Haematology, Oncology and Palliative Care Directorate.

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Bryce Greer
5 years ago
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Anticancer Treatment for Administration on the Somerset Mobile Chemotherapy Unit The table below details the suitability of different types of anticancer treatment for administration on the Somerset

Treatment from the appropriate cycle is indicated with suitability This list should be used as a guideline and the suitability of different regimens must also be based on the patient s Performance

1 Anticancer Treatment for Administration on the Somerset Mobile Chemotherapy Unit The table below details the suitability of different types of anticancer treatment for administration on the Somerset Mobile Chemotherapy Unit. Treatment from the appropriate cycle is indicated with suitability This list should be used as a guideline and the suitability of different regimens must also be based on the patient s Performance Status, suitability for treatment and demographics as well as whether treatment can feasibly be administered on an appropriate day. Any patient who has requested use of the scalp cooler will need to be treated at MPH. COLOUR KEY SUITABLE RESTRICTED INDIVIDUAL PATIENT BASIS NOT SUITABLE BRAIN CANCER BREAST CANCER Abraxane/Gemcitabine 8 hour expiry on Abraxane, difficult to make up 2 1 hour 30 mins Carboplatin (Single Agent) 3 weekly 3 1 hour 30 mins Carboplatin (Single Agent) - weekly 3 Docetaxel (Taxotere ) 3-weekly 3 1 hour 30 mins Docetaxel (Taxotere ) weekly 3 1 hour 30 mins EC 2 1 hour 30 mins Epirubicin (Single Agent) 3-weekly 2 1 hour Epirubicin (Single Agent) weekly 2 1 hour Eribulin 2 4 mins FEC 2 2 hours Paclitaxel + Cyclophosphamide (TC) Paclitaxel (Taxol equiv.) 3-weekly Paclitaxel (Taxol equiv.) weekly 3 2 hours Paclitaxel Albumin (Abraxane ) Drug only has an 8-hour expiry Pamidronate 2 For 1 or 2 hour infusion only (30mg 4 mins, 90mg 2 hours) Trastuzumab (Herceptin ) IV need to be given in the morning. Alternatively vials 2 could be made up on the bus using an aseptic technique (1 hour) Trastuzumab (Herceptin ) SC 2 30 mins Trastuzumab (Herceptin ) + Docetaxel 3 need to be given in the morning. (1hour 30 mins) Trastuzumab (Herceptin ) + Docetaxel + 3 Peruzumab need to be given in the morning. (3hours) Trastuzumab (Herceptin ) + Pertuzumab 3 need to be given in the morning. (3hours) Kadcyla 3 Vinorelbine 2 need to be given in the morning (4 mins) Zoledronate 2 30 mins COLORECTAL CANCER 2 1 Page 1 of

2 -FU (-Fluorouracil) bolus 2 4 mins -FU pump change + Capecitabine 2 + Irinotecan + Capecitabine Cetuximab + Oxaliplatin + Capecitabine Cetuximab + Oxaliplatin + MdG Irinotecan Irinotecan + MdG (FOLFIRI) Irinotecan + MdG (FOLFIRI) + Cetuximab + Irinotecan + MdG Mitomycin-C + Capecitabine 2 need to be given in the morning. (4mins) Mitomycin-C & -FU Infusion Mod de Gramont (MdG) 2 3 hours Oxaliplatin + Capecitabine (XELOX) Oxaliplatin + Capecitabine (XELOX) + Oxaliplatin + MdG (FOLFOX) Oxaliplatin + MdG (FOLFOX) + Panitumumab 3 2hours 30 mins GYNAECOLOGICAL CANCER Carboplatin 3 1 hour 30 mins Carboplatin & Gemcitabine 3 Suitable from #2 Day 8 (2hours) Carboplatin & Paclitaxel (Taxol) Cisplatin Cisplatin + Doxorubicin (MMMT) Cisplatin + -FU (4 days) Cisplatin + Topotecan Doxorubicin Liposomal (Caelyx ) Only has a 24hr expiry Gemcitabine (Day 8) 2 1 hour Paclitaxel (Taxol equiv.) 3-weekly Paclitaxel (Taxol equiv.) weekly 3 2 hours HAEMATOLOGICAL DISORDERS Venofer 3 2 hours Vincristine (single agent) IV Infusion (ITP) 2 4 mins HEAD & NECK CANCER Cisplatin, Doxorubicin & -FU (TPF) Docetaxel 3 1 hour 30 mins Cisplatin + -FU ( 4 / 7 ) IMMUNOGLOBULINS Flebogammadif 3 Prolonged infusion but possible to be given on bus (4 hours) Privagen 3 Prolonged infusion but possible to be given on bus (4 hours) Vigam Impractical to give on bus as infusion is given slower than other IVIGs LEUKAEMIA ADE Alemtuzumab (MabThera ) Arsenic Trioxide Azacytidine Drug only has a 24-hour expiry, cold chain must be maintained Cladribine Day 3 Difficult as Treatment is given over or 7 days 2 1 Page 2 of

