Hodgkin Lymphoma Involving Waldeyer Ring A Clinicopathologic Study of 22 Cases
|
|
- Austen Weaver
- 6 years ago
- Views:
Transcription
1 Hematopathology / HODGKIN LYMPHOMA INVOLVING WALDEYER RING Hodgkin Lymphoma Involving Waldeyer Ring A Clinicopathologic Study of 22 Cases Maria del Pilar Quiñones-Avila, MD, Abel A. Gonzalez-Longoria, MD, Joan H. Admirand, MD, and L. Jeffrey Medeiros, MD Key Words: Hodgkin lymphoma; Waldeyer ring; Epstein-Barr virus Abstract We report 22 cases of Hodgkin lymphoma involving Waldeyer ring seen at our institution during a 31-year interval. There were 16 males (73%) and 6 females (27%) with a median age of 48 years (range, 5-81 years), and 15 (68%) patients had airway obstruction or tonsillar enlargement. For 19 patients, the clinical stage was as follows: I, 7 (32%); II, 11 (50%); and III, 1 (5%). The 3 patients (14%) whose disease was unstaged had concurrent or a history of non-hodgkin lymphoma. Histologically, the neoplasms were classified as follows: lymphocyte-rich classical, 8 (36%); nodular sclerosis, 7 (32%); mixed cellularity, 4 (18%); unclassified, 2 (9%); and lymphocyte depletion, 1 (5%). Of 7 stage I cases, 4 (57%) were the lymphocyte-rich classical type. Reed-Sternberg and Hodgkin cells were positive for CD15 and CD30 in 20 cases assessed. Epstein-Barr virus latent membrane protein type 1 was positive in 12 (67%) of 18 cases assessed. We conclude that Hodgkin lymphoma rarely involves Waldeyer ring, with the lymphocyte-rich classical type being common at this location. The term Waldeyer ring is used to encompass the lymphoid tissues of the faucial tonsils, nasopharynx, base of tongue, and oropharynx and, as defined by others, is an extranodal but not an extralymphatic site. 1 Waldeyer ring may be involved by a variety of neoplasms, and carcinomas, most often metastatic from nearby head and neck sites, are most common. Lymphomas involve Waldeyer ring much less often, 2 and most of these tumors are non-hodgkin lymphomas (NHLs). In published studies, approximately 90% of all lymphomas involving Waldeyer ring are types of NHL, 3 mostly extranodal natural killer/t-cell lymphoma of nasal type and diffuse large B-cell lymphoma, 4-6 with a lesser number of other types, including extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, mantle cell lymphoma, and peripheral T-cell lymphoma. Hodgkin lymphoma (HL) represents approximately 4% of all lymphomas of the head and neck, 7 and most of these neoplasms involve lymph nodes. Extranodal involvement by HL, including Waldeyer ring, is rare. 4,5 Previous studies of patients with HL have reported a low frequency of involvement of Waldeyer ring. For example, Todd and Michaels 8 reported a frequency of 1% for involvement of the nasopharynx and 1.5% for tonsil and oropharynx. Similarly, Kaplan and colleagues 9 reported that 5 (1.8%) of 285 consecutive patients with HL had involvement of Waldeyer ring. As a result, most previously published series of HL involving Waldeyer ring have been small groups of patients or case reports. In addition, most of the larger and better studies were performed before the advent of immunohistochemical analysis and, therefore, lack confirmatory immunophenotypic data. Most of these studies also used older lymphoma classification systems based on morphologic findings, without ancillary data. A study of a series of cases of HL involving Waldeyer ring, classified according Downloaded from Am J Clin Pathol 2005;123:
2 Quiñones-Avila et al / HODGKIN LYMPHOMA INVOLVING WALDEYER RING to the currently used World Health Organization (WHO) classification system, has not been published to date. We describe 22 cases of HL involving Waldeyer ring, including 7 stage I cases, classified according to the WHO classification. Carpinteria, CA, except CD15, which was purchased from BD Biosciences, San Jose, CA. All cases were classified using the criteria of the WHO classification system. 12 Although similar to earlier classifications of HL, the lymphocyte-rich classical type of HL now is recognized as an entity in the WHO classification. Materials and Methods We identified 22 cases of HL involving Waldeyer ring in the files of the Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, from January 1973 to December Eleven cases were treated at this institution and 11 cases were reviewed in consultation. Clinical information was obtained from data submitted at the time of consultation and the medical record. Clinical stage was determined using the Ann-Arbor staging system. We reviewed H&E-stained tissue sections of each case. We also reviewed all immunostains available, performed at the submitting institution or in our laboratory in the past. Immunohistochemical stains also were performed as part of this study, using fixed, paraffin-embedded tissue sections and an avidin-biotin complex method as previously described. 10,11 The panel of monoclonal antibodies used included reagents specific for CD15 (Leu M1), CD20 (L-26), CD30 (Ber H2), CD45 (LCA), CD45RO (UCHL-1), Epstein-Barr virus (EBV) latent membrane protein type 1 (LMP-1; CS1-4), and polyclonal CD3. Antibody dilutions varied during the interval of the study. All antibodies were obtained from DAKO, Results Clinical Findings Clinical data are summarized in Table 1. There were 16 males (73%) and 6 females (27%) with a median age of 48 years (range, 5-81 years). Only 1 patient (5%) was a child. Six patients (27%) were at least 60 years old. The disease was localized (stage I) to Waldeyer ring in 7 cases (32%), involved Waldeyer ring and cervical lymph nodes (stage II) in 11 cases (50%), and was associated with abdominal lymphadenopathy and spleen involvement (stage III) in 1 case (5%). Three patients had a history of NHL, and their disease was not staged. In this subgroup, 1 patient had follicular lymphoma with bone marrow involvement diagnosed in 1989 and was treated with chemotherapy and autologous bone marrow transplantation. The patient experienced a relapse in 1992 with bone marrow involvement by follicular lymphoma but was in clinical remission when HL developed in 1993 with involvement of the mediastinum and liver. Despite chemotherapy, HL involving the bone marrow and then tonsil developed in Two patients had chronic lymphocytic leukemia/small lymphocytic Table 1 Clinical Features in 22 Cases of Hodgkin Lymphoma in Waldeyer Ring Case No./Sex/ History of Age (y) Biopsy Site Symptoms and/or Signs Clinical Stage Lymphoma 1/M/45 Nasopharynx and LN Right-sided neck mass II 2/M/45 Nasopharynx and LN Nasal stuffiness II 3/F/47 Nasopharynx Nasopharyngeal mass I 4/M/49 Tonsil Tonsil enlargement II 5/M/39 Tonsil, cervical and celiac LNs, spleen Tonsil enlargement III 6/F/71 Nasopharynx Nasopharyngeal mass II 7/M/81 Tonsil Tonsil enlargement I 8/F/32 Adenoid and LN Right-sided neck mass II 9/M/69 Nasopharynx and LN Cervical adenopathy II 10/M/37 Adenoid Nasal congestion; LN enlargement II 11/M/32 Tonsil Throat pain I 12/M/53 Tonsil and LN Tonsil enlargement II 13/M/53 Nasopharynx Nasopharyngeal mass I 14/M/24 Nasopharynx Mass in sinuses (HIV+) I 15/M/57 Nasopharynx Nasopharyngeal mass I 16/F/67 Nasopharynx and LN Nasopharyngeal mass; LN enlarged II 17/M/5 Nasopharynx and LN Difficulty breathing II 18/M/41 Adenoids Obstructed airway I 19/M/48 Adenoids and cervical LN Nasal stuffiness II 20/F/57 Mediastinum and LN Mediastinal mass; painful throat + 21/M/70 Tongue and LN Exophytic lesion, base of tongue + 22/F/80 Palate, buccal gingiva Pain in the mouth; ulcers + LN, lymph node; +, positive;, negative. 