American Journal of. Cancer Case Reports
|
|
- Barnaby Bond
- 5 years ago
- Views:
Transcription
1 American Journals of Cancer Case Reports Cancer Case Reports AK H et al. American Journal of Cancer Case Reports 2013, 1:93-97 Vol. 1, Article ID Page , 1 of 5 5 page Case Report American Journal of Adenoid Cystic Carcinoma of the Scalp as a Cause of Recurrent Operations Hakan AK 1*, Sevinç ŞAHİN 2, Tugay ATALAY 1, Selda Seçkin 2 1 Department of Neurosurgery, Bozok University School of Medicine, Turkey 2 Department of pathology, Bozok University School of Medicine, Turkey Abstract Introduction: carcinoma (PACC) is a rare slow-growing tumor. Presentation of the case: We report a 62 year-old woman presented with a nodular lesion on the scalp who had three operations before for recurring lesion at the same localization. In the operation, we detected a lesion which was adherent to the subcutaneous tissue. The lesion was firm and gray-white colored, and invading the surrounding soft tissues. According to histopathological findings, the patient diagnosed with adenoid cystic carcinoma. Conclusions: carcinoma is a rare tumor that the etiology, origin, and treatment are still controversial. The metastases must be ruled out from other sites, especially from the salivary glands after the its pathological diagnosis. Keywords: carcinoma; Scalp; Salivary gland histopathology Peer Reviewer: Giada Bianchi, MD, Deprtment of Hematology-Oncology, Harvard University Dana Farber Cancer Institute, United States; You Zhang, MD, Department of Hematology/Lymphoma Unit, Kunming Medical University, China Academic Editor: Xiaoning Peng, PhD, Hunan Normal University School of Medicine, China Received: August 29, 2013; Accepted: October 10, 2013; Published: October 19, 2013 Competing Interests: The authors have declared that no competing interests exist. Consent: We confirm that the patient has given their informed consent for the case report to be published. Copyright: 2013 Hakan AK et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. * Correspondence to: Hakan AK, Department of Neurosurgery, Bozok University School of Medicine, Turkey; nrsdrhakanak@yahoo.com Introduction Adenoid cystic carcinoma is known commonly as a tumor of salivary glands. However, it also may be seen rarely in lacrimal glands, mucosal glands of the upper respiratory tract, external auditory canal, breast, Bartholin s glands of the vulva, uterine cervix, prostate gland, esophagus, and other sites. It may also involve the skin by direct or perineural invasion or as a site of distant
2 Page 2 of 5 metastases [1]. carcinoma (PACC) is a rare slow-growing tumor and firstly described by Boggio in 1975 [2]. There are about 60 cases in the literature. The most common site of PCACC is the scalp. The other sites are chest, abdomen, back, axilla, eyelid, and perineum. It may be asymptomatic or may present with local hair loss, tenderness, pruritus, or pain. It may recur locally and time interval for recurrence ranges between one month and 35 years [1]. Herein, we are presenting a new case with PCACC of the scalp that had three operations before for recurring lesion at the same localisation with no pathological diagnosis. Case Presentation A 62 year-old woman presented with a nodular lesion on the scalp. It was itching and mildly painful. Her medical history revealed that she was operated three times before for this lesion in the last 2 years. The last operation was about 6 months ago, but there was no histopathological diagnosis. There was no history of weight loss. In the physical examination, a firm nodular lesion was detected on the right parietal region. It was not mobile and was very close to the traces of the previous sutures. Neurological examination was completely intact. Brain computed tomography was performed that did not reveal any intracranial extension of the lesion or any other accompanying lesions. Our clinical approach revealed two suggestions about the nature of the lesion. First, as the lesion was recurring and had no prior diagnosis, it might be any type of tumor. Second, there might be a foreign body reaction due to the previous operations. At the operation, we determined that there was no foreign body. We detected a lesion which was adherent to the subcutaneous tissue. The lesion was firm and gray-white colored, and showed invasion to the surrounding soft tissues. It was excised broadly. Grossly the biopsy was composed of skin and subcutaneous tissue that was measured as 3.2x2.3x0.8 cm. Macroscopic examination revealed a gray-white colored lesion about 1 cm with irregular borders. Microscopically, the lesion was localised in the dermis and subcutaneous tissue without an epidermal connection. The lesion was composed of myoepithelial and basaloid cells forming cystically dilated cribriform and tubular patterns, and focally solid areas (Figure 1). Some true lumina were seen. There were basal membrane like material, positive with PAS histochemically, among the tumor cells. Histochemically, mucin was detected in the cystic spaces and between the tumor cells with Alcian blue (ph: 2.5) (Figure 2). Immunohistochemical analysis revealed strong positivity with EMA, and weak positivity with CEA in true luminal cells. SMA, p63 and S100 immunostained myoepithelial cells. CD117, chromogranin A and synaptophysin were negative. Twenty two mitotic figures were detected in ten high power microscopic fields, and Ki-67 proliferation index was about 40-50%. The lesion was entirely examined but no perineural invasion or angiolymphatic invasion was detected. Coagulation necrosis was present focally in the lesion. Surgical margins were tumor free. The tumor was diagnosed as adenoid cystic carcinoma. After the histopathological diagnosis, tumor markers were examined and found to be negative. Neck, thorax, upper and lower abdominal computed tomography images were performed, and no other lesion was detected. The metastatic tumor was ruled out by these additional examinations and we diagnosed the case as primary cutaneous adenoid cystic carcinoma of the scalp. The patient was advised to receive chemotherapy or radiotherapy because of the high recurrence risk, but she did not accept any therapies. She is still under clinical follow-up without recurrence for 8 months.
