Case 1. Maysa Al-Hussaini MD FRCPath
|
|
- Neal Carr
- 5 years ago
- Views:
Transcription
1 Case 1 Maysa Al-Hussaini MD FRCPath MAYSA King AL-HUSSAINI Hussein Cancer MD Center MRCPATH KING HUSSEIN Amman CANCER Jordan CENTER
2 Clinical history 4 year old boy History of frontal headache, sleepiness. No history of vomiting, blurring of vision, LOC or seizures. CT/MRI done
3
4
5
6
7
8
9
10
11 Vimentin
12 Synaptophysin
13 EMA
14 SMA
15 FAP
16 Ki-67
17 Negative markers included Desmin CD99 transthyretin
18 AND
19 BAF 47
20 Diagnosis
21 Atypical teratoid/rhabdoid tumour
22 Atypical teratoid/rhabdoid tumour First described as "rhabdoid" tumour of the CNS in the eighties. The tumour was recognized as a separate entity in the third edition of WHO classification of tumours of the Central Nervous System in 2000.
23 Atypical teratoid/rhabdoid tumour 1-2% of all CNS tumours, 10% of CNS tumours in infants. Occurs predominantly in children, especially those younger than 3 years of age. Males are slightly more affected than females (1.3:1 ).
24 ATRT/ location The tumour occurs slightly more frequently in the supratentorial location than infratentorially. In supratentorial examples, the tumours are seen mostly in the Cerebral hemispheres. Third ventricle. Exclusive lateral ventricular location is rarely described. In the infratentorial examples, involvement of the cerebello-pontine angle as well as the 4 th ventricle is mostly seen.
25 ATRT/ genetics ATRT is characterized by a variety of cytogenetic abnormalities involving chromosome 22, which is seen in 75% of cases. This results in a biallelic deletion or mutation involving the SMARCB1/INI1 gene at 22q11.2, mostly detected by interphase FISH. This molecular event results in loss of immunohistochemical expression of INI1/Baf47.
26 ATRT/DDx Supratentorial location: CNS-PNET Infratentorial location: Medulloblastoma, especially anaplastic medulloblastoma. Intra-ventricular : choroid plexus carcinoma.
27 ATRT vs CNS-PNET CNS-PNET is a rare tumour that predominantly affects infants and children. A huge heterogeneous mass. Can pose diagnostic difficulty with ATRT, especially in small biopsies. Many ATRTs were diagnosed as CNS-PNET previously, when the INI-1/Baf-47 was not available for use.
28 ATRT vs CPC Choroid plexus carcinoma is an aggressive tumour that presents in infants and young children. Intra-ventricular growth. Immunostains; Epithelial markers especially cytokeratin and less frequently EMA are positive. Other less frequent positive markers include synaptophysin and GFAP. Recently; INI-1/Baf-47 has been described in choroid plexus carcinoma. This has led to the speculation that ATRT and CPC might be related tumours especially that the origin of ATRT is not yet resolved.
29 Rhabdoid Tumour Predisposing Syndrome RTPS is characterized by germline mutations of the INI1 gene (22q11.2). Manifested by a marked predisposition to the development of malignant rhabdoid tumours of infancy and early childhood. 1/3 of ATRT are associated with RTPS.
30 RTPS con ATRT is the typical tumour associated with this syndrome, but other tumours including medulloblastoma, choroid plexus carcinoma, and PNETs have been reported. The most common non-cns tumour is renal rhabdoid tumours.
31 RTPS cont The RTPS is highly suggested in the following clinical scenarios Synchronous occurrence of renal malignant rhabdoid tumour and ATRT Bilateral malignant rhabdoid tumours of the kidney The occurrence of malignant rhabdoid tumours in 2 or more siblings
32 Word of caution!!!! Many malignant neoplasms of the CNS can have rhabdoid morphology, including glioblastoma and meningioma. These tumours show retention of the INI1 protein and are not thought to have INI1 mutations or be a component of the RTPS.
