Y-PET versus 90 Y-Bremsstrahlung SPECT
|
|
- Meghan Cain
- 5 years ago
- Views:
Transcription
1 90 Y-PET versus 90 Y-Bremsstrahlung SPECT First 90 Y microspheres injected intra-arterially imaging 90 Y TOF PET/CT 198 Au rays scan 90 Y bremsstrahlung scan Lhommel et al Simon and Feitelberg 1967 S Walrand Cliniques universitaires saint-luc, Brussels
2 Milestones in 90 Y positron emission studies Ford KW Phys Rev 1955 Nickles et al. IEEE TNM Y micro-derenzo phantom imaged 2 or e + e - with a micro-pet P4 scanner Hypothetical level diagram of 89 Zr as deduced from the neighboring nucleus 89 Y. A first excited 0+ state is expected because of the large mutual interaction of the (g 9/2 ) 2 configuration. Selwyn et al. ARI 2006 e+: 3.2x10-5 2x10-4 e+ observed Johnson et al. Phys Rev 1955
3 The decay of 90Y has a minor branch to the 0+ excited state[1], followed by an internal e + e - creation which happens in 32 out of one million decays [2]. Consequently, 90Y PET scan was proposed in order to assess the biodistribution [3] of 90Y-labelled therapeutic agents. A 61-year-old woman was referred for. 30min 1. Ford. Phys Rev Selwyn et al. Appl Radiat Isot Nickles et al. IEEE Nucl Sci Symp Record 2004 The additional liver low dose CT performed for the 90 Y PET/CT evaluation could be seen as an unjustified additional irradiation of the patient. 90 Y: ± 5000 msv CT: 2 msv amazing epoch
4 Feasibility of 90 Y TOF-PET based dosimetry in liver metastasis therapy using SIR-spheres. true TOF-PET Dosimetry by kernel dose convolution Relative activity 0 1 liver True mgy/mbq TOF-PET mgy/mbq Err (%) Lhommel,..., Walrand EJNMMI 2010
5 90 Y TOF-PET based dosimetry in liver metastasis therapy using resin spheres. necrotic tumour FDG TOF-PET (day 1) FDG TOF-PET (day 57) 90Y TOF-PET (day 15) progressive responding Mean SUV = 5.96 Max. SUV =12.0 Mean SUV = 2.86 Max. SUV = 6.41 Mean dose: 85.3 Gy Max. dose:153.0 Gy Mean dose: 29.9 Gy Max. dose: 37.7 Gy 90Y: 45min acquisition for 2 bed positions, i.e. 27cm Lhommel,..., Walrand EJNMMI 2010
6 Tumour early response-dose relationship in 90 Y liver SIRT 20 survival fraction R 2 = 0.96 R= metabolic ratio at week 7 post therapy HEF x D (Gy) HEF 1 R=0 94 Walrand et al. EJNMMIres Hb level (g/dl)
7 Comparison of different crystals in 90 Y PET GSO LYSO BGO van Elmbt, Vandenberghe, Walrand et al. PMB 2011
8 Comparison of different crystals in 90 Y PET high count rate phantom hot spheres (1.7GBq 90 Y) Gemini TF LYSO TOF Gemini TF LYSO non-tof 36min 24min 12min Allegro GSO Exact HR+ BGO van Elmbt, Vandenberghe, Walrand et al. PMB 2011
9 recovery (%) QUEST multicentric study summary (Willowson et al. EJNMMI 2015) Philips Gemini TF GE Discovery Y Sfactor Siemens Biograph mct Stabin et al. [14-1] van Elmbt et al. [11] Willowson et al. [13] Sfactor TOF + RR TOF + PSF TOF PSF hot sphere diameter (mm) recovery < 90 Y Sfactor local energy deposition method
10 Comparison of different crystals in 90 Y-DOTATOC PET spine: 2.5MBq-12ml plastic vial in 5cm diameter cylinder filled with K 2 HPO 4 solution modeling bone attenuation low count rate kidney MIRD P19 phantom modeling a 1h PET acquisition after a typical first 90 Y-DOTATOC therapy cycle Spline 100MBq Kidney 35MBq CT Gemini TF LYSO Exact HR+ BGO 50% plexiglas 50% H 2 O H 2 O missing activity (radioactivity of LYSO) Relative deviation: -18% -3% 7ml tumours: 11,25 MBq Walrand et al. JNM 2011 dosimetry after each cycle to optimize the next one
11 Fabbri et al. Canc Bioth 2015 PET <> brems-spect in 90 Y-DOTATOC therapy
12 90 Y-based PET and SPECT imaging in locoregional brain treatment for high-grade gliomas Fabbri et al. EJNMMI 2012
13 90Y PET <> brems-spect post synovectomy Barber et al. JMI&RO 2013 PET can provide superior image quality compared with brems-spect and may enable reliable detection of extra-articular 90 Y activity
14 Open issues in liver 90 Y PET 90 Y-PET spurious extra-hepatic counts counts Y vial in air true coincidences radial profile increasing tail measured profile source profile scc profile e+ e- pair production in LSO (X>1MeV)? (van Elmbt-Walrand) 1 90 Y-TOF PET bin acquired on a PET Biograph (courtesy of Dr. Ahmadzadehfar) Gate-GEANT4 simulations did not show any significant e + e - creation in LSO (Strydhorst et al. Med Phys 2016)
15 photon per MeV per decay Internal bremsstrahlung: a forgotten but significant effect in 90 Y SPECT and PET imaging. (Walrand et al. EANM Vienna 2017) nucleus E field Aston 1927 β- 1.E+1 1.E+0 1.E-1 1.E-2 1.E-3 1.E-4 1.E-5 1.E-6 h2o brems G4 fit h2o brems int brems [33] Venkataramaiah et al.1980 int brems [28] Cengiz et al.2004 fit int brems effect discovery knowledge in nuclear medicine e+ emission int. bremss E E (M) Int. Bremss. not modeled in Geant4
16 arbitrary units Internal bremsstrahlung: a forgotten but significant effect in 90 Y SPECT and PET imaging. (Walrand et al. EANM Vienna 2017) A 1.E+0 1.E-1 1.E-2 GSO-PET 111 In spectra 111In acquisition spectra gauss 171keV 171keV gauss gauss 245keV 245keV gauss spectra fit fit 1.E+0 1.E-1 1.E-2 B LYSO-PET 18 F spectra 1.E+0 18F acquisition spectra G4 511-Lu176 pileup 1.E-1 gauss 511keV 511keV gauss spectra fit fit 1.E-2 C LSO-PET 18 F spectra 1.E-3 1.E-4 1.E-3 1.E-4 1.E-3 1.E-4 acquisition 2.80E keV gauss 511keV gauss fit 1.E kev 1.E kev 1.E kev Crystal scintillation exhibits long energy resolution tail
