Nodal Melanocytic Nevi in Sentinel Lymph Nodes Correlation With Melanoma-Associated Cutaneous Nevi
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1 Anatomic Pathology / NODAL NEVI IN SENTINEL NODES Melanocytic Nevi in Sentinel Lymph Nodes Correlation With Melanoma-Associated Cutaneous Nevi John B. Holt, MD, 1 Omar P. Sangueza, 2 Edward A. Levine, MD, 3 Perry Shen, MD, 3 Simon Bergman, MD, 2 Kim R. Geisinger, MD, 2 and Andrew J. Creager, MD 1 Key Words: nevus; Sentinel lymph node; Melanocytic nevus; Breslow thickness; Congenital; Lymph node capsule DOI: /Y5QAD623MYA21PUY Abstract Melanocytic nevi occurring in lymph nodes create diagnostic difficulty by mimicking metastases. Few studies describe nodal nevi in sentinel lymph nodes (SLNs) excised for melanoma. We evaluated 72 cases in which patients had undergone SLN biopsy for melanoma. Lymph nodes and cutaneous melanomas were evaluated according to a standard protocol. nevi were identified in 8 patients (11%). Of these, 6 (75%) had an associated cutaneous nevus (P =.006). Of 21 patients with an associated nevus, 4 (19%) with nodal nevi had a cutaneous nevus with congenital features (P =.01). The incidence of nodal nevus correlated with a Breslow thickness greater than 2.5 mm (P =.02). Nevi were not seen in non-slns. nevi appear more frequently in patients with melanomaassociated cutaneous nevi, particularly if congenital features are present. The increased frequency of nodal nevi in SLNs relative to non-slns suggests an etiology of mechanical transport of nevus cells. Descriptions of intranodal melanocytic nevocellular inclusions (nodal nevi) have been reported periodically over the years. 1-5 nevi predominantly form compact focal aggregates in the fibrous capsule and trabeculae of lymph nodes, although they recently have been described in the nodal parenchyma and sinusoids. 6 The incidence in regional lymph nodes excised for malignancy has been reported to be between 1% and 22%. 5,7,8 From a diagnostic standpoint, nodal nevi might mimic metastases when encountered in regional lymph nodes evaluated for staging patients with melanoma, and it has been reported that their occurrence in this group of patients is greater than in people undergoing regional lymph node excisions for other malignant neoplasms. 7,9,10 The mechanism by which benign melanocytes are transported to lymph nodes is the subject of controversy. Prevailing theories include lymphatic transfer of melanocytes from a cutaneous nevus to a lymph node in the lymphatic drainage basin 3,7 and an embryologic phenomenon whereby neural crest derived melanocytes are transported to lymph nodes during in utero migration. The increasing popularity of sentinel lymph node (SLN) mapping in patients with melanoma in conjunction with more stringent evaluation techniques has led to increased frequency of discovery of nodal nevi in regional lymph nodes excised for the treatment of melanoma. 7 In addition, a correlation between the frequency of nodal nevi and the presence of melanomaassociated cutaneous nevi including those with congenital features has been reported. 7,11 Distinguishing benign nodal nevi from melanoma metastases to an SLN may be difficult, and it is of critical importance for the determination of prognosis and systemic treatment. 12 To our knowledge, only 2 systematic studies describing the characteristics of nodal nevi 58 Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY
2 Anatomic Pathology / ORIGINAL ARTICLE in SLNs excised for melanoma have been published. 7,11 SLN biopsy is an accepted staging procedure, and we expect that it will be used even more widely in the future. Accordingly, the diagnostic dilemma imposed by nodal nevi will continue to be encountered in this setting. 13,14 For this reason, we conducted the present retrospective study in an attempt to define further the features of nodal nevi in patients with melanoma. Materials and Methods Between December 1998 and March 2002, material from all SLN mapping procedures performed for melanoma at the Wake Forest University Baptist Medical Center, Winston-Salem, NC, was retrieved. Only cases in which the corresponding primary melanoma had been reviewed were included in the study. Melanoma was categorized by specific subtypes, Clark level, Breslow thickness, and the presence and type of preexisting melanoma-associated cutaneous nevi. The morphologic features of any associated precursor melanocytic lesion were characterized with particular attention given to the presence or absence of congenital features. For the purposes of this study, congenital features included small cutaneous nevi demonstrating the presence of nevus cells in the lower two thirds of the dermis; splaying of collagen bundles by singly or vertically oriented linear arrays of nevus cells; and extension of cells around nerves, vessels, and adnexa, as previously described. 