What are the new AJCC Staging System changes, and how will they affect my patients?
|
|
- Cory Norman
- 5 years ago
- Views:
Transcription
1 What are the new AJCC Staging System changes, and how will they affect my patients? Emily Y. Chu, M.D., Ph.D. Assistant Professor of Dermatology & Pathology and Laboratory Medicine University of Pennsylvania February 17, 2017 AAD Annual Meeting San Diego, CA
2 DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Emily Y. Chu, MD PhD S047: Managing Patients with Melanoma or Other Melanocytic Neoplasms DISCLOSURES I do not have any relevant relationships with industry.
3 Overview AJCC Staging System 7 th Edition (most recent, until December 31, 2017) 8 th Edition (January 1, 2018 present) Considerations beyond AJCC Staging
4 Why do we care about staging?
5 AJCC (American Joint Committee on Cancer) Creates cancer staging system Stratify patients according to survival 7 th edition (most recent system up until December 31, 2017) from ,000+ patients with melanoma confined to the skin (Stage I and II melanoma) Melanoma-specific survival
6 AJCC Staging System, 7 th Edition Thickness Ulceration 10-year survival Stage IA 1mm - and <1 mitosis 95% Stage IB Stage IIA Stage IIB 1mm + or 1 mitosis 1 2mm - 1 2mm + 2 4mm - 2 4mm + >4mm - 87% 68% 57% Stage IIC >4mm + 40%
7 AJCC Staging System, 7 th Edition Thickness Ulceration 10-year survival Stage IA 1mm - and <1 mitosis 95% Stage IB Stage IIA Stage IIB 1mm + or 1 mitosis 1 2mm - 1 2mm + 2 4mm - 2 4mm + >4mm - 87% 68% 57% Stage IIC >4mm + 40%
8
9
10 Changes for 2018 Different data set Include patients treated after the introduction of sentinel lymph node biopsy procedure Ten different centers around the world contributed data Different committee members
11 7 th Edition AJCC Staging System Thickness Ulceration Stage IA 1mm - and <1 mitosis Stage IB Stage IIA Stage IIB 1mm + or 1 mitosis 1 2mm - 1 2mm + 2 4mm - 2 4mm + >4mm - Stage IIC >4mm +
12 7th Edition AJCC Staging System Thickness Ulceration Stage IA 1mm - and <1 mitosis Stage IB Stage IIA Stage IIB 1mm + or 1 mitosis 1 2mm - 1 2mm + 2 4mm - 2 4mm + >4mm - Stage IIC >4mm +
13 Changes for 2018 Mitoses are no longer included Instead, for lesions <1mm, thickness of 0.8mm is used for stratification Stage IA: no ulceration, <0.8mm Stage IB: ulceration OR 0.8 1mm
14 Changes for 2018 Mitoses are no longer included Instead, for lesions <1mm, thickness of 0.8mm is used for stratification Stage IA: no ulceration, <0.8mm Stage IB: ulceration OR 0.8 1mm <0.8mm, -ulceration = IA <0.8mm, +ulceration = IB 0.8-1mm (regardless of ulceration) = IB
15 Mitoses are still important, though Among patients with clinically node-negative (cn0) primary melanoma in the 8th edition database, increasing mitotic rate was significantly associated with decreasing MSS in univariate analysis Gershenwald et al, Ca Cancer J Clin 2017
16 2018 AJCC Staging System Thickness Ulceration Stage IA <0.8mm - Stage IB Stage IIA Stage IIB <0.8mm mm +/- 1 2mm - 1 2mm + 2 4mm - 2 4mm + >4mm - Stage IIC >4mm +
17 Changes for 2018 Thickness reported to one decimal place rather than two 0.6 mm rather than 0.63 mm Gershenwald et al, Ca Cancer J Clin 2017
18 AJCC Staging System AJCC Staging System has strengths that are also limitations Designed for worldwide use Aim is simplicity and usability But does not capture all that we know
19 AJCC Staging System Limitations/Strengths: Can only include information that ALL pathologists can determine Limited number of characteristics TNM system: only includes tumor characteristics