3 Page 3 of 5 Figure 1 Dermal tumor showing cribriform, tubular and solid patterns (H&E, x40). Inset, infiltrating component of the tumor (H&E, x100). Figure 2 Mucinous secretion in some ducts and between the tumor cells histochemically (Alcian blue 2.5, x200). ph
4 Page 4 of 5 Figure 3 An intraoperative appearance of the tumor Discussion For the diagnosis of PCACC, it is crutial to rule out metastasis because adenoid cystic carcinoma can occur at other sites mostly in salivary glands, palate, submaxillary glands, and rarely in nasopharynx, external auditory canal, breast, prostate gland, uterine cervix or lung etc [3]. PCACC is a slow-growing nodular malignancy and has an indolent course with local recurrences and rarely metastasis. The most common site of PCACC is the scalp and 41% of PCACC arises on it. PCACC shows a mild female predominance between years [3,4,5,6]. The patients with PCACC are usually asymptomatic. However, local hair loss, tenderness, pain, and/or pruritus may occur [1]. Our patient had complaints of itching and mild local pain. Although PCACC is known for more than 35 years, the origin and etiology are still uncertain [3]. There are some reports in the literature suggesting that the tumor may originate from eccrine glands, apocrine glands or modified apocrine glands. Histopathologically, the PCACC is a poorly circumscribed tumor consisting of myoepithelial and basaloid cells with cribriform, tubular, and solid formations in a loose fibrous stroma with mucinous component [3]. The PCACC is reported to show immunoreactivity with pan-cytokeratin, EMA, CEA, CD117, keratin 7 in the basaloid cells, and show immunoreactivity with calponin, p63, CD10, SMA and S100 in the myoepithelial component in the literature. Also, PCACC shows weaker positivity with CEA than the extracutaneous adenoid cystic carcinomas, similar to our case [4]. Histopathological and immunohistochemical findings of the present case were consistent with the cases reported in the literature. Adenoid basal cell carcinoma, cribriform carcinoma, apocrine mixed tumor of the skin, mucinous apocrine carcinoma, cylindroma, and neuroendocrine carcinomas are the tumors that should be ruled out in the histological differential diagnosis [4]. The standard management of PCACC is the surgical excision [4]. Wide local excision with tumor-free margins is the established treatment of choice. Also, Mohs surgery is well defined in the literature with seven cases [7]. In rare instances, use of chemotherapy and radiotherapy has been reported [4,8]. PCACC tends to recur frequently after surgical excision. It is suggested that the main mechanism in the development of recurrence is perineural invasion that is seen in 76% of the PCACC. It is reported that the cases with perineural invasion
5 have recurrence rate about 46%, however the cases without perineural invasion show recurrence rate about 22% [4]. No perineural invasion was detected in the present case but high recurrence rate suggests that the prior excisions might probably show perineural invasion. Recurrence time of the PCACC may vary between one month and 35 years [4,5,6]. Our patient was operated for three times in the last 2 years before the present excision. The last operation was about 6 months ago. We performed a wide excision. Conclusion The PCACC is a rare tumor that the etiology, origin, and treatment are still controversial. The metastases must be ruled out from other sites, especially from the salivary glands after the its pathological diagnosis. References 1. Krishnamurty A, Vaidhyanathan A. carcinoma of scalp. International Journal of Head and Neck Surgery. 2010, 1: R. Boggio. Adenoid cystic carcinoma of scalp. Arch Dermatol.1975, 111: Dores GM, Huycke MM, Devesa SS, Garcia CA. Primary cutaneous adenoid cystic carcinoma in the United States: Incidence, survival, and associated cancers, 1976 to J Am Acad Dermatol. 2010, 63: Naylor E, Sarkar P, Perlis CS, Giri D, Gnepp DR, Robinson-Bostom L. Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol. 2008, 58: Cacchi C, Persechino S, Fidanza L, Bartolazzi A. A primary cutaneous adenoid-cystic carcinoma in a young woman. Differential diagnosis and clinical implications. Rare Tumors. 2011, 30:3:e3 Page 5 of 5 6. Fueston JC, Gloster HM, MutasimDF. carcinoma: a case report and literature review. Cutis. 2006, 77: Xu YG, Hinshaw M, Longley BJI, Ilyas H, Snow SN. Cutaneous adenoid cystic carcinoma with perineural invasion treated bymohs Micrographic surgery A case report with literature review. J Oncol doi: /2010/ Kato N, Yasukawa K, Onozuka T. carcinoma with lymph node metastasis. Am J Dermatopathol. 1998, 20:
Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationSlide seminar. Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana
Slide seminar Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana Case 5 A 57-year-old man with a dermal/subcutaneous lesion on the scalp, which was interpreted
More informationGross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of
Tiền liệt tuyến Tiền liệt tuyến Gross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of solid and microcystic areas.