652 Am J Clin Pathol 2005;123: Downloaded 652 from
3 Hematopathology / ORIGINAL ARTICLE lymphoma (CLL/SLL). One patient had fatigue and tenderness and pain in the mouth related to ulcers. Biopsies of the palate and buccal gingiva showed classical HL, and the patient underwent bone marrow aspiration and biopsy for staging. The bone marrow and flow cytometric immunophenotypic studies showed involvement by CLL/SLL without HL. The other patient had a 5-year history of CLL/SLL that was treated with chemotherapy. The patient was in clinical remission when an exophytic lesion at the base of the tongue and bilateral enlarged cervical lymph nodes developed. A biopsy of the tongue revealed classical HL and CLL/SLL Image 1E. Pathologic and Immunohistochemical Findings Pathologic and immunohistochemical data are summarized in Table 2. According to the WHO classification criteria, all 22 cases were classified as classical HL and 20 cases were further classified as follows: lymphocyte-rich classical Image 1A and Image 1B, 8 (36%); nodular sclerosis Image 1C, 7 (32%); mixed cellularity, 4 (18%); and lymphocyte depletion, 1 (5%). The remaining 2 cases (9%) arose in patients with CLL/SLL (Image 1E) and therefore were not further classifiable. The 7 stage I cases were classified as follows: lymphocyte-rich classical, 4 (57%); mixed cellularity, nodular sclerosis, and lymphocyte depletion, 1 (14%) each. In 20 cases, immunohistochemical studies were performed. (These studies were not performed in 2 cases of nodular sclerosis.) In all cases, the Reed-Sternberg and mononuclear variant cells were positive for CD15 and CD30 Image 1D. EBV LMP-1 was positive in 12 (67%) of 18 cases assessed, and CD20 was variably positive in 5 (28%) of 18 cases assessed. The neoplastic cells were negative for CD45 (n = 14), CD3 (n = 13), and CD45RO (n = 3) in all cases assessed. The 12 cases positive for EBV LMP-1 were classified as follows: lymphocyte-rich classical, 4 (33%); mixed cellularity, 3 (25%); nodular sclerosis, 2 (17%); lymphocyte depletion, 1 (8%); and not classified, 2 (17%) Image 1F. The patient with lymphocyte depletion HL was HIV+. The clinical stage of the neoplasms in these patients was as follows: I, 4; II, 4; III, 1; and not staged, 3. The 3 patients with unstaged disease had concurrent or a history of NHL. Discussion Although HL often involves the head and neck, these neoplasms usually arise in lymph nodes, most frequently in the cervical regions, and extranodal manifestation without nodal involvement is rare. 4,7 The frequency of HL involving extranodal sites of the head and neck is approximately 4%. 7 Among this group, HL involving Waldeyer ring, which encompasses the lymphoid tissues of the tonsils, nasopharynx, base of the tongue, and oropharynx wall, is even more rare. 3,6,13-21 For the present study, we identified 22 cases of HL involving Waldeyer ring obtained from the files of our institution during a 31-year period. Although previous studies of HL involving Waldeyer ring can be found in the literature, many of these studies did not include immunohistochemical data. For example, the largest series in the literature, by Cionini et al, 13 was a group of 28 cases Table 2 Pathologic and Immunophenotypic Findings in 22 Cases of Hodgkin Lymphoma in Waldeyer Ring Case No. Diagnosis CD3 CD15 CD20 CD30 CD45 CD45RO EBV LMP-1 1 MC ND + + ND 2 NS ND + + ND 3 LRC + ND + ND + 4 NS ND ND ND ND ND ND ND 5 MC ND + + ND ND + 6 MC ND + ND + ND + 7 NS ND ND ND ND ND ND ND 8 LRC + + ND + 9 LRC ND LRC + + ND + 11 MC ND ND + 12 NS + + ND 13 LRC + + ND ND + 14 LD ND + 15 LRC + + ND ND ND 16 NS + + ND ND ND 17 NS + + ND + 18 LRC ND 19 LRC + + ND 20 NS ND RS-HL ND ND + 22 RS-HL ND + EBV LMP-1, Epstein-Barr virus latent membrane protein type 1; LD, lymphocyte-depleted; LRC, lymphocyte-rich classical; MC, mixed cellularity; ND, not done; NS, nodular sclerosis; RS-HL, Richter syndrome, Hodgkin lymphoma type; +, positive;, negative. Downloaded from Am J Clin Pathol 2005;123:
4 Quiñones-Avila et al / HODGKIN LYMPHOMA INVOLVING WALDEYER RING A B C D Image 1 Hodgkin lymphoma involving Waldeyer ring. A, Lymphocyte-rich classical Hodgkin lymphoma involving adenoid tissue. Note the nodular growth pattern similar to that seen in nodular lymphocyte-predominant Hodgkin lymphoma (H&E, 50). B, Typical binucleated Reed-Sternberg cell in lymphocyte-rich classical Hodgkin lymphoma (H&E, 400). C, Nodular sclerosis Hodgkin lymphoma involving tonsil. Fibrous collagen bands divide the tissue into nodules (H&E, 100). D, Typical membranous and Golgi pattern of CD30 immunohistochemical staining in Hodgkin cells of nodular sclerosis Hodgkin lymphoma ( 400). without immunophenotypic workup. Because various types of NHL can resemble HL, such as T-cell/histiocyte-rich large B- cell lymphoma and peripheral T-cell lymphoma, immunohistochemical confirmation is needed to establish the diagnosis of most types of HL, with the possible exception of nodular sclerosis. Another drawback of many previous studies is that older lymphoma classification systems were used. Many of these older classification systems were based purely on morphologic findings and did not incorporate immunohistochemical and other ancillary data. As far as we are aware, this is the first study of a series of HL cases involving Waldeyer ring in which the neoplasms are classified according to the WHO classification. 12 Most reports in the literature suggest that mixed cellularity is the most common type of HL involving Waldeyer ring, 3,14-18 although the study by Cionini et al 13 found that lymphocyte predominant HL was most common. Our results are in disagreement with the literature because we had a predominance of the lymphocyte-rich classical (8/22 [36%]) and nodular sclerosis (7/22 [32%]) types of HL. In addition, more than half of localized (stage I) cases were the lymphocyte-rich classical type. This may be attributable, in large part, to the fact that the category of lymphocyte-rich classical HL was not recognized until it was first proposed as a provisional entity in the Revised European-American Lymphoma classification in 654 Am J Clin Pathol 2005;123: Downloaded 654 from