33 ATRT/treatment Surgery. Chemotherapy as high-risk medulloblastoma. +/- radiotherapy. BM stem cell transplantation.
34 Thank you
Case Report Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child
Case Reports in Oncological Medicine Volume 2013, Article ID 815923, 4 pages http://dx.doi.org/10.1155/2013/815923 Case Report Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child Y. T.
More informationAtypical Teratoid / Rhabdoid tumours. Information for parents and carers
Atypical Teratoid / Rhabdoid tumours Information for parents and carers Grace Kelly Ladybird Trust Atypical Teratoid / Rhabdoid tumours This publication is intended to supplement the advice given by your
More informationCNS TUMORS. D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria)
CNS TUMORS D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria) CNS TUMORS The annual incidence of intracranial tumors of the CNS ISmore than intraspinal tumors May be Primary or Secondary
More informationCNS pathology Third year medical students. Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3
CNS pathology Third year medical students Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3 Pilocytic astrocytoma Relatively benign ( WHO grade 1) Occurs in children and young adults Mostly: in the cerebellum
More informationGeneral: Brain tumors are lesions that have mass effect distorting the normal tissue and often result in increased intracranial pressure.
1 Lecture Objectives Know the histologic features of the most common tumors of the CNS. Know the differences in behavior of the different tumor types. Be aware of the treatment modalities in the various
More informationBRAIN TUMORS IN INFANTS
BRAIN TUMORS IN INFANTS Dr Sergio Valenzuela M.D-( ISPN-ESPN-FLANC)&cols. Head Pediatric Neurosurgery Unit I Instituto de NeurocirugiaAsenjo Santiago CHILE RATE OF MENINGEAL,BRAIN AND OTHER CNS MALIGNANT
More informationSYLLABUS SWI/SNF-dependent tumors
SYLLABUS SWI/SNF-dependent tumors F Le Loarer, MD, PhD Centre Leon Berard, Department of Pathology, Lyon, FRANCE Since the seminal description in 1999 of recurrent inactivation of SMARCB1- which encodes
More informationChildhood Central Nervous System Atypical Teratoid/Rhabdoid Tumor Treatment (PDQ )
1 di 10 27/06/2016 08.16 NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute
More informationSTUDY OFPAEDIATRIC CNS TUMORS IN TERTIARY CARE CENTER
IJCRR Section: Healthcare Sci. Journal Impact Factor 4.016 Original Article STUDY OFPAEDIATRIC CNS TUMORS IN TERTIARY CARE CENTER Grishma P. Jobanputra Tutor, Department of Pathology, B.J. Medical College,
More informationBrain tumors: tumor types
Brain tumors: tumor types Tumor types There are more than 120 types of brain tumors. Today, most medical institutions use the World Health Organization (WHO) classification system to identify brain tumors.
More informationHistopathological Study and Categorisation of Brain Tumors
Histopathological Study and Categorisation of Brain Tumors Ruchira Wadhwa 1*, Purvi Patel 2, Hansa Goswami 3 1 Third Year Resident, 2 Assistant Professor, 3 Professor and Head, Department of Pathology,
More informationPediatric Brain Tumors: Updates in Treatment and Care
Pediatric Brain Tumors: Updates in Treatment and Care Writer Classroom Rishi R. Lulla, MD MS Objectives Introduce the common pediatric brain tumors Discuss current treatment strategies for pediatric brain
More informationPrimary atypical teratoid/rhabdoid tumors (AT/RTs) are
ORIGINAL RESEARCH S.P. Meyers Z.P. Khademian J.A. Biegel S.H. Chuang D.N. Korones R.A. Zimmerman Primary Intracranial Atypical Teratoid/Rhabdoid Tumors of Infancy and Childhood: MRI Features and Patient
More informationImaging Findings of CNS Atypical Teratoid/Rhabdoid Tumors
AJNR Am J Neuroradiol 25:476 480, March 2004 Case Report Imaging Findings of CNS Atypical Teratoid/Rhabdoid Tumors Atilla Arslanoglu, Nafi Aygun, Deapak Tekhtani, Leslie Aronson, Ken Cohen, Peter C. Burger,
More informationSPECIAL SLIDE SEMINAR CASE 3
SPECIAL SLIDE SEMINAR CASE 3 Tihana Džombeta, MD Leo Pažanin, MD, PhD Department of Pathology, School of Medicine, University of Zagreb Department of Pathology, Clinical Hospital Centre Sestre milosrdnice
More informationShared Care & Survival CTYA SSCRG (Childhood Cancer Research Group)