More informationRare Presentation Of Adenoidcystic Carcinoma Of External Auditory Canal With Subcutaneous Metastasis In Temporal Region
ISPUB.COM The Internet Journal of Otorhinolaryngology Volume 13 Number 2 Rare Presentation Of Adenoidcystic Carcinoma Of External Auditory Canal With Subcutaneous Metastasis In Temporal Region S Kaushik,
More informationJournal of International Academy of Forensic Science & Pathology (JIAFP)
Journal of International Academy of Forensic Science & Pathology (JIAFP) ISSN 2395-0722 MICROCYSTIC ADNEXAL CARCINOMA-A CASE REPORT WITH REVIEW OF LITERATURE Case Report Sulakshana M S 1,Natarajan M 2
More information- Selected Tumors of the Skin Appendages - Primary vs. Metastasis
- Selected Tumors of the Skin Appendages - Primary vs. Metastasis Napa Valley 2018 Victor G. Prieto, MD, PhD Chair of Pathology UT MD Anderson Cancer Center vprieto@mdanderson.org Napa Valley in May Introduction
More informationCutaneous Adnexal Tumors
Cutaneous Adnexal Tumors Lesions with Predominant Follicular Differentiation Special Emphasis on Basal Cell Carcinoma 2014-04-01 Prof. Dr. med. Katharina Glatz Pathologie Cutaneous Adnexal Tumors Hair
More informationBSD 2015 Case 19. Female 21. Nodule on forehead. The best diagnosis is:
BSD 2015 Case 19 Female 21. Nodule on forehead. The best diagnosis is: A. mixed tumour of skin B. porocarcinoma C. nodular hidradenoma D. metastatic adenocarcinoma BSD 2015 Case 19 Female 21 Nodule on
More informationLesions Mimicking Adenoid Cystic Carcinoma. Diagnostic Problems in Salivary Gland Pathology An Update 5/29/2009
Diagnostic Problems in Salivary Gland Pathology An Update Lesions Mimicking Adenoid Cystic Carcinoma Stacey E. Mills, M.D. W.S. Royster Professor of Pathology Director of Surgical and Cytopathology University
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationInvasive Papillary Breast Carcinoma
410 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license), applicable to the online version of the
More informationDISCUSSION: PLGA accounts for about 2% of all salivary gland tumours and occurs almost exclusively in the minor salivary glands.
