Lung Tumor Cases: Common Problems and Helpful Hints
|
|
- Bathsheba Cannon
- 5 years ago
- Views:
Transcription
1 Lung Tumor Cases: Common Problems and Helpful Hints Brandon T. Larsen, MD, PhD Senior Associate Consultant Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Arizona Society of Pathologists Spring 2018 Meeting April 7, MFMER slide-1 Disclosures Relevant financial relationships: None Off-label usage: None 2013 MFMER slide-2 1
2 Case 1 69 y.o. F with an enlarging 1.4-cm partially ground-glass, partially solid nodule in RUL Core bxs obtained 2013 MFMER slide MFMER slide-4 2
3 2013 MFMER slide MFMER slide-6 3
4 2013 MFMER slide MFMER slide-8 4
5 2013 MFMER slide MFMER slide-10 5
6 2013 MFMER slide MFMER slide-12 6
7 ARS Polling Question How would you classify this lesion? 1. Peribronchiolar metaplasia / reactive 2. AAH 3. AIS 4. MIA 5. Adenocarcinoma, with at least focal invasion 2013 MFMER slide MFMER slide-14 7
8 2013 MFMER slide-15 Case #1: My Diagnosis Adenocarcinoma, with at least focal invasion 2013 MFMER slide-16 8
9 Common Problem #1 PB metaplasia, AAH, AIS, MIA, or invasive adenocarcinoma? Helpful Hints Have a low threshold for calling invasive if stromal reaction or alveolar wall expansion is present AIS is extremely rare Know the CT findings AIS 2013 MFMER slide-17 Case 2 73 y.o. M with history of bx-proven small cell carcinoma in LUL 6 months ago Now with large consolidative opacity in RML/RLL 2013 MFMER slide-18 9
10 2013 MFMER slide MFMER slide-20 10
11 2013 MFMER slide MFMER slide-22 11
12 2013 MFMER slide MFMER slide-24 12
13 2013 MFMER slide MFMER slide-26 13
14 2013 MFMER slide-27 ARS Polling Question How would you classify this lesion? 1. Malignant 2. Suspicious 3. Atypical 4. Benign 5. Unsure I need stains 2013 MFMER slide-28 14
15 Additional Clinical History Recent etoposide and radiation therapy Clinical suspicion: Must be an adverse reaction to etoposide and/or radiation 2013 MFMER slide MFMER slide-30 15
16 2013 MFMER slide-31 Case #2: My Diagnosis Organizing acute lung injury with striking reactive atypia and vacuolization of pneumocytes, consistent with reaction to drug (? etoposide) and/or radiation 2013 MFMER slide-32 16
17 Common Problem #2 Reactive or cancer? Helpful Hints If acute lung injury is present, think twice before diagnosing cancer DAD, AFOP, OP Know the clinical history 2013 MFMER slide-33 Case 3 64 y.o. M with diffuse bilateral pulmonary nodules Clinical impression: Granulomatous disease vs. metastases Transbronchial bxs obtained 2013 MFMER slide-34 17
18 2013 MFMER slide MFMER slide-36 18
19 2013 MFMER slide MFMER slide-38 19
20 2013 MFMER slide-39 ARS Polling Question How would you classify this tumor? 1. Goblet cell metaplasia 2. Atypical but insufficient for dx recommend re-biopsy 3. AIS, mucinous type 4. Invasive mucinous adenocarcinoma 5. I have no idea 2013 MFMER slide-40 20
21 2013 MFMER slide MFMER slide-42 21
22 Case #3: My Diagnosis Invasive mucinous adenocarcinoma 2013 MFMER slide-43 Common Problem #3 Bland mucinous lesion Helpful Hints Remember, mucinous adenoca is: Deceptively bland Deceptively lepidic, but high-grade, aggressive, and virtually always invasive Deceptively enteric 2013 MFMER slide-44 22
23 CDX MFMER slide-45 Case 4 91 y.o. M with bulky lung mass, pleural effusion, hilar lymphadenopathy, and possible metastasis to adrenal gland Pleural bxs obtained 2013 MFMER slide-46 23
24 2013 MFMER slide MFMER slide-48 24
25 2013 MFMER slide-49 Positive Vimentin Pankeratin CAM5.2 CD68 IHC Results Negative S100 HMB45 Melan-A CK5/6 MOC31 CEA BerEP4 CD15 B72.3 desmin CD3 CD20 CD45 CD79a MUM1 CD34 Bcl-2 Calretinin D2-40 SMA 2013 MFMER slide-50 25
26 ARS Polling Question How would you classify this tumor? 1. Sarcomatoid carcinoma 2. Undifferentiated pleomorphic sarcoma 3. Sarcomatoid melanoma 4. Sarcomatoid malignancy, NOS 5. I want more stains 2013 MFMER slide-51 TTF MFMER slide-52 26
27 Case #4: My Diagnosis Sarcomatoid carcinoma, most likely of pulmonary origin with pleural metastasis 2013 MFMER slide-53 Common Problem #4 Spindle cell lesion in lung Helpful Hints For pleomorphic spindle cell tumors in the lung, sarcomatoid carcinoma is most likely Don t forget lymphoma and metastasis (melanoma, GYN, etc.) 2013 MFMER slide-54 27