20 SEX
21 SEX MEN WOMEN
22 SEX WORSE MEN BETTER WOMEN
23 ANATOMIC SITE (From Balch et al, Cutaneous Melanoma, 3 rd Ed.)
24 ANATOMIC SITE AXIAL EXTREMITIES
25 ANATOMIC SITE WORSE AXIAL BETTER EXTREMITIES
26 AGE YOUNGER OLDER
27 AGE BETTER YOUNGER WORSE OLDER
28 Patient characteristics Sex (male is worse) Body site (axial is worse) Age (older is worse) Balch CM, JCO 2001
29 Microscopic Features
30 Vertical Growth Phase
31 Regression
32 Tumor Infiltrating Lymphocytes (TILs) Melanoma Lymphocytes
33 Lymphovascular Invasion
34 Looking Beyond Thickness Survival Penn Pigmented Lesion Group stratification system
35 Penn Pigmented Lesion Group stratification system Vertical growth phase Thickness Mitotic rate Tumor-infiltrating lymphocytes Regression Sex Body site Lymphovascular invasion, ulceration, age
36 Penn Pigmented Lesion Group stratification system
37 Looking Beyond Thickness: Survival Penn System stratifies patients into 3 different groups Higher-risk patients get more frequent exams and may get screening imaging
38 Don t forget Second primary melanoma risk may also play a role in developing a management plan Personal factors Age/Co-morbidity Patient preference
39 Summary AJCC changes in 2018 for Stage I/II are only in Stage IA and IB 0.8mm as a factor instead of mitoses But mitoses are still important (and should still be reported) Other clinical and histopathologic factors also important
40 Penn Multidisciplinary Melanoma Program Medical Dermatology Medical Oncology Michael Ming Lynn Schuchter Rose Elenitsas Ravi Amaravadi Brian Capell Tara Gangadhar Dermatopathology Surgical Oncology Rose Elenitsas Giorgos Karakousis David Elder Derm Surgery George Xu Chris Miller Medical Genetics Joseph Sobanko Kate Nathanson Thuzar Shin Jeremy Etzkorn
41 Thank you!
Update on Genetic Testing for Melanoma
Update on Genetic Testing for Melanoma Emily Y. Chu, M.D., Ph.D. Assistant Professor of Dermatology & Pathology and Laboratory Medicine Hospital of the University of Pennsylvania February 18, 2018 AAD
More informationTranslating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy
American Academy of Dermatology 2018 Annual Meeting San Diego, CA, February 17, 2018 Translating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy Christopher Bichakjian,
More informationMelanoma Update: 8th Edition of AJCC Staging System
Melanoma Update: 8th Edition of AJCC Staging System Rosalie Elenitsas, M.D. Professor of Dermatology Director, Dermatopathology University of Pennsylvania DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY None
More informationAJCC 8 Implementation January 1, 2018 Melanoma of the Skin. Suraj Venna
AJCC 8 Implementation January 1, 2018 Melanoma of the Skin Suraj Venna Personalized Medicine AJCC 8 th Edition This Time It s Personal Traditional AJCC (TNM) population-based analyses of large databases
More informationControversies and Questions in the Surgical Treatment of Melanoma
Controversies and Questions in the Surgical Treatment of Melanoma Giorgos C. Karakousis, M.D. Assistant Professor of Surgery Division of Endocrine and Oncologic Surgery University of Pennsylvania School
More informationMelanoma Patients and the Sentinel Lymph Node (SLN) Procedure: An Oncologic Surgeon s Perspective
Melanoma Patients and the Sentinel Lymph Node (SLN) Procedure: An Oncologic Surgeon s Perspective Giorgos C. Karakousis, M.D. Associate Professor of Surgery Hospital of the University of Pennsylvania Disclosures
More informationTracking skin cancers and melanoma at the microscopic level
Tracking skin cancers and melanoma at the microscopic level Rosalie Elenitsas, M.D. Professor of Dermatology Director of Dermatopathology Hospital of the University of Pennsylvania May 12, 2017 Outline
More informationAdvances in Surgical Management of Primary Melanoma: Identifying Patients Who Need More than Conventional Wide Local Excision
Advances in Surgical Management of Primary Melanoma: Identifying Patients Who Need More than Conventional Wide Local Excision Christopher J. Miller, MD Director of Penn Dermatology Oncology Center Associate
More informationPractical Tips for Caring for Melanoma Patients
Practical Tips for Caring for Melanoma Patients Caroline C. Kim, MD, Director Assistant Professor, Department of Dermatology Harvard Medical School Director, Pigmented Lesion Clinic Associate Director,
More informationCase Scenario 1 Worksheet. Primary Site C44.4 Morphology 8743/3 Laterality 0 Stage/ Prognostic Factors
CASE SCENARIO 1 9/10/13 HISTORY: Patient is a 67-year-old white male and presents with lesion located 4-5cm above his right ear. The lesion has been present for years. No lymphadenopathy. 9/10/13 anterior
More informationQuality ID #397: Melanoma Reporting National Quality Strategy Domain: Communication and Care Coordination
Quality ID #397: Melanoma Reporting National Quality Strategy Domain: Communication and Care Coordination 2018 OPTIONS FOR INDIVIDUAL MEASURES: CLAIMS ONLY MEASURE TYPE: Outcome DESCRIPTION: Pathology
More informationMeasure #397: Melanoma Reporting National Quality Strategy Domain: Communication and Care Coordination
Measure #397: Melanoma Reporting National Quality Strategy Domain: Communication and Care Coordination 2017 OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY ONLY MEASURE TYPE: Outcome DESCRIPTION: Pathology reports
More informationUpdate on 8 th Edition Cutaneous AJCC Staging of Primary Cutaneous Melanoma. Michael T. Tetzlaff MD, PhD
Update on 8 th Edition Cutaneous AJCC Staging of Primary Cutaneous Melanoma Michael T. Tetzlaff MD, PhD Associate Professor Departments of Pathology (Dermatopathology) and Translational and Molecular Pathology
More informationSurgery for Melanoma and What s on the Horizon
and What s on the Horizon Giorgos C. Karakousis, M.D. Assistant Professor of Surgery Perelman School of Medicine at the University of Pennsylvania Background/Overview 76,870 cases of melanoma estimated
More information47. Melanoma of the Skin
1 Terms of Use The cancer staging form is a specific document in the patient record; it is not a substitute for documentation of history, physical examination, and staging evaluation, or for documenting
More informationWHAT DOES THE PATHOLOGY REPORT MEAN?