15 We acknowledge that there is overlap in the histologic features of congenital vs acquired nevi; however, for the purposes of this study, the cutaneous nevi with the aforementioned histologic features were considered to be congenital. In addition, the presence or absence of a geographically separate non melanoma-associated melanocytic lesion in the wide excision specimen was noted. A standard protocol was used to identify the SLN. The tumor bed was injected with technetium sulfur colloid ( mci [ MBq]) preoperatively. A lymphoscintigram was obtained in the nuclear medicine department before the patient s arrival in the operative suite, and a gamma probe (Neoprobe 2000, Neoprobe, Dublin, OH) was used intraoperatively to detect the SLNs. In addition, in all cases, perilesional intradermal injections of isosulfan blue were used intraoperatively to provide visual identification of the SLNs. SLNs then were harvested and sent fresh to the pathology department for intraoperative evaluation and subsequent permanent section evaluation. The SLN was obtained as the initial phase of the surgical procedure, with excision of the primary lesion generally being performed during intraoperative pathologic evaluation of the SLN. This minimized the impact of intraoperative evaluation on the total surgical time. Intraoperative evaluations were performed by imprint cytology as previously described 16 and, if positive, resulted in immediate regional lymph node dissection. If the intraoperative evaluation was not performed, then a lymph node dissection was not performed during the same procedure. SLNs were bisected along the long axis, fixed in 10% buffered formalin, processed in the usual manner, and paraffin embedded. A single H&E-stained section of the paraffin block was examined initially. If this section was negative for melanoma, 3 additional H&E-stained levels cut at 50-µm intervals in conjunction with immunohistochemical stains for S-100 and HMB-45 (DAKO, Carpinteria, CA) on the first of the 3 levels were evaluated. Immunohistochemical studies were performed using the avidin-biotin-peroxidase complex method. 17 Primary antibodies included S-100 and HMB-45. Immunohistochemical stains were considered positive for malignant melanoma if immunoreactivity was detected in cell clusters or individual cells that demonstrated architectural and cytologic features of metastatic tumor cells Image 1 and Image 2. All metastases were compared with the primary melanoma. When discrepancies existed between the intraoperative and permanent section diagnoses, slides were reviewed in an attempt to determine the cause of the discrepancy. nevi were defined as bland nevocellular aggregates cytologically resembling those found in the intradermal component of the associated cutaneous nevus, when present. Generally, inclusions consisted of compact aggregates of cells with pale homogeneous eosinophilic cytoplasm and inconspicuous melanin pigment, indistinct cytoplasmic borders, round nuclei with delicate chromatin, inconspicuous basophilic nucleoli, and minimal, if any, mitotic activity Image 3 and Image 4. Stereotypical locations in the lymph node included the fibrous capsule and trabeculae, although care was exercised to identify nodal nevi in the parenchyma and subcapsular sinus, as recently described. 6 In all cases, nodal nevi were compared with the primary melanoma and any associated cutaneous nevus to distinguish cytologic differences. Non-SLNs were examined using standard pathologic techniques. If the non-slns were more than 4 mm wide, they were sectioned; if they were less than 4 mm wide, the non-slns were submitted whole. Routinely, a single H&Estained section of the non-slns was examined, but in select cases, multiple levels were obtained in an attempt to verify the presence of metastases. Statistical comparisons were made using the Fisher exact test. Results A total of 72 cases with 198 SLNs (mean, 2.8 per patient) were suitable for inclusion in the study. The patients Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY 59