28 Case 5 68 y.o. M with a 20-pack-year smoking hx, with a 3.5 cm round, well-circumscribed, pleuralbased mass Core bx obtained 2013 MFMER slide MFMER slide-56 28
29 2013 MFMER slide MFMER slide-58 29
30 2013 MFMER slide MFMER slide-60 30
31 ARS Polling Question What is the most likely diagnosis? 1. Solitary fibrous tumor 2. Malignant solitary fibrous tumor 3. Sarcomatoid mesothelioma 4. Sarcomatoid carcinoma 5. Something else / not sure 2013 MFMER slide MFMER slide-62 31
32 2013 MFMER slide-63 S MFMER slide-64 32
33 CD MFMER slide-65 Case #5: My Diagnosis Schwannoma, with degenerative changes 2013 MFMER slide-66 33
34 Common Problem #5 Spindle cell lesion in pleura Helpful Hints Think twice about malignancy when a pleomorphic spindle cell tumor lacks mitoses and necrosis Don t forget the chest wall with pleural lesions Know the clinical hx and imaging findings 2013 MFMER slide-67 Case 6 39 y.o. F in motor vehicle accident Incidentally discovered 1.6 cm round, wellcircumscribed nodule in LUL, faintly FDG-avid Wedge resection performed 2013 MFMER slide-68 34
35 2013 MFMER slide MFMER slide-70 35
36 2013 MFMER slide MFMER slide-72 36
37 2013 MFMER slide MFMER slide-74 37
38 2013 MFMER slide MFMER slide-76 38
39 2013 MFMER slide-77 ARS Polling Question What is the most likely diagnosis? 1. Pulmonary hamartoma 2. Myoepithelioma 3. Primary pulmonary myxoid sarcoma 4. Extraskeletal myxoid chondrosarcoma 5. I have no idea 2013 MFMER slide-78 39
40 SMA 2013 MFMER slide-79 IHC Results Positive SMA (weak, focal) Negative AE1/AE3 Desmin Cd34 S100 TTF-1 FISH Testing Positive for EWSR1 rearrangement Negative for NR4A3 rearrangement 2013 MFMER slide-80 40
41 FISH Interpretation Caution! Tumors with EWSR1 gene rearrangement Ewing sarcoma / PNET Clear cell sarcoma of soft tissue Clear cell sarcoma-like tumor of GI tract Desmoplastic small round cell tumor Angiomatoid fibrous histiocytoma Myoepithelial tumors Extraskeletal myxoid chondrosarcoma Primary pulmonary myxoid sarcoma Hyalinizing clear cell carcinoma of salivary / bronchial glands Mesothelioma Hemangioma of bone Low-grade fibromyxoid sarcoma / Sclerosing epithelioid fibrosarcoma Myxoid liposarcoma Osteosarcoma, small cell variant Clear cell odontogenic carcinoma 2013 MFMER slide-81 FISH Interpretation Caution! Tumors with EWSR1-CREB1 translocation Primary pulmonary myxoid sarcoma Angiomatoid fibrous histiocytoma Hyalinizing clear cell carcinoma of bronchial submucosal glands Clear cell sarcoma of soft tissue Clear cell sarcoma-like tumor of the GI tract Hyalinizing clear cell carcinoma of salivary gland 2013 MFMER slide-82 41
42 Case #6: My Diagnosis Primary pulmonary myxoid sarcoma 2013 MFMER slide-83 Common Problem #6 Bland myxoid lesion Helpful Hints FISH is essential, but insufficient; combination of IHC and FISH needed EWSR1 rearrangements and even EWSR1-CREB1 translocations seen in many tumor types 2013 MFMER slide-84 42
43 Case 7 48 y.o. M with extensive smoking history, 7 cm mass in the right lung Core bxs obtained 2013 MFMER slide MFMER slide-86 43
44 2013 MFMER slide MFMER slide-88 44
45 2013 MFMER slide-89 AE1/AE MFMER slide-90 45
46 TTF MFMER slide-91 p MFMER slide-92 46
47 CD MFMER slide-93 CD MFMER slide-94 47
48 ARS Polling Question How would you classify this tumor? 1. AdenoCa, poorly diff. 2. Squamous cell Ca, poorly diff. 3. High-grade lymphoma 4. High-grade angiosarcoma 5. I give up maybe I should retire early 2013 MFMER slide-95 NUT 2013 MFMER slide-96 48
49 NUT 2013 MFMER slide-97 Case #7: My Diagnosis NUT carcinoma 2013 MFMER slide-98 49
50 Common Problem #7 The immunos don t make sense Helpful Hints Repeat markers, maybe in another lab Vascular, melanoma, lymphoma markers Remember tumors with weird IHC patterns: NUT carcinoma SMARCA4-deficient thoracic sarcoma 2013 MFMER slide-99 50
Mesothelioma: diagnostic challenges from a pathological perspective. Naseema Vorajee August 2016
Mesothelioma: diagnostic challenges from a pathological perspective Naseema Vorajee August 2016 Naseema.vorajee@nhls.ac.za Pleural diseases (whether neoplastic, reactive or infective) may have similar