Melanoma WHAT IS MELANOMA? Melanoma is a type of cancer that affects cells called melanocytes. These cells are found mainly in skin but also in the lining of other areas such as nose and rectum, and also
More informationThin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis
Ann Surg Oncol DOI 10.1245/s10434-016-5646-9 ORIGINAL ARTICLE MELANOMAS Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis Giorgos
More informationI have no relevant conflicts of interest to disclose. John T. Seykora MD PhD Departments of Dermatology & Pathology and Laboratory Medicine
Molecular Characterization of Stage 1-3 Melanoma: Are we close to accurate prognostication and prediction? I have no relevant conflicts of interest to disclose. John T. Seykora MD PhD Departments of Dermatology
More informationPatient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival
MOLECULAR AND CLINICAL ONCOLOGY 7: 1083-1088, 2017 Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival FARUK TAS
More informationTalk to Your Doctor. Fact Sheet
Talk to Your Doctor Hearing the words you have skin cancer is overwhelming and would leave anyone with a lot of questions. If you have been diagnosed with Stage I or II cutaneous melanoma with no apparent
More informationSentinel Node Alphabet Soup: MSLT-1, DeCOG-SLT, MSLT-2, UNC
Sentinel Node Alphabet Soup: MSLT-1, DeCOG-SLT, MSLT-2, UNC David W. Ollila MD James and Jesse Millis Professor of Surgery University of North Carolina, Chapel Hill Disclosures: None July 15, 2018 AJCC
More informationMalignant Melanoma in Turkey: A Single Institution s Experience on 475 Cases
Malignant Melanoma in Turkey: A Single Institution s Experience on 475 Cases Faruk Tas, Sidika Kurul, Hakan Camlica and Erkan Topuz Institute of Oncology, Istanbul University, Istanbul, Turkey Received
More informationFOCUS. Friday, May 12, :00 am 3:15 pm. Attend in Person or View Livestream PennMedicine.org/Abramson/Melanoma OPEN TO THE PUBLIC
FOCUS ON HEALTH FREE EDUCATIONAL CONFERENCE Friday, May 12, 2017 8:00 am 3:15 pm Attend in Person or View Livestream PennMedicine.org/Abramson/Melanoma OPEN TO THE PUBLIC Hilton Philadelphia City Avenue
More informationPrecision Surgery for Melanoma
Precision Surgery for Melanoma Giorgos C. Karakousis, M.D. Assistant Professor of Surgery Perelman School of Medicine at the University of Pennsylvania Background 87,110 cases of melanoma estimated in
More informationWhen Do I Consider Myself Cured?