Shared Care & Survival CTYA SSCRG (Childhood Cancer Research Group) January 2013 The NCIN is a UK-wide initiative, working to drive improvements in standards of cancer care and clinical outcomes by improving
More informationNeurosurgical Management of Brain Tumours. Nicholas Little Neurosurgeon RNSH
Neurosurgical Management of Brain Tumours Nicholas Little Neurosurgeon RNSH General Most common tumours are metastatic 10x more common than primary Incidence of primary neoplasms is 20 per 100000 per year
More informationCHAPTER 11 Tumors Originating in the Brain Medulloblastomas, PNETs and Ependymomas
Tumors Originating in the Brain Medulloblastomas, PNETs and Ependymomas Foolishly, I waited 7 months before I joined this (or any) group. By that time, my son had radiation, chemo, and a recurrence of
More informationCase 7391 Intraventricular Lesion
Case 7391 Intraventricular Lesion Bastos Lima P1, Marques C1, Cabrita F2, Barbosa M2, Rebelo O3, Rio F1. 1Neuroradiology, 2Neurosurgery, 3Neuropathology, Coimbra University Hospitals, Portugal. University
More informationPediatric CNS Tumors. Disclosures. Acknowledgements. Introduction. Introduction. Posterior Fossa Tumors. Whitney Finke, MD
Pediatric CNS Tumors Disclosures Whitney Finke, MD Neuroradiology Fellow PGY-6 University of Utah Health Sciences Center Salt Lake City, Utah None Acknowledgements Introduction Nicholas A. Koontz, MD Luke
More informationTumors of the Nervous System
Tumors of the Nervous System Peter Canoll MD. PhD. What I want to cover What are the most common types of brain tumors? Who gets them? How do they present? What do they look like? How do they behave? 1
More informationRapid recurrence of a malignant meningioma: case report
Romanian Neurosurgery Volume XXXI Number 2 2017 April-June Article Rapid recurrence of a malignant meningioma: case report Oguz Baran, Sima Sayyahmeli, Taner Tanriverdi, Pamir Erdincler TURKEY DOI: 10.1515/romneu-2017-0027
More informationNo financial or other disclosures
Case 2014-5 Esther N. Bit-Ivan, DO Northwestern University Jason Wang, MD Jason Park, MD Korgun Koral, MD Children s Medical Center Charles Timmons, MD Veena Rajaram, MD No financial or other disclosures
More informationDr.Dafalla Ahmed Babiker Jazan University
Dr.Dafalla Ahmed Babiker Jazan University Brain tumors are the second commonest malignancy in children Infratentorial tumors are more common As a general rule they do not metastasize out of the CNS, but
More informationPathologic Analysis of CNS Surgical Specimens
2015 Kenneth M. Earle Memorial Neuropathology Review Pathologic Analysis of CNS Surgical Specimens Peter C. Burger, MD Interdisciplinary Quality Control Familiarity with entities Use of diagnostic algorithm
More informationAMERICAN ASSOCIATION OF NEUROPATHOLOGISTS COMPANION SOCIETY MEETING at the 106 th ANNUAL MEETING OF THE USCAP San Antonio, March 4, 2017
AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS COMPANION SOCIETY MEETING at the 106 th ANNUAL MEETING OF THE USCAP San Antonio, March 4, 2017 SYLLABUS Papillary Tumor of the Pineal Region and the Differential
More informationMethoden / Methods inc. ICCC-3 105
Methoden / Methods inc. ICCC-3 105 Internationale Klassifikation der Krebserkrankungen bei Kindern (ICCC-3) Zuordnung von ICD-O-3-Codes für Morphologie und Topographie zu diagnostischen Kategorien International
More informationChildhood brain tumours
Childhood brain tumours Our bodies are made up of billions of cells. Normally, these cells reproduce and repair themselves in a controlled way and do not cause us any problems. If for some reason this
More informationNeuro-oncology Update Andrew Kokkino, MD Medical Director, The Neurosciences Institute at Sacred Heart at Riverbend May 20, 2013
Neuro-oncology Update 2013 Andrew Kokkino, MD Medical Director, The Neurosciences Institute at Sacred Heart at Riverbend May 20, 2013 Case 1 58 year old man with recent facial droop and HA s Thin, cachectic
More informationCase of the month. Dr Charles Bénière, Institut universitaire de pathologie, Lausanne
Case of the month Dr Charles Bénière, Institut universitaire de pathologie, Lausanne Clinical history 39 years old male, smoker (19 pack-year) without any prior medical record nor professional exposure.