5 Hematopathology / ORIGINAL ARTICLE E F Image 1 E, Hodgkin lymphoma associated with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (Hodgkin-variant Richter syndrome); type II morphologic features with Hodgkin cells in a polymorphous inflammatory background. The small lymphocytes expressed CD20 and CD5, characteristic of CLL/SLL (H&E, 400). F, The Hodgkin cells in this case were positive for Epstein-Barr virus latent membrane protein-1( 200) Furthermore, lymphocyte-rich classical HL was refined into nodular and diffuse variants relatively recently, by the European Task Force on Lymphoma project. 23 Many cases classified in the past as mixed cellularity, nodular lymphocyte predominant, or unclassifiable HL might, in retrospect, be better considered the lymphocyte-rich classical type using current terminology and immunohistochemical analysis. 23 Extranodal HL frequently is related to immunodeficiency states, and in affected patients, a variety of anatomic sites can be involved by HL, including Waldeyer ring. 24,25 Thus, immunodeficiency is one possible explanation for involvement of Waldeyer ring by HL in the 4 patients with a history of lymphoma (n = 3) or HIV infection (n = 1). The HL in all 4 of these patients was positive for EBV, also consistent with immunodeficiency. However, 18 patients in this study had no clinical evidence of immunodeficiency, and 8 (57%) of 14 cases assessed in this apparently immunocompetent group also were positive for EBV. This frequency is higher than the frequency of EBV in most types of HL involving lymph nodes in immunocompetent patients. Previous studies have reported that EBV can be detected in approximately 20% to 60% of classical HL, depending on the histologic type, being lowest in nodular sclerosis and higher in mixed cellularity. 26 Because oropharyngeal epithelium is a lifetime reservoir for EBV and many malignant neoplasms arising at this site are positive for EBV, 2,3,14,17,18 it seems likely that anatomic location rather than histologic type explains the higher frequency of EBV in HL involving Waldeyer ring. O Grady and colleagues 27 made a similar suggestion based on the results of their study in which they showed a higher frequency of EBV in localized HL cases involving neck lymph nodes compared with HL cases involving nonneck body sites. Because EBV LMP is known to have oncogenic potential, 28 it seems possible that EBV has a role in pathogenesis rather than simply being a bystander. In agreement with the literature, in the present study, HL involving Waldeyer ring occurred most often in male patients (16/22 [73%]) with local symptoms, and 18 (95%) of 19 patients whose disease was staged had stage I or II disease. 3,14,16,20,21 Three patients had a history of NHL and were not staged; 2 cases in this group were unusual because they had concurrent evidence or a history of CLL/SLL. Thus, these cases can be considered examples of the Hodgkin variant of Richter syndrome. The term Richter syndrome is applied to the development of a secondary aggressive lymphoid malignancy in a patient with a history of CLL/SLL. 29 HL represents almost 15% of all cases of Richter syndrome and occurs in approximately 1% of patients with CLL. 30 Such cases have been referred to as Richter syndrome with HL features or the Hodgkin type or variant of Richter syndrome. The literature recognizes 2 types of the Hodgkin variant of Richter syndrome: type 1 is characterized by Reed-Sternberg and Hodgkin cells scattered in a background of CLL/SLL cells; in type 2, Reed-Sternberg and Hodgkin cells are present within a polymorphous inflammatory tissue. 31 Both cases in the present study were type 2. Richter syndrome has been associated with EBV infection. 32,33 Although we are not aware of other reported cases of Hodgkin-variant Richter syndrome involving Waldeyer ring, the high frequency of EBV at this anatomic site may contribute to onset of this type of Richter syndrome in these patients. Downloaded from Am J Clin Pathol 2005;123:
6 Quiñones-Avila et al / HODGKIN LYMPHOMA INVOLVING WALDEYER RING In summary, HL involving Waldeyer ring is rare; we identified only 22 cases during 31 years. At our institution, the lymphocyte-rich classical and nodular sclerosis types are most common at this anatomic site, with the lymphocyte-rich classical type also predominating (4/7 [57%]) in patients with stage I disease. We suggest that a subset of cases previously described in the literature as mixed cellularity, nodular lymphocyte predominant, and unclassified HL may, in fact, have been cases of lymphocyte-rich classical HL. From the Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston. Address reprint requests to Dr Medeiros: Dept of Hematopathology, Box 72, UT M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX References 1. Paryani S, Hoppe RT, Burke JS, et al. Extralymphatic involvement in diffuse non-hodgkin s lymphoma. J Clin Oncol. 1983;1: Rowley H, McRae RD, Cook JA, et al. Lymphoma presenting to a head and neck clinic. Clin Otolaryngol. 1995;20: Aloulou S, Farhat H, Bosq J, et al. Hodgkin s disease primarily involving the oropharynx: case report and review of the literature. Hematol J. 2002;3: Chan JKC, Ng CS, Lo STH. Immunohistochemical characterization of malignant lymphomas of the Waldeyer s ring other than the nasopharynx. Histopathology. 1987;11: Chan JKC, Ng CS, Lau WH, et al. Most nasal/nasopharyngeal lymphomas are peripheral T cell neoplasms. Am J Surg Pathol. 1987;11: Menarquez J, Mollejo M, Carrion R, et al. Waldeyer ring lymphomas: a clinicopathological study of 79 cases. Histopathology. 1994;24: Urquhart A, Berg R. Hodgkin s and non-hodgkin s lymphoma of the head and neck. Laryngoscope. 2001;111: Todd GB, Michaels L. Hodgkin s disease involving Waldeyer s lymphoid ring. Cancer. 1974;34: Kaplan HS, Dorfman RF, Nelsen TS, et al. Staging laparotomy and splenectomy in Hodgkin s disease: analysis of indications and patterns of involvement in 285 consecutive, unselected patients. Natl Cancer Inst Monogr. 