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1 E-Path A.I. Engine Knowledge Base Enhancements Version April 1, 2018 The major enhancements in the E-Path Knowledge Base from versions through are as follows: 1. Addition/modification of ICD-0-3 morphology and topography terms. Morphology New codes: M Midline carcinoma of children and young adults with NUT rearrangement M NUT carcinoma M NUT midline carcinoma M Condylomatous carcinoma M Warty carcinoma (C60.0-C60.2, C60.9) M Squamous cell carcinoma, HPV-positive M Squamous cell carcinoma, HPV-negative M ACTH-producing tumor M Endocrine tumor, functioning, NOS M Adenocarcinoma, pancreatobiliary-type M Pancreatobiliary-type carcinoma M Minimally invasive adenocarcinoma, non-mucinous M Minimally invasive adenocarcinoma, mucinous M Micropapillary carcinoma, NOS M Micropapillary adenocarcinoma M Follicular thyroid carcinoma (FTC), encapsulated angoinvasive M Seromucinous carcinoma M Low grade appendiceal mucinous neoplasm M Solid papillary carcinoma in situ M Solid papillary carcinoma with invasion M Pleomorphic lobular carcinoma in situ M Mixed acinar ductal carcinoma M Mixed germ cell sex cord-stromal tumor, unclassified M Malignant perivascular epithelial cell tumor M PEComa, malignant M Perivascular epithelioid cell tumor, malignant M Solitary fibrous tumor/hemangiopericytoma Grade 2 (CNS) M Calcifying nested epithelial stromal tumor M Biphenotypic sinonasal sarcoma M Germ cell tumors with associated hematological malignancy M Intimal sarcoma M Pulmonary artery intimal sarcoma M Diffuse midline glioma, H3 K27M-mutant Copyright 2018 Artificial Intelligence In Medicine Inc. Page 1 of 5
2 M Papillary tumor of pineal region M Ependymoma, RELA fusion-positive M Pilomyxoid astrocytoma M Angiocentric glioma M Pituicytoma M Glioblastoma, IDH-mutant M Medulloblastoma, WNT-activated M Medulloblastoma, SHH-activated and TP53 mutant M Medulloblastoma, group 3 M Medulloblastoma, group 4 M Medulloblastoma, non-wnt/non-shh M Embryonal tumor with multilayered rosettes C19MC-altered M Embryonal tumor with multilayered rosettes, NOS M Diffuse leptomeningeal glioneuronal tumor M Papillary glioneuronal tumor M Rosette-forming glioneuronal tumor M Epithelioid malignant peripheral nerve sheath tumor M Indolent systemic mastocytosis M Urachal carcinoma M Combined large cell neuroendocrine carcinoma M High-grade neuroendocrine carcinoma M Neuroendocrine carcinoma, poorly differentiated M Small cell carcinoma pulmonary type M Small cell carcinoma, hypercalcemic type M Lipid-rich urothelial carcinoma M Microcystic urothelial carcinoma M Nested urothelial carcinoma M Squamotransitional cell carcinoma M Urothelial carcinoma with divergent differentiation M Urothelial carcinoma with squamous differentiation M Urothelial carcinoma with trophoblastic differentiation M Clear cell (glycogen-rich) urothelial carcinoma M Minimally invasive adenocarcinoma, NOS M Endocervical adenocarcinoma usual type M Enteric adenocarcinoma M Intestinal-type adenocarcinoma M Mucinous carcinoma, intestinal type M Thymic carcinoma with adenoid cystic carcinoma-like features M Serrated adenocarcinoma M Neuroendocrine tumor, well differentiated M Adenocarcinoma in situ, non-mucinous M Lepidic adenocarcinoma Copyright 2018 Artificial Intelligence In Medicine Inc. Page 2 of 5
3 M Lepidic predominant adenocarcinoma M Mixed invasive mucinous and non-mucinous adenocarcinoma M Endometrioid adenocarcinoma, villoglandular M Villoglandular carcinoma M Hereditary leiomyomatosis & RCC- associated renal cell carcinoma M MiT family translocation renal cell carcinoma M Renal cell carcinoma, unclassified M Acquired cystic disease-associated renal cell carcinoma M Tubulocystic renal cell carcinoma M Non-invasive EFVPTC M Non-invasive encapsulated follicular variant of papillary thyroid carcinoma M Non-invasive follicular thyroid neoplasm with papillary-like nuclear features M Non-invasive FTP M Encapsulated follicular variant of papillary thyroid carcinoma, NOS M Invasive encapsulated follicular variant of papillary thyroid carcinoma M Serous endometrial intraepithelial carcinoma M Serous tubal intraepithelial carcinoma M Intraductal papillary mucinous neoplasm with high-grade dysplasia M Intraductal papillary mucinous neoplasm (IPMN) with an associated invasive carcinoma M Non-invasive low grade serous carcinoma M Serous borderline tumor-micropapillary variant M Low-grade serous carcinoma M High-grade