More informationPediatric Oncology. Vlad Radulescu, MD
Pediatric Oncology Vlad Radulescu, MD Objectives Review the epidemiology of childhood cancer Discuss the presenting signs and symptoms, general treatment principles and overall prognosis of the most common
More informationCase Report Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male
Case Reports in Radiology Volume 2016, Article ID 6434623, 4 pages http://dx.doi.org/10.1155/2016/6434623 Case Report Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male Jordan Nepute,
More informationSupra- and infratentorial brain tumors from childhood to maternity
Supra- and infratentorial brain tumors from childhood to maternity What to expect? I am going to show you the characteristic imaging findings of following tumors: Thierry A.G.M. Huisman, MD, FICIS, EQNR
More informationAnna Maria Buccoliero Department of Biomedicine, Careggi Hospital Florence
PEDIATRIC RHABDOID MENINGIOMA Anna Maria Buccoliero Department of Biomedicine, Careggi Hospital Florence CLINICAL HISTORY A 3-year-old boy, with a recent history of seizures, was admitted to the Neurosurgery
More informationChildhood Brain and Spinal Cord Tumors Treatment Overview (PDQ )
1 di 8 04/03/2017 07.31 NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute
More informationDisclosure. Relevant Financial Relationship(s) None. Off Label Usage None MFMER slide-1
Disclosure Relevant Financial Relationship(s) None Off Label Usage None 2013 MFMER slide-1 Case Presentation A 43 year old male, with partial nephrectomy for a right kidney mass 2013 MFMER slide-2 2013
More informationClinical, radiological, and histopathological features and prognostic factors of brain tumors in children
Journal of Physics: Conference Series PAPER OPEN ACCESS Clinical, radiological, and histopathological features and prognostic factors of brain tumors in children To cite this article: M H Siregar et al
More informationExamining large groups of cancer patients to identify ways of predicting which therapies cancers might respond to.
Stratified Medicine Examining large groups of cancer patients to identify ways of predicting which therapies cancers might respond to. Looking in detail at cancer cells and their genetic make up. Permit
More informationCase Report Disseminated Cerebrospinal Embryonal Tumor in the Adult
Case Reports in Pathology Volume 2016, Article ID 6785459, 5 pages http://dx.doi.org/10.1155/2016/6785459 Case Report Disseminated Cerebrospinal Embryonal Tumor in the Adult Alessandro Caporlingua, 1 Daniele
More informationExtra-renal, extra-neural atypical teratoid/rhabdoid tumor (ATRT): imaging Features of uncommon tumor
Extra-renal, extra-neural atypical teratoid/rhabdoid tumor (ATRT): imaging Features of uncommon tumor Poster No.: C-1244 Congress: ECR 2014 Type: Educational Exhibit Authors: A. Youssef, Y. Mahfouz, T.