1973;36: Lin P, Medeiros LJ, Wilder RB, et al. The activation profile of tumour-associated reactive T-cells differs in the nodular and diffuse patterns of lymphocyte predominant Hodgkin s disease. Histopathology. 2004;44: Park CK, Manning JT, Battifora H, et al. Follicle center lymphoma and Warthin tumor involving the same anatomic site: report of two cases and review of the literature. Am J Clin Pathol. 2000;113: Jaffe ES, Harris NL, Stein H, et al. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001: Cionini L, Bastiani P, Biti GP, et al. Waldeyer s ring (WR) involvement in Hodgkin s disease. Radiother Oncol. 1985;3: Kapadia SB, Roman LN, Kingma DW, et al. Hodgkin s disease of Waldeyer s ring; clinical and histoimmunophenotypic findings and association with Epstein-Barr virus in 16 cases. Am J Surg Pathol. 1995;19: Dunphy CH, Saravia O, Varvares MA. Hodgkin s disease primarily involving Waldeyer s ring: case report and review of the literature. Arch Pathol Lab Med. 1996;120: Sidhu JS, Rigotti R, Schotanus P. Primary adenoidal Hodgkin s disease: report of a case with unusual morphology and review of the literature. Int J Surg Pathol. 2000;8: Moghe GM, Borges AM, Soman CS, et al. Hodgkin s disease involving Waldeyer s ring: a study of four cases. Leuk Lymphoma. 2001;41: Abbes I, Mrad K, Sassi S, et al. Primary Hodgkin s disease of the nasopharynx: a rare but bona fide disease. Pathologica. 2002;94: Anselmo AP, Cavalieri E, Cardarelli L, et al. Hodgkin s disease of the nasopharynx: diagnostic and therapeutic approach with a review of the literature. Ann Hematol. 2002;81: O Reilly BJ, Kershaw JB. Hodgkin s disease of the nasopharynx. J Laryngol Otol. 1987;101: Molony NC, Stewart A, Ah-See K, et al. Hodgkin s lymphoma of the nasopharynx. J Laryngol Otol. 1998;112: Harris NL, Jaffe ES, Stein H, et al. A revised European- American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84: Anagnostopoulos I, Hansmann ML, Franssila K, et al. European Task Force on Lymphoma Project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood. 2000;96: Poluri A, Shah KG, Carew JF, et al. Hodgkin s disease of the head and neck in human immunodeficiency virus infected patients. Am J Otolaryngol. 2002;23: Ree HJ, Strauchen JA, Khan AA, et al. Human immunodeficiency virus associated Hodgkin s disease: clinicopathologic studies of 24 cases and preponderance of mixed cellularity type characterized by the occurrence of fibrohistiocytoid stromal cells. Cancer. 1991;67: Herling M, Rassidakis GZ, Medeiros LJ, et al. Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin s lymphoma: associations with presenting features, serum interleukin 10 levels and clinical outcome. Clin Cancer Res. 2003;9: O Grady J, Stewart S, Elton RA, et al. Epstein-Barr virus in Hodgkin s disease and the site of origin of tumour. Lancet. 1994;343: Wang D, Liebowitz D, Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell. 1985;43: Nemets A, Ben Dor D, Barry T, et al. Variant Richter s syndrome: a rare case of classical Hodgkin s lymphoma developing in a patient with chronic lymphocytic leukemia treated with fludarabine. Leuk Lymphoma. 2003;44: Brecher M, Banks PM. Hodgkin s disease variant of Richter s syndrome: report of eight cases. Am J Clin Pathol. 1990;93: Robak T, Szmigielska-Kaplon A, Smolewski P, et al. Hodgkin s type of Richter s syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. Leuk Lymphoma. 2003;44: Rubin D, Hudnall SD, Aisenberg A, et al. Richter s transformation of chronic lymphocytic leukemia with Hodgkin s-like cells is associated with Epstein-Barr virus infection. Mod Pathol. 1994;7: Ansell SM, Li CY, Lloyd RV, et al. Epstein-Barr virus infection in Richter s transformation. Am J Hematol. 1999;60: Am J Clin Pathol 2005;123: Downloaded 656 from
Mimics of Lymphoma in Routine Biopsies. Mixed follicular and paracortical hyperplasia. Types of Lymphoid Hyperplasia
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco Types of Lymphoid Hyperplasia Follicular hyperplasia (B-cells) Paracortical
More informationMimics of Lymphoma in Routine Biopsies. I have nothing to disclose regarding the information to be reported in this talk.
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco I have nothing to disclose regarding the information to be reported in this
More informationHODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO
HODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO HODGKIN LYMPHOMA CLASSIFICATION Lukes & Butler Rye WHO-2016 Linphocytic and/or histiocytic Nodular & diffuse Nodular Sclerosis Lymphocyte
More informationNon-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL)
Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL) Lymphoid Neoplasms: 1- non-hodgkin lymphomas (NHLs) 2- Hodgkin lymphoma 3- plasma cell neoplasms Non-Hodgkin lymphomas (NHLs) Acute Lymphoblastic Leukemia/Lymphoma
More informationLymphoid Neoplasms Associated With IgM Paraprotein A Study of 382 Patients
Hematopathology / LYMPHOMAS WITH IGM PARAPROTEIN Lymphoid Neoplasms Associated With IgM Paraprotein A Study of 382 Patients Pei Lin, MD, 1 Suyang Hao, MD, 1* Beverly C. Handy, MD, 2 Carlos E. Bueso-Ramos,
More informationIncidence. Bimodal age incidence 15-40, >55 years Childhood form (0-14) more common in developing countries M:F=1.5:1; in all subtypes except NS
Hodgkin Lymphoma Hodgkin Lymphoma 30% of all lymphomas Absolute incidence unchanged Arise in lymph node, cervical region Neoplastic tissues usually contain a small number of tumor cells Incidence Bimodal
More informationLymphoma: What You Need to Know. Richard van der Jagt MD, FRCPC
Lymphoma: What You Need to Know Richard van der Jagt MD, FRCPC Overview Concepts, classification, biology Epidemiology Clinical presentation Diagnosis Staging Three important types of lymphoma Conceptualizing
More informationLEUKAEMIA and LYMPHOMA. Dr Mubarak Abdelrahman Assistant Professor Jazan University
LEUKAEMIA and LYMPHOMA Dr Mubarak Abdelrahman Assistant Professor Jazan University OBJECTIVES Identify etiology and epidemiology for leukemia and lymphoma. Discuss common types of leukemia. Distinguish
More informationLeukaemia Section Short Communication
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL INIST-CNRS Leukaemia Section Short Communication Classification of Hodgkin lymphoma over years Antonino Carbone, Annunziata
More informationCase 3. Ann T. Moriarty,MD
Case 3 Ann T. Moriarty,MD Case 3 59 year old male with asymptomatic cervical lymphadenopathy. These images are from a fine needle biopsy of a left cervical lymph node. Image 1 Papanicolaou Stained smear,100x.