17 cps per bin Internal bremsstrahlung: a forgotten but significant effect in 90 Y SPECT and PET imaging. (Walrand et al. EANM Vienna 2017) A GSO-PET 32 P true cc rate radial profile B B acq G4 int+h2o+gauss G4 h2o+tail G4 int+h2o+gauss theory 32 P vial 1.E+0 1.E kev bin >>250keV bin e- [450,650] kev A BUT
18 On the origin and on the reduction of spurious extrahepatic counts observed in 90Y non-tof PET imaging post radioembolization (Walrand et al. EANM Vienna 2017) Gate-GEANT4 simulations with int+ext bremss. A B C Brems Lu176 LOR-TOF Brems Lu176 3D-RAMLA Brems Lu176 3D-RAMLA D Brems Lu176 LOR-TOF E Brems Lu176 LORDS-3D-RAMLA F Brems Lu176 3D-RAMLA Spurious extrahepatic counts originate from randoms not perfectly corrected in non-tof PET
19 198 Au rays scan 90 Y bremsstrahlung scan Simon and Feitelberg 1967
20 back-scattering Counts / kev / MBq.s 90 Y SPECT: contamination components Total counts Primary photons Scattered photons reduced using a medium energy or high energy collimator >150keV [50,150]keV Camera backscatter Collimator scatter & penetration Lead x-rays geometrical Energy (kev) Pb PET decay emits positron 3D sensitivity: [50,150]keV SPECT 1.5% decay emits bremsstrahlung X ray in [50,150] kev Collimator sensitivity But scattered X rays
21 90 Y SPECT: state of the art MC reconstruction Total 90 Y bremss. in h 2 o without scatter correction Germanium detector with MC scatter correction Rault et al. Med Phys 2010 Dewaraja et al. Med Phys 2017 Not commercial available and collimator-camera dependent The liver concentration of 0.34 MBq/mL used in the phantom was limited by radiation safety requirements of the regulatory authority at our institution. Some radioprotection officers are imposing ALA R A can be a threat to imaging development (dead time, background) and at the end, also a threat patient care
22 90 Y bremsstrahlung Monte Carlo modeling Gate 6.2 : Geant4 9.5-p01 + Geant4 9.6-p02 for atom de-excitations and fluorescence emissions 90 Y source in perpex Lead housing crystal Pyrex lightguide Mu-metal shielding PMTs dynodes GE400 AC Crystal: NaI or BGO BGO camera based on Exact HR+ BGO-PMTs blocks + flat pinhole collimator Walrand et al. Front Oncol 2014
23 MC simulation of camera contaminating x-rays in bremsstrahlung imaging primary camera back-scattering β- MC simulation of the signal to scatter ratio 100 Pb NaI Pyrex Signal to scatter ratio signal > scatter scatter > signal PMT elect. boards E (kev) Walrand et al. Front Oncol 2014
24 MC simulation of camera contaminating x-rays in bremsstrahlung imaging primary β- MC simulation of the signal to scatter ratio 100 Pb BGO Signal to scatter ratio signal > scatter scatter > signal PMT elect. boards E (kev) Walrand et al. Front Oncol 2014
25 MC simulation of camera contaminating x-rays in bremsstrahlung imaging primary β- MC simulation of the signal to scatter ratio 100 Pb BGO Signal to scatter ratio signal > scatter scatter > signal PMT elect. boards E (kev) Continuous energy tomography (CET) Walrand et al. Front Oncol 2014
26 90 Y bremss. NaI-pinhole SPECT SIRT phantom evaluation pinhole SPECT of longitudinally extended organ requires helical acquisition helical non-circular acquisition, bed & camera manually moved positions measured by 3 tape rulers 2 hours for the motions Walrand EJNMMI research 2011 medium energy thyroid pinhole: focal length too long and 1/2 of the crystal area used
27 Bremsstrahlung helical pinhole SPECT is superior to 90 Y-TOF-PET 90Y TOF-PET true helical PH SPECT not commercially available 90Y liver-sirt d a f b e c 36 min 3.6 min 1 min dosimetry in 3min helical PH SPECT in catheterization room optimization patient physicist Walrand EJNMMI research 2011
28 Perspective: dose optimization in catheterization room
29 Perspective: dose optimization in catheterization room 1/3 of maximal MAA based activity 3 min SPECT liver dosimetry if wrong delivery: catheter repositioning or allowed activity to reach maximal safe liver dose
30 SNR (20 min acquisition time) 90 Y+L[Y]SO true CT ps-TOF bremss. helical MEPH 2H SPECT ( S versus MEGP) 500ps-TOF & rand. est. 9 36mm ps-TOF & rand. sub. 1.5 bremss. MEGP 2H SPECT ( T S SR=12mm) activity/4 and 4x20min GSO mm BGO 1.0 L[Y]SO non-tof Y activity (GBq in a liver lobe) van Elmbt... PMB 2011 Walrand... EJNMMI res 2011 kidney PRRT MIRD p19 Walrand... JNM 2010
31 Conclusions in 90 Y imaging PET supersedes commercial bremss. SPECT in all therapies PET is usable for dosimetry purpose (using local energy deposition method) TOF PET is preferable in post radioembolization delivery check State of the art MC reconstruction bremss. SPECT approaches PET performance Standard pinhole bremss. SPECT supersedes TOF-PET and could be used in catheterization room for optimization BGO (or GSO) pinhole bremss. SPECT is the optimal modality
8/1/2017. Disclosures. Outline. SAM Imaging Education Course 90Y-Microsphere Therapy: Emerging Trends and Future Directions
SAM Imaging Education Course Y-Microsphere Therapy: Emerging Trends and Future Directions Matt Vanderhoek, PhD Henry Ford Health System, Detroit, MI Vanessa Gates, MS Northwestern University, Chicago,