The Melanoma Patient Symposium - Science to Survivorship When Do I Consider Myself Cured? 26 September 2009 Jeffrey E. Gershenwald, MD, FACS Professor of Surgery, Dept. of Surgical Oncology Professor,
More informationDisclosures. SLNB for Melanoma 25/02/2014 SENTINEL LYMPH NODE BIOPSY FOR MELANOMA: CURRENT GUIDELINES AND THEIR CLINICAL APPLICATION
8 th Canadian Melanoma Conference February 22, 2014 Rimrock Resort Hotel, Banff, Alberta SENTINEL LYMPH NODE BIOPSY FOR MELANOMA: CURRENT GUIDELINES AND THEIR CLINICAL APPLICATION Christopher Bichakjian,
More informationImpact of Prognostic Factors
Melanoma Prognostic Factors: where we started, where are we going? Impact of Prognostic Factors Staging Management Surgical intervention Adjuvant treatment Suraj Venna, MD Assistant Clinical Professor,
More informationPrimary Cutaneous Melanoma Pathology Reporting Proforma DD MM YYYY. *Tumour site. *Specimen laterality. *Specimen type
Primary Cutaneous Melanoma Pathology Reporting Proforma Includes the International Collaboration on Cancer reporting dataset denoted by * Family name Given name(s) Date of birth DD MM YYYY Sex Male Female
More informationProposed All Wales Vulval Cancer Guidelines. Dr Amanda Tristram
Proposed All Wales Vulval Cancer Guidelines Dr Amanda Tristram Previous FIGO staging FIGO Stage Features TNM Ia Lesion confined to vulva with
More informationUpdates on Melanoma: Are You Following the Latest Guidelines of Care? Jerry Brewer, MD
Updates on Melanoma: Are You Following the Latest Guidelines of Care? Jerry Brewer, MD Disclosure Statement Update on Melanoma Are You Following the Latest Guidelines of Care? I, Jerry D. Brewer, MD, do
More informationProtocol applies to melanoma of cutaneous surfaces only.
Melanoma of the Skin Protocol applies to melanoma of cutaneous surfaces only. Procedures Biopsy (No Accompanying Checklist) Excision Re-excision Protocol revision date: January 2005 Based on AJCC/UICC
More informationMelanoma Underwriting Presented at 2018 AHOU Conference. Hank George FALU
Melanoma Underwriting Presented at 2018 AHOU Conference Hank George FALU MELANOMA EPIDEMIOLOGY 70-80,000 American cases annually Majority are in situ or thin > 20% are diagnosed age 45 8-9,000 melanoma
More informationDENOMINATOR: All melanoma pathology reports for primary malignant cutaneous melanoma
Quality ID #397: Melanoma Reporting National Quality Strategy Domain: Communication and Care Coordination Meaningful Measure Area: Transfer of Health Information and Interoperability 2019 COLLECTION TYPE:
More informationReport Back 12 th Canadian Melanoma Conference February 22 24, 2018
1 Report Back 12 th Canadian Melanoma Conference February 22 24, 2018 2 Below is a report back of major themes gleaned from the 12 th Annual Canadian Melanoma Conference along with some photos, anecdotes,
More informationHow can we reduce the mortality from melanoma in Australia?
How can we reduce the mortality from melanoma in Australia? Professor Grant McArthur MB BS PhD Peter MacCallum Cancer Centre Melbourne, Australia University of Melbourne, Parkville, Australia What is melanoma?
More informationMelanoma Quality Reporting
Melanoma Quality Reporting September 1, 2013 December 31, 2016 Laurence McCahill, MD Surgical Oncologist Metro Health Surgical Oncology Metro Health Professional Building 2122 Health Drive SW Wyoming,
More informationWork-up/Follow-up: Baseline and Surveillance Studies for Cutaneous Melanoma Patients
2018 AAD Annual Meeting, San Diego, CA Work-up/Follow-up: Baseline and Surveillance Studies for Cutaneous Melanoma Patients Susan M. Swetter, MD, FAAD Professor of Dermatology Director, Pigmented Lesion
More informationSpringer Healthcare. Staging and Diagnosing Cutaneous Melanoma. Concise Reference. Dirk Schadendorf, Corinna Kochs, Elisabeth Livingstone
Concise Reference Staging and Diagnosing Cutaneous Melanoma Dirk Schadendorf, Corinna Kochs, Elisabeth Livingstone Extracted from Handbook of Cutaneous Melanoma: A Guide to Diagnosis and Treatment Published
More informationJohan Lyth, J Hansson, C Ingvar, E Mansson-Brahme, P Naredi, U Stierner, G Wagenius and C Lindholm. Linköping University Post Print
Prognostic subclassifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark s level of invasion: results of a population-based study from the Swedish Melanoma Register Johan
More informationMichael T. Tetzlaff MD, PhD
Update on American Joint Cancer Committee (AJCC) staging system for primary cutaneous melanoma Emphasis on concise and accurate reporting of primary and metastatic melanoma for effective risk stratification
More informationTumor Mitotic Rate Added to the Equation: Melanoma Prognostic Factors Changed?