More informationDuring past decades, because of the lack of knowledge
Staging and Classification of Lymphoma Ping Lu, MD In 2004, new cases of non-hodgkin s in the United States were estimated at 54,370, representing 4% of all cancers and resulting 4% of all cancer deaths,
More informationImmunopathology of Lymphoma
Immunopathology of Lymphoma Noraidah Masir MBBCh, M.Med (Pathology), D.Phil. Department of Pathology Faculty of Medicine Universiti Kebangsaan Malaysia Lymphoma classification has been challenging to pathologists.
More informationProtocol for the Examination of Specimens From Patients With Hodgkin Lymphoma*
Protocol for the Examination of Specimens From Patients With Hodgkin Lymphoma* Version: Hodgkin 3.1.0.1 Protocol Posting Date: October 2013 This protocol is NOT required for accreditation purposes *This
More informationLarge cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s
Non Hodgkin s Lymphoma Introduction 6th most common cause of cancer death in United States. Increasing in incidence and mortality. Since 1970, the incidence of has almost doubled. Overview The types of
More informationQ&A Session Collecting Cancer Data: Hematopoietic and Lymphoid Neoplasms Thursday, November 6, 2014
Q&A Session Collecting Cancer Data: Hematopoietic and Lymphoid Neoplasms Thursday, November 6, 2014 Q: If polycythemia ruba vera (PRV) or essential thrombocythemia (ET) is diagnosed by peripheral smear,
More informationConjunctival CD5+ MALT lymphoma and review of literatures
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Conjunctival CD5+ MALT lymphoma and review of literatures M Fard Citation M Fard. Conjunctival CD5+ MALT lymphoma and review of literatures.
More informationDr Rodney Itaki Lecturer Anatomical Pathology Discipline
Lymphoid Neoplasia & Hodgkin s Disease Dr Rodney Itaki Lecturer Anatomical Pathology Discipline Lymphomas Are neoplasms of lymphoid cells. Classified as: Hodgkin Disease (30%) Non-Hodgkin lymphoma (70%).
More informationPlasma cell myeloma (multiple myeloma)
Plasma cell myeloma (multiple myeloma) Common lymphoid neoplasm, present at old age (70 years average) Remember: plasma cells are terminally differentiated B-lymphocytes that produces antibodies. B-cells
More informationLymphoma/CLL 101: Know your Subtype. Dr. David Macdonald Hematologist, The Ottawa Hospital
Lymphoma/CLL 101: Know your Subtype Dr. David Macdonald Hematologist, The Ottawa Hospital Function of the Lymph System Lymph Node Lymphocytes B-cells develop in the bone marrow and influence the immune
More informationCD5 Positive Follicular Lymphomas- A Diagnostic Dilemma in a Resource Restricted Laboratory Setting
Original Article DOI: 10.21276/APALM.1364 CD5 Positive Follicular Lymphomas- A Diagnostic Dilemma in a Resource Restricted Laboratory Setting Sakthi Sankari S 1 *, Arjunan A 2, Bhuvaneswari M.G. 2, Sindhuja
More information7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour
7 Omar Abu Reesh Dr. Ahmad Mansour Dr. Ahmad Mansour -Leukemia: neoplastic leukocytes circulating in the peripheral bloodstream. -Lymphoma: a neoplastic process in the lymph nodes, spleen or other lymphatic
More informationBurkitt lymphoma. Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8
Heme 8 Burkitt lymphoma Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8 Most common is t(8;14) Believed to be the fastest growing tumor in humans!!!! Morphology
More informationUpdate in Lymphoma Imaging
Update in Lymphoma Imaging Victorine V. Muse, MD Lymphoma Update in Lymphoma Imaging Victorine V Muse, MD Heterogeneous group of lymphoid neoplasms divided into two broad histological categories Hodgkin
More informationNodular lymphocyte predominant Hodgkin lymphoma. Lymphoma Tumor Board. January 5, 2018
Nodular lymphocyte predominant Hodgkin lymphoma Lymphoma Tumor Board January 5, 2018 Etiology Subtypes of Classical Hodgkin Lymphoma (chl)* Nodular sclerosing HL Most common subtype Composed of large tumor
More informationLymphoma Update: Lymphoma Update: What s Likely to be New in the New WHO. Patrick Treseler, MD, PhD University of California San Francisco
Lymphoma Update: What s Likely to be New in the New WHO Blood 127:2375; 2016 Patrick Treseler, MD, PhD University of California San Francisco Lymphoma Update: What IS New in the New WHO! Patrick Treseler,
More informationMantle Cell Lymphoma
HEMATOPATHOLOGY Original Article Mantle Cell Lymphoma Morphologic Findings in Bone Marrow Involvement JAY WASMAN, MD, 1 NANCY S. ROSENTHAL, MD,' AND DIANE C. FARHI, MD 2 Although mantle cell lymphoma (MCL),
More informationCD30 expression utilization for the accuracy of classical Hodgkin s lymphoma staging
Romanian Journal of Morphology and Embryology 2006, 47(2):113 117 ORIGINAL PAPER CD30 expression utilization for the accuracy of classical Hodgkin s lymphoma staging CORINA FLANGEA 1), ELENA POTENCZ 2),
More informationContents. vii. Preface... Acknowledgments... v xiii
Contents Preface... Acknowledgments... v xiii SECTION I 1. Introduction... 3 Knowledge-Based Diagnosis... 4 Systematic Examination of the Lymph Node... 7 Cell Type Identification... 9 Cell Size and Cellularity...