More informationWhat is New in the 2015 WHO Lung Cancer Classification? Zhaolin Xu, MD, FRCPC, FCAP
What is New in the 2015 WHO Lung Cancer Classification? Zhaolin Xu, MD, FRCPC, FCAP Professor, Dept of Pathology, Dalhousie University, Canada Pulmonary Pathologist and Cytopathologist, QEII HSC Senior
More informationSpindle Cell Lesions Of The Breast. Emad Rakha Professor of Breast Pathology and Consultant Pathologist
Spindle Cell Lesions Of The Breast Emad Rakha Professor of Breast Pathology and Consultant Pathologist * SCLs comprise a wide spectrum of diseases, ranging from reactive processes to aggressive malignant
More informationImpact of immunostaining of pulmonary and mediastinal cytology
Impact of immunostaining of pulmonary and mediastinal cytology Harman Sekhon MD, PhD Director of Cytopathology Head of Ottawa-site Ontario Tumour Bank June 20, 2014 Disclaimer Pfizer: Honorarium-Advisory
More informationBreast - ductal carcinoma CK7 ER PR GATA3 Mammaglobin (50-70%) GCDFP-15 (50-70%) E-cadherin HMWCK CK20 PAX2 ER/PR/HER2 on all newly diagnosed cases
Adrenal cortical carcinoma Inhibin Synap Melan-A Calretinin Vimentin Chromogr CK7 CK20 Breast - ductal carcinoma CK7 ER PR GATA3 Mammaglobin (50-70%) GCDFP-15 (50-70%) E-cadherin HMWCK CK20 PAX2 ER/PR/HER2
More informationMinimally invasive adenocarcinoma. 5mm or less = microinvasion No necrosis No lymphatic or pleural invasion No spread through air-spaces (STAS)
Minimally invasive adenocarcinoma 5mm or less = microinvasion No necrosis No lymphatic or pleural invasion No spread through air-spaces (STAS) 2b lepidic acinar 2c papillary micropapillary solid 2d cribriform
More informationThe Spectrum of Management of Pulmonary Ground Glass Nodules
The Spectrum of Management of Pulmonary Ground Glass Nodules Stanley S Siegelman CT Society 10/26/2011 No financial disclosures. Noguchi M et al. Cancer 75: 2844-2852, 1995. 236 surgically resected peripheral
More information57th Annual HSCP Spring Symposium 4/16/2016
An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no
More informationACCME/Disclosures. Diagnosing Mesothelioma in Limited Tissue Samples. Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016
Diagnosing Mesothelioma in Limited Tissue Samples Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016 Sanja Dacic, MD, PhD University of Pittsburgh ACCME/Disclosures GENERAL RULES
More informationSlide seminar: Soft tissue and bone pathology
Slide seminar: Soft tissue and bone pathology Unusual tumors of bone and soft tissue or unusual presentations of common ones Gunhild Mechtersheimer Institute of Pathology, Heidelberg/DE (Sylvia Höller,
More informationImmunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD
Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor
More informationDisclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction
Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques
More informationFrom Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology. Songlin Zhang, MD, PhD LSUHSC-Shreveport
From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology Songlin Zhang, MD, PhD LSUHSC-Shreveport I have no Conflict of Interest. FNA on Lymphoproliferative
More informationFinancial disclosures
An update on immunohistochemical markers in mesenchymal neoplasms By Konstantinos Linos MD, FCAP, FASDP Assistant Professor of Pathology Geisel School of Medicine at Dartmouth Dartmouth-Hitchcock Medical
More informationCutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center
More informationPulmonary Nodules & Masses
Pulmonary Nodules & Masses A Diagnostic Approach Heber MacMahon The University of Chicago Department of Radiology Disclosure Information Consultant for Riverain Technology Minor equity in Hologic Royalties
More informationFinancial disclosures
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchc Geisel School of
More informationHistory A 89 year old gentleman presenting with a scalp/forehead nodule. Patient had squamous cell carcinoma 18 m at same site, excised. Outside diagn