3 (2 hours 30 mins) Cytarabine IV 2 2 hours Cytarabine Subcutaneous 2 30 mins Daunorubicin + Clofarabine Daunorubicin + Cytarabine (DA) FC (IV) 2 Difficult as Treatment is given over 3 or days FLA(G) FLA-IDA Fludarabine (IV) Days 1- Day 3 Difficult as Treatment is given over 3 or days Intrathecal Methotrexate / Cytarabine MACE MCP 2 4 mins MiDAC Vincristine (single agent) IV bolus 3 4 mins LUNG CANCER & MESOTHELIOMA Carboplatin (iv) + Etoposide (po) 3 2 hours 30 mins Carboplatin + Gemcitabine 3 2 hours Carboplatin + Pemetrexed (Alimta ) 3 need to be given in the morning. (2hours) Carboplatin + Vinorelbine 3 need to be given in the morning. (2hour 30mins) Cisplatin + Etoposide Cisplatin + Pemetrexed (Alimta ) Cisplatin + Vinorelbine Docetaxel (Taxotere ) 3 1 hour 30 mins Etoposide IV 2 1 hour 1 mins Pamidronate 2 (30mg 4 mins, 90mg 2 hours) Paclitaxel + Gemcitabine Paclitaxel + Pemetrexed (Alimta ) Pemetrexed only has a 24hr expiry Pemetrexed 2 Refer to Healthcare@Home if patient agrees (1 hour) Vinorelbine 2 need to be given in the morning (4 mins) Zolendronate 2 30 mins LYMPHOMA ABVD Not recommended as dacarbazine only has a 24hr expiry and is usually made on day of infusion in view of risk of reaction. BEAM Bendamustine 2 ChlVEP 2 1 hour ChlVPP 2 1 hour CNOP 2 CHOP 2 CODOX-M Difficult as Treatment is given over 2 days although should be possible to administer on a (1 hour 30 mins) 2 1 Page 3 of

4 COP / CVP 2 Cyclophosphamide PBSC DHAP FC (Fludaradine + Cyclophosphamide) IV 2 Fludarabine (IV) 2 FMD (IV) 2 FMD (po) 2 Gemcitabine 2 1 hour Intrathecal Methotrexate / Cytarabine 2 Difficult as Treatment is given over 3 or days Difficult as Treatment is given over days although should be possible to administer on a IVAC MCP / MCD 2 Methylprednisolone IV Stat 2 1 hour Pixantrone 2 R-CEP 3 3 hours 1 mins R-CHOP 3 3 hours 30 mins R-CNOP 3 3 hours 1 mins R-CODOX-M R-CVP 3 3 hours 1 mins R-DHAP R-FC (Fludaradine + Cyclophosphamide) PO 3 3 hours 1 mins R-FC (Fludaradine + Cyclophosphamide) IV Day 2 Difficult as Treatment is given over 3 or days R-MCP 3 3 hours 1 mins Rituximab (single agent) IV 3 3 hours Rituximab SC 3 30 mins (maintenance Ritux to be referred to Healthcare at home if patient agrees) R-MCP 3 3 hours 1 mins MULTIPLE MYELOMA Bortezomib (Velcade ) - Weekly 2 need to be given in the morning. Refer to Healthcare@Home if patient agrees (30 mins) Bortezomib (Velcade ) D1,4,8 & 11 2 Refer to Healthcare@Home if patient agrees. Drug only has a 24-hour expiry so treatment would need to be given in the morning. Caution if having on MCU some doses will need to be given in BDU (30 mins) Melphalan IV Expiry of drug only 2-3 hours Pamidronate 2 (30mg 4 mins, 90mg 2 hours) Zolendronate 2 30 mins RENAL CELL CARCINOMA SARCOMA Cisplatin + Doxorubicin Docetaxel (Taxotere ) + Gemcitabine 3 Doxorubicin (Single Agent) 2 1 hour SKIN CANCER CVD (Cisplatin, Vinblastine & Docetaxel) Dacarbazine (DTIC) Ipilimumab Pembrolizumab 1 Page 4 of

5 Vinblastine Weekly 2 UPPER GASTROINTESTINAL CANCER Abraxane/Gemcitabine Abraxane 8 hour expiry, difficult to make up Cetuximab 2 3 hours Cisplatin + -FU (4-day infusion) Cisplatin + -FU (Continuous) Docetaxel, Cisplatin and -Fluorouracil (TPF) ECarboF 3 Possible with walkmed infusor (2hours) ECisF ECX ECX + Gemcitabine 2 1 hour Octreotide LAR 2 Ranucirumab 2 need to be given in the morning. (2 hours 30 mins) UNKNOWN PRIMARY UROLOGICAL CANCER Cabazitaxel 3 CarboGem 3 Can be given #2 Day 8 (2hours) CarboMV 3 CisMV Cisplatin + -FU ( 4 / 7 ) Docetaxel (Taxotere ) + Prednisolone 3 Mitoxantrone + Prednisolone 2 4 mins Pamidronate 2 Zolendronate Page of

Protocol Number Tumour Group Protocol Name on NCCP website 22/02/ Lung Afatinib Monotherapy 244 Gastrointestinal Regorafenib Monotherapy

Last Updated 22-Feb-18 Date of last update Protocol Number Tumour Group Protocol Name on NCCP website 22/02/2018 221 Afatinib Monotherapy 244 Gastrointestinal Regorafenib Monotherapy 249 Gynaecology Intrathecal