More information88-year-old Female with Lymphadenopathy. Faizi Ali, MD
88-year-old Female with Lymphadenopathy Faizi Ali, MD Clinical History A 88-year-old caucasian female presented to our hospital with the complaints of nausea, vomiting,diarrhea, shortness of breath and
More informationPearls and pitfalls in interpretation of lymphoid lesions in needle biopsies
Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies Megan S. Lim MD PhD University of Pennsylvania October 8, 2018 Objectives To understand how the trend toward less invasive lymph
More informationA Unique Case of Nasal NK/T Cell Lymphoma with Frequent Remission and Relapse Showing Different Histological Features During 12 Years of Follow Up
J Clin Exp Hematopathol Vol. 50, No. 1, May 2010 Case Study A Unique Case of Nasal NK/T Cell Lymphoma with Frequent Remission and Relapse Showing Different Histological Features During 12 Years of Follow
More informationCase Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent
Int J Clin Exp Med 2014;7(1):307-311 www.ijcem.com /ISSN:1940-5901/IJCEM1311029 Case Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent Qilin Ao 2, Ying Wang 1, Sanpeng Xu 2,
More informationGastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR
Gastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR Pages with reference to book, From 305 To 307 Irshad N. Soomro,Samina Noorali,Syed Abdul Aziz,Suhail Muzaffar,Shahid
More informationLymphatic system component
Introduction Lymphatic system component Statistics Overview Lymphoma Non Hodgkin s Lymphoma Non- Hodgkin's is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most
More informationSpectrum of Hodgkin s Disease in Children and Adults: Impact of Combined Morphologic and Phenotypic approach for exclusion of Look-alikes
Spectrum of Hodgkin s Disease in Children and Adults: Impact of Combined Morphologic and Phenotypic approach for exclusion of Look-alikes Pages with reference to book, From 211 To 214 Tanya Siddiqui,Shahid
More informationDETERMINATION OF A LYMPHOID PROCESS
Chapter 2 Applications of Touch Preparation Cytology to Intraoperative Consultations: Lymph Nodes and Extranodal Tissues for Evaluation of Hematolymphoid Disorders INTRODUCTION As discussed in Chap. 1,
More informationNAACCR Webinar Series 1
COLLECTING CANCER DATA: HEMATOPOIETIC AND LYMPHOID NEOPLASMS Jim Hofferkamp, CTR (jhofferkam@naaccr.org) Shannon Vann, CTR (svann@naaccr.org) Q&A Please submit all questions concerning webinar content
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Hodgkin s Lymphoma in Children Aged 6 Years Or Below- Long Term Follow Up Results Giri G V
More informationComposite mantle cell and follicular lymphoma. A case report
Human Pathology (2009) 40, 259 263 www.elsevier.com/locate/humpath Case study Composite mantle cell and follicular lymphoma. A case report Raquel B. Ilgenfritz MD a,, Agnès Le Tourneau MD a, Michel Arborio
More informationExploring the Borderlands between Diffuse Large B-cell Lymphoma and Classical Hodgkin s Lymphoma
Exploring the Borderlands between Diffuse Large B-cell Lymphoma and Classical Hodgkin s Lymphoma Elaine S. Jaffe National Cancer Institute Bethesda, MD, USA On the Pathological Changes In Hodgkin s Disease
More informationThe many faces of extranodal lymphoma
The many faces of extranodal lymphoma Frank Pameijer Departments of Radiology and Radiation Oncology University Medical Center Utrecht Special thanks to Ilona M Schmalfuss, MD University of Florida Gainesville,
More informationEctopic salivary tissue of the tonsil: a case report
International Journal of Pediatric Otorhinolaryngology (2005) 69, 567 571 www.elsevier.com/locate/ijporl CASE REPORT Ectopic salivary tissue of the tonsil: a case report Jeffrey B. Wise a,b, Kriti Sehgal
More informationLymphoma Read with the experts
Lymphoma Read with the experts Marc Seltzer, MD Associate Professor of Radiology Geisel School of Medicine at Dartmouth Director, PET-CT Course American College of Radiology Learning Objectives Recognize
More informationNasopharyngeal lymphoma (NPL) is a type of extranodal
Original Research Head and Neck Surgery Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population-Based Analysis of 1119 Cases Otolaryngology Head and Neck Surgery 2017, Vol. 156(5) 870
More informationA Report of a Rare Case of Anaplastic Large Cell Lymphoma of the Oral Cavity
AJMS Al Ameen J Med Sci (2 0 1 2 )5 (1 ):9 8-1 0 2 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G CASE REPORT A Report of a Rare Case of Anaplastic
More informationPattern of lymph node pathology in a private pathology laboratory
Malaysian J Parhol1999; 21(2): 87-93 Pattern of lymph node pathology in a private pathology laboratory LH KIM, BSc (Biomedical), SC PEH, MBBS, FRCPath, *K S CHAN, MBBS, MPath and SP CHAI, BSc (Biomedical)
More informationTest Utilization: Chronic Lymphocytic Leukemia
Test Utilization: Chronic Lymphocytic Leukemia Initial Evaluation Diagnostic Criteria Selection of Tests for Prognosis Response to Therapy Challenges Assessment for persistent disease Paul J. Kurtin, M.D.
More informationACHIEVING EXCELLENCE IN ABSTRACTING: LYMPHOMA
ACHIEVING EXCELLENCE IN ABSTRACTING: LYMPHOMA ACHIEVING EXCELLENCE IN ABSTRACTING LYMPHOMA Recoding Audit Performed in 2009 260 cases audited 17 data items audited per case 4420 possible discrepancies
More informationRituxan Hycela (rituximab and hyaluronidase human) (Subcutaneous)
Rituxan Hycela (rituximab and hyaluronidase human) (Subcutaneous) Document Number: IC-0322 Last Review Date: 02/06/2018 Date of Origin: 7/20/2010 Dates Reviewed: 09/2010, 12/2010, 02/2011, 03/2011, 05/2011,
More informationLymphocyte Predominant Hodgkin s Lymphoma. Case Presentation. How would you treat the patient?
Lymphocyte Predominant Hodgkin s Lymphoma Wei Ai, MD, PhD Assistant Clinical Professor University of California, San Francisco January 2010 Case Presentation 32 yo male, diagnosed with stage IIIA lymphocyte
More informationLymphoma co existing with Tuberculosis granulomatous
Available online at www.worldscientificnews.com WSN 90 (2017) 265-270 EISSN 2392-2192 SHORT COMMUNICATION Lymphoma co existing with Tuberculosis granulomatous Madeeha Subhan 1, *, Waleed Sadiq 2 1 Ayub
More informationDifferential diagnosis of hematolymphoid tumors composed of medium-sized cells. Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital
Differential diagnosis of hematolymphoid tumors composed of medium-sized cells Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital Lymphoma classification Lymphoma diagnosis starts with morphologic
More informationCLINICAL MEDICATION POLICY
CLINICAL MEDICATION POLICY Policy Name: Opdivo (nivolumab) injection Policy Number: Approved By: Medical Management, Clinical Pharmacy Products: Highmark Health Options Application: All participating hospitals
More informationHAEMATOLOGICAL MALIGNANCY
HAEMATOLOGICAL MALIGNANCY Reference Compulsory reading Haematology at Glance 2 nd ed. Atul Mehta & Victor Hoffbrand Chapters: 20 to 31 Pages: 46 to 69 Pathogenesis of Haematological Malignancy Figure (a)