serous carcinoma M Mucinous cystic tumor with associated invasive carcinoma M Mucinous tubular and spindle cell carcinoma M Mucinous carcinoma, gastric type M Low grade cribriform cystadenocarcinoma M Mammary carcinoma, in situ M Non-invasive mammary carcinoma M Salivary duct carcinoma M Invasive mammary carcinoma M Intraductal papilloma with ductal carcinoma in situ M Intraductal tubulopapillary neoplasm M Intracystic papillary neoplasm with associated invasive carcinoma M Renal medullary carcinoma M Intraductal papilloma with lobular carcinoma in situ M Invasive lobular carcinoma, alveolar type M Invasive lobular carcinoma, solid type M Invasive lobular carcinoma, tubulolobular variant M Pleomorphic lobular carcinoma M Invasive lobular carcinoma M Tubulolobular carcinoma M Acinar cell carcinoma M Endometrioid carcinoma with squamous differentiation M Low grade adenosquamous carcinoma Copyright 2018 Artificial Intelligence In Medicine Inc. Page 3 of 5
4 M Carcinoma with chondroid differentiation M Carcinoma with osseous differentiation M Metaplastic carcinoma with chondroid differentiation M Metaplastic carcinoma with osseous differentiation M Acinar adenocarcinoma, sarcomatoid M Fibromatosis-like metaplastic carcinoma M Adenocarcinoma admixed with neuroendocrine carcinoma M Carcinoma with other types mesenchymal differentiation M Metaplastic carcinoma with other types mesenchymal differentiation M Metaplastic carcinoma of no special type M MIS M MMIS M Meningeal melanoma M Undifferentiated spindle cell sarcoma M Undifferentiated pleomorphic sarcoma M Undifferentiated round cell sarcoma M Undifferentiated epithelioid sarcoma M Undifferentiated uterine sarcoma M Myxoinflammatory fibroblastic sarcoma M Solitary fibrous tumor/hemangiopericytoma Grade 1 M Solitary fibrous tumor/hemangiopericytoma Grade 3 M Low-grade myofibroblastic sarcoma M Myofibroblastic sarcoma M Malignant fibrous histiocytoma (MFH) of bone M Undifferentiated high-grade pleomorphic sarcoma M Fibrosarcomatous dermatofibrosarcoma protuberans M Low-grade fibromyxoid sarcoma M Sclerosing epithelioid fibrosarcoma M Ossifying fibromyxoid tumor, malignant M Pulmonary myxoid sarcoma with EWSR1-CREB1 translocation M Sclerosing rhabdomyosarcoma M Mullerian adenosarcoma M Adenomyoepithelioma with carcinoma M Phosphaturic mesenchymal tumor, malignant M Periductal stromal tumor, low grade M Adenocarcinoma of rete ovarii M Epithelioid hemangioendothelioma M Low-grade central osteosarcoma M Low-grade intramedullary osteosarcoma M Chondrosarcoma grade 2/3 M Ghost cell odontogenic carcinoma M Clear cell odontogenic carcinoma M Anaplastic oligoastrocytoma M Oligoastrocytoma, NOS M Diffuse astrocytoma, IDH-mutant Copyright 2018 Artificial Intelligence In Medicine Inc. Page 4 of 5
5 M Diffuse astrocytoma, IDH-wildtype M Anaplastic astrocytoma, IDH-mutant M Anaplastic astrocytoma, IDH-wildtype M Anaplastic pleomorphic xanthroastrocytoma M Epithelioid glioblastoma M Glioblastoma, IDH wildtype M Oligodendroglioma, IDH-mutant and 1p/19q-codeleted M Anaplastic oligodendroglioma, IDH-mutant and 1p/19q codeleted M Medulloblastoma, classic M Medulloblastoma, SHH-activated and TP53-wildtype M CNS Embryonal tumor with rhabdoid features M Embryonal tumor with rhabdoid features M Melanotic schwannoma Disable concepts: C52.9 colposcopy Colposcopy is a procedure that examines multiple sites such as cervix, vagina as well as uterus. C57.4 Adnexa Adnexa by itself could refer to any appendages, not just uterine, hence disabled. Topography: C02.9 Oral tongue C44.4 Skin vertex C44.4 Scalp vertex C77.3 Deltopectoral lymph node AIM concepts: AIM005.7 High Grade Aim400.5 Tumor Marker p16 AIM400.6 Tumor Marker Ki67 The above custom codes were added for Louisiana Tumor Registry CDC Audit 2. Additional of synonyms and spelling variants to the ICD-O-3 Morphology and Topography library. 3. Improvements to text processing, context modification and negation detection to improve report selection sensitivity and specificity. Copyright 2018 Artificial Intelligence In Medicine Inc. Page 5 of 5
Effective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific
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Effective January 1, 2018 codes, behaviors and terms are site specific Status /N 8010/3 Urachal carcinoma (C65.9, C66.9, C67. _, C68._) 8013/3 Combined large cell neuroendocrine carcinoma (C34. _, C37.9)
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