Ann Surg Oncol (2015) 22:2978 2987 DOI 10.1245/s10434-014-4349-3 ORIGINAL ARTICLE MELANOMAS Tumor Mitotic Rate Added to the Equation: Melanoma Prognostic Factors Changed? A Single-Institution Database
More informationNodal Treatment in Melanoma: Snow to MSLT-II
Nodal Treatment in Melanoma: Snow to MSLT-II Mark B. Faries, MD, FACS Director, Donald L. Morton Melanoma Research Program Program Director, JWCI Complex General Surgical Oncology Fellowship Director,
More informationPoor prognosis for thin ulcerated melanomas and implications for a more aggressive approach to treatment
Poor prognosis for thin ulcerated melanomas and implications for a more aggressive approach to treatment Makenzie L. Hawkins, MSPH 1 Matthew J. Rioth, MD 1,2 Megan M. Eguchi, MPH 1 Myles Cockburn, Phd
More informationSKIN CANCER. Most common cancer diagnosis 40% of all cancers
SKIN CANCER Most common cancer diagnosis 40% of all cancers OBJECTIVES Review common and uncommon cancers of the skin. Special emphasis on melanoma and dysplastic nevus Review pathology/tnm/staging, which
More informationMichael T. Tetzlaff MD, PhD
American Joint Cancer Committee (AJCC) staging system for primary cutaneous melanoma (8 th Edition) and principles of sentinel lymph node evaluation Emphasis on concise and accurate reporting of primary
More informationKatsuhiro Yamada, Natsuko Noguti, Masaaki Tsuda, Hazime Nagato, Naoko Hasunuma, Yoshihiro Umebayashi and Motomu Manabe
Akita J Med 36 : 45-52, 2009 45 Katsuhiro Yamada, Natsuko Noguti, Masaaki Tsuda, Hazime Nagato, Naoko Hasunuma, Yoshihiro Umebayashi and Motomu Manabe (Received 22 December 2008, Accepted 15 January 2009)
More information6. Cervical Lymph Nodes and Unknown Primary Tumors of the Head and Neck
1 Terms of Use The cancer staging form is a specific document in the patient record; it is not a substitute for documentation of history, physical examination, and staging evaluation, or for documenting
More informationAJCC Cancer Staging 8 th Edition
AJCC Cancer Staging 8 th Edition Colon and Rectal Cancer Staging Update Webinar George J Chang, MD, MS Deputy Chair, Department of Surgical Oncology Chief, Colon and Rectal Surgery Professor of Surgical
More information> 6000 Mutations in Melanoma. Tests That Cay Be Employed. FISH for Additions/Deletions. Comparative Genomic Hybridization
Winter Clinical 2017: The Assessment and Diagnosis of Melanoma Whitney A. High, MD, JD, MEng Associate Professor, Dermatology & Pathology Director of Dermatopathology (Dermatology) University of Colorado
More informationWho is the Ideal Candidate for PEG Intron?
Who is the Ideal Candidate for PEG Intron? Sanjiv S. Agarwala, MD Chief, Oncology & Hematology St. Luke s Cancer Center Professor, Temple University School of Medicine Philadelphia, PA, USA Overview Introduction
More informationCitation for published version (APA): Francken, A. B. (2007). Primary and metastatic melanoma: aspects of follow-up and staging s.n.
University of Groningen Primary and metastatic melanoma Francken, Anne Brecht IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check
More informationProtocol for the Examination of Specimens From Patients With Melanoma of the Skin
Protocol for the Examination of Specimens From Patients With Melanoma of the Skin Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition, AJCC Staging Manual For accreditation
More informationNPQR Quality Payment Program (QPP) Measures 21_18247_LS.
NPQR Quality Payment Program (QPP) Measures 21_18247_LS MEASURE ID: QPP 99 MEASURE TITLE: Breast Cancer Resection Pathology Reporting pt Category (Primary Tumor) and pn Category (Regional Lymph Nodes)
More informationCutaneous Melanoma: Epidemiology (USA) The Sentinel Node in Head and Neck Melanoma. Cutaneous Melanoma: Epidemiology (USA)
The Sentinel Node in Head and Neck Melanoma Cutaneous Melanoma: Epidemiology (USA) 6 th leading cause of cancer among men and women 68,720 new cases of invasive melanoma in 2009 8,650 deaths from melanoma
More information$884,000 to Melanoma Research
$884,000 to Melanoma Research EVERY DOLLAR IN GOES OUT! The Miller family funds all event and foundation costs so that every dollar raised goes directly to research and is 100% tax deductible. $734,000
More informationWhich melanoma patients benefit from genetic testing?