More informationIntegrated PET/CT systems State of the art and Clinical Applications
Integrated PET/CT systems State of the art and Clinical Applications V. Bettinardi Nuclear Medicine Dep. Scientific Institute San Raffaele Hospital Milan Italy The announcement of a new Diagnostic Imaging
More informationCalculation methods in Hermes Medical Solutions dosimetry software
Calculation methods in Hermes Medical Solutions dosimetry software Helena McMeekin MSc. Clinical Applications Scientist, Hermes Medical Solutions MRTDosimetry Scientific Workshop The Principals and Clinical
More informationTypical PET Image. Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located?
Typical PET Image Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located? PET/CT Oncology Imaging Anatometabolic fusion images are useful in the management
More informationInternal Pair Production of 90 Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept
Internal Pair Production of Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept Vanessa L. Gates 1, Abdulredha A.H. Esmail 2, Karen Marshall 3, Stewart Spies 1, and Riad
More informationPost-Y90 Radioembolisation imaging with bremsstrahlung SPECT-CT and PET-CT
Post-Y90 Radioembolisation imaging with bremsstrahlung SPECT-CT and PET-CT Poster No.: C-2264 Congress: ECR 2012 Type: Scientific Exhibit Authors: S.-C. M. Wang, S. Evans, B. Camden, D. Farlow; Westmead,
More informationFuture Needs for Standards in 90 Y Microsphere Therapy. CIRMS 2012 Reed Selwyn, PhD, DABR 24 October 2012
Future Needs for Standards in 90 Y Microsphere Therapy CIRMS 2012 Reed Selwyn, PhD, DABR 24 October 2012 Objectives I. General Description Microsphere Distribution Product Comparison II. Dosimetry Models
More informationThe Clinical Utility of Yttrium-90 PET after SIRT
The Clinical Utility of Yttrium-90 PET after SIRT Dr Yung Hsiang Kao Department of Nuclear Medicine Austin Health Melbourne, Australia 2 nd Asia Pacific Symposium on Liver-Directed Y-90 Microspheres Therapy
More informationY90 SIRT Therapy Dosimetric Aspects
Y90 SIRT Therapy Dosimetric Aspects David Chee-Eng Ng MBBS, BSc, MSc, MRCP, FAMS, FRCP (Edin) Head and Senior Consultant, Department of Nuclear Medicine and PET Singapore General Hospital Adjunct Assistant
More informationFirst Clinical Experience with
First Clinical Experience with Discovery MI Digital PET/CT Martin Huellner Department of Nuclear Medicine University Hospital Zurich / University of Zurich Switzerland Agenda BelNuc GE Symposium 1. Digital
More informationIN VIVO IMAGING Proton Beam Range Verification With PET/CT
IN VIVO IMAGING Proton Beam Range Verification With PET/CT Antje-Christin Knopf 1/3 K Parodi 2, H Paganetti 1, T Bortfeld 1 Siemens Medical Solutions Supports This Project 1 Department of Radiation Oncology,
More informationPrecision of pre-sirt predictive dosimetry
International Course on THERANOSTICS AND MOLECULAR RADIOTHERAPY Precision of pre-sirt predictive dosimetry Hugo Levillain Department of Nuclear Medicine Medical Physics Jules Bordet Institute, Université
More informationQuantifying Y-90 PET. The Challenges Associated With the QUEST Study. Michael Tapner Research & Development Project Manager Sirtex
Quantifying Y-90 PET. The Challenges Associated With the QUEST Study Michael Tapner Research & Development Project Manager Sirtex Internal Dosimetry with 90 Y Resin Microspheres: QUEST COUNT MAP ACTIVITY
More informationRadiation Detection and Measurement
Radiation Detection and Measurement Range of charged particles (e.g.,!: µm; ": mm) Range of high energy photons (cm) Two main types of interactions of high energy photons Compton scatter Photoelectric
More informationDosimetry (Dose Estimation) of Internal Emitters. Outline. For Radiation Effects, is Dose the only Answer? Estimation of Dose and not Dosimetry
Dosimetry (Dose Estimation) of Internal Emitters. Lawrence E. Williams, PhD City of Hope National Medical Center Duarte CA 91010 lwilliams@coh.org Outline 1. Dose Estimation Formula D = S*Ã 2. Determination
More informationAustin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate)
Austin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate) Overview Ga-68 dotatate binds to somatostatin receptors, with highest affinity for subtype 2 receptors (sstr2). It binds to cells that express
More informationQuantitative Theranostics in Nuclear Medicine
Quantitative Theranostics in Nuclear Medicine M. Lassmann Klinik und Poliklinik für Nuklearmedizin Direktor: Prof. Dr. A. Buck Contents What is Theranostics? Potential Targets Basic Principles of Quantitative
More informationSimulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy. Using GATE
GATE Simulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy Using GATE Quick tour & Highlights! GATE Training, INSTN-Saclay, October 2015 Albertine
More informationMartin Law, PhD, DABSNM, DABMP Physicist ic Radiology/QMH
A practical measure in personnel dose reduction for 90 Y-micropsheres liverdirected radioembolization: from radiology department to patient ward Martin Law, PhD, DABSNM, DABMP Physicist ic Radiology/QMH
More informationPhysical Bases : Which Isotopes?