SWELLING ON THE HARD PALATE PRESENTING AS POLYMORPHOUS LOW GRADE ADENOCARCINOMA: A AND REVIEW OF LITERATURE Swapnil D. Chandekar 1, Sunita S. Dantkale 2, Rahul R. Narkhede 3, Snehal V. Chavhan 4, Khushboo
More information04/09/2018. Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances
Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory
More informationMaram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine
Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine The most common non-skin malignancy of women 2 nd most common cause of cancer deaths in women, following
More informationCase Report Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical
Int J Clin Exp Pathol 2012;5(3):254-259 www.ijcep.com /ISSN: 1936-2625/IJCEP1110004 Case Report Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical
More informationSalivary Gland FNA ATYPICAL : Criteria and Controversies
Salivary Gland FNA ATYPICAL : Criteria and Controversies W.C. Faquin, M.D., Ph.D. Director, Head and Neck Pathology Massachusetts General Hospital Massachusetts Eye and Ear Infirmary Harvard Medical School
More informationCranium eroding sweat gland carcinoma: a case report
Cranium eroding sweat gland carcinoma: a case report Mehmet Arslan, Ahmet N. Karadeniz, Görkem Aksu, Murat Güveli Istanbul University, Institute of Oncology, Istanbul, Turkey Background. Sweat gland carcinomas
More informationأملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5
Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs
More informationGlycogen-rich adenocarcinoma in the lower lip: report of a case with particular emphasis on differential diagnosis
Open Journal of Stomatology, 2011, 1, 109-113 doi:10.4236/ojst.2011.13017 Published Online September 2011 (http://www.scirp.org/journal//). Glycogen-rich adenocarcinoma in the lower lip: report of a case
More informationAbstracting Upper GI Cancer Incidence and Treatment Data Quiz 1 Multiple Primary and Histologies Case 1 Final Pathology:
Abstracting Upper GI Cancer Incidence and Treatment Data Quiz 1 Multiple Primary and Histologies Case 1 A 74 year old male with a history of GERD presents complaining of dysphagia. An esophagogastroduodenoscopy
More informationDiseases of the breast (1 of 2)
Diseases of the breast (1 of 2) Introduction A histology introduction Normal ducts and lobules of the breast are lined by two layers of cells a layer of luminal cells overlying a second layer of myoepithelial
More informationKidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
More informationCase Report A Case of Primary Submandibular Gland Oncocytic Carcinoma
Case Reports in Otolaryngology Volume 2013, Article ID 384238, 4 pages http://dx.doi.org/10.1155/2013/384238 Case Report A Case of Primary Submandibular Gland Oncocytic Carcinoma Kunihiko Tokashiki, Kiyoaki
More informationCase Report Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge
Hindawi Volume 2017, Article ID 6343709, 4 pages https://doi.org/10.1155/2017/6343709 Case Report Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge Mary Anne Brett, Samih Salama,
More informationBasement membrane in lobule.
Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.
More informationBASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY Divvya B 1, Rehana Tippoo 2, P. Viswanathan 3, B. Krishnaswamy 4, A.
BASAL CELL CARCINOMA WITH ECCRINE DIFFERENTIATION: A RARE ENTITY Divvya B 1, Rehana Tippoo 2, P. Viswanathan 3, B. Krishnaswamy 4, A. Anvar Ali 5 HOW TO CITE THIS ARTICLE: Divvya B, Rehana Tippoo, P. Viswanathan,
More information04/10/2018. Intraductal Papillary Neoplasms Of Breast INTRADUCTAL PAPILLOMA
Intraductal Papillary Neoplasms Of Breast Savitri Krishnamurthy MD Professor of Pathology Deputy Division Head The University of Texas MD Anderson Cancer Center 25 th Annual Seminar in Pathology Pittsburgh,
More informationDISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV
DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV NEOPLASMS A) Epithelial I. Benign Pleomorphic adenoma( Mixed tumour) Adenolymphoma (Warthin s tumour) Oxyphil adenoma (Oncocytoma)
More informationR. F. Falkenstern-Ge, 1 S. Bode-Erdmann, 2 G. Ott, 2 M. Wohlleber, 1 and M. Kohlhäufl Introduction. 2. Histology
Case Reports in Oncological Medicine Volume 2013, Article ID 167585, 4 pages http://dx.doi.org/10.1155/2013/167585 Case Report Late Lung Metastasis of a Primary Eccrine Sweat Gland Carcinoma 10 Years after
More informationIntroduction. Results. Discussion. Histopathologic and immunohistochemical findings. Results. conclusions,
1/5 2/5 Carcinoma distinctive carcinoma. form erysipeloides (CE), metastasis. which clinically Itfrom has resembles been termed erysipelas, is an uncommon, but may extend It164 toclassically back, presents
More information(CYLINDROMA) ATLAS OF HEAD AND NECK PATHOLOGY ADENOID CYSTIC CARCINOMA
(CYLINDROMA) This malignant tumor is poorly encapsulated and while seemingly well defined within the affected gland, there is usually infiltration of surrounding tissue on closer examination. The cut surface
More informationCase Scenario 1 History and Physical 3/15/13 Imaging Pathology
Case Scenario 1 History and Physical 3/15/13 The patient is an 84 year old white female who presented with an abnormal mammogram. The patient has a five year history of refractory anemia with ringed sideroblasts
More informationCytokeratin immunoprofile of primary and metastatic adenoid cystic carcinoma of salivary glands: a report of two cases
Article / Clinical Case Report Cytokeratin immunoprofile of primary and metastatic adenoid cystic carcinoma of salivary glands: a report of two cases Cibele Pidorodeski Nagano a, Cláudia Malheiros Coutinho-Camillo
More informationAppendageal skin tumors
Appendageal skin tumors Ibrahim Khalifeh, M.D. Associate Professor Department of Pathology American University of Beirut Medical Center Beirut, Lebanon Appendageal tumors Neoplasms whose differentiation
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationSalivary Glands 3/7/2017
Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.