3 Holt et al / NODAL NEVI IN SENTINEL NODES were 48 males and 24 females with an age range of 11 to 82 years (mean, 54.8 years). Primary melanomas were located on the head and neck in 19 patients, the trunk in 32 patients, the upper extremity in 10 patients, and the lower extremity in 11 patients. The types were as follows: nodular, 31 (6 with associated cutaneous nevi); superficial spreading, 25 (15 with associated cutaneous nevi); lentigo maligna melanoma, 6 (0 with associated cutaneous nevi); desmoplastic, 6 (0 with associated cutaneous nevi); and not specified, 4 (0 with associated cutaneous nevi). The Clark levels of the primary melanomas were as follows: level II, 5; level III, 14; level IV, 49; and level V, 4 (mean, 3.7). The Breslow thickness ranged from 0.52 to 8.5 mm (mean, 2.3 mm). Twenty-six patients additionally underwent completion regional lymph node dissection, yielding 287 non-slns. Image 1 A small cluster of melanocytes subjacent to the lymph node capsule demonstrates cytologic atypia typical of metastatic melanoma (H&E, 40). Image 2 The cells of the metastatic melanoma demonstrate strong expression of S-100 protein (hematoxylin counterstain, 40). Image 3 A cluster of melanocytes embedded within the lymph node capsule shows typical features of a nodal melanocytic nevus. The cells demonstrate a nested, more orderly appearance with bland cytologic features (H&E, 20). Image 4 The nevus also demonstrates strong expression of S-100. Cytologic features, mitotic rate, and other markers (such as Ki-67) might be necessary to distinguish a nodal melanocytic nevus from metastatic melanoma (Hematoxylin counterstain, 20). 60 Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY
4 Anatomic Pathology / ORIGINAL ARTICLE Eighteen patients had SLNs containing metastatic melanoma, all of which were detected on the initial H&E-stained section evaluation. nevi were identified in 8 patients (11%) and 10 SLNs (5%). Of these, 6 patients (75%) with 8 SLNs (80%) had a melanoma-associated precursor melanocytic lesion (P =.006 and P =.002, respectively) Table 1. All nodal nevi were detected in the initial H&E-stained sections and were located in the lymph node capsule and/or trabeculae. All nodal nevi were positive for S-100 protein, while only 3 were positive for HMB-45. HMB-45 immunoreactivity in nodal nevi tended to be focal and weak, while metastatic melanoma cells demonstrated diffuse, strong immunoreactivity. Of 21 patients with a melanoma-associated precursor melanocytic lesion, 4 patients (19%) with 6 SLNs (9%) had nodal nevi when the lesion demonstrated congenital features (P =.01 and P =.004, respectively) Table 2. The presence of nodal nevi was associated with a Breslow thickness greater than 2.5 mm Table 3. When a separate cutaneous nevus (not associated with the primary melanoma) was present in the excision, no correlation with nodal nevi could be identified Table 4. For patients who underwent SLN biopsy followed by completion regional lymph node dissection, no nodal nevi were identified in non-slns. Only 1 patient had a lymph node with both a nevus and a metastatic melanoma, a coincidence that did not reach statistical significance (P =.67 per patient; P = 1.0 per SLN). Discussion Since the initial description of benign nodal nevi by Stewart and Copeland 1 in 1931, controversy has existed regarding the means whereby benign nevocellular aggregates come to reside in lymph nodes, and this issue is largely unresolved. Both embryologic and mechanical transport hypotheses have been postulated. 2,7,8,11,18-21 The majority of investigators believe these inclusions to be benign, and similarities between nodal nevus cells and cutaneous nevocytes have been documented by electron microscopic and immunohistochemical studies. 9,10,22,23 A recent study demonstrated some immunohistochemical differences between nodal nevi and primary melanomas in an attempt to aid in their distinction. 12 Substantial evidence favors the mechanical transport hypothesis. Early observations of cutaneous blue nevi that exhibited the apparent phenomenon of benign metastasis have been reported. 18,19,23,24 Studies have demonstrated an increased incidence of nodal nevi in the lymph nodes excised from the drainage basin of a primary melanoma compared with lymph nodes excised for other malignant neoplasms. 7,11 Correlations between the presence of nodal nevi and melanomas that have an associated precursor melanocytic lesion, with and without congenital features, have been reported. 7,10,11,25 In the present study, nodal nevi were found only in SLNs, and their correlation with the presence of Table 1 Nevi vs Melanoma-Associated Precursor Melanocytic Lesion (PML) Table 2 Nevi vs Precursor Melanocytic Lesion With Congenital Features (PML-CF) Nevus Present Nevus Absent Nevus Present Nevus Absent PML present 6 15 PML absent 2 49 PML present 8 57 PML absent * P =.006. P =.002. PML-CF present 4 1 PML-CF absent 2 14 PML-CF present 6 12 PML-CF absent 2 45 * P =.01. P =.004. Table 3 Nevi vs Breslow Thickness 2.5 mm >2.5 mm nevus present 3 3 nevus absent 15 0 nevus present 3 5 nevus absent 53 4 * P =.02. P = Table 4 Nevi vs Separate Melanocytic Lesion (SML) Nevus Present Nevus Absent SML present 3 13 SML absent 5 51 SML present 3 37 SML absent * P =.36. P =.43. Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY 61