Which melanoma patients benefit from genetic testing? Michael A. Marchetti, MD Assistant Attending, Dermatology Service Memorial Sloan Kettering Cancer Center American Academy of Dermatology Annual Meeting
More information1
www.clinicaloncology.com.ua 1 Prognostic factors of appearing micrometastases in sentinel lymph nodes in skin melanoma M.N.Kukushkina, S.I.Korovin, O.I.Solodyannikova, G.G.Sukach, A.Yu.Palivets, A.N.Potorocha,
More informationMelanoma. Lynn Schuchter, M.D. Associate Professor of Medicine Abramson Cancer Center of the University of Pennsylvania
Melanoma Lynn Schuchter, M.D. Associate Professor of Medicine Abramson Cancer Center of the University of Pennsylvania WHAT IS MELANOMA? Melanoma is a type of skin cancer (a serious skin cancer because
More informationMalignant tumors of melanocytes : Part 3. Deba P Sarma, MD., Omaha
Malignant tumors of melanocytes : Part 3 Deba P Sarma, MD., Omaha Let s go over one case of melanoma using the following worksheet. Of the various essential information that needs to be included in the
More informationYou Are Going to Cut How Much Skin? Locoregional Surgical Treatment. Justin Rivard MD, MSc, FRCSC September 21, 2018
You Are Going to Cut How Much Skin? Locoregional Surgical Treatment Justin Rivard MD, MSc, FRCSC September 21, 2018 Presenter Disclosure Faculty/Speaker: Justin Rivard Relationships with financial sponsors:
More informationClinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience
2015;23(2):122-129 CLINICAL ARTICLE Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience Damir Homolak 1, Mirna Šitum 2,3, Hrvoje
More informationFinancial Disclosure. Learning Objectives. Review and Impact of the NCDB PUF. Moderator: Sandra Wong, MD, MS, FACS, FASCO
Review and Impact of the NCDB PUF Moderator: Sandra Wong, MD, MS, FACS, FASCO Financial Disclosure I do not have personal financial relationships with any commercial interests Learning Objectives At the
More informationNAACCR Webinar Series 1
Collecting Cancer Data: Melanoma 2013 2014 NAACCR Webinar Series April 3, 2014 Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching
More informationWhat's New in Oncodermatopathology: Immunotherapy Reactions
What's New in Oncodermatopathology: Immunotherapy Reactions Emily Y. Chu, M.D., Ph.D. Assistant Professor of Dermatology & Pathology and Laboratory Medicine Hospital of the University of Pennsylvania March
More informationResearch Article Prediction of Sentinel Node Status and Clinical Outcome in a Melanoma Centre
Skin Cancer Volume 2013, Article ID 904701, 7 pages http://dx.doi.org/10.1155/2013/904701 Research Article Prediction of Sentinel Node Status and Clinical Outcome in a Melanoma Centre Vera Teixeira, 1
More informationThin Melanoma. N Context. The incidence of malignant melanoma is
Thin Melanoma David E. Elder, MB ChB, FRCPA N Context. The incidence of malignant melanoma is increasing and a preponderance of the melanomas diagnosed today are thin in terms of Breslow criteria. Although
More informationJ Clin Oncol 27: by American Society of Clinical Oncology INTRODUCTION
VOLUME 27 NUMBER 36 DECEMBER 2 29 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T From Johns Hopkins Medical Institutions, Baltimore, MD; The University of Texas M. D. Anderson Cancer Center,
More informationORIGINAL ARTICLE. Clinical Node-Negative Thick Melanoma
ORIGINAL ARTICLE Clinical Node-Negative Thick Melanoma George I. Salti, MD; Ashwin Kansagra, MD; Michael A. Warso, MD; Salve G. Ronan, MD ; Tapas K. Das Gupta, MD, PhD, DSc Background: Patients with T4
More informationMelanoma. Kaushik Mukherjee MD A. Scott Pearson MD
Melanoma Kaushik Mukherjee MD A. Scott Pearson MD Disclosures You still have to study Not all inclusive No Western blots Extensive use of Google Image Search and Sabiston Melanoma Basics 8 th most common
More informationThe New AJCC: 8 th Edition and Beyond. 8th Edition AJCC Melanoma Staging System. Jeffrey E. Gershenwald, MD, FACS. AJCC Physician to Physician
AJCC Physician to Physician 8th Edition AJCC Melanoma Staging System Jeffrey E. Gershenwald, MD, FACS Dr. John M. Skibber Professor, Department of Surgical Oncology Professor, Department of Cancer Biology
More informationMelanoma. Walt Mudie - Block 5
Melanoma Walt Mudie - Block 5 Melanoma Graphic Warning Medical names: cutaneous melanoma (melanoma of skin), intraocular melanoma (melanoma of eye) Affects mainly skin, can also affect eye, vagina or anus
More informationPredictive Factors for the Positivity of the Sentinel Lymph Node in Malignant Melanoma