More informationLos Angeles Society Of Pathologists Dr. Shobha Castelino Prabhu
Los Angeles Society Of Pathologists Dr. Shobha Castelino Prabhu Loma Linda University Medical Center June 12, 2007 CASE 1 76 year-old gentleman Status post right parotidectomy 1 year ago for a rare tumor
More informationCase Report Basaloid ductal carcinoma in situ arising in salivary gland metaplasia of the breast: a case report
Int J Clin Exp Pathol 2014;7(9):6370-6374 www.ijcep.com /ISSN:1936-2625/IJCEP0001480 Case Report Basaloid ductal carcinoma in situ arising in salivary gland metaplasia of the breast: a case report Eun
More informationBasaloid neoplasms of the head and neck. Basaloid SCC. Clinico-pathologic features 5/5/11. Basaloid Tumors Head and Neck
Basaloid neoplasms of the head and neck Richard Jordan DDS PhD FRCPath Professor & Director UCSF Oral Pathology Laboratory University of California San Francisco Basaloid Tumors Head and Neck Basaloid
More informationWhat is ACC? (Adenoid Cystic Carcinoma)
What is ACC? (Adenoid Cystic Carcinoma) 10-9-10 Where ACC Occurs ACC (Adenoid Cystic Carcinoma) is a rare and unique form of cancer that is known to be unpredictable in nature, with a typical growth pattern
More informationFORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT
I: 2047-2051 ISSN: 2277 4998 FORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT ABEDI G 1, HESARAKI S 2, ASGHARI A 1* 1: Department of Clinical Science, Science and Research branch, Islamic Azad University,
More informationCase 18. M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is:
Case 18 M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is: A. Pilomatrical carcinoma B. Adnexal carcinoma NOS C. Metastatic squamous cell carcinoma D.Primary squamous cell carcinoma
More informationNeuroendocrine Carcinoma. Lebanon Neuroendocrine Neoplasms of H&N Nov /7/2011. Broad Classification:
H&N Neuroendocrine Neoplasms: Classification and Diagnostic Considerations Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas Broad Classification: A. Epithelial:
More informationCase Scenario 1 Worksheet. Primary Site C44.4 Morphology 8743/3 Laterality 0 Stage/ Prognostic Factors
CASE SCENARIO 1 9/10/13 HISTORY: Patient is a 67-year-old white male and presents with lesion located 4-5cm above his right ear. The lesion has been present for years. No lymphadenopathy. 9/10/13 anterior
More informationPOLYMORPHOUS LOW GRADE ADENOCARCINOMA - CASE REPORT AND REVIEW OF LITERATURE
POLYMORPHOUS LOW GRADE ADENOCARCINOMA - CASE REPORT AND REVIEW OF LITERATURE S.Sunil 1 B.S. Sreenivasan 2 Jisha Titus 3 Soma Susan 4 Jubin Thomas 4 Antony George 4 Devi Gopakumar 5 1 Reader, 2 Professor,
More informationMy Journey into the World of Salivary Gland Sebaceous Neoplasms
My Journey into the World of Salivary Gland Sebaceous Neoplasms Douglas R. Gnepp Warren Alpert Medical School at Brown University Rhode Island Hospital Pathology Department Providence RI Asked to present
More informationBreast pathology. 2nd Department of Pathology Semmelweis University
Breast pathology 2nd Department of Pathology Semmelweis University Breast pathology - Summary - Benign lesions - Acute mastitis - Plasma cell mastitis / duct ectasia - Fat necrosis - Fibrocystic change/
More informationEpithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev
Epithelial tumors Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Tumors from the epithelium are the most frequent among tumors. There are 2 group features of these tumors: The presence in most
More informationBasal cell carcinoma diagnosed on Fine-Needle Aspiration Cytology A. Pathological Case Report
Basal cell carcinoma diagnosed on Fine-Needle Aspiration Cytology A Abstract Dr. Madhuri S.Kate 1, Dr. Preeti Jain 2, Dr. Shailesh S. Patne 3 Introduction: Basal cell carcinoma (BCC) is a locally invasive
More informationA 60-year old Man with Left Jaw Mass. Simon Chiosea, MD University of Pittsburgh medical Center 3/15/2016
ACCME/Disclosures The USCAP requires that anyone in a position to influence or control the content of CME disclose any relevant financial relationship WITH COMMERCIAL INTERESTS which they or their spouse/partner
More informationReview and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors
Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors. Monophasic tumors : myoepithelioma, acinic cell carcinoma, and salivary duct carcinoma. Biphasic tumors includes
