molecular oncology services

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1 Molecular Oncology molecular oncology services ATIENTS.ANSWERS.RESULTS. MARCH 2018 Information in this brochure is current as of March All content is subject to change. lease contact ARU Client Services at (800) with any questions or concerns.

2 ARU LABORATORIES As a nonprofit, academic institution of the University of Utah and its Department of athology, ARU believes in collaborating, sharing knowledge, and contributing to laboratory science in ways that benefit our clients and their patients. Our test menu is one of the broadest in the industry, encompassing more than 3,000 tests, including highly specialized and esoteric assays. We offer comprehensive testing in the areas of genetics, molecular oncology, pediatrics, and pain management, among others. ARU s clients include many of the nation s university teaching hospitals and children s hospitals, as well as multihospital groups, major commercial laboratories, and group purchasing organizations. We do not compete with our clients for physician office business, choosing instead to support clients existing test menus by offering highly complex assays and accompanying consultative support so clients can provide exceptional patient care in their local communities. Offering analytics, consulting, and decision support services, ARU provides clients with the utilization management tools necessary to prosper in this time of value-based care. Our UM+ program helps clients control utilization, reduce costs, and improve patient care. In addition, ARU is a worldwide leader in innovative laboratory research and development, led by the efforts of the ARU Institute for Clinical and Experimental athology. ARU s reputation for quality is supported by our ability to meet or exceed the requirements of multiple regulatory and accrediting agencies and organizations. ARU participates in the CA laboratory accreditation program and has CLIA certification through the Centers of Medicare and Medicaid Services. In December 2016, ARU earned accreditation to the ISO 15189:2012 standard under CA. We believe in collaborating, sharing knowledge, and contributing to laboratory science in ways that provide the best value for the patient. Together, ARU and its clients will improve patient care today and in the future. patients. answers. results. A laboratory test is more than a number; it is a person, an answer, a diagnosis

3 ARU LABORATORIES MOLECULAR ONCOLOGY SERVICES Molecular diagnostics is an important component of clinical oncology, supplying pertinent information for diagnosis, prognosis, and prediction of response to tailored chemotherapeutic agents. ARU Laboratories offers a wide range of molecular diagnostic tests designed to answer important clinical questions regarding diagnosis, prognosis, and pharmacogenetics. Using state-of-the-art methodologies, including fluorescence in situ hybridization (FISH), polymerase chain reaction (CR), and next-generation sequencing analysis, ARU Laboratories supplies pertinent clinical information for a variety of cancers. This brochure has been organized into two sections: 1 Test Categories, which includes diagnostic markers, pharmacogenetic markers, and prognostic markers 2 Diagnostic Categories/Tumor ARU Laboratories is committed to supplying high-quality molecular diagnostic testing in a timely fashion and will continuously expand its test menu as new procedures and markers of clinical utility are identified.

