PRACTICAL ROADMAP EPITHELIUM A. JOVANOVIĆ

Transcription

1 PRACTICAL ROADMAP EPITHELIUM A. JOVANOVIĆ

2 Epithelia Simple epithelia Stratified epithelia Simple squamous Simple cuboidal Simple columnar Pseudostratified Stratified squamous - non keratinized - keratinized Transitional

3 SIMPLE EPITHELIA Slide 66 Choroid plexus Simple squamous epithelium Simple cuboidal epithelium

4 Choroid Plexus Slide 66 Choroid plexus Ventricle Brain tissue

5 Choroid Plexus Ventricle Vascular choroid plexus Brain tissue

6 Choroid Plexus Ependymal cells Capillary Ventricle

7 Choroid Plexus Simple cuboidal epithelium (Ependymal cells) Ventricle Simple squamous epithelium (Endothelium of capillary)

8 Simple epithelia Slide 85 Jejunum Simple columnar epithelium

9 Jejunum Lumen of jejunum Wall of jejunum

10 Plica circulares (Plicae circulares plural) Lumen Villi (plural) Villus (singular)

11 Plica circulares with a core of connective tissue - submucosa Simple columnar epithelium Villus Submucosa Lumen

12 Villus with a core of connective tissue lamina propria Columnar cell Lamina propria Lumen Microvillus (striated) boarder Goblet cell

13 Simple epithelia Slide 32 Trachea and Oesophagus Trachea - Pseudostratified ciliated columnar epithelium with goblet cells

14 Trachea and Oesophagus C shaped hyaline cartilage ring Lumen Trachea Folded oesophageal epithelium Oesophagus

15 Cartilage Epithelium Lumen Glands in the submucosa

16 Submucosal glands Epithelium Lumen Submucosa with a hyaline cartilage Lamina propria Muscularis mucosae

17 Note how nuclei of different cells lay on different levels within this simple epithelium, giving the false stratified appearance (hence the name) Basement membrane Goblet cell Cilia Columnar cell Lumen Pseudostratified ciliated columnar epithelium with goblet cells

18 STRATIFIED EPITHELIA Slide 32 Oesophagus and Trachea Oesophagus Stratified squamous nonkeratinized epithelium

19 Oesophagus and Trachea Slide 32 Lumen Epithelium

20 Oesophagus Lumen Lamina propria Epithelium Muscularis mucosa

21 Note: Black arrows are pointing at the nuclei present within the uppermost layer of squamous epithelial cells Lumen Note: Multiple layers of epithelial cells changing the shape from the basement membrane towards the lumen of the organ Stratified squamous non keratinized epithelium

22 Note: Black arrows pointing at the nuclei present within the uppermost layer of squamous epithelial cells Lumen Islands of connective tissue within epidermis

23 Stratified epithelia Slide 35 Thick skin Stratified squamous keratinized epithelium

24 Thick skin Epidermis Dermis Hypodermis Free surface

25 Epidermis Dermis Free surface Hypodermis Epidermal ridge Dermal papilla

26 Numerous layers of keratinized epithelial cells which will eventually peel off Islands of connective tissue within epidermis Stratified squamous keratinized epithelium

27 Stratified squamous keratinized epithelium Clear cell Note: The change in the cell shape from the cuboidal, nucleated cells laying on the basement membrane to the squamous keratinized cells in the uppermost layers

28 Stratified epithelia Slide 43 Urinary bladder Transitional epithelium (Urothelium)

29 Urinary Bladder Slide 43 Note the folded epithelium of the urinary bladder in the relaxed state Lumen Mucosa Serosa Smooth muscle

30 Note: Mucosa consists of epithelium (urothelium) and connective tissue lamina propria Urothelium Lumen Lamina propria Mucosa Smooth muscle

31 Note: The number of cell layers (6-8) in the relaxed state of this stratified epithelium will decrease (3-4) when the bladder fills up with urine. Dome shaped umbrella cells will become flattened Umbrella shaped cells, some binucleated Lumen Urothelium Urothelium Lamina propria

32 Note: Umbrella cells are large, elliptical often binucleated cells with prominent nucleoli, vacuolated cytoplasm and apical plaques containing uroplakins. They cover multiple underlying transitional cells in a parasol-like fashion. Intermediate cells are cuboidal to low columnar while basal cells are more cylindrical, can be flat when bladder wall is stretched and lie on continuous basement membrane. Apical plaques Intermediate cells Vacuolated cytoplasm Umbrella shaped cells Basal cells Lumen