ORIGINAL RESEARCH SURGERY // ANATOMO-PATHOLOGY Predictive Factors for the Positivity of the Sentinel Lymph Node in Malignant Melanoma Călin Crăciun, Orsolya Hankó- Bauer, Zalán Benedek, Sorin Sorlea, Marius
More informationRebecca Vogel, PGY-4 March 5, 2012
Rebecca Vogel, PGY-4 March 5, 2012 Historical Perspective Changes In The Staging System Studies That Started The Talk Where We Go From Here Cutaneous melanoma has become an increasingly growing problem,
More information14. Mucosal Melanoma of the Head and Neck
1 Terms of Use The cancer staging form is a specific document in the patient record; it is not a substitute for documentation of history, physical examination, and staging evaluation, or for documenting
More informationPublished Ahead of Print on December 14, 2009 as /JCO J Clin Oncol by American Society of Clinical Oncology
Published Ahead of Print on December 14, 2009 as 10.1200/JCO.2009.24.7734 The latest version is at http://jco.ascopubs.org/cgi/doi/10.1200/jco.2009.24.7734 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L
More informationUpdate on Lymph Node Management in Melanoma
Update on Lymph Node Management in Melanoma John T. Vetto MD, FACS Professor of Surgery Division of Surgical Oncology Oregon Health & Science University Portland, Oregon Lymph Nodes in Melanoma Outline
More informationPrognosticators of melanoma, the melanoma report, and the sentinel lymph node
& 2006 USCAP, Inc All rights reserved 0893-3952/06 $30.00 www.modernpathology.org Prognosticators of melanoma, the melanoma report, and the sentinel lymph node A Neil Crowson 1, Cynthia M Magro 2 and Martin
More informationMichi Shinohara MD Associate Professor University of Washington/Seattle Cancer Care Alliance Dermatology, Dermatopathology
Michi Shinohara MD Associate Professor University of Washington/Seattle Cancer Care Alliance Dermatology, Dermatopathology Agenda Overview of cutaneous T and B- cell lymphomas Diagnosis, Staging, Prognosis
More informationDr. Brent Doolan, BSc MBBS MPH
Impact of partial biopsies on the need for complete excisional surgery in the management of cutaneous melanomas: A multi-centre review Dr. Brent Doolan, BSc MBBS MPH Peter MacCallum Cancer Centre, Melbourne
More informationSummary of 2009 MMIG Meeting (Merkel cell carcinoma Multi-center Interest Group)
Summary of 2009 MMIG Meeting (Merkel cell carcinoma Multi-center Interest Group) Friday March 6, 2009 American Academy of Dermatology Annual Meeting San Francisco, CA Prepared by Drs. Jayasri Iyer & Paul
More information6/22/2015. Original Paradigm. Correlating Histology and Molecular Findings in Melanocytic Neoplasms
6 Correlating Histology and Molecular Findings in Melanocytic Neoplasms Pedram Gerami MD, Associate Professor of Dermatology and Pediatrics at Northwestern University Disclosures: I have been a consultant
More informationMalignant Melanoma Early Stage. A guide for patients
This melanoma patient brochure is designed to help educate melanoma patients and their caregivers. It was developed under the guidance of Dr. Michael Smylie, Professor, Department of Oncology, University
More informationAn Overview of Melanoma. Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center
An Overview of Melanoma Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center Melanoma Statistics Median age at presentation 45-55 55 years Incidence: 2003 54,200 cases
More informationWhy Should I Be a Guinea Pig?
Why Should I Be a Guinea Pig? Jeffrey E. Lee, M.D. Section of Melanoma Surgery, Department of Surgical Oncology Medical Director, Ben Love/El Paso Corporation Melanoma and Skin Center Melanoma patient
More informationStaging for Residents, Nurses, and Multidisciplinary Health Care Team
Staging for Residents, Nurses, and Multidisciplinary Health Care Team Donna M. Gress, RHIT, CTR Validating science. Improving patient care. Learning Objectives Introduce the concept and history of stage
More informationEpithelial Cancer- NMSC & Melanoma
Epithelial Cancer- NMSC & Melanoma David Chin MB, BCh, BAO, LRCP, LRCS (Ireland) MCh(MD), PhD (UQ), FRCS, FRACS (Plast) Plastic & Reconstructive Surgeon Visiting Scientist Melanoma Genomic Group & Drug
More informationProtocol for the Examination of Specimens From Patients With Melanoma of the Skin
Protocol for the Examination of Specimens From Patients With Melanoma of the Skin Protocol applies to melanoma of cutaneous surfaces only. Based on AJCC/UICC TNM, 7th edition Protocol web posting date:
More informationSeventh Edition Staging 2017 Melanoma. Overview. This webinar is sponsored by. the Centers for Disease Control and Prevention.