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER VULVAR
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER VULVAR Last Revision Date July 2015 1 Site Group: Gynecologic Cancer Vulvar Author: Dr. Stephane Laframboise 1. INTRODUCTION
More informationDiseases of the vulva
Diseases of the vulva 1. Bartholin Cyst - Infection of the Bartholin gland produces an acute inflammation within the gland (adenitis) and may result in an abscess. Bartholin duct cysts - Are relatively
More informationEQA Circulation 43 Educational Cases
EQA Circulation 43 Educational Cases E1-E2 Monica Agarwal Monklands Hospital E1 38 yrs male Submandibular gland tumour E1 Formal excision following diagnosis of poorly differentiated carcinoma on core
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationPrimary Cutaneous Apocrine Carcinoma of Sweat Glands: A Rare Case Report
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license), applicable to the online version of the article
More informationTumor in tumor : A Rare Carcinoma Arising in Benign Cystic Teratoma of Ovary
Case Report American Journal of Cancer Case Reports http://ivyunion.org/index.php/ajccr/ Page 1 of 5 Tumor in tumor : A Rare Carcinoma Arising in Benign Cystic Teratoma of Ovary Priti Chatterjee *, Sandeep
More informationSEBACEOUS NEOPLASMS. Dr. Prachi Saraogi Clinical Fellow in Dermatology
SEBACEOUS NEOPLASMS Dr. Prachi Saraogi Clinical Fellow in Dermatology Sebaceous neoplasms Sebaceous adenoma (Benign) Sebaceous carcinoma (Malignant) SEBACEOUS ADENOMA Benign tumours composed of incompletely
More informationDesmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC
R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o
More informationTriple Negative Breast Cancer
Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional
More informationPitfalls in thyroid tumor pathology. Prof.Valdi Pešutić-Pisac MD, PhD
Pitfalls in thyroid tumor pathology Prof.Valdi Pešutić-Pisac MD, PhD Too many or... Tumour herniation through a torn capsule simulating capsular invasion fibrous capsule with a sharp discontinuity, suggestive
More informationCatholic University of Louvain, St - Luc University Hospital Head and Neck Oncology Programme. Anatomopathology. Pathology 1 Sept.
Anatomopathology Pathology 1 Anatomopathology Biopsies Frozen section Surgical specimen Peculiarities for various tumor site References Pathology 2 Biopsies Minimum data, which should be given by the pathologist
More informationCase Scenario 1. Discharge Summary
Case Scenario 1 Discharge Summary A 69-year-old woman was on vacation and noted that she was becoming jaundiced. Two months prior to leaving on that trip, she had had a workup that included an abdominal
More informationMALIGNANT POROMA SYNONYM: POROCARCINOMA ECCRINE POROMA MALIGNANT Divvya B 1, M. Valluvan 2, Rehana Tippoo 3, P. Viswanathan 4, R.
MALIGNANT POROMA SYNONYM: POROCARCINOMA ECCRINE POROMA MALIGNANT Divvya B 1, M. Valluvan 2, Rehana Tippoo 3, P. Viswanathan 4, R. Ramesh 5 HOW TO CITE THIS ARTICLE: Divvya B, M. Valluvan, Rehana Tippoo,
More informationApocrine Hidradenocarcinoma of the Scalp: A Classification Conundrum
Head and Neck Pathol (2009) 3:42 46 DOI 10.1007/s12105-008-0096-8 CASE REPORT Apocrine Hidradenocarcinoma of the Scalp: A Classification Conundrum Marc Cohen Æ David S. Cassarino Æ Hubert B. Shih Æ Elliot
More informationCase Report Adenoid cystic carcinoma metastasis to kidney disguised as primary renal cell carcinoma: a case report and review of literature
Int J Clin Exp Med 2017;10(12):16715-16720 www.ijcem.com /ISSN:1940-5901/IJCEM0058687 Case Report Adenoid cystic carcinoma metastasis to kidney disguised as primary renal cell carcinoma: a case report
More informationDifferential Diagnosis of Oral Masses. Palatal Lesions
Differential Diagnosis of Oral Masses Palatal Lesions Palatal Masses Periapical Abscess Torus Palatinus Mucocele Lymphoid Hyperplasia Adenomatous Hyperplasia Benign Salivary Neoplasms Malignant Salivary
More informationHuman Papillomavirus and Head and Neck Cancer. Ed Stelow, MD
Human Papillomavirus and Head and Neck Cancer Ed Stelow, MD No conflict of interest Declaration Cancer 1974 Lancet Oncol 2016; 17: e477-8 JAMA 1984; 252: 1857 JAMA 1988;259(13):1943-1944 Clin Cancer Res
More informationMaligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT
Maligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT Two different neoplasia in the same biopsy material called
More informationconfusing, especially in small, limited biopsies. One such case of digital papillary adnexal adenocarcinoma with unusual histologic features will be
1 Cutaneous Adnexal Lesions: The Must-Know Stuff 2011 USCAP Annual Meeting Dermatopathology Companion Meeting Doina Ivan, M.D. University of Texas MD Anderson Medical Center, Houston, TX The diagnosis
More informationRetrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series
Waqas et al. Journal of Medical Case Reports (2017) 11:67 DOI 10.1186/s13256-017-1212-8 CASE REPORT Open Access Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a
More informationDisorders of Cell Growth & Neoplasia. Histopathology Lab
Disorders of Cell Growth & Neoplasia Histopathology Lab Paul Hanna April 2010 Case #84 Clinical History: 5 yr-old, West Highland White terrier. skin mass from axillary region. has been present for the
More informationEnterprise Interest None
Enterprise Interest None What are triple negative breast cancers? A synopsis of their histological patterns Ian Ellis Molecular Medical Sciences, University of Nottingham Department of Histopathology,
More informationPapillary Lesions of the Breast A Practical Approach to Diagnosis. (Arch Pathol Lab Med. 2016;140: ; doi: /arpa.
Papillary Lesions of the Breast A Practical Approach to Diagnosis (Arch Pathol Lab Med. 2016;140:1052 1059; doi: 10.5858/arpa.2016-0219-RA) Papillary lesions of the breast Span the spectrum of benign,
More informationRecent advances in breast cancers
Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response
More informationCase Report Five-Year Survival after Surgery for Invasive Micropapillary Carcinoma of the Stomach
Case Reports in Surgery Volume 2013, Article ID 560712, 4 pages http://dx.doi.org/10.1155/2013/560712 Case Report Five-Year Survival after Surgery for Invasive Micropapillary Carcinoma of the Stomach Shigeo
More informationSection 1: Personal information
A survey on the use of ultrasound examination of the regional lymph nodes in the follow up of patients with high-risk cutaneous squamous cells carcinomas (SCCs). Note: In the definition of cutaneous squamous
More informationMajor Topic. Malignant Melanoma Plastic and Reconstructive Surgery R3 陸尊惠 /VS 吳瑞星
Major Topic Malignant Melanoma Plastic and Reconstructive Surgery R3 陸尊惠 /VS 吳瑞星 Patient Data Name: OOO Age: 70 Gender: Male Date of admission: Day 1 Chief Complaint Black skin tumor at the back of the
More informationFINE NEEDLE ASPIRATION OF ENLARGED LYMPH NODE: Metastatic squamous cell carcinoma
Case Scenario 1 HNP: A 70 year old white male presents with dysphagia. The patient is a current smoker, current user of alcohol and is HPV positive. A CT of the Neck showed mass in the left pyriform sinus.
More informationCutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology
Cutaneous metastases Thaddeus Mully University of California, San Francisco Professor, Departments of Pathology and Dermatology DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Thaddeus Mully Course C005 Essential
More information1 NORMAL HISTOLOGY AND METAPLASIAS
1 NORMAL HISTOLOGY AND METAPLASIAS, MD Anatomy and Histology 1 Metaplasias 2 ANATOMY AND HISTOLOGY The female breast is composed of a branching duct system, which begins at the nipple with the major lactiferous
More informationBREAST PATHOLOGY. Fibrocystic Changes
BREAST PATHOLOGY Lesions of the breast are very common, and they present as palpable, sometimes painful, nodules or masses. Most of these lesions are benign. Breast cancer is the 2 nd most common cause
More informationA712(19)- Test slide, Breast cancer tissues with corresponding normal tissues
A712(19)- Test slide, Breast cancer tissues with corresponding normal tissues (formalin fixed) For research use only Specifications: No. of cases: 12 Tissue type: Breast cancer tissues with corresponding
More informationAcantholytic Anaplastic Extramammary Paget s Disease: A Case Report and Review of the Literature
Ann Dermatol Vol. 23, Suppl. 2, 2011 http://dx.doi.org/10.5021/ad.2011.23.s2.s226 CASE REPORT Acantholytic Anaplastic Extramammary Paget s Disease: A Case Report and Review of the Literature Yu-Jin Oh,