More informationInt J Clin Exp Pathol 2014;7(5): /ISSN: /IJCEP
Int J Clin Exp Pathol 2014;7(5):2411-2420 www.ijcep.com /ISSN:1936-2625/IJCEP0000182 Original Article Primary atypical teratoid/rhabdoid tumor of central nervous system in children: a clinicopathological
More informationRESEARCH ARTICLE. Atypical Teratoid/ Rhabdoid Tumor of Brain: a Clinicopathologic Study of Eleven Patients and Review of Literature
DOI:10.22034/APJCP.2017.18.4.949 Atypical Teratoid/Rhabdoid Tumor RESEARCH ARTICLE Atypical Teratoid/ Rhabdoid Tumor of Brain: a Clinicopathologic Study of Eleven Patients and Review of Literature Nasir
More informationChildhood Brain and Spinal Cord Tumors Treatment Overview (PDQ )
1 di 14 27/11/2016 17.42 NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute
More informationTumors of the Central Nervous System
Tumors of the Central Nervous System 1 Financial Disclosures I have NO SIGNIFICANT FINANCIAL, GENERAL, OR OBLIGATION INTERESTS TO REPORT Introduction General: Brain tumors are lesions that have mass effect
More informationCURRENTLY ENROLLING ONCOLOGY TREATMENT STUDIES (as of 4/27/2017)
CURRENTLY ENROLLING ONCOLOGY TREATMENT STUDIES (as of 4/27/2017) Leukemia AALL0932 closed after Induction Treatment of Patients with Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized
More informationSURGICAL MANAGEMENT OF BRAIN TUMORS
SURGICAL MANAGEMENT OF BRAIN TUMORS LIGIA TATARANU, MD, Ph D NEUROSURGICAL CLINIC, BAGDASAR ARSENI CLINICAL HOSPITAL BUCHAREST, ROMANIA SURGICAL INDICATIONS CONFIRMING HISTOLOGIC DIAGNOSIS REDUCING TUMOR
More informationPediatric Brain Tumors Pre, Intra & Post Op Evaluation and Management. Timothy M. George, MD, FACS, FAAP
Pediatric Brain Tumors Pre, Intra & Post Op Evaluation and Management Timothy M. George, MD, FACS, FAAP PEDIATRIC BRAIN TUMORS BACKGROUND: Incidence: Third most common pediatric tumor type (leukemia, neuroblastoma,
More informationSite Specific Coding Rules MALIGNANT CENTRAL NERVOUS SYSTEM TUMORS
Multiple Primary and Histology Site Specific Coding Rules MALIGNANT CENTRAL NERVOUS SYSTEM TUMORS 1 Prerequisites 2 Completion of Multiple Primary and Histology General Coding Rules 3 There are many ways
More informationEarly detection of Retinoblastoma in children. Max Mantik
Early detection of Retinoblastoma in children Max Mantik Introduction The most common primary intraocular malignancy of childhood 10 to 15 % of cancers that occur within the first year of life Typical
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM MEDULLOBLASTOMA AND PNET CNS Site Group Medulloblastoma and PNET Author: Dr. Norm Laperriere 1. INTRODUCTION 3 2. PREVENTION
More informationNeuropathology Evening Session: Case 3
Neuropathology Evening Session: Case 3 Christine E. Fuller, MD Cincinnati Children s Hospital Medical Center Disclosure of Relevant Financial Relationships USCAP requires that all faculty in a position
More informationOligodendrogliomas & Oligoastrocytomas
Oligodendrogliomas & Oligoastrocytomas ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Founded in 1973, the American Brain Tumor Association (ABTA) was the first national nonprofit organization dedicated solely
More informationEpidemiology and Outcome of Brain Disorders & Damage Across the Life Span: Some Notes. Vincent W. Hevern, SJ, Ph.D. 2016
Epidemiology and Outcome of Brain Disorders & Damage Across the Life Span: Some Notes Cerebrovascular Disease or Stroke Vincent W. Hevern, SJ, Ph.D. 2016 A. Epidemiology of Brain Disorders & Damage Number
More informationEpidemiology and Outcome of Brain Disorders & Damage Across the Life Span: Some Notes. Vincent W. Hevern, SJ, Ph.D. 2018
