Supplementary data Table S3. GO terms, pathways and networks enriched among the significantly correlating genes using Tox-Profiler

Transcription

1 Supplementary data Table S3. GO terms, pathways and networks enriched among the significantly correlating genes using Tox-Profiler DR CALUX Boys Girls Database Systemic lupus erythematosus KEGG RNA binding GO Neuroactive ligand-receptor interaction KEGG Natural killer cell mediated cytotoxicity KEGG nucleosome GO nucleosome assembly GO TGF-beta Receptor Signaling Pathway WikiPathways B Cell Receptor Signaling Pathway WikiPathways mrna processing GO T Cell Receptor Signaling Pathway BioCarta T Cell Receptor Signaling Pathway WikiPathways Electron Transport Chain WikiPathways Cytoplasmic Ribosomal Proteins WikiPathways Oxidative phosphorylation KEGG T cell receptor signaling pathway KEGG Ribosome KEGG RNA splicing GO mrna processing WikiPathways B cell receptor signaling pathway KEGG TNF-alpha-NF-kB Signaling Pathway WikiPathways nuclear speck GO Signaling Pathway from G-Protein Families BioCarta Huntington's disease KEGG nucleolus GO pathway GO translational elongation GO BCR Signaling Pathway BioCarta Parkinson's disease KEGG GPCRs, Class A Rhodopsin-like WikiPathways Proteasome Degradation WikiPathways Phagosome KEGG ERa CALUX Boys Girls Database Spliceosome KEGG mrna processing WikiPathways RNA splicing GO mrna processing GO RNA binding GO immune response GO cytosolic small ribosomal subunit GO nucleolus GO translational elongation GO structural constituent of ribosome GO ribosome GO cytosolic large ribosomal subunit GO

2 Graft-versus-host disease KEGG Autoimmune thyroid disease KEGG Allograft rejection KEGG Ribosome KEGG Viral myocarditis KEGG Antigen processing and presentation KEGG Natural killer cell mediated cytotoxicity KEGG T Cell Receptor Signaling Pathway WikiPathways Cytoplasmic Ribosomal Proteins WikiPathways spliceosomal complex GO Cell adhesion molecules (CAMs) KEGG B Cell Receptor Signaling Pathway WikiPathways Leishmaniasis KEGG Neuroactive ligand-receptor interaction KEGG cellular defense response GO Type I diabetes mellitus KEGG Intestinal immune network for IgA production KEGG TNF-alpha-NF-kB Signaling Pathway WikiPathways Staphylococcus aureus infection KEGG RNA transport KEGG cell surface receptor linked signaling pathway GO T Cell Receptor Signaling Pathway BioCarta Leukocyte transendothelial migration KEGG nucleoplasm GO rrna processing GO rrna binding GO MHC class I receptor activity GO heterogeneous nuclear ribonucleoprotein complex GO ion transport GO Systemic lupus erythematosus KEGG sequence-specific DNA binding GO AR CALUX Boys Girls Database ribosome GO structural constituent of ribosome GO Ribosome KEGG immune response GO ubiquitin-dependent protein catabolic process GO cytosolic small ribosomal subunit GO translational elongation GO cytosolic large ribosomal subunit GO Cytoplasmic Ribosomal Proteins WikiPathways modification-dependent protein catabolic process GO Cytokine-cytokine receptor interaction KEGG Staphylococcus aureus infection KEGG Graft-versus-host disease KEGG Autoimmune thyroid disease KEGG Allograft rejection KEGG Cell adhesion molecules (CAMs) KEGG Antigen processing and presentation KEGG

3 Type I diabetes mellitus KEGG cell surface receptor linked signaling pathway GO Ubiquitin mediated proteolysis KEGG Lck and Fyn tyrosine kinases in initiation of TCR Activation BioCarta CTL mediated immune response against target cells BioCarta ligase activity GO RNA splicing GO Systemic lupus erythematosus KEGG Neuroactive ligand-receptor interaction KEGG pathway GO threonine-type endopeptidase activity GO nucleosome GO Valine, leucine and isoleucine degradation KEGG Proteasome Complex BioCarta sensory perception of smell GO nucleosome assembly GO GPCRs, Class A Rhodopsin-like WikiPathways AA Hb Boys Girls Database cytosolic small ribosomal subunit GO translational elongation GO cytosolic large ribosomal subunit GO Ribosome KEGG Cytoplasmic Ribosomal Proteins WikiPathways structural constituent of ribosome GO ribosome GO endoplasmic reticulum GO Primary immunodeficiency KEGG Lysosome KEGG Electron Transport Chain WikiPathways endoplasmic reticulum membrane GO Oxidative phosphorylation KEGG Proteasome KEGG T Cell Receptor Signaling Pathway WikiPathways Diurnally regulated genes with circadian orthologs WikiPathways Cell adhesion molecules (CAMs) KEGG RNA splicing GO mrna processing WikiPathways Spliceosome KEGG spliceosomal complex GO GA Hb Boys Girls Database translational elongation GO Cytoplasmic Ribosomal Proteins WikiPathways Ribosome KEGG actin binding GO structural constituent of ribosome GO

4 MHC class II protein complex GO antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO Type I diabetes mellitus KEGG Bacterial invasion of epithelial cells KEGG Asthma KEGG Autoimmune thyroid disease KEGG Allograft rejection KEGG T Cell Receptor Signaling Pathway WikiPathways IL-3 Signaling Pathway WikiPathways B Cell Receptor Signaling Pathway WikiPathways Role of MEF2D in T-cell Apoptosis BioCarta Endocytosis KEGG Leukocyte transendothelial migration KEGG Wnt signaling pathway KEGG Focal adhesion KEGG MN Boys Girls Database translational elongation GO structural constituent of ribosome GO ribosome GO Ribosome KEGG Cytoplasmic Ribosomal Proteins WikiPathways Spliceosome KEGG spliceosomal complex GO mrna processing WikiPathways RNA splicing GO mrna processing GO RNA binding GO Hypertrophic cardiomyopathy (HCM) KEGG Proteasome KEGG Neuroactive ligand-receptor interaction KEGG cytosolic large ribosomal subunit GO Proteasome Degradation WikiPathways Leukocyte transendothelial migration KEGG T Cell Receptor Signaling Pathway WikiPathways IL-3 Signaling Pathway WikiPathways Natural killer cell mediated cytotoxicity KEGG cytosolic small ribosomal subunit GO Pathways in cancer KEGG nucleolus GO Phagosome KEGG pathway GO B Cell Receptor Signaling Pathway WikiPathways keratin filament GO Focal adhesion KEGG IL-2 Signaling Pathway WikiPathways TNF-alpha-NF-kB Signaling Pathway WikiPathways immune response GO

5 Antigen processing and presentation KEGG EGFR1 Signaling Pathway WikiPathways