Seventh Edition Staging 2017 Melanoma Donna M. Gress, RHIT, CTR Validating science. Improving patient care. No materials in this presentation may be repurposed in print or online without the express written
More informationClinical Pathological Conference. Malignant Melanoma of the Vulva
Clinical Pathological Conference Malignant Melanoma of the Vulva History F/48 Chinese Married Para 1 Presented in September 2004 Vulval mass for 2 months Associated with watery and blood stained discharge
More informationA PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL
A PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL OBJECTIVES Discuss current trends and changing concepts in our understanding of
More informationNOTES ON THE 7 TH EDITION ON TNM CLASSIFICATION OF SKIN TUMORS COMENTARII CU PRIVIRE LA CEA DE-A 7-A EDIȚIE A CLASIFICÃRII TNM A TUMORILOR CUTANATE
NOTES ON THE 7 TH EDITION ON TNM CLASSIFICATION OF SKIN TUMORS COMENTARII CU PRIVIRE LA CEA DE-A 7-A EDIȚIE A CLASIFICÃRII TNM A TUMORILOR CUTANATE Keywords: Skin tumours, TNM classification, Skin carcinoma,
More informationSkin Cancer. 5 Warning Signs. American Osteopathic College of Occupational and Preventive Medicine OMED 2012, San Diego, Monday, October 8, 2012 C-1
Skin Cancer AMERICAN OSTEOPATHIC COLLEGE OF OCCUPATIONAL & PREVENTIVE MEDICINE OMED 2012 October 8, 2012 E. Robert Wanat II, D.O., M.P.H. Learning Objectives: Identify the 3 Basic Types of Skin Cancer
More informationMerkel cell carcinoma: Diagnosis, staging, sentinel lymph node biopsy and prognostic markers
Merkel cell carcinoma: Diagnosis, staging, sentinel lymph node biopsy and prognostic markers Michael T. Tetzlaff MD, PhD Associate Professor Departments of Pathology (Dermatopathology) and Translational
More informationMELANOMA FOCUS ON 16 TH ANNUAL. Friday, May 11, :00 am 3:10 pm. Attend in Person or View Livestream PennMedicine.org/Abramson/Melanoma
16 TH ANNUAL FOCUS ON MELANOMA FREE EDUCATIONAL PROGRAM Friday, May 11, 2018 8:00 am 3:10 pm Attend in Person or View Livestream PennMedicine.org/Abramson/Melanoma OPEN TO THE PUBLIC Hilton Philadelphia
More informationLymph node ratio is an important and independent prognostic factor for patients with stage III melanoma.
Thomas Jefferson University Jefferson Digital Commons Department of Surgery Faculty Papers Department of Surgery 1-1-2012 Lymph node ratio is an important and independent prognostic factor for patients
More informationCarol Davila University of Medicine and Pharmacy, Bucharest, Romania b
Mædica - a Journal of Clinical Medicine MAEDICA a Journal of Clinical Medicine 2015; 10(3): 226-230 ORIGINAL PAPERS Improving Melanoma Path Reports: the Importance of Histopathological Parameters in Diagnosis
More informationBreslow Thickness and Clark Level Evaluation in Albanian Cutaneous Melanoma
Research DOI: 10.6003/jtad.16104a2 Breslow Thickness and Clark Level Evaluation in Albanian Cutaneous Melanoma Daniela Xhemalaj, MD, Mehdi Alimehmeti, MD, Susan Oupadia, MD, Majlinda Ikonomi, MD, Leart
More informationProtocol for the Examination of Specimens From Patients With Merkel Cell Carcinoma of the Skin
Protocol for the Examination of Specimens From Patients With Merkel Cell Carcinoma of the Skin Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition, AJCC Staging Manual
More informationDesmoplastic Melanoma: Surgical Management and Adjuvant Therapy
Desmoplastic Melanoma: Surgical Management and Adjuvant Therapy Dale Han, MD Assistant Professor Department of Surgery Section of Surgical Oncology No disclosures Background Desmoplastic melanoma (DM)
More informationUICC TNM 8 th Edition Errata
UICC TNM 8 th Edition Errata ions are in italics Page 28 Oropharynx p16 positive Pathological Stage II,T2 N2 M0 T3 N0,N1 M0 Stage II,T2 N2 M0 T3,T4 N0,N1 M0 Page 61 Oesophagus Adenocarcinoma Pathological
More information