Epidemiology and Outcome of Brain Disorders & Damage Across the Life Span: Some Notes Cerebrovascular Disease or Stroke Vincent W. Hevern, SJ, Ph.D. 2018 A. Epidemiology of Brain Disorders & Damage Number
More informationClassification of spontaneous brain tumors in rats
Classification of spontaneous brain tumors in rats Central Nervous System Neoplasms in the Rat (Solleveld HA, et al., 1991) 1. Tumors of Neuroepithelial Tissue A. Astrocytic and oligodendroglial tumors
More informationAstroblastoma : A Case Report
J Korean Med Sci 2004; 19: 772-6 ISSN 1011-8934 Copyright The Korean Academy of Medical Sciences Astroblastoma : A Case Report Astroblastoma is one of the very unusual type of tumors, whose histogenesis
More informationCase Presentation Diana Lim, MBBS, FRCPA, FRCPath Senior Consultant Department of Pathology, National University Health System, Singapore Assistant Pr
Case Presentation Diana Lim, MBBS, FRCPA, FRCPath Senior Consultant Department of Pathology, National University Health System, Singapore Assistant Professor Yong Loo Lin School of Medicine, National University
More informationSoft Tissue High Grade Myoepithelial Carcinoma With Round Cell Morphology: Report Of A Newly Described Entity With EWSR1 Gene Rearrangement
Soft Tissue High Grade Myoepithelial Carcinoma With Round Cell Morphology: Report Of A Newly Described Entity With EWSR1 Gene Rearrangement Abstract M. El-Kabany, R. Al-Abdulghani, A. E. Ali, I. M. Francis,
More informationImmunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD
Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationCT & MRI Evaluation of Brain Tumour & Tumour like Conditions
CT & MRI Evaluation of Brain Tumour & Tumour like Conditions Dr. Anjana Trivedi 1, Dr. Jay Thakkar 2, Dr. Maulik Jethva 3, Dr. Ishita Virda 4 1 M.D. Radiology, Professor and Head, P.D.U. Medical College
More informationProtocol Abstract and Schema
Protocol Abstract and Schema A Phase I Trial of p28 (NSC745104), a Non-HDM2 mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive CNS tumors Description and
More informationCase 1. Clinical history
Case 1 Case 1 Clinical history 17-month-old boy with a kidney tumor found during routine childhood care program. CT scan showed a solid mass. Chemotherapy was given for 4 weeks using actinomycin D and
More information1 Department of Pediatric Hematology and Oncology, University. 3 Department of Pediatrics, University of Erlangen, Erlangen,
Pediatr Blood Cancer 2011;57:978 985 Frequency, Risk-Factors and Survival of Children With Atypical Teratoid Rhabdoid Tumors (AT/RT) of the CNS Diagnosed between 1988 and 2004, and Registered to the German
More informationCorporate Medical Policy
Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CNS Embryonal Tumors File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cns_embryonal_tumors
More informationWHAT ARE PAEDIATRIC CANCERS
WHAT ARE PAEDIATRIC CANCERS INTRODUCTION Childhood cancers are RARE 0.5% of all cancers in the West Overall risk that a child will develop cancer during first 15 years of life is 1 in 450 and 1 in 600
More informationImmunohistochemical Evaluation Of Small Round Cell Tumors Of Childhood
Immunohistochemical Evaluation Of Small Round Cell Tumors Of Childhood Pages with reference to book, From 87 To 89 Sajid H. Shah,Irshad N. Soomro,M. Shahid Siddiqui,Shahid Pervez,Sheema H. Hassan ( Department
More informationChapter 1 Introduction
Chapter 1 Introduction Men think epilepsy divine, merely because they do not understand it. But if they called everything divine which they do not understand, why, there would be no end to divine things.