4 TEST CATEGORIES Diagnostic Markers p/19q Deletion by FISH Acute Lymphocytic Leukemia anel by FISH, Adult, BM Acute Lymphocytic Leukemia anel by FISH, ediatric, BM Acute Myeloid Leukemia anel by FISH, BM Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS) or Therapy- Related AML by FISH Aggressive B-Cell Lymphoma FISH Reflex, Tissue ALK Gene Rearrangements by FISH, Lung, BM B-Cell Clonality Screening (IgH and IgK) by CR, BM, FF BCL6 (3q27) Gene Rearrangement by FISH BCL6 Rearrangement (3q27), BM BCR-ABL1 Fusion t(9;22)(q34;q11.2) by FISH, BM BCR-ABL1 Major (p210),, BM BCR-ABL1 Minor (p190),, BM BCR-ABL1, Qualitative with Reflex to BCR-ABL1,, BM MALT1 (18q21) gene rearrangement by FISH, BM BRAF Codon 600 Mutation Detection by yrosequencing BRAF Codon 600 Mutation Detection with Reflex to MLH1 romoter Methylation Eosinophilia anel by FISH, BM ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH EWSR1 (22q12) Rearrangement by FISH EWSR1 (22q12) Gene Rearrangement by FISH Familial Adenomatous olyposis (AC) Familial Adenomatous olyposis anel: AC, (AC) and Deletion/, (MUTYH) 2 Mutations Familial Mutation, Target (HNCC/ Lynch Syndrome) FOXO1 (FKHR) (13q13) Gene Rearrangement by FISH FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH Gastrointestinal Hereditary Cancer anel, and, 16 Genes Gastrointestinal Stromal Tumor Mutation Hereditary Cancer anel,, 36 Genes Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel Hereditary araganglioma-heochromocytoma (SDHB) and, BM BRAF V600E Mutation Detection in Hairy Cell Leukemia by Real-Time CR,, BM Hereditary araganglioma-heochromocytoma (SDHC) and CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM Hereditary araganglioma-heochromocytoma (SDHD) and CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM CBFB-MYH11 inv(16) Detection,, BM HNCC/Lynch Syndrome (MLH1) and Central Nervous System Hereditary Cancer anel, and, 15 Genes HNCC/Lynch Syndrome (MSH2) and Chromosone Analysis, Bone Marrow BM Chromosome Analysis, Lymph Node HNCC/Lynch Syndrome (MSH6) and Chromosome Analysis, Leukemic Blood Chromosone Analysis, Solid Tumor HNCC/Lynch Syndrome (MS2) and Cytogenomic Molecular Inversion robe Array, FFE Tissue Oncology HNCC/Lynch Syndrome MLH1, MSH2, MSH6, or MS Cytogenomic SN Microarray, Oncology, BM DDIT3 (CHO) (12q13) Gene Rearrangement by FISH DDIT3 (CHO) (12q13) Gene Rearrangement by FISH +, T EGFR Mutation Detection by yrosequencing, FNA Endocrine Hereditary Cancer anel, and, 13 Genes Hyperdiploidy with Trisomy 4 and 10 for ediatric ALL, BM IGH Rearrangement 14q32, BM IGH-BCL2 Fusion, t(14;18) by FISH IGH-BCL2 Fusion, t(14;18)(q32;q21) by FISH, BM IGH-CCND1 Fusion, t(11;14) by FISH IGH-CCND1 Fusion, t(11;14)(q13;q32) by FISH, BM + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit

5 TEST CATEGORIES Diagnostic Markers, continued IGH-MYC Fusion, t(8;14) by FISH JAK2 Exon 12 Mutation Analysis by CR, BM JAK2 Gene, V617F Mutation, Qualitative, BM JAK2 Gene, V617F Mutation, Qualitative with Reflex to JAK2 Exon 12 Mutation Analysis by CR JAK2 Gene, V617F Mutation, Qualitative with Reflex to CALR (Calreticulin) Exon 9 Mutation Analysis by CR with Reflex to ML codon 515 Mutation Detection by yrosequencing, JAK2 Gene, V617F Mutation, Juvenile olyposis (SMAD4) Juvenile olyposis (SMAD4) and, BM, BM Juvenile olyposis Syndrome (BMR1A) Juvenile olyposis Syndrome (BMR1A) and KIT (D816V) Mutation by CR KIT Mutations in AML by Fragment Analysis and KIT Mutations, Melanoma Li-Fraumeni (T53) Li-Fraumeni (T53) and Deletion/ Melanoma Hereditary Cancer anel, and, 6 Genes MGMT Methylation Detection by CR Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR, BM,, FF, BM MYD88 L265 Mutation Detection by CR,, BM, ancreatobiliary FISH VARIES CA3 rostate Cancer Biomarker UR DGFRA Rearrangement 4q12 by FISH, BM DGFRB Rearrangement 5q33.1 by FISH, BM ML-RARA Translocation, t(15;17) by RT-CR, ML-RARA Translocation by FISH BM TEN-Related Disorders (TEN) TEN-Related Disorders (TEN) and Renal Hereditary Cancer anel, and, 15 Genes RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, SS18 (SYT) (18q11) Gene Rearrangement by FISH, BM, BM, BM SS18 (SYT) Rearrangement by FISH +, T T-Cell Clonality Screening by CR, BM, FF, TCF3 (E2A) Rearrangement 19p13 by FISH, BM UroVysion FISH UR von Hippel-Lindau (VHL) von Hippel-Lindau (VHL) and Deletion/ MLH1 romoter Methylation, araffin ML Codon 515 Mutation Detection by yrosequencing, Multiple Endocrine Neoplasia (MEN1) Multiple Endocrine Neoplasia (MEN1) and Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by MUTYH-Associated olyposis (MUTYH) 2 Mutations MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to MUTYH-Associated olyposis (MUTYH) MYC (8q24) Gene Rearrangement by FISH MYC Rearrangement 8q24 by FISH, BM MYCN (N-MYC) Gene Rearrangement by FISH FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine

6 TEST CATEGORIES harmacogenetic and Targeted Therapy Markers Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 7 Mutations KIT (D816V) Mutation by CR, BM,, FF ALK Gene Rearrangements by FISH, Lung BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH KIT Mutations, Melanoma KRAS Mutation Detection BCR-ABL1 Mutation Analysis by Next-Generation, BM KRAS Mutation Detection with Reflex to BRAF Codon 600 Mutation Detection BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR Lung Cancer anel Lung Cancer anel with KRAS Colon Cancer Gene anel, Somatic Cytochrome 450 2C19 (CY2C19) 9 Mutations Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations Cytochrome 450 2C9 (CY2C9) 2 Mutations NRAS Mutation Detection by yrosequencing Cytochrome 450 2D6 (CY2D6) 15 Variants and Gene DGFRA by FISH, BM DGFRB by FISH, BM EGFR Mutation Detection by yrosequencing, FNA ML-RARA Translocation by FISH, BM EGFR T790M Mutation Detection in Circulating Tumor DNA by Digital Droplet CR ML-RARA Translocation, t(15;17) by RT-CR,, BM ERBB2 (HER-2/neu) Gene Amplification by FISH Solid Tumor Mutation anel by Next-Generation, FNA LeukoStrat CDx FLT3 Mutation Detection by CR, BM Gastrointestinal Stromal Tumor Mutation UD-Glucuronosyltransferase 1A1 (UGT1A1) Genotyping rognostic Markers Aggressive B-Cell Lymphoma FISH Reflex, Tissue BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM Cancer anel, Hereditary, and, 47 Genes BCR-ABL1 Mutation Analysis by Next-Generation, BM CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM CBFB-MYH11 inv(16) Detection,, BM BCR-ABL1 Major (p210),, BM BCR-ABL1 Minor (p190),, BM CEBA Mutation Detection, BM Chronic Lymphocytic Leukemia (CLL) anel by FISH, BM BCR-ABL1 Qualitative with Reflex to BCR-ABL1, BM EGFR Gene Amplification by FISH EGFR Mutation Detection by yrosequencing, FNA Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) and Deletion/ Eosinophilia anel by FISH, BM ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH Familial Adenomatous olyposis (AC), BM Breast and Ovarian Hereditary Cancer anel, and, 20 Genes CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM Familial Adenomatous olyposis anel: (AC) and, (MUTYH) 2 Mutations + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit

7 TEST CATEGORIES rognostic Markers, continued Familial Mutation, Targeted (HNCC/ Lynch Syndrome) MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel MUTYH-Associated olyposis (MUTYH) MUTYH-Associated olyposis (MUTYH) 2 Mutations Myelodysplastic Syndrome (MDS) anel by FISH BM, Hereditary araganglioma-heochromocytoma (SDHB) and Hereditary araganglioma-heochromocytoma (SDHC) and NM1 Mutation Detection by RT-CR,, BM, CA3 rostate Cancer Biomarker by Transcription-Mediated Amplification ML-RARα FISH, BM UR Hereditary araganglioma-heochromocytoma (SDHD) and ML-RARA Translocation, t(15;17) by RT-CR,, BM HNCC/Lynch Syndrome (MLH1) and RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH, BM HNCC/Lynch Syndrome (MSH2) and RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection,, BM HNCC/Lynch Syndrome (MSH6) and TCF3 (E2A) Rearrangement, BM WT1 Mutations by, BM HNCC/Lynch Syndrome (MS2) and IDH1 and IDH2 Mutation Analysis, Exon 4, BM IDH1 and IDH2 Mutation Analysis, Exon 4, Formalin-Fixed, araffin-embedded (FFE) Tissue IGHV Mutation Analysis by, BM KIT Mutations in AML by Fragment Analysis and, BM LeukoStrat CDx FLT3 Mutation Detection by CR, BM Li-Fraumeni (T53) Li-Fraumeni (T53) and Deletion/ MET Gene Amplification by FISH Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR MLL Rearrangement 11q23 by FISH, BM Multiple Endocrine Neoplasia (MEN1) Multiple Endocrine Neoplasia (MEN1) and Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by Multiple Myeloma anel by FISH, BM FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine

8 Alveolar Rhabdomyosarcoma FKHR (FOX01) 13q13 by FISH FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH Bladder Cancer (Urothelial Carcinoma) UroVysion FISH UR Breast Cancer (Breast Carcinoma) Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) and Deletion/ DIAGNOSTIC CATEGORIES/TUMOR TYE HNCC/Lynch Syndrome (MLH1) and HNCC/Lynch Syndrome (MSH2) and HNCC/Lynch Syndrome (MSH6) and HNCC/Lynch Syndrome (MS2) and HNCC/Lynch Syndrome MLH1, MSH2, MSH6, or MS Juvenile olyposis (SMAD4) Breast and Ovarian Hereditary Cancer anel, and, 20 Genes Juvenile olyposis (SMAD4) and ERBB2 (HER-2/neu) Gene Amplification by FISH TEN-Related Disorders (TEN) TEN-Related Disorders (TEN) and Li-Fraumeni (T53) Li-Fraumeni (T53) and Deletion/ eutz-jeghers Syndrome (STK11) eutz-jeghers Syndrome (STK11) and Colon Cancer (Colonic Adenocarcinoma) 5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 7 Mutations BRAF Codon 600 Mutation Detection by yrosequencing BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR BRAF Codon 600 Mutation Detection with Reflex to MLH1 romoter Methylation Cancer anel, Hereditary,, 46 Genes Cancer anel, Hereditary, and, 47 Genes Colon Cancer Gene anel, Somatic Epi procolon Familial Adenomatous olyposis (AC) Familial Adenomatous olyposis anel: (AC) and, (MUTYH) 2 Mutations Familial Mutation, Targeted (HNCC/ Lynch Syndrome) Gastrointestinal Hereditary Cancer anel, and, 16 genes Juvenile olyposis Syndrome (BMR1A) Juvenile olyposis Syndrome (BMR1A) and KRAS Mutation Detection KRAS Mutation Detection with Reflex to BRAF Codon 600 Mutation Detection Li-Fraumeni (T53) Li-Fraumeni (T53) and Deletion/ Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR Mismatch Repair by IHC with Reflex to BRAF Codon 600 Mutation and MLH1 romoter Methylation MLH1 romoter Methylation, araffin MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to MUTYH-Associated olyposis (MUTYH) MUTYH-Associated olyposis (MUTYH) 2 Mutations NRAS Mutation Detection by yrosequencing eutz-jeghers Syndrome (STK11) eutz-jeghers Syndrome (STK11) and Solid Tumor Mutation anel by Next-Generation UD-Glucuronosyltransferase 1A1 (UGT1A1) Genotyping, FNA CNS/ Renal Cell Carcinoma/ heochromocytoma Central Nervous System Hereditary Cancer anel, and, 15 Genes von Hippel-Lindau (VHL) von Hippel-Lindau (VHL) and Deletion/ + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit

9 Endometrial Carcinoma Mismatch Repair by IHC with Reflex to MLH1 romoter Methylation Ewing Sarcoma EWSR1 (22q12) Gene Rearrangement by FISH EWSR1 Rearrangement by FISH + Gastrointestinal Stromal Tumor (GIST) Gastrointestinal Stromal Tumor Mutation DIAGNOSTIC CATEGORIES/TUMOR TYE Neuroblastoma MYCN (N-Myc) Gene Amplification by FISH Oligodendroglioma p/19q Deletion by FISH araganglioma/heochromocytoma Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel Solid Tumor Mutation anel by Next-Generation Glioblastoma EGFR Gene Amplification by FISH EGFR Mutation Detection by yrosequencing, FNA IDH1 and IDH2 Mutation Analysis, Exon MGMT Methylation Detection by CR Lung Carcinoma ALK Gene Rearrangements by FISH, Lung BRAF Codon 600 Mutation Detection by yrosequencing Hereditary araganglioma-heochromocytoma (SDHB) and Hereditary araganglioma-heochromocytoma (SDHC) and Hereditary araganglioma-heochromocytoma (SDHD) and arathyroid/ituitary/ancreatic Multiple Endocrine Neoplasia (MEN1) Multiple Endocrine Neoplasia (MEN1) and Round Cell/Myxoid Liposarcoma BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR DDIT3 (CHO) (12q13) Gene Rearrangement by FISH TOUCH RE, EGFR Mutation Detection by yrosequencing, FNA EGFR T790M Mutation Detection in Circulating Tumor DNA by Digital Droplet CR KRAS Mutation Detection Lung Cancer anel Lung Cancer anel with KRAS MET Gene Amplification by FISH RET Gene Rearrangements by FISH ROS1 by FISH Solid Tumor Mutation anel by Next-Generation Melanoma, FNA DDIT3 (CHO) (12q13) Gene Rearrangement by FISH MDM2 Gene Amplification by FISH Synovial Sarcoma SS18 (SYT) (18q11) Gene Rearrangement by FISH Systemic Mastocytosis KIT (D816V) Mutation by CR Thyroid Carcinoma BRAF Codon 600 Mutation Detection by yrosequencing BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR, BM, FF, BRAF Codon 600 Mutation Detection by yrosequencing Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR Cancer anel, Hereditary,, 46 Genes RET Gene Rearrangements by FISH Solid Tumor Mutation anel by Next-Generation, FNA KIT Mutations, Melanoma Melanoma Hereditary Cancer anel, and, 6 Genes NRAS Mutation Detection by yrosequencing Solid Tumor Mutation anel by Next-Generation, FNA FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine

10 Acute Lymphoblastic Leukemia (ALL) Acute Lymphocytic Leukemia (ALL) anel by FISH, Adult Acute Lymphocytic Leukemia (ALL) anel by FISH, ediatric LEUKEMIA/LYMHOMA BM, BM, BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM BCR-ABL1 Qualitative with Reflex to BCR-ABL1, BM BCR-ABL1 Minor (p190),, BM NM1 Mutation Detection by RT-CR, RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH, BM, FF,, BM, BM WT1 Mutations by, BM Acute romyelocytic Leukemia (AL) ML-RARA Translocation by FISH, BM BCR-ABL1 Mutation Analysis by Next-Generation, BM CDKN2 p16 Deletion 9p21 by FISH, BM ML-RARA Translocation, t(15;17) by RT-CR, B- and T-Cell Markers Lymphoma, BM Chromosome Analysis, Bone Marrow with Reflex to Genomic Microarray BM B-Cell Clonality Screening (IgH and IgK) by CR, BM, FF Chromosome Analysis, Leukemic Blood with Reflex to Genomic Microarray MYD88 L265 Mutation Detection by CR,, BM, Cytogenomic SN Microarray Oncology BM, ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH, BM Hyperdiploidy with Trisomy 4 and 10, BM IGH Rearrangement 14q32 by FISH, BM Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations MLL Rearrangement 11q23 by FISH, BM TCF3 (E2A) Rearrangement 19p13 by FISH, BM Acute Myelogenous Leukemia (AML) Acute Myeloid Leukemia anel by FISH, BM Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS) or Therapy- Related AML by FISH Bone Marrow Failure, 35 Genes, BM CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM CBFB-MYH11 inv(16) Detection,, BM CEBA Mutation Detection, BM Chromosome Analysis, Bone Marrow with Reflex to Genomic Microarray Cytogenomic SN Microarray Oncology BM, IDH1 and IDH2 Mutation Analysis, Exon 4, BM KIT Mutations in AML by Fragment Analysis and BM, BM LeukoStrat CDx FLT3 Mutation Detection by CR, BM MLL Rearrangement 11q23 by FISH, BM T-Cell Clonality Screening by CR Burkitt Lymphoma Aggressive B-Cell Lymphoma FISH Reflex, Tissue BCL6 (3q27) Gene Rearrangement by FISH IGH-MYC Fusion t(8;14) by FISH MYC (8q24) Gene Rearrangement by FISH, BM, FF, MYC Rearrangement 8q24 by FISH, BM Chronic Lymphocytic Leukemia (CLL) Chronic Lymphocytic Leukemia (CLL) anel by FISH, BM IGHV Mutation Analysis by, BM Chronic Myelogenous Leukemia (CML) BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM BCR-ABL1 Mutation Analysis by Next-Generation, BM BCR-ABL1 Major (p210),, BM BCR-ABL1 Minor (p190),, BM BCR-ABL1 Qualitative with Reflex to BCR-ABL1 Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations Follicular Lymphoma/Diffuse Large-Cell Lymphoma Aggressive B-Cell Lymphoma FISH Reflex, Tissue, BM BCL6 Rearrangement (3q27) by FISH, BM Myeloid Malignancies anel by Next-Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM BCL6 (3q27) Gene Rearrangement by FISH IGH-BCL2 Fusion, t(14;18)(q32;q21) by FISH, BM IGH-BCL2 Fusion, t(14;18) by FISH + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit

11 Hairy Cell Leukemia LEUKEMIA/LYMHOMA Myeloproliferative Neoplasms (MN) BRAF V600E Mutation Detection in Hairy Cell Leukemia by Real-Time CR, Lymphoproliferative Disorders (LD), BM Lymphoma (Aggressive) anel by FISH BM, Trisomy 12 by FISH, BM Mantle Cell Non-Hodgkins Lymphoma IGH Rearrangement by FISH, BM IGH-CCND1 Fusion, t(11;14) by FISH IGH-CCND1 Fusion, t(11;14)(q13;q32) by FISH, BM Marginal Zone B-Cell Lymphoma MALT1 (18q21) gene rearrangement by FISH BM, Multiple Myeloma Multiple Myeloma anel by FISH BM, Myelodysplastic Syndrome (MDS) 20q Deletion (D20S108) del(20)(q12) by FISH, BM 5q Deletion (EGR1)/Monosomy 5 del(5)(q31)/-5 by FISH 7q Deletion (D7S486)/Monosomy 7 del(7)(q31)/-7 by FISH Bone Marrow Failure, 35 Genes Cytogenomic Molecular Inversion robe Array, FFE Tissue Oncology, BM, BM Myelodysplastic Syndrome (MDS) anel by FISH BM, Myeloid Malignancies anel by Next-Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM Trisomy 8 by FISH, BM CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM Eosinophilia anel by FISH, BM JAK2 Exon 12 Mutation Analysis by CR BM, JAK2 Gene, V617F Mutation, Qualitative BM, JAK2 Gene, V617F Mutation, JAK2 Gene, V617F Mutation, Qualitative with Reflex to JAK2 Exon 12 Mutation Analysis by CR JAK2 Gene, V617F Mutation, Qualitative with Reflex to CALR (Calreticulin) Exon 9 Mutation Analysis by CR with Reflex to ML codon 515 Mutation Detection by yrosequencing, ML Codon 515 Mutation Detection by yrosequencing, Myeloid Malignancies Mutation anel by Next Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM, BM, BM Myeloproliferative Disorders anel by FISH BM, DGFRA-FI1L1 Fusion by FISH (CHIC2 Deletion), BM DGFRB Rearrangement 5q33.1 by FISH, BM Trisomy 8 by FISH, BM Trisomy 9 by FISH, BM rimary Effusion Lymphoma Epstein-Barr Virus (EBV) by in situ Hybridization, araffin FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine

12 ARU LABORATORIES 500 Chipeta Way Salt Lake City, UT hone: (800) Fax: (801) ARU is a nonprofit enterprise of the University of Utah and its Department of athology ARU Laboratories BD-TS-026, Rev 8, March 2018