Case III History A 89 year old gentleman presenting with a scalp/forehead nodule. Patient had squamous cell carcinoma 18 m at same site, excised. Outside diagnoses: Squamous cell carcinoma. R/O: SCC, Melanoma,
More informationOBJECTIVES. Solitary Solid Spiculated Nodule. What would you do next? Case Based Discussion: State of the Art Management of Lung Nodules.
Organ Imaging : September 25 2015 OBJECTIVES Case Based Discussion: State of the Art Management of Lung Nodules Dr. Elsie T. Nguyen Dr. Kazuhiro Yasufuku 1. To review guidelines for follow up and management
More informationRadiology Pathology Conference
Radiology Pathology Conference Sharlin Johnykutty,, MD, Cytopathology Fellow Sara Majewski, MD, Radiology Resident Friday, August 28, 2009 Presentation material is for education purposes only. All rights
More informationMesothelioma Pathobasic. Lukas Bubendorf Pathology
Mesothelioma Pathobasic Lukas Bubendorf Pathology Mechanisms of Asbestos Carcinogenesis in Mesothelioma Asprin High-mobility group protein B1 master switch HMGB1 Initiation/ perpetuation of inflamm. response
More informationEffective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific
Effective January 1, 2018 codes, behaviors and terms are site specific /N 8551/3 Acinar adenocarcinoma (C34. _) Lung primaries diagnosed prior to 1/1/2018 use code 8550/3 For prostate (all years) see 8140/3
More informationEffective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific
Effective January 1, 2018 codes, behaviors and terms are site specific Status /N 8010/3 Urachal carcinoma (C65.9, C66.9, C67. _, C68._) 8013/3 Combined large cell neuroendocrine carcinoma (C34. _, C37.9)
More informationSlide Seminar Spanish Society of Pathology
Slide Seminar Spanish Society of Pathology John R. Goldblum, M.D. Chairman, Department of Anatomic Pathology Cleveland Clinic Professor of Pathology Cleveland Clinic Lerner College of Medicine 1921 Original
More informationEnterprise Interest Nothing to declare
Enterprise Interest Nothing to declare Diagnoses one would not like to miss in soft tissue pathology early in your career Marta Sbaraglia, MD Department of Pathology Hospital of Treviso University of Padua
More informationUpdate on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved.
1 Our speaker for this program is Dr. Anja Roden, an associate professor of Laboratory Medicine and Pathology at Mayo Clinic as well as consultant in the Anatomic Pathology Laboratory and co-director of
More informationGround Glass Opacities
Ground Glass Opacities A pathologist s perspective Marie-Christine Aubry, M.D. Professor of Pathology Mayo Clinic Objectives Discuss the proposed new pathologic classification of adenocarcinoma with historical
More informationRespiratory Interactive Session. Elaine Borg
Respiratory Interactive Session Elaine Borg Case 1 Respiratory Cytology 55 year old gentleman Anterior mediastinal mass EBUS FNA Case 1 Respiratory Cytology 55 year old gentleman with anterior mediastinal
More informationPathology Mystery and Surprise
Pathology Mystery and Surprise Tim Smith, MD Director Anatomic Pathology Medical University of South Carolina Disclosures No conflicts to declare Some problem cases Kidney tumor Scalp tumor Bladder tumor
More information3/27/2017. Disclosure of Relevant Financial Relationships
Ophthalmic Pathology Evening Specialty Conference USCAP 2017 5 th March, 2017 Mukul K. Divatia, MD Assistant Professor Department of Pathology & Genomic Medicine Weill Cornell Medical College Houston Methodist
More informationBiopsy Interpretation of Spindle cell proliferations of the Serosa
Biopsy Interpretation of Spindle cell proliferations of the Serosa Richard Attanoos, Cardiff. U.K. Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee)
More informationKlinisch belang van chromosomale translocatie detectie in sarcomen
Translocations in sarcomas Klinisch belang van chromosomale translocatie detectie in sarcomen Judith V.M.G. Bovée, M.D., Ph.D. Department of Pathology Leiden University Medical Center RNA binding DNA binding
More informationClassification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al.