More informationUSCAP 2012: Companion Meeting of the AAOOP. Update on lacrimal gland neoplasms: Molecular pathology of interest
USCAP 2012: Companion Meeting of the AAOOP Vancouver BC, Canada, March 17, 2012 Update on lacrimal gland neoplasms: Molecular pathology of interest Valerie A. White MD, MHSc, FRCPC Department of Pathology
More informationCarcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY
Carcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY SEARCHING FOR THE PRIMARY? P r o f J P P r e t o r i u s H e a d : C l i n i c a l U n i t C r i t i c a l C a r e U n i v e r s i t y O f
More informationCase Report Clear Cell Basal Cell Carcinoma
SAGE-Hindawi Access to Research Volume 2011, Article ID 386921, 4 pages doi:10.4061/2011/386921 Case Report Clear Cell Basal Cell Carcinoma Deba P. Sarma, 1 Daniel Olson, 1 Jennifer Olivella, 1 Tracey
More informationSkin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs
Skin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs Classification of Body Membranes Epithelial membranes Cutaneous
More informationCLINICAL SIGNIFICANCE OF BENIGN EPITHELIAL CHANGES
Papillomas. Papillomas are composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by luminal and myoepithelial cells ( Fig. 23-11 ). Growth occurs within a dilated
More informationPruritus Ani in an Elderly Man
Pruritus Ani in an Elderly Man Pedro Redondo, MD; Michel Idoate, MD; Agustín España, MD; Emilio Quintanilla, MD; University of Navarra, Pamplona, Spain REPORT OF A CASE A 78-year-old man presented with
More informationCase Presentation 主治醫師 : 宋文鑫日期 :
Case Presentation 主治醫師 : 宋文鑫日期 : 2015-2-28 General Data Name:OOO Chart Number:OOOOOOO Date of Admission:2014 年 08 月 04 日 Age: 33 y/o Sex:female Occupation : 會計 Chief Complaint Palpable soft tissue mass
More informationBladder Case 1 SURGICAL PATHOLOGY REPORT. Procedure: Cystoscopy, transurethral resection of bladder tumor (TURBT)
Bladder Case 1 February 17, 2007 Specimen (s) received: Bladder Tumor Pre-operative Diagnosis: Bladder Cancer Post operative Diagnosis: Bladder Cancer Procedure: Cystoscopy, transurethral resection of
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationCase Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery.
Case Scenario 1 July 10, 2010 A 67-year-old male with squamous cell carcinoma of the mid thoracic esophagus presents for surgical resection. The patient has completed preoperative chemoradiation. This
More informationMapping Basal Cell and Squamous Carcinoma By 10 Min CK5 Direct Immunohistochemistry on Frozen Section Skin Tissues during Mohs Micrographic Surgery
Mapping Basal Cell and Squamous Carcinoma By 10 Min CK5 Direct Immunohistochemistry on Frozen Section Skin Tissues during Mohs Micrographic Surgery Robert Glinert, MD and Song Q. Zhao, MD, Ph.D., MPH Department
More informationEccrine porocarcinoma of the vulva: a case report and review of the literature
Fujimine-Sato et al. Journal of Medical Case Reports (2016) 10:319 DOI 10.1186/s13256-016-1106-1 CASE REPORT Open Access Eccrine porocarcinoma of the vulva: a case report and review of the literature Ayako
More informationSquamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22
Squamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22 History of ITET/CASTLE First Report Gross Appearance and Prognosis 1) Miyauchi A et al: Intrathyroidal epithelial
More informationCASE REPORT GASTRIC ADENOCARCINOMA METASTASIS TO THE BREAST- A DIFFERENTIAL DIAGNOSIS WITH PRIMARY BREAST ADENOCARCINOMA AND REVIEW OF LITERATURE.
GASTRIC ADENOCARCINOMA METASTASIS TO THE BREAST- A DIFFERENTIAL DIAGNOSIS WITH PRIMARY BREAST ADENOCARCINOMA AND REVIEW OF LITERATURE. Ashwin Hebbar.K 1, Shashidar. K 2, Kamal Kishor 3, Manjunath 4, Shivakumar.H.
More informationAmerican Journal of Cancer Case Reports. Invasive Papillary Carcinoma of Male Breast: A Rare Case Report
American Journal of Cancer Case Reports http://ivyunion.org/index.php/ajccr SantraAetal. American Journal of Cancer Case Reports 2014, 3:56-61 Page 1 of 6 Vol 3 Article ID 20140617, 6 pages Case Report
More informationMelanoma Case Scenario 1
Melanoma Case Scenario 1 History and physical 11/5/16 Patient is a single, 48-year-old male in good health who presented to his primary physician for a yearly physical exam during which a 3.4 x 2.8 x 1.5
More information