Physical Bases : Which Isotopes? S. Gnesin Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland 1/53 Theranostic Bruxelles, 2 Octobrer 2017 Theranostic : use of diagnostic
More informationEvaluation of yttrium-90 positron emission tomography dosimetry
Purdue University Purdue e-pubs Open Access Dissertations Theses and Dissertations Fall 2014 Evaluation of yttrium-90 positron emission tomography dosimetry Katherine N. Tapp Purdue University Follow this
More informationApplication of 3D Printing to Molecular Radiotherapy Phantoms. Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester
Application of 3D Printing to Molecular Radiotherapy Phantoms Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester Molecular Radiotherapy Radionuclide administered to patient
More informationSelective Internal Radiation Therapy. Jefferson R. Pagsisihan, MD, DPSNM The Medical City St. Luke s Medical Center
Selective Internal Radiation Therapy Jefferson R. Pagsisihan, MD, DPSNM The Medical City St. Luke s Medical Center S Selective Internal Radiation Therapy catheter-based liver directed modality for patients
More informationLu-DOTATATE PRRT dosimetry:
177 Lu-DOTATATE PRRT dosimetry: From theory to practice Silvano Gnesin Medical Physics department Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland Gwennaëlle Marin Medical
More informationEN TERAPIA METAByLICA NO ESTrNDAR CON 177 Lu, 90 Y y 223 Ra
Jornada científica RADIOFuSICA DE LA DOSIMETRuA INTERNA EN LOS PROCEDIMIENTOS TERAPÉUTICOS CON RADIOFrRMACOS DOSIMETRIA FuSICA Y CLuNICA EN TERAPIA METAByLICA NO ESTrNDAR CON 177 Lu, 90 Y y 223 Ra Pablo
More informationA Snapshot on Nuclear Cardiac Imaging
Editorial A Snapshot on Nuclear Cardiac Imaging Khalil, M. Department of Physics, Faculty of Science, Helwan University. There is no doubt that nuclear medicine scanning devices are essential tool in the
More informationQuantitative Imaging: A hospital physicist s perspective James Scuffham
Quantitative Imaging: A hospital physicist s perspective James Scuffham Clinical Scientist, Royal Surrey County Hospital NHS Foundation Trust Associate Tutor, University of Surrey Background The Royal
More information45 Hr PET Registry Review Course
45 HR PET/CT REGISTRY REVIEW COURSE Course Control Document Timothy K. Marshel, MBA, R.T. (R), (N)(CT)(MR)(NCT)(PET)(CNMT) The PET/CT Training Institute, Inc. SNMMI-TS 028600-028632 45hr CEH s Voice Credits
More informationUsing PET/MRI to Assess Hepatic Radioembolization of Yttrium-90 Microspheres
Washington University in St. Louis Washington University Open Scholarship Engineering and Applied Science Theses & Dissertations Engineering and Applied Science Spring 5-15-2017 Using PET/MRI to Assess
More informationIndividualised Treatment Planning for Radionuclide therapy (Molecular Radiotherapy)
Individualised Treatment Planning for Radionuclide therapy (Molecular Radiotherapy) FMU/ICRP workshop 2017 Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK ICRP Task Group 101
More informationStandardization of Radiopharmaceutical Dosimetry
Standardization of Radiopharmaceutical Dosimetry Jonathon A. Nye, PhD Department of Radiology and Imaging Sciences Emory University SEAAPM 2011 Myrtle Beach, SC Review of Dosimetry Nomenclature Dose Gray
More informationSIRT in Neuroendocrine Tumors
SIRT in Neuroendocrine Tumors Marnix G.E.H. Lam, MD PhD Professor of Nuclear Medicine AVL Amsterdam UMC Utrecht ENETS Center of Excellence, The Netherlands Disclosure of speaker s interests Consultant
More informationSPECT/CT image based dosimetry for Yttrium 90 radionuclide therapy: Application to treatment response
Received: 8 January 2018 Revised: 17 May 2018 Accepted: 29 May 2018 DOI: 10.1002/acm2.12400 RADIATION ONCOLOGY PHYSICS SPECT/CT image based dosimetry for Yttrium radionuclide therapy: Application to treatment
More informationTracking Doses in the Pediatric Population
Tracking Doses in the Pediatric Population Frederic H. Fahey DSc Boston Children s Hospital Harvard Medical School frederic.fahey@childrens.harvard.edu Disclosures Sadly, none that pay me any money! SNMMI
More informationTheragnostics for bone metastases. Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK
Theragnostics for bone metastases Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK NPL 2015 Ra-223 Biodistribution & dosimetry Ra-223: 11.4 days half-life, range of 100 µm Six
More informationInternal dosimetry for radioembolization therapy with Yttrium-90 microspheres
Received: 13 July 2016 Accepted: 21 December 2016 DOI: 10.1002/acm2.12042 MEDICAL IMAGING Internal dosimetry for radioembolization therapy with Yttrium-90 microspheres Maryam Fallahpoor 1 Mehrshad Abbasi
More informationRadiation Exposure to Staff Using PET/CT Facility
Egyptian J. Nucl. Med., Vol. 8, No. 2, December 2013 1 Editorial Radiation Exposure to Staff Using PET/CT Facility Taalab, Kh; and Mohsen, Z Department of Nuclear Medicine, International Medical Center;
More informationSingle Photon Emission Tomography Approach for Online Patient Dose Assessment in Boron Neutron Capture Therapy
Single Photon Emission Tomography Approach for Online Patient Dose Assessment in Boron Neutron Capture Therapy Daniel M Minsky a,b,c*, Alejandro Valda a,b, Andrés J Kreiner a,b,c and Alejandro A Burlon
More information7/13/2015. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Educational Objectives TRANS-ARTERIAL LIVER-DIRECTED THERAPIES
Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry Armeen Mahvash, MD S. Cheenu Kappadath, PhD The University of Texas MD Anderson Cancer Center, Houston, Texas AAPM Annual Meeting
More informationY-Microspheres Radioembolization for Selective Internal Radiation Therapy of Primary and Metastatic Cancer in the Liver
90 Y-Microspheres Radioembolization for Selective Internal Radiation Therapy of Primary and Metastatic Cancer in the Liver Pr Francesco Giammarile CHLS Lyon Faculté de Lyon Sud «Aut tace aut loquere meliora
More informationAustin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF)
Austin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF) Overview Indication Sodium Fluoride F18 injection is a radioactive diagnostic agent for positron emission
More informationQuantitative Molecular Imaging Using PET/CT to Assess Response to Therapy
Quantitative Molecular Imaging Using PET/CT to Assess Response to Therapy Paul Kinahan, PhD Director of PET/CT Physics Imaging Research Laboratory, Department of Radiology University of Washington, Seattle,
More informationBasics of nuclear medicine
Basics of nuclear medicine Prof. dr. Davor Eterović Prof. dr. Vinko Marković Radioisotopes are used both in diagnostics and in therapy Diagnostics gamma emitters are used since gamma rays can penetrate
More informationInternal Dosimetry Development and Evaluation of Methods and Models
Internal Dosimetry Development and Evaluation of Methods and Models Jönsson, Lena M Published: 2007-01-01 Link to publication Citation for published version (APA): Jönsson, L. M. (2007). Internal Dosimetry
More informationY-90 Microsphere Therapy: Nuclear Medicine Perspective
Y-90 Microsphere Therapy: Nuclear Medicine Perspective Carl Hoh, M.D. Dept. Radiology UCSD Medical Center ckhoh@ucsd.edu Learning Objectives Role of Nuclear Medicine in patient selection Technical Issues
More informationReproducibility of Uptake Estimates in FDG PET: a Monte Carlo study
Reproducibility of Uptake Estimates in FDG PET: a Monte Carlo study Juliette Feuardent, Marine Soret, Irène Buvat 1 Abstract Tumor glucose metabolism measurements from Fluoro-deoxyglucose (FDG) Positron
More informationBiases affecting tumor uptake measurements in FDG-PET
Biases affecting tumor uptake measurements in FDG-PET M. Soret, C. Riddell, S. Hapdey, and I. Buvat Abstract-- The influence of tumor diameter, tumor-tobackground activity ratio, attenuation, spatial resolution,
More informationAn Overview of Clinical PET/CT
1 INVITED ARTICLE An Overview of Clinical PET/CT Arman Rahmim 1* PhD and Richard L. Wahl 2 MD Department of Radiology, School of Medicine Johns Hopkins University, Baltimore MD, USA (Received 10 November
More informationFacilitating Lu 177 Personalized Dosimetry for Neuroendocrine Tumours CANM 2017
Facilitating Lu 177 Personalized Dosimetry for Neuroendocrine Tumours CANM 2017 CANM ANNUAL SCIENTIFIC MEETING APRIL 20-23, 2017 TORONTO, ONTARIO I do not have a financial interest, arrangement or affiliation
More informationA. DeWerd. Michael Kissick. Larry. Editors. The Phantoms of Medical. and Health Physics. Devices for Research and Development.