Non-epithelial tumours and nonepithelial tumour-like lesions of the bladder Dr Jonathan H Shanks The Christie NHS Foundation Trust, Manchester, UK Classification (1) Myofibroblastic proliferations and
More information2018 ICD-O-3 Updates in Table Format with Annotation for Reference
Status Histology Description (this may be preferred term or a synonym) Report Comments New term 8010 3 Urachal carcinoma (C65.9, C66.9, C67._, C68._) New term 8013 3 Combined large cell neuroendocrine
More informationLung Cytology: Lessons Learned from Errors in Practice
Lung Cytology: Lessons Learned from Errors in Practice Stephen S. Raab, M.D. Department of Laboratory Medicine Eastern Health and Memorial University of Newfoundland, St. John s, NL and University of Washington,
More informationRespiratory Cytology and Ancillary diagnostic techniques. Dr Alex Rice Royal Brompton Hospital
Respiratory Cytology and Ancillary diagnostic techniques Dr Alex Rice Royal Brompton Hospital Overview Specialist Cardiothoracic centre BAL specimens and cell differential counts EBUS Diagnostic pitfalls
More informationNon Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק
Non Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק 26.06.09 Lecture outlines WHO histological classification Macro/Micro assessment Early diagnosis Minimal pathology Main subtypes SCC, AdCa, LCLC
More informationChest Radiology Interpretation: Findings of Tuberculosis
Chest Radiology Interpretation: Findings of Tuberculosis Get out your laptops, smart phones or other devices pollev.com/chestradiology Case #1 1 Plombage Pneumonia Cancer 2 Reading the TB CXR Be systematic!
More informationPathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON
Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma
More informationDifficult Diagnoses and Controversial Entities in Neoplastic Lung
Difficult Diagnoses and Controversial Entities in Neoplastic Lung Lynette M. Sholl, M.D. Associate Pathologist, Brigham and Women s Hospital Chief, Pulmonary Pathology Service Associate Professor, Harvard
More informationCASE year old male with a PET avid nodule in the left adrenal gland
CASE 1 55 year old male with a PET avid nodule in the left adrenal gland Case 1 Adrenal gland parenchyma partly replaced by a spindle cell tumour with mild nuclear pleomorphism Atypical mitoses present
More information04/09/2018. Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances
Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory
More informationProblem 1: Differential of Neuroendocrine Carcinoma 3/23/2017. Disclosure of Relevant Financial Relationships
Differential of Neuroendocrine Carcinoma Alain C. Borczuk,MD Weill Cornell Medicine Disclosure of Relevant Financial Relationships USCAP requires that all faculty in a position to influence or control
More informationTumores de células pequeñas, redondas y azules: diagnóstico diferencial cuando el tiempo apremia
Tumores de células pequeñas, redondas y azules: diagnóstico diferencial cuando el tiempo apremia Sílvia Bagué Servei de Patologia Hospital de Sant Pau Barcelona Soft tissue sarcomas Heterogeneous group
More informationDifferential diagnosis of HCC
Hepatocellular Carcinoma Quest for an Ideal Immunohistochemical Panel Sanjay Kakar, MD UCSF Differential diagnosis of HCC Hepatocellular lesions Adenoma, FNH, HG dysplasia Adenocarcinoma CholangioCA, metastasis
More informationNewer soft tissue entities
Newer soft tissue entities Examples among fibroblastic tumors Turku, May 6, 2010 Markku Miettinen, M.D. AFIP, Washington, DC Fibroblastic neoplasms Solitary fibrous tumor /Hemangiopericytoma Low-grade
More informationDisclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction
Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationThe role of immunohistochemistry in surgical pathology of the uterine corpus and cervix
The role of immunohistochemistry in surgical pathology of the uterine corpus and cervix Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationSelected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis
Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN folpe.andrew@mayo.edu 2016 MFMER slide-1
More informationobjectives Pitfalls and Pearls in PET/CT imaging Kevin Robinson, DO Assistant Professor Department of Radiology Michigan State University
objectives Pitfalls and Pearls in PET/CT imaging Kevin Robinson, DO Assistant Professor Department of Radiology Michigan State University To determine the regions of physiologic activity To understand
More information1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma
2016 MFMER slide-1 2016 MFMER slide-2 2016 MFMER slide-3 Soft Tissue Tumors Showing Melanocytic Differentiation Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester,
More informationMolecular Diagnosis of Soft Tissue Tumors: Avoid Pitfalls
Molecular Diagnosis of Soft Tissue Tumors: Avoid Pitfalls Cristina Antonescu, MD Department of Pathology Memorial Sloan-Kettering Cancer Center, New York Overview I. When should we rely on the help of
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationDesmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC
R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o
More information05/07/2018. Types of challenges. Challenging cases in uterine pathology. Case 1 ` 65 year old female Post menopausal bleeding Uterine Polyp
Types of challenges Challenging cases in uterine pathology Nafisa Wilkinson Gynaecological Pathologist UCLH London Lack of complete history often, NO clinical history at all! Cases from other centres often
More informationSurgical Pathology Evening Specialty Conference USCAP 2015
Surgical Pathology Evening Specialty Conference USCAP 2015 John R. Goldblum, M.D. Chairman, Department of Pathology, Cleveland Clinic Professor of Pathology, Cleveland Clinic Lerner College of Medicine
More informationDifferential Diagnosis of Oral Masses. Palatal Lesions
Differential Diagnosis of Oral Masses Palatal Lesions Palatal Masses Periapical Abscess Torus Palatinus Mucocele Lymphoid Hyperplasia Adenomatous Hyperplasia Benign Salivary Neoplasms Malignant Salivary
More informationEffusion Cytology: Diagnostic Challenges
Effusion Cytology: Diagnostic Challenges Tarik M. Elsheikh, MD Professor and Medical Director, Anatomic Pathology Cleveland Clinic Outside Consult Case 45 year old woman, presented with nausea, dyspnea,
More information2 Berkeley Street, Suite 403, Toronto, Ontario M5A 2W3 Visit us at: Tel: Fax:
E-Path A.I. Engine Knowledge Base Enhancements Version 1.0.0.29 April 1, 2018 The major enhancements in the E-Path Knowledge Base from versions 1.0.0.28 through 1.0.0.29 are as follows: 1. Addition/modification
More informationProstate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1)
Prostate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1) Jae Y. Ro, MD, PhD June 7, 2012 Ten Leading Cancer Types for the Estimated New Cancer Cases and Deaths By Sex, United States,
More informationThoracic CT pattern in lung cancer: correlation of CT and pathologic diagnosis
19 th Congress of APSR PG of Lung Cancer (ESAP): Update of Lung Cancer Thoracic CT pattern in lung cancer: correlation of CT and pathologic diagnosis Kazuma Kishi, M.D. Department of Respiratory Medicine,
More informationLUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia
LUNG CANCER pathology & molecular biology Izidor Kern University Clinic Golnik, Slovenia 1 Pathology and epidemiology Small biopsy & cytology SCLC 14% NSCC NOS 4% 70% 60% 50% 63% 62% 61% 62% 59% 54% 51%
More informationContents Part I Introduction 1 General Description 2 Natural History: Importance of Size, Site, Histopathology
Contents Part I Introduction 1 General Description... 3 1.1 Introduction... 3 1.2 Incidence and Prevalence... 5 1.3 Predisposing and Genetic Factors... 8 References... 16 2 Natural History: Importance
More informationNon-Small Cell Lung Carcinoma - Myers