More informationECP meeting, Lisbon, september 2012 Slide seminar New and old challenges in the diagnosis of peripheral T-cell lymphomas
ECP meeting, Lisbon, september 2012 Slide seminar New and old challenges in the diagnosis of peripheral T-cell lymphomas Philippe Gaulard, Dept of Pathology, INSERM U955, Hôpital Henri Mondor, 94010 -
More informationHIV and Malignancy Alaka Deshpande, Himanshu Soni
HIV and Malignancy Alaka Deshpande, Himanshu Soni Emergence of new infectious disease was documented in 1981. Within a short span of time it became a pandemic. It was Acquired Immunodeficiency Syndrome
More informationDeilson Elgui de Oliveira, MS, Maura M. Bacchi, MD, Eliane S. Abreu, MD, Ligia Niero-Melo, MD, and Carlos E. Bacchi, MD. Abstract
Hematopathology / HODGKIN DISEASE IN BRAZIL Hodgkin Disease in Adult and Juvenile Groups From Two Different Geographic Regions in Brazil Characterization of Clinicopathologic Aspects and Relationship With
More informationWHO Classification. B-cell chronic lymphocytic leukemia/small T-cell granular lymphocytic leukemia
Blood Malignancies-II Prof. Dr. Herman Hariman, a Ph.D, SpPK (KH). Prof. Dr. Adikoesoema Aman, SpPK (KH) Dept. of Clinical Pathology, School of Medicine, University of North Sumatra WHO classification
More informationYiyan Liu. 1. Introduction
AIDS Research and Treatment Volume 2012, Article ID 764291, 6 pages doi:10.1155/2012/764291 Clinical Study Concurrent FDG Avid Nasopharyngeal Lesion and Generalized Lymphadenopathy on PET-CT Imaging Is
More information3/24/2017 DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS. Disclosure of Relevant Financial Relationships
DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason L. Hornick, M.D., Ph.D. Director of Surgical Pathology and Immunohistochemistry Brigham and Women s Hospital Professor
More informationNon-Hodgkin lymphoma
Non-Hodgkin lymphoma Non-Hodgkin s lymphoma Definition: - clonal tumours of mature and immature B cells, T cells or NK cells - highly heterogeneous, both histologically and clinically Non-Hodgkin lymphoma
More informationVENTANA hematopathology solutions. Deliver diagnostic confidence
VENTANA hematopathology solutions Deliver diagnostic confidence 2 Hematopathology diagnostic solutions Contents VENTANA hematopathology assays 3 Detecting and subtyping hematological cancers 4 The importance
More informationMorphological Typing of Lymphomas with Immunohistochemistry
Indian Medical Gazette APRIL 2015 127 Original Article Morphological Typing of Lymphomas with Immunohistochemistry Aparna Bhardwaj, Assosciate Professor, Sanjeev Kishore, Professor Department of Pathology,
More informationHead and Neck Squamous Subtypes
1 Head and Neck Squamous Subtypes Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas HNSCC 5 th -6 th most common cancer 400,000/year 50% mortality Considerable
More informationCME/SAM. Olga Pozdnyakova, MD, PhD, 1 Svetlana Kondtratiev, MD, 1,2 Betty Li, MS, 1 Karry Charest, 1 and David M. Dorfman, MD, PhD 1.
Hematopathology / New Mastocytosis Flow Cytometry Approach High-Sensitivity Flow Cytometric Analysis for the Evaluation of Systemic Mastocytosis Including the Identification of a New Flow Cytometric Criterion
More information두경부영역의악성림프종 태경 1 이형석 1 서인석 1 이용섭 1 조석현 1 최정혜 2 안명주 2. Hodgkin s and Non-Hodgkin s Lymphoma of Head and Neck
KISEP Head and Neck Korean J Otolaryngol 2003;46:324-30 한양대학교의과대학이비인후과학교실, 1 내과학교실 2 태경 1 이형석 1 서인석 1 이용섭 1 조석현 1 최정혜 2 안명주 2 Hodgkin s and Non-Hodgkin s Lymphoma of Head and Neck Kyung Tae, MD 1, Hyung
More informationNON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary)
NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) Reviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and Dr.
More informationLYMPHOMAS an overview of some subtypes of NHLs
One of the confusing aspects of the lymphoid neoplasms concerns the use of the descriptive terms "leukemia" and "lymphoma." LYMPHOMAS an overview of some subtypes of NHLs Leukemia is used for lymphoid
More informationUtility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers
& 2012 USCAP, Inc. All rights reserved 0893-3952/12 $32.00 1637 Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers
More informationPage 1 of 9 Title Authored By Course No Contact Hours 2 ABCs of Lymphoma Anita Rothera RNC, BS, CDE LYM020108 Purpose The goal of this course is to help health care professionals learn about the different
More informationFine-Needle Aspiration Cytology in the Diagnosis of Lymphoma The Next Step
Fine-Needle Aspiration Cytology in the Diagnosis of Lymphoma The Next Step Linda M. Sandhaus, MD Since 985, almost 2 articles have been published in the medical literature on the subject of fine-needle
More informationPrimary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report Pages with reference to book, From 148 To 149 Suhail Muzaffar,Irshad Nabi Soomro,Naila Kayani,Shahid Siddiqui ( Departments of Pathology, The Aga
More informationVENTANA hematopathology solutions Comprehensive aids for detecting and subtyping
VENTANA hematopathology solutions Comprehensive aids for detecting and subtyping 1 12/4/2015 9:47:24 AM 2 Hematopathology diagnostic solutions Contents VENTANA hematopathology assays 3 Detecting and subtyping
More informationCystic carcinoma of the neck
Case Report Brunei Int Med J. 2010; 6 (1): 56-60 Cystic carcinoma of the neck Prathibha Parampalli SUBRHAMANYA, Ghazala KAFEEL, Hla OO, Pemasiri Upali TELISINGHE, Department of Pathology, RIPAS Hospital,
More informationUnknown Case 6. Ann T. Moriarty, MD
Unknown Case 6 Ann T. Moriarty, MD Unknown Case 6 61 year old male with an enlarged cervical lymph node. He has a history of lung carcinoma, renal cell carcinoma and lymphoma. Case 6 Image 1: Fine needle
More informationHemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma
Hemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma Katherine Devitt, M.D., Benjamin Chen, M.D., Ph.D., Hongbo Yu, M.D., Ph.D., Bruce Woda, M.D. 1 1 Department
More informationCase Report Esophageal Plasmacytoma Diagnosed in a Patient Presenting with Cardiac Symptoms: A Novel Case
Volume 2013, Article ID 121670, 4 pages http://dx.doi.org/10.1155/2013/121670 Case Report Esophageal Plasmacytoma Diagnosed in a Patient Presenting with Cardiac Symptoms: A Novel Case Cheryl Rimmer, 1
More informationBlastic NK-Cell Leukemia / Lymphoma
* * Blastic NK-Cell Leukemia / Lymphoma A Case Report Chun-Ming Lin Shu-Hui Wang Tseng-tong Kuo* Ching-Chi Chi Hsin-Chun Ho Hong-Shang Hong Blastic natural killer (NK) cell lymphoma / leukemia is a rare
More informationImmunophenotypic Profile of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia
Hematopathology / IMMUNOPHENOTYPE OF LPL/WM Immunophenotypic Profile of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Sergej Konoplev, MD, PhD, L. Jeffrey Medeiros, MD, Carlos E. Bueso-Ramos,
More informationExtranodal natural killer/t-cell lymphoma with long-term survival and repeated relapses: does it indicate the presence of indolent subtype?