5 Holt et al / NODAL NEVI IN SENTINEL NODES precursor melanocytic lesions, particularly those with congenital features, was confirmed. The high incidence of nodal nevi in SLNs strongly supports the hypothesis of mechanical transport through lymphatics, although it must be pointed out that the low coincidence (1 case) of metastatic melanoma in conjunction with nodal nevi in SLNs might confound this finding. This is an interesting finding, as increased Breslow thickness correlated significantly and independently with the presence of metastatic melanoma and with the presence of nodal nevi. In the context of a primary melanoma with an associated precursor melanocytic lesion, one potential explanation for the increased incidence of nodal nevi, particularly in SLNs, is that invading neoplastic melanocytes displace adjacent benign nevus cells that then are transported into lymphatics. Alternatively, the biopsy procedure itself might result in displacement of nevus cells into lymphatics, although this hypothesis is less attractive, as most nodal nevi in the capsule and trabeculae seem well encased in fibrous tissue, suggesting chronicity to their presence. In addition, a recent report of sinusoidal nevi 6 suggests that mechanical disruption might be involved, whether it occurs by biopsy or invading tumor. The relative paucity of descriptions of nodal nevi in deep intra-abdominal and intrathoracic lymph nodes, which presumably do not collect material from cutaneous drainage basins, also tends to support the mechanical transport theory, although, to our knowledge, this observation has not been well documented. Some have argued that the statistically significant association of nodal nevi with congenital nevi supports an embryologic origin. 11 In the present study, we compared melanomas with a melanoma-associated precursor melanocytic lesion or a geographically separate (non melanoma-associated) melanocytic lesion present in the wide excision specimen. If the embryologic hypothesis of nodal nevus origin is correct, then one would expect nodal nevi to occur with relatively equal frequency in patients from both of these categories. However, we demonstrated a statistically significant increased frequency of nodal nevi only in patients whose melanoma had an associated precursor melanocytic lesion (Table 4). If a mechanism exists that involves mechanical dislocation of nevocytes into lymphatics, it would intuitively make sense that nevi that show closer association with lymphatic vessels would be even more likely to exhibit benign metastasis behavior. Therefore, an increased frequency of nodal nevi when the associated precursor lesion has congenital features would be expected and was observed in this series. In the present study, no non-slns contained nevi. Previous studies describing the incidence of nodal nevi in lymph node dissections performed for other malignant neoplasms, such as breast or prostate carcinoma, have demonstrated a very low incidence of nodal nevi. 5,7,26,27 To our knowledge, only 1 other study exists that evaluated the incidence of nodal nevi in dissections for which SLNs and non-slns were distinguished. 7 By using large numbers of cases, that study identified an incidence of nodal nevi in non- SLNs removed for breast carcinoma of 0.1%, while 3.9% of SLNs and 1.0% of non-slns removed for melanoma contained nevi. While none of the non-slns in our series contained a nevus, this is almost certainly the result of the relatively smaller number of cases evaluated in our study and would suggest that the numeric power was insufficient to detect the low incidence of nodal nevi in non-slns. In addition, it should be noted that non-slns were not examined at multiple levels of section or with immunohistochemical analysis, as is our protocol with SLNs. As all metastases and capsular nevi in the present study were identified with H&E staining, this correlation seemed appropriate; however, bias likely exists. Furthermore, the accuracy of the