Larry Editors A. DeWerd Michael Kissick The Phantoms of Medical and Health Physics Devices for Research and Development ^ Springer Contents 1 Introduction to Phantoms of Medical and Health Physics 1 1.1
More informationPHYSICS 2: HSC COURSE 2 nd edition (Andriessen et al) CHAPTER 20 Radioactivity as a diagnostic tool (pages 394-5)
PHYSICS 2: HSC COURSE 2 nd edition (Andriessen et al) CHAPTER 20 Radioactivity as a diagnostic tool (pages 394-5) 1. (a) A radioisotope is an isotope that is unstable and will emit particles from the nucleus
More informationSELECTIVE INTERNAL RADIATION THERAPY FOR TREATMENT OF LIVER CANCER
SELECTIVE INTERNAL RADIATION THERAPY FOR TREATMENT OF LIVER CANCER SIR-Spheres*: A New Treatment Option for Non-Resectable Liver Tumors Treatment Overview SIRT: Selective Internal Radiation Therapy Concept
More informationDescription of the consecutive stages (which took place from December 2002 to July 2003)
Radiation Protection Issues in a PET/CT Installation M. Coronado 1, R. Plaza 2, R. Couto 1, MD. Marin 1, C. Huerga 2, J. Coya 1, LM Martin Curto 1, M. Téllez de Cepeda 2 1 Servicio de Medicina Nuclear,
More informationJoint ICTP-IAEA Advanced School on Internal Dosimetry. Trieste, April 2010
Joint ICTP-IAEA Advanced School on Internal Dosimetry Trieste, 12-16 April 2010 Dosimetry in PRRT: what for Dosimetry has the purpose to address %&!"# '!&!"#!(%)* $ *!$+ Most Used Radiopeptides for PRRT
More informationPET-CT for radiotherapy planning in lung cancer: current recommendations and future directions
PET-CT for radiotherapy planning in lung cancer: current recommendations and future directions Gerry Hanna Centre for Cancer Research and Cell Biology Queen s University of Belfast @gerryhanna Talk Outline
More informationOutline. Lifetime Attributable Risk 10 mgy in 100,000 exposed persons (BEIR VII 2006) SPECT/CT and PET/CT Dosimetry
SPECT/CT and PET/CT Dosimetry Lifetime Attributable Risk 10 mgy in 100,000 exposed persons (BEIR VII 2006) All Solid Tumors Leukemia Frederic H. Fahey DSc Male Female Male Female Children s Hospital Boston
More informationPatient dosimetry for 90 Y selective internal radiation treatment based on 90 Y PET imaging
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 14, NUMBER 5, 2013 Patient dosimetry for 90 Y selective internal radiation treatment based on 90 Y PET imaging Sherry C. Ng, 1a Victor H. Lee, 2 Martin
More informationUse Of MCNP With Voxel-Based Image Data For Internal Dosimetry Applications
Use Of MCNP With Voxel-Based Image Data For Internal Dosimetry Applications The Monte Carlo Method: Versatility Unbounded In A Dynamic Computing World Chattanooga, TN, USA, April 17-21, 2005 M. G. Stabin
More informationMedical Imaging. Alex Elliott Western Infirmary Glasgow
Medical Imaging Alex Elliott Western Infirmary Glasgow History of medical imaging X-rays - Roentgen, 1895 Nuclear medicine - Cassen, 1951 Ultrasound Donald, 1962 SPECT - Kuhl, Edwards, 1963 PET Ter-Pogossian,
More informationRadionuclides in Medical Imaging. Danielle Wilson
Radionuclides in Medical Imaging Danielle Wilson Outline Definitions History and development Radionuclide applications & techniques in imaging Conclusion Definition #1 : Radionuclide An unstable nucleus
More informationPublishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy
Publishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy Overview The overall aim of this project is to provide the metrology for the clinical
More informationFDG-18 PET/CT - radiation dose and dose-reduction strategy
FDG-18 PET/CT - radiation dose and dose-reduction strategy Poster No.: C-1856 Congress: ECR 2014 Type: Authors: Keywords: DOI: Scientific Exhibit P. Nicholson, S. McSweeney, K. O'Regan; Cork/IE Radiation
More informationImpact of ICRP-89 Based Models on Dose Estimates for Radiopharmaceuticals and CT Exams. Stabin MG, Kost SD, Clark JH, Pickens DR, Price RR, Carver DE
Impact of ICRP-89 Based Models on Dose Estimates for Radiopharmaceuticals and CT Exams Stabin MG, Kost SD, Clark JH, Pickens DR, Price RR, Carver DE Vanderbilt University, Nashville, TN, USA Abstract New
More informationPOSITRON EMISSION TOMOGRAPHY PHANTOM STUDIES FOR RADIATION THERAPY TARGET DELINEATION MICHAEL VINTSON LAWRENCE
POSITRON EMISSION TOMOGRAPHY PHANTOM STUDIES FOR RADIATION THERAPY TARGET DELINEATION BY MICHAEL VINTSON LAWRENCE A Dissertation Submitted to the Graduate Faculty of WAKE FOREST UNIVERSITY GRADUATE SCHOOL
More informationAustin Radiological Association BRAIN AMYLOID STUDY (F-18-Florbetapir)
Austin Radiological Association BRAIN AMYLOID STUDY (F-18-Florbetapir) Overview The Brain Amyloid Study with F-18-florbetapir depicts the extracellular deposition of B- amyloid (Aβ) peptides (or plaques
More informationImage based in-vivo dosimetry: from PET to in-beam SPECT
Image based in-vivo dosimetry: from PET to in-beam SPECT 2nd Workshop on Hadron Beam Therapy of Cancer Erice, Sicily, Italy May 25th, 2011 Fine Fiedler Institute of Radiation Physics Text optional: Institutsname
More informationRadiopharmacy. Prof. Dr. Çetin ÖNSEL. CTF Nükleer Tıp Anabilim Dalı
Prof. Dr. Çetin ÖNSEL CTF Nükleer Tıp Anabilim Dalı What is Nuclear Medicine? Nuclear Medicine is the branch of medicine concerned with the use of radionuclides in the study and the diagnosis of diseases.
