcg/ml Under therapeutic steady-state conditions with twice daily oral doses of 200 mg, plasma itraconazole concentrations were 1.9 +/ mcg/ml. A trough serum level greater than 0.25 mcg/ml is necessary for effective protection against fungal infection. The blood to plasma ratio is not known for this compound. 2460SP Itraconazole, Serum/Plasma Specimen Requirements were changed. Specimen Requirements (Special Handling) were changed. Reference Comment was changed. Methods/CPT Codes were changed [LC-MS/MS (83789)] Page 6 of 9
7 Test Changes 1 ml Serum or Plasma Plastic container (preservative-free) Serum: Collect sample in Red top tube Plasma: Collect sample in or Pink top tube. Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. Polymer gel separation tube (SST or PST). Room Temperature: 14 day(s) : 30 day(s) LC-MS/MS (83789): Itraconazole Compound Name Units Reference Comment Itraconazole mcg/ml Under therapeutic steady-state conditions with twice daily oral doses of 200 mg, plasma itraconazole concentrations were 1.9 +/ mcg/ml. A trough serum level greater than 0.25 mcg/ml is necessary for effective protection against fungal infection. 2485B Ketoconazole, Blood Specimen Requirements were changed. Reference Comment was changed. Methods/CPT Codes were changed [LC-MS/MS (83789)] Room Temperature: 30 day(s) : 30 day(s) LC-MS/MS (83789): Ketoconazole Page 7 of 9
8 Test Changes Compound Name Units Reference Comment Ketoconazole mcg/ml Peak plasma levels of 5.4 +/- 1.7 mcg/ml occurred at approximately 1 hour following a single 200 mg dose and peak plasma levels of 22 +/- 3 mcg/ml occurred at approximately 2 hours following a single 800 mg dose of ketoconazole. The blood to plasma ratio is 0.6 for this compound. 2485SP Ketoconazole, Serum/Plasma Specimen Requirements were changed. Specimen Requirements (Special Handling) were changed. Reference Comment was changed. Methods/CPT Codes were changed [LC-MS/MS (83789)] 1 ml Serum or Plasma Plastic container (preservative-free) Serum: Collect sample in Red top tube Plasma: Collect sample in or Pink top tube. Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. Polymer gel separation tube (SST or PST). Room Temperature: 30 day(s) : 30 day(s) LC-MS/MS (83789): Ketoconazole Compound Name Units Reference Comment Ketoconazole mcg/ml Peak plasma levels of 5.4 +/- 1.7 mcg/ml occurred at approximately 1 hour following a single 200 mg dose and peak plasma levels of 22 +/- 3 mcg/ml occurred at approximately 2 hours following a single 800 mg dose of ketoconazole. 9560B Synthetic Cannabinoids Screen, Blood (Forensic) Scope of Analysis was changed. Order of Reporting was changed. Page 8 of 9
9 Test Changes 4782B Voriconazole, Blood Room Temperature: 2 day(s) : 14 day(s) LC-MS/MS (80100): JWH-200, AM-2201, JWH-250, AM-694, RCS-4, JWH-073, JWH-018, JWH-081, JWH-122, JWH-019, JWH-210, RCS-8 Page 9 of 9
Tests recently added to the NMS Labs test menu. New Tests are effective immediately.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
Tests recently added to the NMS Labs test menu. New Tests are effective immediately.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
April 28, RE: Immediate Action test change notification. Dear Valued Client:
April 28, 2010 RE: Immediate Action test change notification Dear Valued Client: The following pages detail important information regarding a test requiring database modifications. Please be advised that
Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements.
In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed below are the
Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements.
Updates In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed below
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Modified Date: 01/12/2012 In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform.
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