VOLUME 47 ㆍ NUMBER 3 ㆍ September 2012 THE KOREAN JOURNAL OF HEMATOLOGY ORIGINAL ARTICLE Extranodal natural killer/t-cell lymphoma with long-term survival and repeated relapses: does it indicate the presence
More informationMany of the hematolymphoid disorders are derived
REVIEW ARTICLE Practical Immunohistochemistry in Hematopathology: A Review of Useful Antibodies for Diagnosis Ji Lu, MD and Karen L. Chang, MD Abstract: This review article offers some useful panels of
More informationT cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma
T cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma Sylvia Hartmann Dr. Senckenberg Institute of Pathology Goethe University Frankfurt Overview Borderline ALCL classical HL Borderline
More informationProtocol for the Examination of Specimens From Patients With Hodgkin Lymphoma
Protocol for the Examination of Specimens From Patients With Hodgkin Lymphoma Protocol applies to Hodgkin lymphoma involving any site. # Based on AJCC/UICC TNM, 7 th Edition Protocol web posting date:
More informationUsefulness of K-i (CD-30) Marker in Hodgkin s Disease
Usefulness of K-i (CD-30) Marker in Hodgkin s Disease K.A. Shakoor,A. Saleh,M.S. Khanzada ( Department of Pathology, BMSI, Jinnah Postgraduate Medical Centre, Karachi. ) Abstract Objective:To identify
More information10/31/2017. Immunodeficiencies. Outline. Discuss EBV. Non-destructive Polymorphic Monomorphic Therapies Challenges
I have no financial disclosures Joo Y. Song, MD Assistant Professor of Clinical Pathology City of Hope National Medical Center Immunodeficiencies Outline Transplant Congenital Autoimmunity T-cell/immune
More informationClusterin Expression Correlates With Stage and Presence of Large Cells in Mycosis Fungoides
Anatomic Pathology / Clusterin Expression in Mycosis Fungoides Clusterin Expression Correlates With Stage and Presence of Large Cells in Mycosis Fungoides Pranil Chandra, DO, 1 Jose A. Plaza, MD, 2,4 Zhuang
More informationChapter 4. F.H. Heyning 1, P.C.W. Hogendoorn 2, M.H.H. Kramer 3, C.T.Q. Holland 2, E. Dreef 2, P.M. Jansen 2
Primary Lymphoma of Bone: Extranodal Lymphoma with Favourable Survival Independent of Germinal Centre, Post Germinal Centre, or Indeterminate Phenotype F.H. Heyning 1, P.C.W. Hogendoorn 2, M.H.H. Kramer
More informationBone Marrow Involvement in Malignant Lymphomas (Non-Hodgkin ' s) Eman Sadiq Jalal MSc
MSc Abstract: Background: Bone marrow biopsies are taken routinely in the initial investigation of patients with non-hodgkin, s lymphomas to estimate the progression of disease at time of presentation
More information, , 2011 HODGKIN LYMPHOMA
European Federation of Cytology Societies 4tu Annual Tutorial in Cytopathology Trieste, June 6-10, 2011 HODGKIN LYMPHOMA Classification The World Health Organization Classification of Lymphomas (2001)
More informationFollicular dendritic cell sarcoma of inguinal lymph node A case report
Malaysian J Pathol 2008; 30(2) : 115 119 CASE REPORT Follicular dendritic cell sarcoma of inguinal lymph node A case report Jayalakshmi PAILOOR, MPath, FRCPath, Krishnan R IYENGAR, MD, DNB, CHAN KS, MPath*
More informationNeoplasms/Lymphoma/Leukemia
Neoplasms/Lymphoma/Leukemia Session Guidelines This is a 15 minute webinar session for CNC physicians and staff CNC holds webinars monthly to address topics related to risk adjustment documentation and
More informationUnderstanding your diagnosis. Dr Graham Collins Consultant Haemtologist Oxford University Hospitals
Understanding your diagnosis Dr Graham Collins Consultant Haemtologist Oxford University Hospitals Common questions I get asked What is lymphoma? What subtype do I have and what does that mean? What are
More informationHepatic Lymphoma Diagnosis An Algorithmic Approach
Hepatic Lymphoma Diagnosis An Algorithmic Approach Ryan M. Gill, M.D., Ph.D. University of California, San Francisco PLEASE TURN OFF YOUR CELL PHONES Disclosure of Relevant Financial Relationships USCAP
More informationJKAU: Med. Sci., Vol. 14 No. 1, pp: 3-17 (2007 A.D. / 1428 A.H.) Composite Lymphoma
JKAU: Med. Sci., Vol. 14 No. 1, pp: 3-17 (2007 A.D. / 1428 A.H.) Composite Lymphoma Fadwa J. Altaf, FRCPC, F. I. A. C and Jaudah A. Al Maghrabi, FRCPC, FCAP Department of Pathology, Faculty of Medicine
More informationLymphoma. Types of Lymphoma. Clinical signs
Lymphoma Lymphoma is a tumour originating from lymphoid tissue, either nodal (lymph ) or extranodal (thymus, spleen, mucosa, conjunctiva, or skin-associated lymphoid tissue). It is one of the most common
More informationPathology #07. Hussein Al-Sa di. Dr. Sohaib Al-Khatib. Mature B-Cell Neoplasm. 0 P a g e
Pathology #07 Mature B-Cell Neoplasm Hussein Al-Sa di Dr. Sohaib Al-Khatib 0 P a g e Thursday 18/2/2016 Our lecture today (with the next 2 lectures) will be about lymphoid tumors This is a little bit long
More informationMECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA. April 16, 2008
MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA April 16, 2008 FACULTY COPY GOAL: Learn the appearance of normal peripheral blood elements and lymph nodes. Recognize abnormal peripheral blood
More information3.1 Introduction. It is emphasised that not all tests are necessarily required in every case. 3.2 Taxonomic structure
CHAPTER 3 CLASSIFICATION 3.1 Introduction Accurate diagnosis underpins lymphoma management. Historically, competing lymphoma classifications have been a source of frustration to pathologists, clinicians
More informationRare Dermatologic Condition That Belongs in the Differential of Granulomatous Cutaneous Disorders
Rare Dermatologic Condition That Belongs in the Differential of Granulomatous Cutaneous Disorders 2013 Annual Meeting of the Medical Dermatology Society February 28, 2013 Amanda Champlain MD, Emily Keimig
More informationUpdate on the Classification of Aggressive B-cell Lymphomas and Hodgkin Lymphoma
Update on the Classification of Aggressive B-cell Lymphomas and Hodgkin Lymphoma Nancy Lee Harris, M. D. Massachusetts General Hospital Harvard Medical School Aggressive B-cell Lymphomas WHO 4 th Edition
More information