SLN technique is less than 100%, which limits the conclusions that may be drawn regarding non-sentinel nodal nevi. It also is important to note that none of the intraoperative touch preparations that were made from SLN material were interpreted as false-positive as a result of nodal nevi. While definitive resolution of the question of nodal nevus origin awaits further study, we confirm the correlation between the incidence of nodal nevi and the presence of melanoma with an associated precursor melanocytic lesion. Moreover, the association of nodal nevi with Breslow thickness favors a mechanism of mechanical transport of benign nevocytes to lymph nodes. Although our study does not specifically address the issue, the appearance of nodal nevi in a large majority of SLNs for which there are no melanoma metastases might raise potential diagnostic and prognostic issues. From the 1 Department of Pathology, Duke University Medical Center, Durham, NC; and 2 Department of Pathology and 3 Surgical Oncology Service, Department of Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, NC. Address reprint requests to Dr Creager: Dept of Pathology, Box 3712, Duke University Medical Center, Durham, NC References 1. Stewart FW, Copeland MM. Neurogenic sarcoma. Am J Cancer. 1931;15: von Albertini M. Sur un cas de neuro-naevus avec metastase ganglionnaiere de meme caractere. Bull Soc Fr Dermatol Syphiligr. 1935;42: Johnson WT, Helwig EB. Benign nevus cells in the capsule of lymph nodes. Cancer. 1969;23: Hart WR. Primary nevus of a lymph node. Am J Clin Pathol. 1971;55: Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY
6 Anatomic Pathology / ORIGINAL ARTICLE 5. Ridolfi RL, Rosen PP, Thaler H. Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance. Cancer. 1977;39: Biddle DA, Evans HL, Kemp BL, et al. Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma. Am J Surg Pathol. 2003;27: Carson KF, Wen DR, Li PX, et al. nevi and cutaneous melanomas. Am J Surg Pathol. 1996;20: McCarthy SW, Palmer AA, Bale PM, et al. Naevus cells in lymph nodes. Pathology. 1974;6: Fisher CJ, Hill S, Millis RR. Benign lymph node inclusions mimicking metastatic carcinoma. J Clin Pathol. 1994;47: Hara K. Melanocytic lesions in lymph nodes associated with congenital naevus. Histopathology. 1993;23: Fontaine D, Parkhill W, Greer W, et al. Nevus cells in lymph nodes: an association with congenital cutaneous nevi. Am J Dermatopathol. 2002;24: Lohmann CM, Iversen K, Jungbluth AA, et al. Expression of melanocyte differentiation antigens and Ki-67 in nodal nevi and comparison of Ki-67 expression with metastatic melanoma. Am J Surg Pathol. 2002;26: Messina JL, Glass LF, Cruse CW, et al. Pathologic examination of the sentinel lymph node in malignant melanoma. Am J Surg Pathol. 1999;23: Cochran AJ. The pathologist s role in sentinel lymph node evaluation. Semin Nucl Med. 2000;30: Mark GJ, Mihm MC, Liteplo MG, et al. Congenital melanocytic nevi of the small and garment type: clinical, histologic, and ultrastructural studies. Hum Pathol. 1973;4: Creager AJ, Shiver SA, Shen P, et al. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Cancer. 2002;94: Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29: Goldman RL. Blue naevus of lymph node capsule: report of a unique case. Histopathology. 1981;5: Azzopardi JG, Ross CM, Frizzera G. Blue naevi of lymph node capsule. Histopathology. 1977;1: Bell ME, Hill DP, Bhargava MK. Lymphatic invasion in pigmented nevi. Am J Clin Pathol. 1979;72: Subramony C, Lewin JR. Nevus cells within lymph nodes: possible metastases from a benign intradermal nevus. Am J Clin Pathol. 1985;84: Erlandson RA, Rosen PP. Electron microscopy of a nevus cell aggregate associated with an axillary lymph node. Cancer. 1982;49: Epstein JI, Erlandson RA, Rosen PP. blue nevi: a study of three cases. Am J Surg Pathol. 1984;8: Lamovec J. Blue nevus of the lymph node capsule: report of a new case with review of the literature. Am J Clin Pathol. 1984;81: Hruban RH, Eckert F, Baricevic B. Melanocytes of a melanocytic nevus in a lymph node from a patient with a primary cutaneous melanoma associated with a small congenital nevus. Am J Dermatopathol. 1990;12: Andreola S, Clemente C. Nevus cells in axillary from radical mastectomy specimens. Pathol Res Pract. 1985;179: Bautista NC, Cohen S, Anders KH. Benign nevus cells in axillary lymph nodes: a prospective incidence and immunohistochemical study with literature review. Am J Clin Pathol. 1994;102: Am J Clin Pathol 2004;121: DOI: /Y5QAD623MYA21PUY 63
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