Role of Routine Histology and Special Testing in Managing Patients with Non- Small Cell Lung Carcinoma Jeffrey L. Myers, M.D. A. James French Professor Director, Anatomic Pathology & MLabs University of
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Royal National Orthopaedic Hospital NHS Trust Brockley Hill Stanmore Middlesex HA7 4LP Contact: Professor Adrienne Flanagan Tel: +44 (0)20
More informationObjectives. Salivary Gland FNA: The Milan System. Role of Salivary Gland FNA 04/26/2018
Salivary Gland FNA: The Milan System Dr. Jennifer Brainard Section Head Cytopathology Cleveland Clinic Objectives Introduce the Milan System for reporting salivary gland cytopathology Define cytologic
More informationKeywords solitary fibrous tumor, dedifferentiation, dedifferentiated solitary fibrous tumor, STAT6, GRIA2, cytokeratin, rhabdomyosarcomatous
758452IJSXXX10.1177/1066896918758452International Journal of Surgical PathologyCreytens et al research-article2018 Pitfalls in Pathology Multifocal Cytokeratin Expression in a Dedifferentiated Solitary
More informationMayo Medical Laboratories
Mayo Medical Laboratories Virtual Lectures 2014 MFMER 2016 MFMER slide-1 Virtual Lectures Planning Committee Disclosure Summary As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo
More informationLOOK-ALIKES IN SPINDLE AND EPITHELIOID TUMORS: Immunohistochemistry. Cytogenetics Flow cytometry Molecular diagnostics
LOOK-ALIKES IN SPINDLE AND EPITHELIOID TUMORS: Ultrastructural value and pitfalls in diagnosis Guillermo A Herrera Department of Pathology and Translational Pathobiology Louisiana State University Health
More informationI have nothing to disclose
A 47 year old female with multiple lung nodules Disclosure of Relevant Financial Relationships Tamar Giorgadze, MD, PhD Professor of Pathology Medical College of Wisconsin Milwaukee, Wisconsin USCAP requires
More informationRadiology Pathology Conference
Radiology Pathology Conference Nadia F. Yusaf, M.D. PGY-3 1/29/2010 Presentation material is for education purposes only. All rights reserved. 2010 URMC Radiology Page 1 of 90 Case 1 60 year- old man presents
More informationUpdate on Cutaneous Mesenchymal Tumors. Thomas Brenn
Update on Cutaneous Mesenchymal Tumors Thomas Brenn Cutaneous Mesenchymal Tumours Wide morphological and biological spectrum Myofibroblastic, smooth muscle, neural, vascular, apidocytic, undifferentiated;
More informationThe International Association for the Study of Lung Cancer (IASLC) Lung Cancer Staging Project, Data Elements
Page 1 Contents 1.1. Registration... 2 1.2. Patient Characteristics... 3 1.3. Laboratory Values at Diagnosis... 5 1.4. Lung Cancers with Multiple Lesions... 6 1.5. Primary Tumour Description... 10 1.6.
More informationApproach to Pulmonary Nodules
Approach to Pulmonary Nodules Edwin Jackson, Jr., DO Assistant Professor-Clinical Director, James Early Detection Clinic Department of Internal Medicine Division of Pulmonary, Allergy, Critical Care and
More informationHistopathology of NSCLC, IHC markers and ptnm classification
ESMO Preceptorship on Non-Small Cell Lung Cancer November 15 th & 16 th 2017 Singapore Histopathology of NSCLC, IHC markers and ptnm classification Prof Keith M Kerr Department of Pathology, Aberdeen University
More informationThursday, March 17, pm ET
Virtual Molecular Tumor Board Host: MedStar Georgetown University Hospital Leader: Dr. John Marshall Thursday, March 17, 2016 5 pm ET Patient 1 The information contained in these slides is provided for
More informationCase Scenario 1. The patient agreed to a CT guided biopsy of the left upper lobe mass. This was performed and confirmed non-small cell carcinoma.
Case Scenario 1 An 89 year old male patient presented with a progressive cough for approximately six weeks for which he received approximately three rounds of antibiotic therapy without response. A chest
More informationLung /4/18. Please submit all questions concerning the webinar content through the Q&A panel.