More informationBrain Tumors in Children
Brain Tumors in Children Michael A. Grotzer University Children s Hospital of Zurich, Switzerland Incidence of Childhood Cancer CNS Tumors Acute lymphoblastic Leukemia Neuroblastoma Non-Hodgkin Lymphoma
More informationSOLID TUMOURS IN CHILDHOOD
SOLID TUMOURS IN CHILDHOOD Fareed Omar Paediatric Oncology Steve Biko Academic hospital Introduction 1 Introduction Lymphomas and Leukemias make up about 40% of all childhood Cancers (Systemic cancers)
More informationAMERICAN BRAIN TUMOR ASSOCIATION. Oligodendroglioma and Oligoastrocytoma
AMERICAN BRAIN TUMOR ASSOCIATION Oligodendroglioma and Oligoastrocytoma ACKNOWLEDGEMENTS ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Founded in 1973, the American Brain Tumor Association (ABTA) was the
More informationA Case Report of Atypical Teratoid/Rhabdoid Tumour in a 9-Year-Old Girl
Case Report A Case Report of Atypical Teratoid/Rhabdoid Tumour in a 9-Year-Old Girl Kin Hup Chan 1, Mohammed Saffari Mohammed Haspani 2, Yew Chin Tan 1, Fauziah Kassim 3 Submitted: 22 Oct 2009 Accepted:
More informationCME/SAM. Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus
AJCP / Original Article Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus Wang Xingfu, MD, 1 Zhang Lifeng, MD, 2 Chen Yupeng, MD, 1 Liu Xueyong, MD,
More informationWhat are brain and spinal cord tumours? Contents
13 11 20 Information and support What are brain and spinal cord tumours? Contents The brain and spinal cord Brain function What is a brain or spinal cord tumour? What types of tumours are there? How common
More informationFor identification, support and follow up related to Familial Gastrointestinal Cancer conditions. South Island Cancer Nurses Network September 2013
For identification, support and follow up related to Familial Gastrointestinal Cancer conditions South Island Cancer Nurses Network September 2013 Who are we? Specialist multidisciplinary team: Nurse coordinators,
More informationH3F3A K27M Mutation in Pediatric CNS Tumors. A Marker for Diffuse High-Grade Astrocytomas
Anatomic Pathology / H3.3 Mutations in Pediatric Diffuse High-Grade Astrocytomas H3F3A K27M Mutation in Pediatric CNS Tumors A Marker for Diffuse High-Grade Astrocytomas Gerrit H. Gielen, MD, 1 Marco Gessi,
More informationPeter Canoll MD. PhD.
Tumors of the Nervous System Peter Canoll MD. PhD. What I want to cover What are the most common types of brain tumors? Who gets them? How do they ypresent? What do they look like? How do they behave?
More informationHistological pattern of central nervous system neoplasms
ecommons@aku Department of Pathology and Laboratory Medicine Medical College, Pakistan April 2001 Histological pattern of central nervous system neoplasms Z. Ahmed Aga Khan University S. Muzaffar Aga Khan
More informationThe importance of radiotherapy in paediatric atypical teratoid rhabdoid tumour of the brain
The importance of radiotherapy in paediatric atypical teratoid rhabdoid tumour of the brain Elżbieta KORAB CHRZANOWSKA 1, Joanna BARTOSZEWSKA 2, Monika DROGOSIEWICZ 3, Stanisław KWIATKOWSKI 4, Anna SKOWROŃSKA-GARDAS
More informationmonotonous, stippled, round, smoothcontoured nuclei and scanty acidophilic or
monotonous, stippled, round, smoothcontoured nuclei and scanty acidophilic or vacuolated cytoplasm. The cells are surrounded by a loose fibrillary stroma that is traversed by delicate capillaries. Ill
More information2018 Diagnostic Slide Session Case #8
2018 Diagnostic Slide Session Case #8 Angela N. Viaene, MacLean P. Nasrallah, and Zissimos Mourelatos Hospital of the University of Pennsylvania AANP June 9, 2018 Disclosures: none Clinical History Healthy,
More informationJoana Ramalho, MD C. Ryan Miller, MD, PhD
Joana Ramalho, MD C. Ryan Miller, MD, PhD Case 1 3 month old baby girl Presented with new onset of seizures Newborn. Questionable blurring of the gray-white junction within the right occipital lobe. Findings
More informationDiffusion-weighted imaging and ADC mapping in the differentiation of intraventricular brain tumors
Diffusion-weighted imaging and ADC mapping in the differentiation of intraventricular brain tumors Poster No.: C-2652 Congress: ECR 2010 Type: Educational Exhibit Topic: Neuro Authors: M. Gavrilov, T.