More informationTechnological leapfrogging at a hospital near you What s going on and why it matters?
Technological leapfrogging at a hospital near you What s going on and why it matters? Antonis Kalemis, PhD MBA Philips - Advanced Molecular Imaging Snr Manager, Clinical Science AIPES (European Association
More informationGATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT
GATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT R Aamir, C Lowe, J Damet, P Carbonez, A P H Butler, N Schleich, N G Anderson MARFO, Emmanuel Geant4 User Workshop 2017, Wollongong Overview MARS
More informationPhysics of MBI (~10 slides)
Physics of MBI (~10 slides) Molecular Breast Imaging (MBI) physics and performance testing JW Hugg, BR Simrak, PD Smith, BE Patt Gamma Medica, Inc., Northridge, CA Molecular Breast Imaging (MBI) is an
More informationClinical Implementation of patient-specific dosimetry, comparison with absorbed fraction-based method
Clinical Implementation of patient-specific dosimetry, comparison with absorbed fraction-based method George Sgouros, Ph.D. Russell H. Morgan Dept of Radiology & Radiological Science Johns Hopkins University,
More informationQuantitative comparison of 124I PET/CT and 131I SPECT/CT detectability
Journal of Nuclear Medicine, published on October 22, 2015 as doi:10.2967/jnumed.115.162750 Quantitative comparison of 124I PET/CT and 131I SPECT/CT detectability Casper Beijst 1,2, Jakob W. Kist 3,4,
More informationImaging in epilepsy: Ictal perfusion SPECT and SISCOM
Imaging in epilepsy: Ictal perfusion SPECT and SISCOM Patrick Dupont Laboratory for Cognitive Neurology Laboratory for Epilepsy Research Medical Imaging Research Center KU Leuven, Belgium E-mail: Patrick.Dupont@med.kuleuven.be
More informationBiases Affecting the Measurements of Tumor-to-Background Activity Ratio in PET
2112 IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 49, NO. 5, OCTOBER 2002 Biases Affecting the Measurements of Tumor-to-Background Activity Ratio in PET M. Soret, C. Riddell, S. Hapdey, and I. Buvat Abstract
More informationDosimetry and radiobiology for Peptide Receptor Radionuclide Therapy
Dosimetry and radiobiology for Peptide Receptor Radionuclide Therapy Short-ranged particle emitters for targeted radionuclide therapy require specific dosimetry and radiobiology Mark Konijnenberg Melodi
More informationDouglas J. Simpkin, Ph.D. Aurora St. Luke s Medical Center Milwaukee, Wisconsin. www.
PET/CT Shielding Design Examples Douglas J. Simpkin, Ph.D. Aurora St. Luke s Medical Center Milwaukee, Wisconsin dsimpkin@wi.rr.com www. http://geocities.com/djsimpkin 1 Sources of Exposure: F-18 in Patients
More informationThe value of 99m Tc-MAA SPECT/CT for lung shunt estimation in 90 Y radioembolization: a phantom and patient study
Allred et al. EJNMMI Research (2018) 8:50 https://doi.org/10.1186/s13550-018-0402-8 ORIGINAL RESEARCH Open Access The value of 99m Tc-MAA SPECT/CT for lung shunt estimation in 90 Y radioembolization: a
More informationHepatic metastases of neuroendocrine tumors: treatment options and outcomes of local patients treated with radioembolization
Hepatic metastases of neuroendocrine tumors: treatment options and outcomes of local patients treated with radioembolization JP King PGY2 May 22, 2015 Neuroendocrine Tumor (NET) WHO Classification Location
More informationBone PET/MRI : Diagnostic yield in bone metastases and malignant primitive bone tumors
Bone PET/MRI : Diagnostic yield in bone metastases and malignant primitive bone tumors Lars Stegger, Benjamin Noto Department of Nuclear Medicine University Hospital Münster, Germany Content From PET to
More informationBioMedical quantitative X-Ray Imaging. Emmanuel Brun Researcher Inserm Université Grenoble Alpes
BioMedical quantitative X-Ray Imaging Emmanuel Brun Researcher Inserm Université Grenoble Alpes 1 Outline Introduction K-Edge Imaging Patient imaging at the European synchrotron Medical Phase Contrast
More informationGa68 Imaging. Roland HUSTINX Division of Nuclear Medicine and Oncologic Imaging Centre Hospitalier Universitaire de Liège Belgium
Ga68 Imaging Roland HUSTINX Division of Nuclear Medicine and Oncologic Imaging Centre Hospitalier Universitaire de Liège Belgium 68 Ga Produced by a 68 Ge/ 68 Ga generator Decays by positron emission
More informationSORAMIC: NM Procedures
: NM Procedures J. Ruf Klinik für Radiologie und Nuklearmedizin : NM Procedures Evaluation - 99m Tc MAA Scintigraphy Lung shunt assessment Treatment activity determination Therapy - 90 Y-SIR-Spheres Procedure
More informationNeutrons. ρ σ. where. Neutrons act like photons in the sense that they are attenuated as. Unlike photons, neutrons interact via the strong interaction
Neutrons Neutrons act like photons in the sense that they are attenuated as I = I 0 e μx where Unlike photons, neutrons interact via the strong interaction μ = The cross sections are much smaller than
More informationImaging of Scattered Radiation for Real Time Tracking of Tumor Motion During Lung SBRT
Imaging of Scattered Radiation for Real Time Tracking of Tumor Motion During Lung SBRT April 25 nd, 2015 Lung Cancer Lung cancer is the most lethal cancer: Over 224,000 new diagnoses in the U.S. predicted
More informationAAPM Task Group 108: PET and PET/CT Shielding Requirements
AAPM Task Group 108: PET and PET/CT Shielding Requirements Mark T. Madsen Radiology, University of Iowa Jon A. Anderson Radiology, University of Texas Southwest Texas Medical Center at Dallas James R.