Lung NAACCR 2018 2019 WEBINAR SERIES 1 Q&A Please submit all questions concerning the webinar content through the Q&A panel. If you have participants watching this webinar at your site, please collect
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationأملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5
Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs
More informationCase Report Desmoplastic Small Round Cell Tumor, a (Floating Island) Pattern in Pleural Fluid Cytology: A Case Report and Review of the Literature
Case Reports in Pathology Volume 2015, Article ID 676894, 5 pages http://dx.doi.org/10.1155/2015/676894 Case Report Desmoplastic Small Round Cell Tumor, a (Floating Island) Pattern in Pleural Fluid Cytology:
More informationEQA Circulation 43 Educational Cases
EQA Circulation 43 Educational Cases E1-E2 Monica Agarwal Monklands Hospital E1 38 yrs male Submandibular gland tumour E1 Formal excision following diagnosis of poorly differentiated carcinoma on core
More informationMolecular pathology in soft tissue tumors. Sylvia Höller Pathologie
Molecular pathology in soft tissue tumors Sylvia Höller Pathologie When do we perform molecular testing? Morphology and IHC are not clearly fitting with an entity some translocations are entity specific
More informationSELECTED DILEMMAS IN RESPIRATORY CYTOPATHOLOGY (2 CASES)
SELECTED DILEMMAS IN RESPIRATORY CYTOPATHOLOGY (2 CASES) Dr. Mariamma Joseph Professor of Pathology Division Head Cytopathology Department of Pathology and Laboratory Medicine LHSC and Western University
More informationLung Neoplasia II Resection specimens Pathobasic. Lukas Bubendorf Pathology
Lung Neoplasia II Resection specimens Pathobasic Lukas Bubendorf Pathology Agenda Preneoplastic lesions Histological subtypes of lung cancer Histological patterns of AC Cells of origin and characteristic
More informationApplications of IHC. Determination of the primary site in metastatic tumors of unknown origin
Applications of IHC Determination of the primary site in metastatic tumors of unknown origin Classification of tumors that appear 'undifferentiated' by standard light microscopy Precise classification
More informationGrading of Bone Tumors
Grading of Bone Tumors Joon Hyuk Choi, M.D. Department of Pathology College of Medicine, Yeungnam University Introduction to grading system of bone tumor used at Mayo Clinic WHO Histologic Classification
More informationReview of the AP Part II Practical Examination. Dr David Clift Co Chief Examiner
Review of the AP Part II Practical Examination Dr David Clift Co Chief Examiner General Remarks The part II practical examination involved 15 cases which were presented with sufficient clinical data to
More informationDisclosure of Relevant Financial Relationships
Ewing and Ewing like sarcomas Using Genetic Signatures in Refining Small Blue Round Cell Tumor Classification Cristina Antonescu, MD Department of Pathology Disclosure of Relevant Financial Relationships
More informationDisclosure of Relevant Financial Relationships
Evening Specialty Conference - Genitourinary Pathology Case 2 Disclosure of Relevant Financial Relationships Sean R Williamson, MD Henry Ford Health System, Detroit, MI @Williamson_SR USCAP requires that
More informationUncommon Lung Tumors:
4th World Congress of Thoracic Imaging Uncommon Lung Tumors: Exhibit Category: Thoracic Neoplasms 1 Tae Jung Kim, 1 Boda Nam, 2 Joungho Han, 1 Kyung Soo Lee Department of 1 Radiology and 2 Pathology Samsung
More information4/17/2015. Case 1. A 37 year old man with a 2.2 cm solitary left thyroid mass.
Case 1 A 37 year old man with a 2.2 cm solitary left thyroid mass. Case 1 Case 1 1 Case 1: Diagnosis? A. Benign B. Atypia of undetermined significance/follicular lesion of undetermined significance C.
More informationCarcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY
Carcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY SEARCHING FOR THE PRIMARY? P r o f J P P r e t o r i u s H e a d : C l i n i c a l U n i t C r i t i c a l C a r e U n i v e r s i t y O f
More informationSlide seminar. Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana
Slide seminar Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana Case 5 A 57-year-old man with a dermal/subcutaneous lesion on the scalp, which was interpreted
More informationIntroduction to Musculoskeletal Tumors. James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon
Introduction to Musculoskeletal Tumors James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon www.tumorsurgery.org Definitions Primary Bone / Soft tissue tumors Mesenchymally derived tumors (Mesodermal)
More information4/12/2018. MUSC Pathology Symposium Kiawah Island April 18, Jesse K. McKenney, MD
MUSC Pathology Symposium Kiawah Island April 18, 2018 Jesse K. McKenney, MD 1 Urothelial Carcinoma with Alternative Differentiation 2 Urothelial Carcinoma with Alternative Differentiation Recognition as
More informationFinancial disclosures
Mesenchymal Neoplasms with Melanocytic Differentiation By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel
More informationEnterprise Interest No disclosures.
Enterprise Interest No disclosures. Secondary Tumours in Uropathology Case 2 PRESENTED AT: EUROPEAN CONGRESS OF PATHOLOGY 18 #ECP2018 Slides are the property of the author. Permission required for reuse.
More information