More informationIntrarenal Extension. sinus
Intrarenal Extension into sinus Document Capsular Penetration sinus 16 Pediatric Renal Tumor Staging Stage I Limited to Kidney & Completely Resected Intact Renal Capsule No Previous Rupture or Biopsy Renal
More informationRhabdoid Meningioma In A Background Of Atypical Meningioma With Lipomatous Metaplasia: Case Report And Review Of Literature
ISPUB.COM The Internet Journal of Neurosurgery Volume 5 Number 1 Rhabdoid Meningioma In A Background Of Atypical Meningioma With Lipomatous Metaplasia: Case Report And Review Of Literature S Shuja, T Lucey,
More informationEnterprise Interest Nothing to declare
Enterprise Interest Nothing to declare Diagnoses one would not like to miss in soft tissue pathology early in your career Marta Sbaraglia, MD Department of Pathology Hospital of Treviso University of Padua
More informationPITFALLS AND TRAPS IN THE DIAGNOSIS AND STAGING OF RENAL TUMOURS OF CHILDHOOD. Gordan M. Vujanić Cardiff, U.K.
PITFALLS AND TRAPS IN THE DIAGNOSIS AND STAGING OF RENAL TUMOURS OF CHILDHOOD Gordan M. Vujanić Cardiff, U.K. RENAL TUMOURS OF CHILDHOOD - CLASSIFICATION (2016) Nephroblastic tumours Mesenchymal tumours
More informationCorrespondence should be addressed to I. Sokolakis;
Hindawi Case Reports in Urology Volume 2017, Article ID 6597592, 4 pages https://doi.org/10.1155/2017/6597592 Case Report Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented
More informationAMERICAN BRAIN TUMOR ASSOCIATION. Oligodendroglioma and Oligoastrocytoma
AMERICAN BRAIN TUMOR ASSOCIATION Oligodendroglioma and Oligoastrocytoma ACKNOWLEDGEMENTS ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Founded in 1973, the American Brain Tumor Association (ABTA) was the
More informationTumores de células pequeñas, redondas y azules: diagnóstico diferencial cuando el tiempo apremia
Tumores de células pequeñas, redondas y azules: diagnóstico diferencial cuando el tiempo apremia Sílvia Bagué Servei de Patologia Hospital de Sant Pau Barcelona Soft tissue sarcomas Heterogeneous group
More informationUpdate on Pediatric Brain Tumors
Update on Pediatric Brain Tumors David I. Sandberg, M.D. Director of Pediatric Neurosurgery & Associate Professor Dr. Marnie Rose Professorship in Pediatric Neurosurgery Pre-talk Questions for Audience
More informationRegence. Next Review: 08/2019 Last Review: 08/2018 Medicare Link(s) Revised: 10/01/2018 IMPORTANT REMINDER
Regence Medicare Advantage Policy Manual Policy ID: M-TRA45 Stem Cell / Bone Marrow Transplants Published: 10/01/2018 Next Review: 08/2019 Last Review: 08/2018 Medicare Link(s) Revised: 10/01/2018 IMPORTANT
More informationdoi: /j.prp
doi: 10.1016/j.prp.2013.06.007 Satomi. et. al.1 Epidermal growth factor receptor abnormalities in atypical teratoid / rhabdoid tumors and an unusual case with gene amplification Kaishi Satomi, Yukio Morishita,
More informationEmbryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
745208SCO0010.1177/2050313X17745208SAGE Open Medical Case ReportsTariq et al. case-report2017 Case Report SAGE Open Medical Case Reports Embryonal tumor with multilayered rosettes, C19MC-altered: Report
More informationPathology Research and Practice
Pathology Research and Practice 209 (2013) 521 526 Contents lists available at ScienceDirect Pathology Research and Practice j ourna l h om epage: www.elsevier.com/locate/prp Original article Epidermal
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationChildhood cancer registration in England: 2015 to 2016
Childhood cancer registration in England: 2015 to 2016 Report on behalf of the Children, Teenagers and Young Adults Site Specific Clinical Reference Group, National Cancer Registration and Analysis Service
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM MENINGIOMA CNS Site Group Meningioma Author: Dr. Norm Laperriere Date: February 20, 2018 1. INTRODUCTION 3 2. PREVENTION
More information