More informationPhoton Attenuation Correction in Misregistered Cardiac PET/CT
Photon Attenuation Correction in Misregistered Cardiac PET/CT A. Martinez-Möller 1,2, N. Navab 2, M. Schwaiger 1, S. G. Nekolla 1 1 Nuklearmedizinische Klinik der TU München 2 Computer Assisted Medical
More informationAn audit of radiation dose of 4D CT in a radiotherapy department
An audit of radiation dose of 4D CT in a radiotherapy department Poster No.: R-0097 Congress: Type: Authors: Keywords: DOI: 2014 CSM Scientific Exhibit T. Hubbard, J. Callahan, J. Cramb, R. Budd, T. Kron;
More informationCEREBRAL BLOOD FLOW AND METABOLISM
Supported by: HURO/0901/069/2.3.1 HU-RO-DOCS CEREBRAL BLOOD FLOW AND METABOLISM Part 3 Modern imaging methods SPECT, PET, nmri History of Nuclear Medicine Starts with the invention of the X-ray 1946: radioactive
More informationThe Management of Imaging Procedure Dose Nuclear Medicine Dose Indices
The Management of Imaging Procedure Dose Nuclear Medicine Dose Indices Wesley E. Bolch, PhD, PE, DABHP, FHPS, FAAPM Director, Advanced Laboratory for Radiation Dosimetry Studies Department of Biomedical
More informationRadiation physics and radiation protection. University of Szeged Department of Nuclear Medicine
Radiation physics and radiation protection University of Szeged Department of Nuclear Medicine Radiation doses to the population 1 Radiation doses to the population 2 Sources of radiation 1 Radiation we
More informationA Real-Time Monte Carlo System for Internal Dose Evaluation Using an Anthropomorphic Phantom with Different Shapes of Tumors Inserted
A Real-Time Monte Carlo System for Internal Dose Evaluation Using an Anthropomorphic Phantom with Different Shapes of Tumors Inserted J. Wu, S. J. Chang, B. J. Chang, I. J. Chen, J. H. Chiu Health Physics
More informationAustin Radiological Association Nuclear Medicine Procedure THYROID UPTAKE MEASUREMENT (I-123 or I-131 as Sodium Iodide)
Austin Radiological Association Nuclear Medicine Procedure THYROID UPTAKE MEASUREMENT (I-123 or I-131 as Sodium Iodide) Overview Indications The Thyroid Uptake Measurement measures the metabolic activity
More informationJournal of Radiation Research and Applied Sciences 8 (2015) 317e322. Available online at ScienceDirect
Journal of Radiation Research and Applied Sciences 8 (2015) 317e322 HOSTED BY Available online at www.sciencedirect.com ScienceDirect Journal of Radiation Research and Applied Sciences journal homepage:
More informationApplications of radioactivity in medicine
Lec.3 Applications of radioactivity in medicine -Nuclear medicine (N.M) -Applications of radioactive material in medicine Nuclear Medicine:- The clinical uses of radioactivity for the diagnosis of disease.
More informationDevelopment of a portable gamma imaging system for absorbed radia4on dose control in targeted radionuclide therapy
Development of a portable gamma imaging system for absorbed radia4on dose control in targeted radionuclide therapy PhD Student Group IIRIC (Instrument. & Imagerie Radio-isotopique Clinique) L. Ménard,
More informationADVANCES IN RADIATION TECHNOLOGIES IN THE TREATMENT OF CANCER
ADVANCES IN RADIATION TECHNOLOGIES IN THE TREATMENT OF CANCER Bro. Dr. Collie Miller IARC/WHO Based on trends in the incidence of cancer, the International Agency for Research on Cancer (IARC) and WHO
More informationSIRT Dosimetry: Sometimes Less Is More
SIRT Dosimetry: Sometimes Less Is More Navesh K. Sharma, DO, PhD Assistant Professor, Departments of Radiation Oncology, Diagnostic Radiology and Nuclear Medicine Medical Director, Radiation Oncology,
More informationImproving personal dosimetry of medical staff wearing radioprotective garments: Design of a new whole-body dosimeter using Monte Carlo simulations
Improving personal dosimetry of medical staff wearing radioprotective garments: Design of a new whole-body dosimeter using Monte Carlo simulations Clarita Saldarriaga Vargas, Corinne Amalberto, Lara Struelens,
More informationNon-target dose from radiotherapy: Magnitude, Evaluation, and Impact. Stephen F. Kry, Ph.D., D.ABR.
Non-target dose from radiotherapy: Magnitude, Evaluation, and Impact Stephen F. Kry, Ph.D., D.ABR. Goals Compare out-of-field doses from various techniques Methods to reduce out-of-field doses Impact of
More informationMeasures taken by the authority. to reduce extremity doses. in nuclear medicine facilities. in Switzerland
Measures taken by the authority to reduce extremity doses in nuclear medicine facilities in Switzerland Dr. phil nat Nicolas Stritt Swiss Federal Office of Public Health (SFOPH) Division Radioprotection
More information